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Magnetic resonance evaluation of hepatic and myocardial iron deposition in transfusion-independent thalassemia intermedia compared to regularly transfused thalassemia major patients

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dc.contributor.author Taher A.T.
dc.contributor.author Musallam K.M.
dc.contributor.author Wood J.C.
dc.contributor.author Cappellini M.D.
dc.contributor.editor
dc.date Apr-2010
dc.date.accessioned 2017-10-05T15:39:30Z
dc.date.available 2017-10-05T15:39:30Z
dc.date.issued 2010
dc.identifier 10.1002/ajh.21626
dc.identifier.isbn
dc.identifier.issn 03618609
dc.identifier.uri http://hdl.handle.net/10938/16909
dc.description.abstract Extremely diverse phenotypes exist within the homozygous and compound heterozygote states for β-thalassemia. The terms thalassemia major (TM) and intermedia (TI) lack specific molecular correlates, but encompass a wide spectrum of clinical and laboratory abnormalities [1]. At the severe end of the spectrum are patients whose clinical course is characterized by profound anemia, who present to medical attention in the first year of life, and who subsequently require regular transfusions for survival, the condition known as TM. But many patients with inheritance of two mutant beta alleles have a milder illness, with a broad range of severity including, at least in early childhood, a virtually asymptomatic state. Patients in this group who present to medical attention in later childhood and remain largely transfusion free are said to have TI [1]. The pathophysiology, clinical consequences, and treatment of iron overload in regularly transfused patients with TM have been extensively studied; however, in transfusion-independent patients with TI data remain limited. Recent advances in the assessment of organ-specific iron deposition using magnetic resonance imaging (MRI) are promising and could potentially aid understanding the pathophysiology of iron in patients with TI.
dc.format.extent
dc.format.extent Pages: (288-290)
dc.language English
dc.publisher HOBOKEN
dc.relation.ispartof Publication Name: American Journal of Hematology; Publication Year: 2010; Volume: 85; no. 4; Pages: (288-290);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Magnetic resonance evaluation of hepatic and myocardial iron deposition in transfusion-independent thalassemia intermedia compared to regularly transfused thalassemia major patients
dc.type Article
dc.contributor.affiliation Taher, A.T., Hematology-Oncology Division, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Musallam, K.M., Hematology-Oncology Division, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Wood, J.C., Division of Pediatric Cardiology, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States, Division of Radiology, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, United States
dc.contributor.affiliation Cappellini, M.D., Department of Internal Medicine, Universitá di Milano, Policlinico Foundation, Milan, Italy
dc.contributor.authorAddress Taher, A. T.; Department of Medicine, Hematology and Oncology, Department of Internal Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon; email: ataher@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Hematology-Oncology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Hematology-Oncology
dc.contributor.authorEmail ataher@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Taher, AT
dc.contributor.authorInitials Musallam, KM
dc.contributor.authorInitials Wood, JC
dc.contributor.authorInitials Cappellini, MD
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Taher, AT (reprint author), Amer Univ Beirut, Med Ctr, Dept Internal Med, Div Hematol Oncol, POB 11-0236,Riad El Solh 1107 2020, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 19
dc.description.citedTotWOSCount 22
dc.description.citedWOSCount 22
dc.format.extentCount 3
dc.identifier.articleNo
dc.identifier.coden AJHED
dc.identifier.pubmedID 20143405
dc.identifier.scopusID 77950377763
dc.identifier.url
dc.publisher.address DIV JOHN WILEY and SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
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dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Am. J. Hematol.
dc.relation.ispartOfIssue 4
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle American Journal of Hematology
dc.relation.ispartofPubTitleAbbr Am. J. Hematol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 85
dc.source.ID WOS:000276519700018
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS ferritin, 9007-73-2
dc.subject.otherChemCAS hemoglobin, 9008-02-0
dc.subject.otherChemCAS iron, 14093-02-8, 53858-86-9, 7439-89-6
dc.subject.otherChemCAS Ferritins, 9007-73-2
dc.subject.otherChemCAS Iron, 7439-89-6
dc.subject.otherIndex ferritin
dc.subject.otherIndex hemoglobin
dc.subject.otherIndex iron
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex blood sampling
dc.subject.otherIndex clinical article
dc.subject.otherIndex female
dc.subject.otherIndex ferritin blood level
dc.subject.otherIndex heart muscle
dc.subject.otherIndex hemoglobin blood level
dc.subject.otherIndex human
dc.subject.otherIndex iron chelation
dc.subject.otherIndex iron overload
dc.subject.otherIndex liver
dc.subject.otherIndex male
dc.subject.otherIndex nuclear magnetic resonance imaging
dc.subject.otherIndex priority journal
dc.subject.otherIndex thalassemia
dc.subject.otherIndex thalassemia intermedia
dc.subject.otherIndex thalassemia major
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Adult
dc.subject.otherIndex Anemia
dc.subject.otherIndex beta-Thalassemia
dc.subject.otherIndex Blood Transfusion
dc.subject.otherIndex Female
dc.subject.otherIndex Ferritins
dc.subject.otherIndex Humans
dc.subject.otherIndex Iron
dc.subject.otherIndex Iron Overload
dc.subject.otherIndex Liver
dc.subject.otherIndex Magnetic Resonance Imaging
dc.subject.otherIndex Male
dc.subject.otherIndex Matched-Pair Analysis
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Myocardium
dc.subject.otherIndex Organ Specificity
dc.subject.otherIndex Severity of Illness Index
dc.subject.otherIndex Young Adult
dc.subject.otherKeywordPlus SICKLE-CELL-DISEASE
dc.subject.otherKeywordPlus LIVER IRON
dc.subject.otherKeywordPlus CARDIAC IRON
dc.subject.otherKeywordPlus BETA-THALASSEMIA
dc.subject.otherKeywordPlus SERUM FERRITIN
dc.subject.otherKeywordPlus OVERLOAD
dc.subject.otherKeywordPlus HEART
dc.subject.otherKeywordPlus CHELATION
dc.subject.otherKeywordPlus HEPCIDIN
dc.subject.otherWOS Hematology


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