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Age but not gender modulates the relationship between PTH and vitamin D

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dc.contributor.author Arabi A.
dc.contributor.author Baddoura R.
dc.contributor.author El-Rassi R.
dc.contributor.author El-Hajj Fuleihan G.
dc.contributor.editor
dc.date Aug-2010
dc.date.accessioned 2017-10-05T15:39:32Z
dc.date.available 2017-10-05T15:39:32Z
dc.date.issued 2010
dc.identifier 10.1016/j.bone.2010.05.002
dc.identifier.isbn
dc.identifier.issn 87563282
dc.identifier.uri http://hdl.handle.net/10938/16930
dc.description.abstract Context: It is unclear whether the relationship between 25-OHD and PTH is modulated by age or gender. Objective: To assess the 25-OHD-PTH relationship in 340 adolescents (10-17. years) and 443 elderly (65-85. years) of the same ethnic group, and living in the same sunny country. Assessments: Calcium intake was estimated. Serum calcium, phosphorus, 25-OHD and PTH were measured. Body fat was determined by DXA. Results: 25-OHD levels were lower in the elderly in the overall group (p 0.001) and within genders. 25-OHD levels were lower in females in the overall group and within age subgroups (p 0.05). PTH levels were higher in the elderly in the overall population and in both genders (p 0.001). There were no gender differences in PTH levels within age subgroups. For the same 25-OHD level, PTH levels were comparable across genders but were 1.5-2 folds higher in the elderly compared to adolescents (p 0.001). PTH correlated positively with age (p 0.001), body fat (p= 0.02), and negatively with calcium intake (p 0.001), and 25-OHD (p 0.001). The magnitude of the correlation with 25-OHD decreased after adjustment for age but not for gender. In multivariate analyses, age, 25-OHD and fat mass were independent predictors for PTH. In the elderly, after adjustment for serum creatinine, only 25-OHD and creatinine were independent predictors of PTH. Conclusion: The negative relationship between 25-OHD and PTH is modulated by age but not gender. Desirable 25-OHD levels derived from examining the 25-OHD-PTH relationship should therefore take into account the age of the population of interest. © 2010 Elsevier Inc.
dc.format.extent
dc.format.extent Pages: (408-412)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Bone; Publication Year: 2010; Volume: 47; no. 2; Pages: (408-412);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Age but not gender modulates the relationship between PTH and vitamin D
dc.type Article
dc.contributor.affiliation Arabi, A., Calcium Metabolism and Osteoporosis Program, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon, Department of Rheumatology, Saint Joseph University, Beirut, Lebanon
dc.contributor.affiliation Baddoura, R., Calcium Metabolism and Osteoporosis Program, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon, Department of Rheumatology, Saint Joseph University, Beirut, Lebanon
dc.contributor.affiliation El-Rassi, R., Calcium Metabolism and Osteoporosis Program, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon, Department of Rheumatology, Saint Joseph University, Beirut, Lebanon
dc.contributor.affiliation El-Hajj Fuleihan, G., Calcium Metabolism and Osteoporosis Program, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon, Department of Rheumatology, Saint Joseph University, Beirut, Lebanon
dc.contributor.authorAddress Arabi, A.; Calcium Metabolism and Osteoporosis Program, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; email: aa22@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail aa22@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Arabi, A
dc.contributor.authorInitials Baddoura, R
dc.contributor.authorInitials El-Rassi, R
dc.contributor.authorInitials Fuleihan, GEH
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Arabi, A (reprint author), Amer Univ Beirut, Calcium Metab and Osteoporosis Program, Med Ctr, Dept Internal Med, Bliss St, Beirut 1136044, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 17
dc.description.citedTotWOSCount 15
dc.description.citedWOSCount 14
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden BONED
dc.identifier.pubmedID 20452474
dc.identifier.scopusID 77955980582
dc.identifier.url
dc.publisher.address 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Bone
dc.relation.ispartOfIssue 2
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Bone
dc.relation.ispartofPubTitleAbbr Bone
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 47
dc.source.ID WOS:000280449300029
dc.type.publication Journal
dc.subject.otherAuthKeyword Adolescents
dc.subject.otherAuthKeyword Age
dc.subject.otherAuthKeyword Elderly
dc.subject.otherAuthKeyword Gender
dc.subject.otherAuthKeyword PTH
dc.subject.otherAuthKeyword Vitamin D
dc.subject.otherChemCAS 25 hydroxyvitamin D, 64719-49-9
dc.subject.otherChemCAS parathyroid hormone, 12584-96-2, 68893-82-3, 9002-64-6
dc.subject.otherChemCAS Parathyroid Hormone
dc.subject.otherChemCAS Vitamin D, 1406-16-2
dc.subject.otherIndex 25 hydroxyvitamin D
dc.subject.otherIndex parathyroid hormone
dc.subject.otherIndex vitamin D
dc.subject.otherIndex adolescent
dc.subject.otherIndex age distribution
dc.subject.otherIndex aged
dc.subject.otherIndex article
dc.subject.otherIndex calcium blood level
dc.subject.otherIndex calcium intake
dc.subject.otherIndex child
dc.subject.otherIndex controlled study
dc.subject.otherIndex creatinine blood level
dc.subject.otherIndex dual energy X ray absorptiometry
dc.subject.otherIndex ethnicity
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex phosphate blood level
dc.subject.otherIndex questionnaire
dc.subject.otherIndex school child
dc.subject.otherIndex sex difference
dc.subject.otherIndex vitamin blood level
dc.subject.otherIndex Aged
dc.subject.otherIndex Aged, 80 and over
dc.subject.otherIndex Aging
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex Parathyroid Hormone
dc.subject.otherIndex Sex Characteristics
dc.subject.otherIndex Vitamin D
dc.subject.otherKeywordPlus PARATHYROID-HORMONE LEVELS
dc.subject.otherKeywordPlus BONE-MINERAL DENSITY
dc.subject.otherKeywordPlus BODY-MASS INDEX
dc.subject.otherKeywordPlus OLDER-ADULTS
dc.subject.otherKeywordPlus POSTMENOPAUSAL WOMEN
dc.subject.otherKeywordPlus CALCIUM-ABSORPTION
dc.subject.otherKeywordPlus AFRICAN-AMERICANS
dc.subject.otherKeywordPlus HYPOVITAMINOSIS-D
dc.subject.otherKeywordPlus D SUFFICIENCY
dc.subject.otherKeywordPlus D DEFICIENCY
dc.subject.otherWOS Endocrinology and Metabolism


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