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Absence of cardiac siderosis despite hepatic iron overload in Italian patients with thalassemia intermedia: An MRI T2* study

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dc.contributor.author Roghi A.
dc.contributor.author Cappellini M.D.
dc.contributor.author Wood J.C.
dc.contributor.author Musallam K.M.
dc.contributor.author Patrizia P.
dc.contributor.author Fasulo M.R.
dc.contributor.author Cesaretti C.
dc.contributor.author Taher A.T.
dc.contributor.editor
dc.date Jun-2010
dc.date.accessioned 2017-10-05T15:39:30Z
dc.date.available 2017-10-05T15:39:30Z
dc.date.issued 2010
dc.identifier 10.1007/s00277-009-0879-3
dc.identifier.isbn
dc.identifier.issn 09395555
dc.identifier.uri http://hdl.handle.net/10938/16916
dc.description.abstract Cardiac involvement in patients with thalassemia intermedia (TI) is characterized by a high-output state and pulmonary hypertension, with systolic left ventricle function usually being preserved. Myocardial iron overload in patients with TI has not been extensively studied. We conducted a cross-sectional study of 49 Italian patients with TI. Patient charts were reviewed and data collected for transfusion and iron chelation history, status of the spleen, and comorbid illnesses or infections. Blood samples were obtained for assessment of hemoglobin, serum ferritin, and liver enzyme levels. Doppler echocardiography was done for all patients. Cardiac and hepatic iron levels were measured by magnetic resonance imaging T2*. The mean age was 40.5∈±∈8.3 years, with a male to female ratio of 29:20. A total of 34 (69.4percent) patients were splenectomized, and four patients had evidence of hepatitis C infection. Around 45percent of patients were transfusion naïve while the rest received infrequent (47percent) or regular (8percent) transfusions. A total of 31 (63.3percent) patients were maintained on iron chelation therapy. None of the patients had evidence of heart failure. Mean serum ferritin and liver iron concentration were 1,060.2 ng-ml and 8.2 mg Fe per gram dry weight, respectively. None of the patients had evidence of cardiac iron overload (mean cardiac T2*∈=∈38.7∈±∈11.0 ms). There were no statistically significant correlation between cardiac T2* values and liver iron concentration, serum ferritin, or any patient, disease, or treatment-related parameters. Patients with TI show absence of cardiac iron overload even if hepatic iron accumulation is significant. © 2009 Springer-Verlag.
dc.format.extent
dc.format.extent Pages: (585-589)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Annals of Hematology; Publication Year: 2010; Volume: 89; no. 6; Pages: (585-589);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Absence of cardiac siderosis despite hepatic iron overload in Italian patients with thalassemia intermedia: An MRI T2* study
dc.type Article
dc.contributor.affiliation Roghi, A., Cardiac MR Unit, De Gasperis' Department of Cardiology, Niguarda Ca' Granda Hospital, Milan, Italy
dc.contributor.affiliation Cappellini, M.D., Policlinico Foundation IRCCS, Universitá di Milano, Milan, Italy, Mangiagalli, Regina Elena IRCCS, Universitá di Milano, Fondazione Ospedale Maggiore Policlinico, Milan, Italy
dc.contributor.affiliation Wood, J.C., Divisions of Pediatric Cardiology and Radiology, Children's Hospital Los Angeles and Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
dc.contributor.affiliation Musallam, K.M., Department of Internal Medicine, Hematology-Oncology Division, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Patrizia, P., Cardiac MR Unit, De Gasperis' Department of Cardiology, Niguarda Ca' Granda Hospital, Milan, Italy
dc.contributor.affiliation Fasulo, M.R., Policlinico Foundation IRCCS, Universitá di Milano, Milan, Italy
dc.contributor.affiliation Cesaretti, C., Policlinico Foundation IRCCS, Universitá di Milano, Milan, Italy
dc.contributor.affiliation Taher, A.T., Department of Internal Medicine, Hematology-Oncology Division, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Cappellini, M. D.; Policlinico Foundation IRCCS, Universitá di Milano, Milan, Italy; email: maria.cappellini@unimi.it
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Hematology-Oncology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Hematology-Oncology
dc.contributor.authorEmail maria.cappellini@unimi.it
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Roghi, A
dc.contributor.authorInitials Cappellini, MD
dc.contributor.authorInitials Wood, JC
dc.contributor.authorInitials Musallam, KM
dc.contributor.authorInitials Patrizia, P
dc.contributor.authorInitials Fasulo, MR
dc.contributor.authorInitials Cesaretti, C
dc.contributor.authorInitials Taher, AT
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Cappellini, MD (reprint author), Univ Milan, Fdn Osped Maggiore Policlin, Regina Elena IRCCS, Milan, Italy.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 20
dc.description.citedTotWOSCount 20
dc.description.citedWOSCount 20
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden ANHEE
dc.identifier.pubmedID 20016898
dc.identifier.scopusID 77951624081
dc.identifier.url
dc.publisher.address 233 SPRING ST, NEW YORK, NY 10013 USA
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dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Ann. Hematol.
dc.relation.ispartOfIssue 6
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Annals of Hematology
dc.relation.ispartofPubTitleAbbr Ann. Hematol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 89
dc.source.ID WOS:000276739100008
dc.type.publication Journal
dc.subject.otherAuthKeyword Heart
dc.subject.otherAuthKeyword Iron overload
dc.subject.otherAuthKeyword Liver
dc.subject.otherAuthKeyword Magnetic resonance imaging
dc.subject.otherAuthKeyword Thalassemia intermedia
dc.subject.otherChemCAS deferasirox, 201530-41-8
dc.subject.otherChemCAS deferoxamine, 70-51-9
dc.subject.otherChemCAS ferritin, 9007-73-2
dc.subject.otherChemCAS hemoglobin, 9008-02-0
dc.subject.otherIndex deferasirox
dc.subject.otherIndex deferoxamine
dc.subject.otherIndex ferritin
dc.subject.otherIndex hemoglobin
dc.subject.otherIndex liver enzyme
dc.subject.otherIndex adult
dc.subject.otherIndex age distribution
dc.subject.otherIndex article
dc.subject.otherIndex beta thalassemia
dc.subject.otherIndex blood transfusion
dc.subject.otherIndex clinical article
dc.subject.otherIndex comorbidity
dc.subject.otherIndex controlled study
dc.subject.otherIndex cross-sectional study
dc.subject.otherIndex Doppler echocardiography
dc.subject.otherIndex dry weight
dc.subject.otherIndex female
dc.subject.otherIndex ferritin blood level
dc.subject.otherIndex heart failure
dc.subject.otherIndex heart hemosiderosis
dc.subject.otherIndex hepatitis C
dc.subject.otherIndex human
dc.subject.otherIndex Italy
dc.subject.otherIndex male
dc.subject.otherIndex medical record
dc.subject.otherIndex nuclear magnetic resonance imaging
dc.subject.otherIndex priority journal
dc.subject.otherIndex sex ratio
dc.subject.otherIndex spleen disease
dc.subject.otherIndex splenectomy
dc.subject.otherIndex cohort analysis
dc.subject.otherIndex heart disease
dc.subject.otherIndex hepatitis C
dc.subject.otherIndex iron overload
dc.subject.otherIndex liver disease
dc.subject.otherIndex methodology
dc.subject.otherIndex middle aged
dc.subject.otherIndex radiography
dc.subject.otherIndex siderosis
dc.subject.otherIndex thalassemia
dc.subject.otherIndex Adult
dc.subject.otherIndex Cohort Studies
dc.subject.otherIndex Cross-Sectional Studies
dc.subject.otherIndex Female
dc.subject.otherIndex Heart Diseases
dc.subject.otherIndex Hepatitis C
dc.subject.otherIndex Humans
dc.subject.otherIndex Iron Overload
dc.subject.otherIndex Liver Diseases
dc.subject.otherIndex Magnetic Resonance Imaging
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Siderosis
dc.subject.otherIndex Thalassemia
dc.subject.otherIndex Young Adult
dc.subject.otherKeywordPlus SICKLE-CELL-DISEASE
dc.subject.otherKeywordPlus TRANSFUSION-DEPENDENT THALASSEMIA
dc.subject.otherKeywordPlus MAGNETIC-RESONANCE
dc.subject.otherKeywordPlus MYOCARDIAL IRON
dc.subject.otherKeywordPlus LIVER IRON
dc.subject.otherKeywordPlus BETA-THALASSEMIA
dc.subject.otherKeywordPlus SERUM FERRITIN
dc.subject.otherKeywordPlus HEART-DISEASE
dc.subject.otherKeywordPlus HEPCIDIN
dc.subject.otherKeywordPlus CHELATION
dc.subject.otherWOS Hematology


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