AUB ScholarWorks

Antiphospholipid syndrome: Endocrinologic manifestations and organ involvement

Show simple item record

dc.contributor.author Mehdi A.A.
dc.contributor.author Salti I.
dc.contributor.author Uthman I.
dc.contributor.editor
dc.date Feb-2011
dc.date.accessioned 2017-10-05T15:38:02Z
dc.date.available 2017-10-05T15:38:02Z
dc.date.issued 2011
dc.identifier 10.1055/s-0030-1270071
dc.identifier.isbn
dc.identifier.issn 00946176
dc.identifier.uri http://hdl.handle.net/10938/16092
dc.description.abstract Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombotic tendency that affects most organ systems in the human body. In this report, we present a review of the endocrinologic manifestations associated with APS by evaluating the medical literature from 1968 to 2009 using MEDLINE and these keywords: APS, antiphospholipid syndrome, antiphospholipid antibodies, anticardiolipin antibodies, lupus anticoagulant, anti -2 glycoprotein I, pituitary, adrenal, thyroid, parathyroid, ovary, testes, diabetes mellitus, and diabetes insipidus. Adrenal insufficiency was found to be the most common endocrine manifestation associated with APS. Autoimmune thyroid disease was associated with increased titers of antiphospholipid antibodies (aPL) without any APS clinical manifestations. In addition, hypopituitarism and Sheehan syndrome are increasingly being reported in association with aPL. Data regarding the prevalence and significance of aPL in diabetic patients remains uncertain. Finally, only a few cases of ovarian and testicular derangements have been reported. APS should be considered in any patient with adrenal insufficiency even in the absence of other thrombotic manifestations. It is also advisable to assess aPL in the sera of patients presenting with pituitary insufficiency. Further studies are needed to clarify the relationship between aPL and thyroid disorders and diabetes mellitus. © 2011 by Thieme Medical Publishers, Inc.
dc.format.extent
dc.format.extent Pages: (49-57)
dc.language English
dc.relation.ispartof Publication Name: Seminars in Thrombosis and Hemostasis; Publication Year: 2011; Volume: 37; no. 1; Pages: (49-57);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Antiphospholipid syndrome: Endocrinologic manifestations and organ involvement
dc.type Article
dc.contributor.affiliation Mehdi, A.A., Division of Rheumatology, American University of Beirut, Beirut, Lebanon, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Salti, I., Division of Endocrinology, American University of Beirut, Beirut, Lebanon, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Uthman, I., Division of Rheumatology, American University of Beirut, Beirut, Lebanon, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.authorAddress Uthman, I.; Department of Internal Medicine, American University of Beirut, Medical Center, Riad El-Solh 1107, 2020 Beirut, Lebanon; email: iuthman@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials empty
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited
dc.description.citedCount 9
dc.description.citedTotWOSCount
dc.description.citedWOSCount
dc.format.extentCount 9
dc.identifier.articleNo
dc.identifier.coden STHMB
dc.identifier.pubmedID 21305801
dc.identifier.scopusID 79251520447
dc.identifier.url
dc.publisher.address
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr
dc.relation.ispartOfIssue 1
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Seminars in Thrombosis and Hemostasis
dc.relation.ispartofPubTitleAbbr Semin. Thromb. Hemost.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 37
dc.source.ID
dc.type.publication Journal
dc.subject.otherAuthKeyword adrenal
dc.subject.otherAuthKeyword Antiphospholipid syndrome
dc.subject.otherAuthKeyword diabetes
dc.subject.otherAuthKeyword pituitary
dc.subject.otherAuthKeyword thyroid
dc.subject.otherChemCAS vasopressin, 11000-17-2
dc.subject.otherIndex phospholipid antibody
dc.subject.otherIndex vasopressin
dc.subject.otherIndex adrenal gland
dc.subject.otherIndex adrenal insufficiency
dc.subject.otherIndex antiphospholipid syndrome
dc.subject.otherIndex article
dc.subject.otherIndex autoimmune thyroiditis
dc.subject.otherIndex clinical assessment
dc.subject.otherIndex cross reaction
dc.subject.otherIndex diabetes mellitus
dc.subject.otherIndex endocrine disease
dc.subject.otherIndex human
dc.subject.otherIndex hypophysis
dc.subject.otherIndex hypopituitarism
dc.subject.otherIndex Medline
dc.subject.otherIndex ovary
dc.subject.otherIndex parathyroid gland
dc.subject.otherIndex prevalence
dc.subject.otherIndex priority journal
dc.subject.otherIndex testis
dc.subject.otherIndex Adrenal Insufficiency
dc.subject.otherIndex Adult
dc.subject.otherIndex Antiphospholipid Syndrome
dc.subject.otherIndex Endocrine System Diseases
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Thyroid Diseases
dc.subject.otherKeywordPlus
dc.subject.otherWOS


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


Browse

My Account