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Hepatocellular carcinoma in two patients with cardiac cirrhosis

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dc.contributor.author Saliba T.
dc.contributor.author Dorkhom S.
dc.contributor.author O'reilly E.M.
dc.contributor.author Ludwig E.
dc.contributor.author Gansukh B.
dc.contributor.author Abou-Alfa G.K.
dc.contributor.editor
dc.date 2010
dc.date.accessioned 2017-10-05T15:39:31Z
dc.date.available 2017-10-05T15:39:31Z
dc.date.issued 2010
dc.identifier 10.1097/MEG.0b013e32832e2bec
dc.identifier.isbn
dc.identifier.issn
dc.identifier.uri http://hdl.handle.net/10938/16925
dc.description.abstract Hepatocellular carcinoma has been commonly associated with multiple etiologic factors including hepatitis B and C, alcoholic liver disease, and more rarely congenital metabolic liver diseases. 'Cardiac cirrhosis' is the cirrhosis resulting from prolonged passive liver venous congestion secondary to right-sided congestive heart failure; hepatocellular carcinoma is a rarely reported outcome. In this study we present two female patients with congenital heart defects treated with the Fontan procedure who survived into their third decade, and developed hepatocellular carcinoma in the setting of cardiac cirrhosis. The Fontan procedure diverts blood from the inferior vena cava and superior vena cava to the pulmonary arteries, thereby increasing survival in infants born with a single effective ventricle. As such patients live longer, however elevated pulmonary and right-sided heart pressures cause chronic passive liver congestion and eventual cardiac cirrhosis. The two patients in this study had no risk factors for hepatocellular carcinoma other than cardiac cirrhosis secondary to their prolonged survival after their Fontan procedure. In conclusion, we suggest that cardiac cirrhosis may be a risk factor for developing hepatocellular carcinoma and recommend close follow-up and hepatocellular carcinoma screening for patients with known right heart failure and passive hepatic congestion. © 2010 Wolters Kluwer Health | Lippincott Williams and Wilkins.
dc.format.extent
dc.format.extent Pages: (889-891)
dc.language English
dc.publisher PHILADELPHIA
dc.relation.ispartof Publication Name: European Journal of Gastroenterology and Hepatology; Publication Year: 2010; Volume: 22; no. 7; Pages: (889-891);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Hepatocellular carcinoma in two patients with cardiac cirrhosis
dc.type Article
dc.contributor.affiliation Saliba, T., Department of Medicine, American University of Beirut, Beirut, United States
dc.contributor.affiliation Dorkhom, S., Department of Medicine, St. Luke's-Roosevelt-University Hospitals of Columbia University, New York, United States
dc.contributor.affiliation O'reilly, E.M., Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, United States
dc.contributor.affiliation Ludwig, E., Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, United States
dc.contributor.affiliation Gansukh, B., Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, United States
dc.contributor.affiliation Abou-Alfa, G.K., Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, United States
dc.contributor.authorAddress Abou-Alfa, G. K.; Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, NY 10065, United States; email: abou-alg@mskcc.org
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Gastroenterology and Hepatology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Gastroenterology and Hepatology
dc.contributor.authorEmail abou-alg@mskcc.org
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Saliba, T
dc.contributor.authorInitials Dorkhom, S
dc.contributor.authorInitials O'Reilly, EM
dc.contributor.authorInitials Ludwig, E
dc.contributor.authorInitials Gansukh, B
dc.contributor.authorInitials Abou-Alfa, GK
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Abou-Alfa, GK (reprint author), Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10065 USA.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Abou-Alfa GK, 2006, J CLIN ONCOL, V24, P4293, DOI 10.1200-JCO.2005.01.3441; Barberis VI, 2006, ECHOCARDIOGR-J CARD, V23, P417, DOI 10.1111-j.1540-8175.2006.00226.x; FONTAN F, 1971, THORAX, V26, P240, DOI 10.1136-thx.26.3.240; Ghaferi AA, 2005, J THORAC CARDIOV SUR, V129, P1348, DOI 10.1016-j.jtcvs.2004.10.005; Gomaa AI, 2008, WORLD J GASTROENTERO, V14, P4300, DOI 10.3748-wjg.14.4300; HO SSK, 1990, MED J AUSTRALIA, V152, P553; Izumi Y, 2005, J GASTROENTEROL, V40, P204, DOI 10.1007-s00535-004-1525-4; Kiesewetter CH, 2007, HEART, V93, P579, DOI 10.1136-hrt.2006.094516; Matsui S, 2000, J GASTROEN HEPATOL, V15, P1205, DOI 10.1046-j.1440-1746.2000.02303.x; Mok TSK, 2005, J CLIN ONCOL, V23, P8041, DOI 10.1200-JCO.2005.01.9927
dc.description.citedCount 18
dc.description.citedTotWOSCount 16
dc.description.citedWOSCount 16
dc.format.extentCount 3
dc.identifier.articleNo
dc.identifier.coden EJGHE
dc.identifier.pubmedID 19550346
dc.identifier.scopusID 77953973424
dc.identifier.url
dc.publisher.address 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
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dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
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dc.relation.ispartOfISOAbbr Eur. J. Gastroenterol. Hepatol.
dc.relation.ispartOfIssue 7
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle European Journal of Gastroenterology and Hepatology
dc.relation.ispartofPubTitleAbbr Eur. J. Gastroenterol. Hepatol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 22
dc.source.ID WOS:000278569900020
dc.type.publication Journal
dc.subject.otherAuthKeyword cardiac cirrhosis
dc.subject.otherAuthKeyword Fontan procedure
dc.subject.otherAuthKeyword hepatocellular carcinoma
dc.subject.otherChemCAS cisplatin, 15663-27-1, 26035-31-4, 96081-74-2
dc.subject.otherChemCAS fluorouracil, 51-21-8
dc.subject.otherChemCAS sorafenib, 284461-73-0
dc.subject.otherIndex cisplatin
dc.subject.otherIndex fluorouracil
dc.subject.otherIndex sorafenib
dc.subject.otherIndex adult
dc.subject.otherIndex anorexia
dc.subject.otherIndex arteriovenous malformation
dc.subject.otherIndex article
dc.subject.otherIndex ascites
dc.subject.otherIndex cardiomegaly
dc.subject.otherIndex case report
dc.subject.otherIndex computer assisted tomography
dc.subject.otherIndex congenital heart malformation
dc.subject.otherIndex congestive heart failure
dc.subject.otherIndex continuous infusion
dc.subject.otherIndex edema
dc.subject.otherIndex female
dc.subject.otherIndex Fontan procedure
dc.subject.otherIndex gastrointestinal hemorrhage
dc.subject.otherIndex great vessels transposition
dc.subject.otherIndex heart atrium septum defect
dc.subject.otherIndex heart cirrhosis
dc.subject.otherIndex heart right ventricle failure
dc.subject.otherIndex heart valve prosthesis
dc.subject.otherIndex heart ventricle septum defect
dc.subject.otherIndex human
dc.subject.otherIndex human tissue
dc.subject.otherIndex liver cell carcinoma
dc.subject.otherIndex liver cirrhosis
dc.subject.otherIndex liver congestion
dc.subject.otherIndex liver necrosis
dc.subject.otherIndex priority journal
dc.subject.otherIndex right heart hypoplasia
dc.subject.otherIndex splenomegaly
dc.subject.otherIndex tricuspid valve atresia
dc.subject.otherIndex varicosis
dc.subject.otherIndex venous congestion
dc.subject.otherIndex Adult
dc.subject.otherIndex Carcinoma, Hepatocellular
dc.subject.otherIndex Fatal Outcome
dc.subject.otherIndex Female
dc.subject.otherIndex Fibrosis
dc.subject.otherIndex Fontan Procedure
dc.subject.otherIndex Heart Defects, Congenital
dc.subject.otherIndex Heart Failure
dc.subject.otherIndex Humans
dc.subject.otherIndex Liver Neoplasms
dc.subject.otherIndex Myocardium
dc.subject.otherKeywordPlus
dc.subject.otherWOS Gastroenterology and Hepatology


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