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Parental consanguinity and family history of coronary artery disease strongly predict early stenosis

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dc.contributor.author Youhanna S.
dc.contributor.author Platt D.E.
dc.contributor.author Rebeiz A.
dc.contributor.author Lauridsen M.
dc.contributor.author Deeb M.E.
dc.contributor.author Nasrallah A.
dc.contributor.author Alam S.
dc.contributor.author Puzantian H.
dc.contributor.author Kabbani S.
dc.contributor.author Ghoul M.
dc.contributor.author Zreik T.G.
dc.contributor.author el Bayeh H.
dc.contributor.author Abchee A.
dc.contributor.author Zalloua P.
dc.contributor.editor
dc.date Oct-2010
dc.date.accessioned 2017-10-05T15:39:32Z
dc.date.available 2017-10-05T15:39:32Z
dc.date.issued 2010
dc.identifier 10.1016/j.atherosclerosis.2010.07.013
dc.identifier.isbn
dc.identifier.issn 00219150
dc.identifier.uri http://hdl.handle.net/10938/16935
dc.description.abstract Background: Coronary artery disease (CAD) is a multifactorial disease with acquired and inherited components. Aim: We investigated the roles of family history and consanguinity on CAD risk and age at diagnosis in 4284 patients. The compounded impact of diabetes, hyperlipidemia, hypertension, smoking, and BMI, which are known CAD risk factors, on CAD risk and age at diagnosis was also explored. Methods: CAD was determined by cardiac catheterization. Logistic regression and stratification were performed to determine the impact of family history and consanguinity on risk and onset of CAD, controlling for diabetes, hyperlipidemia, hypertension, smoking, and BMI. Results: Family history of CAD and gender significantly increased the risk for young age at diagnosis of CAD (p 0.001). Consanguinity did not promote risk of CAD (p= 0.38), but did affect age of disease diagnosis (p 0.001). The mean age at disease diagnosis was lowest, 54.8 years, when both family history of CAD and consanguinity were considered as unique risk factors for CAD, compared to 62.8 years for the no-risk-factor patient category (p 0.001). Conclusions: Family history of CAD and smoking are strongly associated with young age at diagnosis. Furthermore, parental consanguinity in the presence of family history lowers the age of disease diagnosis significantly for CAD, emphasizing the role of strong genetic and cultural CAD modifiers. These findings highlight the increased role of genetic determinants of CAD in some population subgroups, and suggest that populations and family structure influence genetic heterogeneity between patients with CAD. © 2010 Elsevier Ireland Ltd.
dc.format.extent
dc.format.extent Pages: (559-563)
dc.language English
dc.publisher CLARE
dc.relation.ispartof Publication Name: Atherosclerosis; Publication Year: 2010; Volume: 212; no. 2; Pages: (559-563);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Parental consanguinity and family history of coronary artery disease strongly predict early stenosis
dc.type Article
dc.contributor.affiliation Youhanna, S., Lebanese American University, School of Medicine, Beirut 1102 2801, Lebanon
dc.contributor.affiliation Platt, D.E., Bioinformatics and Pattern Discovery, IBM T. J. Watson Research Centre, Yorktown Hgts, NY 10598, United States
dc.contributor.affiliation Rebeiz, A., Division of Cardiology, American University of Beirut, Bliss St, Beirut, Lebanon
dc.contributor.affiliation Lauridsen, M., Novo Nordisk A-S, Novo Nordisk Park, DK-2760 Måløv, Denmark
dc.contributor.affiliation Deeb, M.E., Lebanese American University, School of Medicine, Beirut 1102 2801, Lebanon
dc.contributor.affiliation Nasrallah, A., Division of Cardiology, American University of Beirut, Bliss St, Beirut, Lebanon
dc.contributor.affiliation Alam, S., Division of Cardiology, American University of Beirut, Bliss St, Beirut, Lebanon
dc.contributor.affiliation Puzantian, H., Division of Cardiology, American University of Beirut, Bliss St, Beirut, Lebanon
dc.contributor.affiliation Kabbani, S., Rafic Hariri University Hospital, Division of Cardiology, Beirut, Lebanon
dc.contributor.affiliation Ghoul, M., Division of Cardiology, American University of Beirut, Bliss St, Beirut, Lebanon
dc.contributor.affiliation Zreik, T.G., Lebanese American University, School of Medicine, Beirut 1102 2801, Lebanon
dc.contributor.affiliation el Bayeh, H., Lebanese American University, School of Medicine, Beirut 1102 2801, Lebanon
dc.contributor.affiliation Abchee, A., Division of Cardiology, American University of Beirut, Bliss St, Beirut, Lebanon
dc.contributor.affiliation Zalloua, P., Lebanese American University, School of Medicine, Beirut 1102 2801, Lebanon, Harvard School of Public Health, Boston, MA 02215, United States
dc.contributor.authorAddress Zalloua, P.; Lebanese American University, School of Medicine, Chouran, Beirut 1102 2801, Lebanon; email: pzalloua@lau.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Cardiology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Cardiology
dc.contributor.authorEmail pzalloua@lau.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Youhanna, S
dc.contributor.authorInitials Platt, DE
dc.contributor.authorInitials Rebeiz, A
dc.contributor.authorInitials Lauridsen, M
dc.contributor.authorInitials Deeb, ME
dc.contributor.authorInitials Nasrallah, A
dc.contributor.authorInitials Alam, S
dc.contributor.authorInitials Puzantian, H
dc.contributor.authorInitials Kabbani, S
dc.contributor.authorInitials Ghoul, M
dc.contributor.authorInitials Zreik, TG
dc.contributor.authorInitials el Bayeh, H
dc.contributor.authorInitials Abchee, A
dc.contributor.authorInitials Zalloua, P
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Zalloua, P (reprint author), Lebanese Amer Univ, Sch Med, Beirut 1102 2801, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Abchee A, 2006, THROMB RES, V117, P631, DOI 10.1016-j.thromres.2005.05.022; Abu-Amero KK, 2006, BMC MED GENET, V7, DOI 10.1186-1471-2350-7-31; ALAWADI SA, 1985, CLIN GENET, V27, P483; Barlow-Stewart K, 2007, AUST FAM PHYSICIAN, V36, P802; Bittles AH, 2010, P NATL ACAD SCI USA, V107, P1779, DOI 10.1073-pnas.0906079106; HAFEZ M, 1983, J MED GENET, V20, P58, DOI 10.1136-jmg.20.1.58; Hartl DL, 2007, PRINCIPLES POPULATIO; Hauser ER, 2003, AM HEART J, V145, P602, DOI 10.1067-mhj.2003.13; Helgadottir A, 2005, AM J HUM GENET, V76, P505, DOI 10.1086-428066; Humphries KH, 2003, CAN MED ASSOC J, V168, P1001; KHLAT M, 1988, AM J HUM GENET, V43, P188; KHOURY SA, 1992, AM J MED GENET, V43, P769, DOI 10.1002-ajmg.1320430502; Lewis Jannet F, 2002, Curr Womens Health Rep, V2, P110; Modell B, 2002, NAT REV GENET, V3, P225, DOI 10.1038-nrg754; Nordlie MA, 2005, J MOL CELL CARDIOL, V39, P667, DOI 10.1016-j.yjmcc.2005.06.006; Scheuner MT, 1997, AM J MED GENET, V71, P315, DOI 10.1002-(SICI)1096-8628(19970822)71:3315::AID-AJMG123.0.CO;2-N; Scheuner MT, 2004, PRIMARY CARE, V31, P711, DOI 10.1016-j.pop.2004.04.001; Scheuner MT, 2004, PRIMARY CARE, V31, pxi; Valdez R, 2007, PEDIATRICS, V120, pS78, DOI 10.1542-peds.2007-1010G; van der Mooren MJ, 2001, MATURITAS, V38, P227, DOI 10.1016-S0378-5122(01)00179-7; Wilson PWF, 1998, CIRCULATION, V97, P1837; Yasar AS, 2008, ACTA CARDIOL, V63, P19, DOI 10.2143-AC.63.1.2025327
dc.description.citedCount 7
dc.description.citedTotWOSCount 7
dc.description.citedWOSCount 7
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden ATHSB
dc.identifier.pubmedID 20691447
dc.identifier.scopusID 77957712074
dc.identifier.url
dc.publisher.address ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Atherosclerosis
dc.relation.ispartOfIssue 2
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Atherosclerosis
dc.relation.ispartofPubTitleAbbr Atherosclerosis
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 212
dc.source.ID WOS:000282678500034
dc.type.publication Journal
dc.subject.otherAuthKeyword Atherosclerosis
dc.subject.otherAuthKeyword CAD
dc.subject.otherAuthKeyword Consanguinity
dc.subject.otherAuthKeyword Family History
dc.subject.otherAuthKeyword Stenosis
dc.subject.otherChemCAS
dc.subject.otherIndex article
dc.subject.otherIndex body mass
dc.subject.otherIndex cardiovascular risk
dc.subject.otherIndex consanguinity
dc.subject.otherIndex controlled study
dc.subject.otherIndex coronary artery disease
dc.subject.otherIndex diabetes mellitus
dc.subject.otherIndex family history
dc.subject.otherIndex female
dc.subject.otherIndex genetic heterogeneity
dc.subject.otherIndex heart catheterization
dc.subject.otherIndex heredity
dc.subject.otherIndex human
dc.subject.otherIndex hyperlipidemia
dc.subject.otherIndex hypertension
dc.subject.otherIndex logistic regression analysis
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex normal human
dc.subject.otherIndex prediction
dc.subject.otherIndex priority journal
dc.subject.otherIndex smoking
dc.subject.otherIndex Aged
dc.subject.otherIndex Case-Control Studies
dc.subject.otherIndex Consanguinity
dc.subject.otherIndex Constriction, Pathologic
dc.subject.otherIndex Coronary Artery Disease
dc.subject.otherIndex Family Health
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Regression Analysis
dc.subject.otherIndex Risk Factors
dc.subject.otherKeywordPlus HORMONE REPLACEMENT THERAPY
dc.subject.otherKeywordPlus HEART-DISEASE
dc.subject.otherKeywordPlus RISK
dc.subject.otherKeywordPlus POPULATION
dc.subject.otherKeywordPlus MARRIAGE
dc.subject.otherKeywordPlus GENOTYPES
dc.subject.otherKeywordPlus GENETICS
dc.subject.otherWOS Peripheral Vascular Disease


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