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Potential mechanisms for renal damage in beta-thalassemia

Show simple item record Mallat N.S. Mallat S.G. Musallam K.M. Taher A.T.
dc.contributor.editor Sep-2013 2017-10-05T15:38:28Z 2017-10-05T15:38:28Z 2013
dc.identifier 10.5301/jn.5000253
dc.identifier.issn 11218428
dc.description.abstract Improvement of survival in patients with β-thalassemia has allowed several clinical morbidities to manifest, including renal complications. Patients may experience proximal tubular dysfunctions and abnormalities in glomerular filtration rate. Several risk factors have been proposed. Hypoxia may lead to renal damage with resulting proximal tubular epithelial cell dysfunction and interstitial fibrosis, while anemia induces renal hemodynamic changes. Iron overload secondary to regular transfusion therapy can also result in an increase in oxidative stress and direct cytotoxicity to the kidney. Moreover, the use of certain iron-chelating agents is associated with a transient, nonprogressive increase in serum creatinine levels. However, most available evidence comes from small, cross-sectional studies. Longitudinal follow-up of patients is needed to better understand the mechanisms of renal abnormalities in this patient population. © 2013 Società Italiana di Nefrologia.
dc.format.extent Pages: (821-828)
dc.language English
dc.publisher MILAN
dc.relation.ispartof Publication Name: Journal of Nephrology; Publication Year: 2013; Volume: 26; no. 5; Pages: (821-828);
dc.source Scopus
dc.title Potential mechanisms for renal damage in beta-thalassemia
dc.type Review
dc.contributor.affiliation Mallat, N.S., Department of Internal Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Mallat, S.G., Department of Internal Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Musallam, K.M., Department of Medicine and Medical Specialties, IRCCS Ca' Granda Foundation, Maggiore Policlinico Hospital, Milan, Italy
dc.contributor.affiliation Taher, A.T., Department of Internal Medicine, American University of Beirut, Beirut, Lebanon, Chronic Care Center, Hazmieh, Lebanon
dc.contributor.authorAddress Taher, A. T.; Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11-0236, Riad El-Solh 1107 2020, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Mallet, NS
dc.contributor.authorInitials Mallet, SG
dc.contributor.authorInitials Musallam, KM
dc.contributor.authorInitials Taher, AT
dc.contributor.authorReprintAddress Taher, AT (reprint author), Amer Univ Beirut, Med Ctr, Dept Internal Med, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 3
dc.description.citedTotWOSCount 2
dc.description.citedWOSCount 2
dc.format.extentCount 8
dc.identifier.coden JLNEE
dc.identifier.pubmedID 23475461
dc.identifier.scopusID 84884662918
dc.publisher.address 72-74 VIA FRIULI, 20135 MILAN, ITALY
dc.relation.ispartOfISOAbbr J. Nephrol.
dc.relation.ispartOfIssue 5
dc.relation.ispartofPubTitle Journal of Nephrology
dc.relation.ispartofPubTitleAbbr J. Nephrol.
dc.relation.ispartOfVolume 26
dc.source.ID WOS:000327582200004
dc.type.publication Journal
dc.subject.otherAuthKeyword Anemia
dc.subject.otherAuthKeyword Hypoxia
dc.subject.otherAuthKeyword Iron chelation
dc.subject.otherAuthKeyword Iron overload
dc.subject.otherAuthKeyword Kidney
dc.subject.otherAuthKeyword Thalassemia
dc.subject.otherChemCAS adenosine triphosphate, 15237-44-2, 56-65-5, 987-65-5
dc.subject.otherChemCAS deferasirox, 201530-41-8
dc.subject.otherChemCAS deferiprone, 30652-11-0
dc.subject.otherChemCAS deferoxamine mesylate, 138-14-7, 5115-09-3
dc.subject.otherChemCAS malonaldehyde, 542-78-9
dc.subject.otherChemCAS n acetyl beta glucosaminidase, 37278-88-9
dc.subject.otherChemCAS nitric oxide, 10102-43-9
dc.subject.otherChemCAS procollagen proline 2 oxoglutarate 4 dioxygenase, 9028-06-2
dc.subject.otherChemCAS vasculotropin, 127464-60-2
dc.subject.otherIndex adenosine triphosphate
dc.subject.otherIndex deferasirox
dc.subject.otherIndex deferiprone
dc.subject.otherIndex deferoxamine mesylate
dc.subject.otherIndex endothelin
dc.subject.otherIndex endothelin A receptor antagonist
dc.subject.otherIndex hypoxia inducible factor
dc.subject.otherIndex malonaldehyde
dc.subject.otherIndex n acetyl beta glucosaminidase
dc.subject.otherIndex nitric oxide
dc.subject.otherIndex procollagen proline 2 oxoglutarate 4 dioxygenase
dc.subject.otherIndex vasculotropin
dc.subject.otherIndex abdominal pain
dc.subject.otherIndex anemia
dc.subject.otherIndex beta 2 microglobulin urine level
dc.subject.otherIndex beta thalassemia
dc.subject.otherIndex blood transfusion
dc.subject.otherIndex creatinine blood level
dc.subject.otherIndex diarrhea
dc.subject.otherIndex drug dose reduction
dc.subject.otherIndex drug overdose
dc.subject.otherIndex drug substitution
dc.subject.otherIndex drug withdrawal
dc.subject.otherIndex Fanconi renotubular syndrome
dc.subject.otherIndex glomerulus filtration rate
dc.subject.otherIndex human
dc.subject.otherIndex hyperchloremic acidosis
dc.subject.otherIndex hypoxia
dc.subject.otherIndex iron chelation
dc.subject.otherIndex iron overload
dc.subject.otherIndex kidney disease
dc.subject.otherIndex kidney failure
dc.subject.otherIndex kidney fibrosis
dc.subject.otherIndex long term survival
dc.subject.otherIndex nausea
dc.subject.otherIndex nonhuman
dc.subject.otherIndex oxidative stress
dc.subject.otherIndex pathogenesis
dc.subject.otherIndex patient compliance
dc.subject.otherIndex rash
dc.subject.otherIndex renal protection
dc.subject.otherIndex renin angiotensin aldosterone system
dc.subject.otherIndex review
dc.subject.otherIndex side effect
dc.subject.otherIndex thalassemia minor
dc.subject.otherIndex tubular dysfunction
dc.subject.otherKeywordPlus ACUTE INTERSTITIAL NEPHRITIS
dc.subject.otherKeywordPlus TRANSFUSIONAL IRON OVERLOAD
dc.subject.otherKeywordPlus CHRONIC KIDNEY-DISEASE
dc.subject.otherKeywordPlus DEFEROXAMINE OVERDOSE
dc.subject.otherKeywordPlus LIPID-PEROXIDATION
dc.subject.otherKeywordPlus PEDIATRIC-PATIENTS
dc.subject.otherKeywordPlus ENDOTHELIAL-CELLS
dc.subject.otherKeywordPlus CHELATION-THERAPY
dc.subject.otherKeywordPlus FANCONI SYNDROME
dc.subject.otherKeywordPlus CHRONIC HYPOXIA
dc.subject.otherWOS Urology and Nephrology

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