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Febrile neutropenia and hemorrhagic stroke in a thalassemia major patient

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dc.contributor.author Sheikh-Taha M.
dc.contributor.author Koussa S.
dc.contributor.author Inati A.
dc.contributor.author Taher A.
dc.contributor.editor
dc.date Oct-2007
dc.date.accessioned 2017-10-05T15:39:05Z
dc.date.available 2017-10-05T15:39:05Z
dc.date.issued 2007
dc.identifier 10.1080/03630260701641211
dc.identifier.isbn
dc.identifier.issn 03630269
dc.identifier.uri http://hdl.handle.net/10938/16669
dc.description.abstract A 36-year-old transfusion-dependent thalassemia major patient presented with febrile neutropenia and anemia. Deferiprone (L1) was discontinued as it was suspected to be the offending agent and prompt broad-spectrum antibiotic therapy was initiated after which the patient improved. After 11 days the patient developed hemorrhagic stroke and seizure whereby aspirin was discontinued and supportive therapy was given. Agranulocytosis is the most serious complication reported with L1 but, to the best of our knowledge, there are no previous reports on hemorrhagic stroke associated with the use of the agent, and hence, the etiology of the stroke which followed agranulocytosis caused by L1 remains obscure. Copyright © Informa Healthcare USA, Inc.
dc.format.extent
dc.format.extent Pages: (499-501)
dc.language English
dc.publisher PHILADELPHIA
dc.relation.ispartof Publication Name: Hemoglobin; Publication Year: 2007; Volume: 31; no. 4; Pages: (499-501);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Febrile neutropenia and hemorrhagic stroke in a thalassemia major patient
dc.type Article
dc.contributor.affiliation Sheikh-Taha, M., Lebanese American University, Byblos, Lebanon
dc.contributor.affiliation Koussa, S., Chronic Care Center, Hazmieh, Lebanon
dc.contributor.affiliation Inati, A., Chronic Care Center, Hazmieh, Lebanon
dc.contributor.affiliation Taher, A., Chronic Care Center, Hazmieh, Lebanon, American University of Beirut Medical Center, Beirut, Lebanon, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon, P.O. Box 11-0236, Riad El Solh 1107 2020, Lebanon
dc.contributor.authorAddress Taher, A.; Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon; email: ataher@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail ataher@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Sheikh-Taha, M
dc.contributor.authorInitials Koussa, S
dc.contributor.authorInitials Inati, A
dc.contributor.authorInitials Taher, A
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Taher, A (reprint author), Amer Univ Beirut, Med Ctr, Dept Internal Med, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited ALREFAIE FN, 1995, BRIT J HAEMATOL, V91, P224, DOI 10.1111-j.1365-2141.1995.tb05274.x; ALREFAIE FN, 1992, BLOOD, V80, P593; Ceci A, 2002, BRIT J HAEMATOL, V118, P330, DOI 10.1046-j.1365-2141.2002.03554.x; Cohen AR, 2003, BLOOD, V102, P1583, DOI 10.1182-blood-2002-10-3280; Thrift AG, 1999, BRIT MED J, V318, P759
dc.description.citedCount 1
dc.description.citedTotWOSCount 2
dc.description.citedWOSCount 2
dc.format.extentCount 3
dc.identifier.articleNo
dc.identifier.coden HEMOD
dc.identifier.pubmedID 17994386
dc.identifier.scopusID 36248991398
dc.identifier.url
dc.publisher.address 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Hemoglobin
dc.relation.ispartOfIssue 4
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Hemoglobin
dc.relation.ispartofPubTitleAbbr Hemoglobin
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 31
dc.source.ID WOS:000250921600014
dc.type.publication Journal
dc.subject.otherAuthKeyword Deferiprone (L1)
dc.subject.otherAuthKeyword Febrile neutropenia
dc.subject.otherAuthKeyword Hemorrhagic stroke
dc.subject.otherAuthKeyword Thalassemia major
dc.subject.otherChemCAS acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1
dc.subject.otherChemCAS cefepime, 88040-23-7
dc.subject.otherChemCAS deferiprone, 30652-11-0
dc.subject.otherChemCAS phenytoin, 57-41-0, 630-93-3
dc.subject.otherChemCAS recombinant granulocyte colony stimulating factor, 121181-53-1
dc.subject.otherChemCAS teicoplanin, 61036-62-2, 61036-64-4
dc.subject.otherChemCAS valproic acid, 1069-66-5, 99-66-1
dc.subject.otherChemCAS deferiprone, 30652-11-0
dc.subject.otherChemCAS Iron Chelating Agents
dc.subject.otherChemCAS Pyridones
dc.subject.otherIndex acetylsalicylic acid
dc.subject.otherIndex antibiotic agent
dc.subject.otherIndex cefepime
dc.subject.otherIndex deferiprone
dc.subject.otherIndex granulocyte colony stimulating factor receptor
dc.subject.otherIndex phenytoin
dc.subject.otherIndex recombinant granulocyte colony stimulating factor
dc.subject.otherIndex teicoplanin
dc.subject.otherIndex valproic acid
dc.subject.otherIndex adult
dc.subject.otherIndex agranulocytosis
dc.subject.otherIndex anamnesis
dc.subject.otherIndex anemia
dc.subject.otherIndex article
dc.subject.otherIndex blood cell count
dc.subject.otherIndex blood culture
dc.subject.otherIndex blood transfusion
dc.subject.otherIndex brain angiography
dc.subject.otherIndex brain hemorrhage
dc.subject.otherIndex case report
dc.subject.otherIndex computer assisted tomography
dc.subject.otherIndex drug substitution
dc.subject.otherIndex drug withdrawal
dc.subject.otherIndex febrile neutropenia
dc.subject.otherIndex female
dc.subject.otherIndex hemorrhagic stroke
dc.subject.otherIndex human
dc.subject.otherIndex laboratory test
dc.subject.otherIndex leukocyte count
dc.subject.otherIndex seizure
dc.subject.otherIndex stroke
dc.subject.otherIndex thalassemia major
dc.subject.otherIndex throat culture
dc.subject.otherIndex treatment outcome
dc.subject.otherIndex urine culture
dc.subject.otherIndex Adult
dc.subject.otherIndex Agranulocytosis
dc.subject.otherIndex beta-Thalassemia
dc.subject.otherIndex Blood Transfusion
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Intracranial Hemorrhages
dc.subject.otherIndex Iron Chelating Agents
dc.subject.otherIndex Neutropenia
dc.subject.otherIndex Pyridones
dc.subject.otherIndex Splenectomy
dc.subject.otherKeywordPlus DEFERIPRONE
dc.subject.otherKeywordPlus THERAPY
dc.subject.otherKeywordPlus SAFETY
dc.subject.otherWOS Biochemistry and Molecular Biology
dc.subject.otherWOS Hematology


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