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The cardiorenal syndrome in diabetes mellitus

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dc.contributor.author Karnib H.H.
dc.contributor.author Ziyadeh F.N.
dc.contributor.editor
dc.date 2010
dc.date.accessioned 2017-10-05T15:39:34Z
dc.date.available 2017-10-05T15:39:34Z
dc.date.issued 2010
dc.identifier 10.1016/j.diabres.2010.05.022
dc.identifier.isbn
dc.identifier.issn 01688227
dc.identifier.uri http://hdl.handle.net/10938/16965
dc.description.abstract The cardiorenal syndrome in patients with diabetes mellitus represents a systemic condition that affects both the cardiovascular and renal systems. Diabetes is a well established risk factor for cardiovascular disease (CVD), and a significant proportion of diabetic patients go on to develop clinically significant nephropathy. In the diabetic state the kidney is involved by progressive sclerosis-fibrosis and proteinuria, due most likely to overactivity of the transforming growth factor-beta system and, to some extent, the vascular endothelial growth factor system, respectively. The pathogenesis of CVD in diabetes is multifactorial, involving hemodynamic forces, humoral-metabolic factors, and oxidative stress. Additionally, it has been suggested that endothelial dysfunction may lead to simultaneous development and progression of renal and cardiac pathology in diabetes. The risk of microvascular complications can be reduced by intensive glycemic control in patients with type 1 and type 2 diabetes mellitus whereas benefit to the cardiovascular system is less clear. However, intensified intervention involving other CVD risk factors like hypertension and dyslepidemia and interception of the rennin-angiotensin-aldosterone system in patients with type 2 diabetes have been shown to be associated with significant reduction in the risk for renal disease progression that was paralleled by a significant reduction in cardiovascular disease burden. © 2010 Elsevier Ireland Ltd.
dc.format.extent
dc.format.extent Pages: (201-208)
dc.language English
dc.publisher CLARE
dc.relation.ispartof Publication Name: Diabetes Research and Clinical Practice; Publication Year: 2010; Volume: 89; no. 3; Pages: (201-208);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title The cardiorenal syndrome in diabetes mellitus
dc.type Review
dc.contributor.affiliation Karnib, H.H., Departments of Physiology and Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Ziyadeh, F.N., Departments of Physiology and Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.authorAddress Karnib, H.H.; Departments of Physiology, Faculty of Medicine, American University of Beirut, P.O. Box 11-0236, Riad El-Solh 1107 2020, Beirut, Lebanon; email: hk19@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail hk19@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Karnib, HH
dc.contributor.authorInitials Ziyadeh, FN
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Karnib, HH (reprint author), Amer Univ Beirut, Fac Med, Dept Physiol, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 12
dc.description.citedTotWOSCount 11
dc.description.citedWOSCount 10
dc.format.extentCount 8
dc.identifier.articleNo
dc.identifier.coden DRCPE
dc.identifier.pubmedID 20599286
dc.identifier.scopusID 77955416176
dc.identifier.url
dc.publisher.address ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
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dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Diabetes Res. Clin. Pract.
dc.relation.ispartOfIssue 3
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Diabetes Research and Clinical Practice
dc.relation.ispartofPubTitleAbbr Diabetes Res. Clin. Pract.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 89
dc.source.ID WOS:000281263000001
dc.type.publication Journal
dc.subject.otherAuthKeyword Angiotensin II receptor antagonists
dc.subject.otherAuthKeyword Angiotensin-converting enzyme inhibitors
dc.subject.otherAuthKeyword Cardiorenal syndrome
dc.subject.otherAuthKeyword Cardiovascular risks
dc.subject.otherAuthKeyword Chronic kidney disease
dc.subject.otherAuthKeyword Diabetes mellitus
dc.subject.otherAuthKeyword Diabetic nephropathy
dc.subject.otherAuthKeyword Endothelial dysfunction
dc.subject.otherAuthKeyword Glycemic control
dc.subject.otherAuthKeyword Heart failure
dc.subject.otherAuthKeyword Microalbu
dc.subject.otherChemCAS acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1
dc.subject.otherChemCAS glyceryl trinitrate, 55-63-0
dc.subject.otherChemCAS hemoglobin A1c, 62572-11-6
dc.subject.otherChemCAS nesiritide, 124584-08-3, 189032-40-4
dc.subject.otherChemCAS vasculotropin, 127464-60-2
dc.subject.otherIndex acetylsalicylic acid
dc.subject.otherIndex angiotensin 2 receptor antagonist
dc.subject.otherIndex angiotensin receptor antagonist
dc.subject.otherIndex dipeptidyl carboxypeptidase inhibitor
dc.subject.otherIndex diuretic agent
dc.subject.otherIndex glyceryl trinitrate
dc.subject.otherIndex hemoglobin A1c
dc.subject.otherIndex nesiritide
dc.subject.otherIndex transforming growth factor beta
dc.subject.otherIndex vasculotropin
dc.subject.otherIndex vasopressin antagonist
dc.subject.otherIndex albuminuria
dc.subject.otherIndex behavior therapy
dc.subject.otherIndex cardiorenal syndrome
dc.subject.otherIndex cardiovascular disease
dc.subject.otherIndex cardiovascular risk
dc.subject.otherIndex chronic kidney disease
dc.subject.otherIndex clinical trial
dc.subject.otherIndex diabetic nephropathy
dc.subject.otherIndex disease classification
dc.subject.otherIndex disease course
dc.subject.otherIndex disease exacerbation
dc.subject.otherIndex dyslipidemia
dc.subject.otherIndex endothelial dysfunction
dc.subject.otherIndex glomerulus filtration rate
dc.subject.otherIndex glycemic control
dc.subject.otherIndex heart infarction
dc.subject.otherIndex hemodynamics
dc.subject.otherIndex high risk patient
dc.subject.otherIndex human
dc.subject.otherIndex hyperglycemia
dc.subject.otherIndex hypertension
dc.subject.otherIndex insulin dependent diabetes mellitus
dc.subject.otherIndex kidney disease
dc.subject.otherIndex kidney dysfunction
dc.subject.otherIndex kidney failure
dc.subject.otherIndex kidney fibrosis
dc.subject.otherIndex microangiopathy
dc.subject.otherIndex mortality
dc.subject.otherIndex non insulin dependent diabetes mellitus
dc.subject.otherIndex oxidative stress
dc.subject.otherIndex pathogenesis
dc.subject.otherIndex proteinuria
dc.subject.otherIndex renin angiotensin aldosterone system
dc.subject.otherIndex review
dc.subject.otherIndex risk management
dc.subject.otherIndex risk reduction
dc.subject.otherIndex vascular endothelium
dc.subject.otherIndex Cardiovascular Diseases
dc.subject.otherIndex Diabetes Complications
dc.subject.otherIndex Diabetes Mellitus
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Kidney Diseases
dc.subject.otherIndex Male
dc.subject.otherKeywordPlus URINARY ALBUMIN EXCRETION
dc.subject.otherKeywordPlus CORONARY-HEART-DISEASE
dc.subject.otherKeywordPlus CHRONIC KIDNEY-DISEASE
dc.subject.otherKeywordPlus ACUTE MYOCARDIAL-INFARCTION
dc.subject.otherKeywordPlus MILD RENAL-INSUFFICIENCY
dc.subject.otherKeywordPlus BLOOD-GLUCOSE CONTROL
dc.subject.otherKeywordPlus OPTIMAL TREATMENT HOT
dc.subject.otherKeywordPlus CARDIOVASCULAR-DISEASE
dc.subject.otherKeywordPlus ENDOTHELIAL DYSFUNCTION
dc.subject.otherKeywordPlus RANDOMIZED-TRIAL
dc.subject.otherWOS Endocrinology and Metabolism


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