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Brain positron emission tomography in splenectomized adults with β-thalassemia intermedia: Uncovering yet another covert abnormality

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dc.contributor.author Musallam K.M.
dc.contributor.author Nasreddine W.
dc.contributor.author Beydoun A.
dc.contributor.author Hourani R.
dc.contributor.author Hankir A.
dc.contributor.author Koussa S.
dc.contributor.author Haidar M.
dc.contributor.author Taher A.T.
dc.contributor.editor
dc.date Feb-2012
dc.date.accessioned 2017-10-05T15:38:04Z
dc.date.available 2017-10-05T15:38:04Z
dc.date.issued 2012
dc.identifier 10.1007/s00277-011-1291-3
dc.identifier.isbn
dc.identifier.issn 09395555
dc.identifier.uri http://hdl.handle.net/10938/16118
dc.description.abstract Covert brain infarction is an emerging concern in patients with β-thalassemia intermedia (TI). We have recently observed a high prevalence (60percent) of silent brain infarction on brain magnetic resonance imaging (MRI) in 30 splenectomized adults with TI. In this work, we further evaluate cerebral involvement in the same 30 patients using fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) scanning. The median age was 32 years (range, 18-54 years) with a male to female ratio of 13:17. Nineteen patients (63.3percent) had evidence of decreased neuronal function on PET-CT. Involvement was mostly left sided, multiple, and most commonly in the temporal and parietal lobes. Elevated liver iron concentration, beyond 15 mg Fe-g dry weight, characterized patients with decreased neuronal function. The concordance rate between brain MRI and PET-CT for the detection of brain abnormality was only 36.7percent (Kappa 0.056, P = 0.757), highlighting that both modalities reveal different types of brain pathology. Decreased neuronal function is a common finding in patients with TI and is associated with iron overload. Moreover, the addition of PET-CT to MRI identifies a greater proportion of TI patients with silent neuroimaging abnormalities. © 2011 Springer-Verlag.
dc.format.extent
dc.format.extent Pages: (235-241)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Annals of Hematology; Publication Year: 2012; Volume: 91; no. 2; Pages: (235-241);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Brain positron emission tomography in splenectomized adults with β-thalassemia intermedia: Uncovering yet another covert abnormality
dc.type Article
dc.contributor.affiliation Musallam, K.M., Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Riad El-Solh P.O. Box: 11-0236, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Nasreddine, W., Division of Neurology, Rafik Hariri University Hospital, Beirut, Lebanon
dc.contributor.affiliation Beydoun, A., Division of Neurology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Hourani, R., Department of Diagnostic Radiology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Hankir, A., Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Riad El-Solh P.O. Box: 11-0236, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Koussa, S., Chronic Care Center, Hazmieh, Lebanon
dc.contributor.affiliation Haidar, M., Department of Nuclear Medicine, PET Center, Mount Lebanon Hospital, Beirut, Lebanon
dc.contributor.affiliation Taher, A.T., Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Riad El-Solh P.O. Box: 11-0236, Beirut 1107 2020, Lebanon
dc.contributor.authorAddress Taher, A.T.; Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Riad El-Solh P.O. Box: 11-0236, Beirut 1107 2020, Lebanon; email: ataher@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Neurology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Neurology
dc.contributor.authorEmail ataher@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Musallam, KM
dc.contributor.authorInitials Nasreddine, W
dc.contributor.authorInitials Beydoun, A
dc.contributor.authorInitials Hourani, R
dc.contributor.authorInitials Hankir, A
dc.contributor.authorInitials Koussa, S
dc.contributor.authorInitials Haidar, M
dc.contributor.authorInitials Taher, AT
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Taher, AT (reprint author), American Univ, Beirut Med Ctr, Dept Internal Med, Div Hematol and Oncol, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 9
dc.description.citedTotWOSCount 12
dc.description.citedWOSCount 12
dc.format.extentCount 7
dc.identifier.articleNo
dc.identifier.coden ANHEE
dc.identifier.pubmedID 21750926
dc.identifier.scopusID 84857366913
dc.identifier.url
dc.publisher.address 233 SPRING ST, NEW YORK, NY 10013 USA
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dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Ann. Hematol.
dc.relation.ispartOfIssue 2
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Annals of Hematology
dc.relation.ispartofPubTitleAbbr Ann. Hematol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 91
dc.source.ID WOS:000299055000010
dc.type.publication Journal
dc.subject.otherAuthKeyword Brain
dc.subject.otherAuthKeyword Iron overload
dc.subject.otherAuthKeyword PET
dc.subject.otherAuthKeyword Splenectomy
dc.subject.otherAuthKeyword Thalassemia intermedia
dc.subject.otherChemCAS ferritin, 9007-73-2
dc.subject.otherChemCAS fluorodeoxyglucose f 18, 63503-12-8
dc.subject.otherChemCAS Fluorodeoxyglucose F18, 63503-12-8
dc.subject.otherIndex ferritin
dc.subject.otherIndex fluorodeoxyglucose f 18
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex beta thalassemia
dc.subject.otherIndex brain disease
dc.subject.otherIndex brain function
dc.subject.otherIndex clinical article
dc.subject.otherIndex computer assisted tomography
dc.subject.otherIndex controlled clinical trial
dc.subject.otherIndex controlled study
dc.subject.otherIndex disease association
dc.subject.otherIndex dry weight
dc.subject.otherIndex female
dc.subject.otherIndex frontal lobe
dc.subject.otherIndex histopathology
dc.subject.otherIndex human
dc.subject.otherIndex human tissue
dc.subject.otherIndex intermethod comparison
dc.subject.otherIndex iron overload
dc.subject.otherIndex liver
dc.subject.otherIndex male
dc.subject.otherIndex nuclear magnetic resonance imaging
dc.subject.otherIndex occipital lobe
dc.subject.otherIndex parietal lobe
dc.subject.otherIndex positron emission tomography
dc.subject.otherIndex priority journal
dc.subject.otherIndex risk factor
dc.subject.otherIndex sensitivity and specificity
dc.subject.otherIndex sex ratio
dc.subject.otherIndex splenectomy
dc.subject.otherIndex temporal lobe
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Adult
dc.subject.otherIndex beta-Thalassemia
dc.subject.otherIndex Brain Infarction
dc.subject.otherIndex Female
dc.subject.otherIndex Fluorodeoxyglucose F18
dc.subject.otherIndex Humans
dc.subject.otherIndex Iron Overload
dc.subject.otherIndex Magnetic Resonance Imaging
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Positron-Emission Tomography and Computed Tomography
dc.subject.otherIndex Prospective Studies
dc.subject.otherIndex Risk Factors
dc.subject.otherIndex Splenectomy
dc.subject.otherKeywordPlus SICKLE-CELL-DISEASE
dc.subject.otherKeywordPlus MAGNETIC-RESONANCE
dc.subject.otherKeywordPlus HYPERCOAGULABLE STATE
dc.subject.otherKeywordPlus GLUCOSE-METABOLISM
dc.subject.otherKeywordPlus CHILDREN
dc.subject.otherKeywordPlus IRON
dc.subject.otherKeywordPlus ANEMIA
dc.subject.otherKeywordPlus STROKE
dc.subject.otherKeywordPlus ACCUMULATION
dc.subject.otherKeywordPlus MANAGEMENT
dc.subject.otherWOS Hematology


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