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Fetal hemoglobin levels and morbidity in untransfused patients with β-thalassemia intermedia

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dc.contributor.author Musallam K.M.
dc.contributor.author Sankaran V.G.
dc.contributor.author Cappellini M.D.
dc.contributor.author Duca L.
dc.contributor.author Nathan D.G.
dc.contributor.author Taher A.T.
dc.contributor.editor
dc.date Jan-2012
dc.date.accessioned 2017-10-05T15:38:03Z
dc.date.available 2017-10-05T15:38:03Z
dc.date.issued 2012
dc.identifier 10.1182/blood-2011-09-382408
dc.identifier.isbn
dc.identifier.issn 00064971
dc.identifier.uri http://hdl.handle.net/10938/16115
dc.description.abstract To evaluate the association between fetal hemoglobin (HbF) levels and morbidity in β-thalassemia intermedia (TI), we analyzed data from 63 untransfused patients who had also never received HbF induction therapy. Patient records were reviewed for any history of 10 predefined morbidities. Laboratory measurements for markers of ineffective erythropoiesis were also obtained. The mean age of patients was 32.1 years, 47.6percent were males, and the median HbF level was 37.2percent. HbF levels correlated positively with total hemoglobin, yet negatively with growth differentiation factor-15 and non-transferrin-bound iron levels. Median HbF levels were significantly lower in patients with the majority of evaluated morbidities than in those without. There was a strong negative adjusted linear correlation between the HbF level and the total number of morbidities (R 2 = 0.825, P andlt; .001). The HbF threshold of 63.7percent had 95.5percent sensitivity and 100percent specificity for ensuring absence of morbidity. There exists a strong association between HbF levels and morbidity in the subset of untransfused patients with TI. © 2012 by The American Society of Hematology.
dc.format.extent
dc.format.extent Pages: (364-367)
dc.language English
dc.publisher WASHINGTON
dc.relation.ispartof Publication Name: Blood; Publication Year: 2012; Volume: 119; no. 2; Pages: (364-367);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Fetal hemoglobin levels and morbidity in untransfused patients with β-thalassemia intermedia
dc.type Article
dc.contributor.affiliation Musallam, K.M., Department of Medicine and Medical Specialties, Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS), Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy
dc.contributor.affiliation Sankaran, V.G., Department of Medicine, Children's Hospital Boston, Boston, MA, United States
dc.contributor.affiliation Cappellini, M.D., Department of Medicine and Medical Specialties, Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS), Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy
dc.contributor.affiliation Duca, L., Department of Medicine and Medical Specialties, Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS), Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy
dc.contributor.affiliation Nathan, D.G., Department of Medicine, Children's Hospital Boston, Boston, MA, United States, Dana-Farber Cancer Institute, Boston, MA, United States
dc.contributor.affiliation Taher, A.T., Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11-0236, Riad El-Solh 1107 2020, Beirut, Lebanon
dc.contributor.authorAddress Taher, A.T.; Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11-0236, Riad El-Solh 1107 2020, Beirut, Lebanon; email: ataher@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail ataher@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Musallam, KM
dc.contributor.authorInitials Sankaran, VG
dc.contributor.authorInitials Cappellini, MD
dc.contributor.authorInitials Duca, L
dc.contributor.authorInitials Nathan, DG
dc.contributor.authorInitials Taher, AT
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Taher, AT (reprint author), Amer Univ Beirut Med Ctr, Dept Internal Med, POB 11-0236,Riad El Solh 1107 2020, Beirut, Lebanon.
dc.contributor.authorResearcherID Duca, Lorena-K-6909-2012
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 14
dc.description.citedTotWOSCount 17
dc.description.citedWOSCount 17
dc.format.extentCount 4
dc.identifier.articleNo
dc.identifier.coden BLOOA
dc.identifier.pubmedID 22096240
dc.identifier.scopusID 84855848552
dc.identifier.url
dc.publisher.address 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA
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dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Blood
dc.relation.ispartOfIssue 2
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Blood
dc.relation.ispartofPubTitleAbbr Blood
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 119
dc.source.ID WOS:000299268900013
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS ferritin, 9007-73-2
dc.subject.otherChemCAS hemoglobin F, 9034-63-3
dc.subject.otherChemCAS iron, 14093-02-8, 53858-86-9, 7439-89-6
dc.subject.otherChemCAS Erythropoietin, 11096-26-7
dc.subject.otherChemCAS Fetal Hemoglobin, 9034-63-3
dc.subject.otherChemCAS Receptors, Transferrin
dc.subject.otherIndex ferritin
dc.subject.otherIndex growth differentiation factor 15
dc.subject.otherIndex hemoglobin F
dc.subject.otherIndex iron
dc.subject.otherIndex non transferrin bound iron
dc.subject.otherIndex unclassified drug
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex aged
dc.subject.otherIndex article
dc.subject.otherIndex beta thalassemia
dc.subject.otherIndex beta thalassemia intermedia
dc.subject.otherIndex child
dc.subject.otherIndex erythrocyte count
dc.subject.otherIndex erythropoiesis
dc.subject.otherIndex female
dc.subject.otherIndex ferritin blood level
dc.subject.otherIndex human
dc.subject.otherIndex laboratory test
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex medical history
dc.subject.otherIndex medical record review
dc.subject.otherIndex morbidity
dc.subject.otherIndex priority journal
dc.subject.otherIndex school child
dc.subject.otherIndex splenectomy
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Adult
dc.subject.otherIndex Aged
dc.subject.otherIndex beta-Thalassemia
dc.subject.otherIndex Child
dc.subject.otherIndex Cross-Sectional Studies
dc.subject.otherIndex Erythropoiesis
dc.subject.otherIndex Erythropoietin
dc.subject.otherIndex Female
dc.subject.otherIndex Fetal Hemoglobin
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Morbidity
dc.subject.otherIndex Receptors, Transferrin
dc.subject.otherIndex Young Adult
dc.subject.otherKeywordPlus SICKLE-CELL-DISEASE
dc.subject.otherKeywordPlus RISK-FACTORS
dc.subject.otherKeywordPlus IRON OVERLOAD
dc.subject.otherKeywordPlus ERYTHROPOIESIS
dc.subject.otherKeywordPlus MANAGEMENT
dc.subject.otherKeywordPlus HBS1L-MYB
dc.subject.otherKeywordPlus VARIANTS
dc.subject.otherKeywordPlus BCL11A
dc.subject.otherKeywordPlus RATES
dc.subject.otherKeywordPlus PAIN
dc.subject.otherWOS Hematology


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