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Cardiac sarcoidosis responding to monotherapy with infliximab

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dc.contributor.author Uthman I.
dc.contributor.author Touma Z.
dc.contributor.author Khoury M.
dc.contributor.editor
dc.date Nov-2007
dc.date.accessioned 2017-10-05T15:39:05Z
dc.date.available 2017-10-05T15:39:05Z
dc.date.issued 2007
dc.identifier 10.1007/s10067-007-0614-1
dc.identifier.isbn
dc.identifier.issn 07703198
dc.identifier.uri http://hdl.handle.net/10938/16666
dc.description.abstract Cardiac involvement is a rare and potentially life-threatening complication of sarcoidosis. We report the case of a young previously healthy woman who presented with complete atrioventricular heart block. Further evaluation revealed non-caseating granulomas in the hilar and mediastinal regions. A pacemaker was inserted, and she was treated with four doses of infliximab after she refused treatment with steroids. Rapid resolution of the pulmonary lymph nodes was documented and repeated interrogations of the pacemaker 1 year after her last infliximab infusion documented that she was in sinus rhythm. Infliximab may be considered as an alternative first-line therapy in sarcoidosis with serious organ involvement. © Clinical Rheumatology 2007.
dc.format.extent
dc.format.extent Pages: (2001-2003)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Clinical Rheumatology; Publication Year: 2007; Volume: 26; no. 11; Pages: (2001-2003);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Cardiac sarcoidosis responding to monotherapy with infliximab
dc.type Article
dc.contributor.affiliation Uthman, I., Department of Internal Medicine, Faculty of Medicine, American University of Beirut Medical Center, Hamra Street, Beirut 1103 2090, Lebanon
dc.contributor.affiliation Touma, Z., Department of Internal Medicine, Faculty of Medicine, American University of Beirut Medical Center, Hamra Street, Beirut 1103 2090, Lebanon
dc.contributor.affiliation Khoury, M., Department of Internal Medicine, Faculty of Medicine, American University of Beirut Medical Center, Hamra Street, Beirut 1103 2090, Lebanon
dc.contributor.authorAddress Uthman, I.; Department of Internal Medicine, Faculty of Medicine, American University of Beirut Medical Center, Hamra Street, Beirut 1103 2090, Lebanon; email: iuthman@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail iuthman@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Uthman, I
dc.contributor.authorInitials Touma, Z
dc.contributor.authorInitials Khoury, M
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Uthman, I (reprint author), Amer Univ Beirut, Ctr Med, Dept Internal Med, Fac Med, Hamra St 1103, Beirut 2090, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Baughman RP, 2001, SARCOIDOSIS VASC DIF, V18, P70; Baughman RP, 2006, AM J RESP CRIT CARE, V174, P795, DOI 10.1164-rccm.200603-402OC; Carter JD, 2004, AM J MED, V117, P277, DOI 10.1016-j.amjmed.2004.03.013; Chapelon-Abric C, 2004, MEDICINE, V83, P315, DOI 10.1097-01.md.0000145367.17934.75; Chung ES, 2003, CIRCULATION, V107, P3133, DOI 10.1161-01.CIR.0000077913.60364.D2; Doty JD, 2005, CHEST, V127, P1064, DOI 10.1378-chest.127.3.1064; IWAI K, 1994, SARCOIDOSIS, V11, P26; Prior C, 1996, EUR RESPIR J, V9, P47, DOI 10.1183-09031936.96.09010047; Roach DR, 2002, J IMMUNOL, V168, P4620; Shabetai R, 2000, CURR TREAT OPTIONS C, V2, P385, DOI 10.1007-s11936-000-0034-x; Sharma OP, 2003, CHEST, V123, P18, DOI 10.1378-chest.123.1.18; SILVERMAN KJ, 1978, CIRCULATION, V58, P1204; Ulbricht KU, 2003, ARTHRITIS RHEUM, V48, P3542, DOI 10.1002-art.11357; Veinot JP, 1998, J FORENSIC SCI, V43, P715; Yee AMF, 2001, ANN INTERN MED, V135, P27
dc.description.citedCount 32
dc.description.citedTotWOSCount 24
dc.description.citedWOSCount 23
dc.format.extentCount 3
dc.identifier.articleNo
dc.identifier.coden CLRHD
dc.identifier.pubmedID 17394036
dc.identifier.scopusID 34948841526
dc.identifier.url
dc.publisher.address 233 SPRING STREET, NEW YORK, NY 10013 USA
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dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
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dc.relation.ispartOfISOAbbr Clin. Rheumatol.
dc.relation.ispartOfIssue 11
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Clinical Rheumatology
dc.relation.ispartofPubTitleAbbr Clin. Rheumatol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 26
dc.source.ID WOS:000249813700044
dc.type.publication Journal
dc.subject.otherAuthKeyword Heart block
dc.subject.otherAuthKeyword Infliximab
dc.subject.otherAuthKeyword Sarcoidosis
dc.subject.otherAuthKeyword Tumor necrosis factor
dc.subject.otherChemCAS infliximab, 170277-31-3
dc.subject.otherChemCAS Antibodies, Monoclonal
dc.subject.otherChemCAS Antirheumatic Agents
dc.subject.otherChemCAS infliximab
dc.subject.otherIndex corticosteroid
dc.subject.otherIndex infliximab
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex artificial heart pacemaker
dc.subject.otherIndex atrioventricular block
dc.subject.otherIndex bradycardia
dc.subject.otherIndex bronchoscopy
dc.subject.otherIndex case report
dc.subject.otherIndex clinical feature
dc.subject.otherIndex drug response
dc.subject.otherIndex electrocardiogram
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex human tissue
dc.subject.otherIndex lung biopsy
dc.subject.otherIndex lung granuloma
dc.subject.otherIndex monotherapy
dc.subject.otherIndex priority journal
dc.subject.otherIndex sarcoidosis
dc.subject.otherIndex Adult
dc.subject.otherIndex Antibodies, Monoclonal
dc.subject.otherIndex Antirheumatic Agents
dc.subject.otherIndex Female
dc.subject.otherIndex Heart Block
dc.subject.otherIndex Heart Diseases
dc.subject.otherIndex Humans
dc.subject.otherIndex Lymph Nodes
dc.subject.otherIndex Myocardium
dc.subject.otherIndex Sarcoidosis
dc.subject.otherIndex Treatment Outcome
dc.subject.otherKeywordPlus NECROSIS-FACTOR-ALPHA
dc.subject.otherKeywordPlus THERAPY
dc.subject.otherWOS Rheumatology


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