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A randomized single-blind trial of split-dose PEG-electrolyte solution without dietary restriction compared with whole dose PEG-electrolyte solution with dietary restriction for colonoscopy preparation

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dc.contributor.author Aoun E.
dc.contributor.author Abdul-Baki H.
dc.contributor.author Azar C.
dc.contributor.author Mourad F.
dc.contributor.author Barada K.
dc.contributor.author Berro Z.
dc.contributor.author Tarchichi M.
dc.contributor.author Sharara A.I.
dc.contributor.editor
dc.date Aug-2005
dc.date.accessioned 2017-10-05T15:38:19Z
dc.date.available 2017-10-05T15:38:19Z
dc.date.issued 2005
dc.identifier 10.1016/S0016-5107(05)00371-8
dc.identifier.isbn
dc.identifier.issn 00165107
dc.identifier.uri http://hdl.handle.net/10938/16272
dc.description.abstract Background: Colonoscopy preparation regimens are poorly tolerated, requiring the use of a large volume of an unpalatable solution and diet restriction for adequate cleansing. The aim of this study was to compare the efficacy of two regimens of bowel preparation before colonoscopy: a whole dose of polyethylene glycol electrolyte solution (PEG-E), with diet restriction vs. a split dose with no diet restriction. Methods: A total of 141 patients (ages 20-84 years, 81 men) were randomly assigned to receive either 4 L PEG-E, along with a liquid diet the day before colonoscopy (Group A) or 2 L PEG-E with a regular diet the day before colonoscopy followed by another 2 L PEG-E on the day of the procedure (Group B). The quality of the preparation was graded by the endoscopist (poor to excellent), who was blinded to the type of preparation. Tolerability of the assigned preparation and adverse effects were recorded by an independent investigator by using a questionnaire administered before colonoscopy. Intra- and interobserver variability was studied by using randomly chosen videotapes of colonoscopies performed as part of the study. Results: There were 73 patients in Group A and 68 patients in Group B. The quality of the preparation was significantly better in Group B (p = 0.011). The tolerability of the preparation regimen was not different overall between study groups in terms of side effects (except for bloating, which was more frequent in Group B, p = 0.039) or willingness to repeat the preparation. There was a nonsignificant trend toward improved adherence to the assigned preparation in favor of Group B (p = 0.062). Inter- and intraobserver variability analysis showed good to excellent correlation among endoscopists. Conclusions: Colonic preparation with split-dose PEG-E and no dietary restriction provides better quality colon cleansing than whole-dose preparation, with no significant impact on patient tolerability and side effects. Copyright © 2005 by the American Society for Gastrointestinal Endoscopy.
dc.format.extent
dc.format.extent Pages: (213-218)
dc.language English
dc.publisher ST LOUIS
dc.relation.ispartof Publication Name: Gastrointestinal Endoscopy; Publication Year: 2005; Volume: 62; no. 2; Pages: (213-218);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title A randomized single-blind trial of split-dose PEG-electrolyte solution without dietary restriction compared with whole dose PEG-electrolyte solution with dietary restriction for colonoscopy preparation
dc.type Article
dc.contributor.affiliation Aoun, E., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Abdul-Baki, H., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Azar, C., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Mourad, F., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Barada, K., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Berro, Z., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Tarchichi, M., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Sharara, A.I., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon, Gastroenterology Division, American University, Beirut Medical Center, P.O. Box 11-0236, Beirut 1107 2020, Lebanon
dc.contributor.authorAddress Sharara, A.I.; Gastroenterology Division, American University, Beirut Medical Center, P.O. Box 11-0236, Beirut 1107 2020, Lebanon
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Gastroenterology and Hepatology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Gastroenterology and Hepatology
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Aoun, E
dc.contributor.authorInitials Abdul-Baki, H
dc.contributor.authorInitials Azar, C
dc.contributor.authorInitials Mourad, F
dc.contributor.authorInitials Barada, K
dc.contributor.authorInitials Berro, Z
dc.contributor.authorInitials Tarchichi, M
dc.contributor.authorInitials Sharara, AI
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Sharara, AI (reprint author), Amer Univ Beirut, Med Ctr, Dept Internal Med, Div Gastroenterol, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 134
dc.description.citedTotWOSCount 128
dc.description.citedWOSCount 126
dc.format.extentCount 6
dc.identifier.articleNo
dc.identifier.coden GAENB
dc.identifier.pubmedID 16046981
dc.identifier.scopusID 22544438469
dc.identifier.url
dc.publisher.address 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Gastrointest. Endosc.
dc.relation.ispartOfIssue 2
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Gastrointestinal Endoscopy
dc.relation.ispartofPubTitleAbbr Gastrointest. Endosc.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 62
dc.source.ID WOS:000231031000004
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS macrogol 4000, 88747-22-2
dc.subject.otherChemCAS Electrolytes
dc.subject.otherChemCAS Polyethylene Glycols
dc.subject.otherIndex laxative
dc.subject.otherIndex macrogol 4000
dc.subject.otherIndex abdominal cramp
dc.subject.otherIndex adult
dc.subject.otherIndex aged
dc.subject.otherIndex article
dc.subject.otherIndex bloating
dc.subject.otherIndex clinical trial
dc.subject.otherIndex colonoscopy
dc.subject.otherIndex controlled clinical trial
dc.subject.otherIndex controlled study
dc.subject.otherIndex correlation analysis
dc.subject.otherIndex diet restriction
dc.subject.otherIndex drug safety
dc.subject.otherIndex drug tolerability
dc.subject.otherIndex endoscopy
dc.subject.otherIndex female
dc.subject.otherIndex headache
dc.subject.otherIndex human
dc.subject.otherIndex intestine preparation
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex nausea
dc.subject.otherIndex priority journal
dc.subject.otherIndex questionnaire
dc.subject.otherIndex randomized controlled trial
dc.subject.otherIndex single blind procedure
dc.subject.otherIndex sleep disorder
dc.subject.otherIndex statistical significance
dc.subject.otherIndex videotape
dc.subject.otherIndex vomiting
dc.subject.otherIndex Adult
dc.subject.otherIndex Aged
dc.subject.otherIndex Aged, 80 and over
dc.subject.otherIndex Colonoscopy
dc.subject.otherIndex Diet
dc.subject.otherIndex Drug Tolerance
dc.subject.otherIndex Electrolytes
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Patient Acceptance of Health Care
dc.subject.otherIndex Polyethylene Glycols
dc.subject.otherIndex Single-Blind Method
dc.subject.otherKeywordPlus ORAL SODIUM-PHOSPHATE
dc.subject.otherKeywordPlus 3 BOWEL PREPARATIONS
dc.subject.otherKeywordPlus POLYETHYLENE-GLYCOL
dc.subject.otherKeywordPlus LAVAGE SOLUTION
dc.subject.otherKeywordPlus BISACODYL
dc.subject.otherKeywordPlus TOLERANCE
dc.subject.otherKeywordPlus EFFICACY
dc.subject.otherKeywordPlus CHILDREN
dc.subject.otherKeywordPlus VOLUME
dc.subject.otherKeywordPlus WATER
dc.subject.otherWOS Gastroenterology and Hepatology


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