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Levels of growth differentiation factor-15 are high and correlate with clinical severity in transfusion-independent patients with β thalassemia intermedia

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dc.contributor.author Musallam K.M.
dc.contributor.author Taher A.T.
dc.contributor.author Duca L.
dc.contributor.author Cesaretti C.
dc.contributor.author Halawi R.
dc.contributor.author Cappellini M.D.
dc.contributor.editor
dc.date Dec-2011
dc.date.accessioned 2017-10-05T15:39:41Z
dc.date.available 2017-10-05T15:39:41Z
dc.date.issued 2011
dc.identifier 10.1016/j.bcmd.2011.07.005
dc.identifier.isbn
dc.identifier.issn 10799796
dc.identifier.uri http://hdl.handle.net/10938/17035
dc.description.abstract Transfusion-independent patients with thalassemia intermedia (TI) experience a variety of clinical complications attributed to the underlying ineffective erythropoiesis and subsequent anemia, hemolysis, and iron overload. Growth differentiation factor-15 (GDF-15) was recently investigated as a marker of ineffective erythropoiesis in several anemias. In this work, we evaluated GDF-15 levels in 55 patients with TI. The mean GDF-15 level was 25,197.8.. 16,208.9. pg-ml which is lower than values reported for patients with thalassemia major, yet considerably higher than those reported in patients with other congenital and acquired anemias. GDF-15 levels were significantly higher in splenectomized compared to non-splenectomized patients and correlated with anemia, markers of iron overload, and a pre-defined clinical severity score. Further studies are needed to determine the practical utility of GDF-15 measurement and its potential to reflect the severity of the clinical course in TI patients. © 2011 Elsevier Inc.
dc.format.extent
dc.format.extent Pages: (232-234)
dc.language English
dc.publisher SAN DIEGO
dc.relation.ispartof Publication Name: Blood Cells, Molecules, and Diseases; Publication Year: 2011; Volume: 47; no. 4; Pages: (232-234);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Levels of growth differentiation factor-15 are high and correlate with clinical severity in transfusion-independent patients with β thalassemia intermedia
dc.type Article
dc.contributor.affiliation Musallam, K.M., Department of Internal Medicine, Division of Hematology and Oncology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Taher, A.T., Department of Internal Medicine, Division of Hematology and Oncology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Duca, L., Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Policlinico, Universit di Milano, Milano, Italy
dc.contributor.affiliation Cesaretti, C., Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Policlinico, Universit di Milano, Milano, Italy, Clinical Genetics unit, Fondazione IRCCS Ca' Granda Ospedale Policlinico, Universit di Milano, Milano, Italy
dc.contributor.affiliation Halawi, R., Department of Internal Medicine, Division of Hematology and Oncology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Cappellini, M.D., Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Policlinico, Universit di Milano, Milano, Italy
dc.contributor.authorAddress Cappellini, M.D.; Department of Internal Medicine, Fondazione IRCSS Ca' Granda Ospedale Policlinico, Universit di Milano, Pad. Granelli, Via Francesco Sforza, 35, 20122 Milano, Italy; email: maria.cappellini@unimi.it
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Hematology-Oncology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Hematology-Oncology
dc.contributor.authorEmail maria.cappellini@unimi.it
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Musallam, KM
dc.contributor.authorInitials Taher, AT
dc.contributor.authorInitials Duca, L
dc.contributor.authorInitials Cesaretti, C
dc.contributor.authorInitials Halawi, R
dc.contributor.authorInitials Cappellini, MD
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Cappellini, MD (reprint author), Univ Milan, Fdn IRCSS Ca Granda Osped Policlin, Dept Internal Med, Via Francesco Sforza 35, I-20122 Milan, Italy.
dc.contributor.authorResearcherID Duca, Lorena-K-6909-2012
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 9
dc.description.citedTotWOSCount 15
dc.description.citedWOSCount 14
dc.format.extentCount 3
dc.identifier.articleNo
dc.identifier.coden BCMDF
dc.identifier.pubmedID 21865063
dc.identifier.scopusID 82955187600
dc.identifier.url
dc.publisher.address 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
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dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Blood Cells Mol. Dis.
dc.relation.ispartOfIssue 4
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Blood Cells, Molecules, and Diseases
dc.relation.ispartofPubTitleAbbr Blood Cells Mol. Dis.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 47
dc.source.ID WOS:000297610100004
dc.type.publication Journal
dc.subject.otherAuthKeyword Clinical complications
dc.subject.otherAuthKeyword Growth differentiation factor-15
dc.subject.otherAuthKeyword Ineffective erythropoiesis
dc.subject.otherAuthKeyword Iron overload
dc.subject.otherAuthKeyword Thalassemia intermedia
dc.subject.otherChemCAS ferritin, 9007-73-2
dc.subject.otherChemCAS hemoglobin, 9008-02-0
dc.subject.otherChemCAS Growth Differentiation Factor 15
dc.subject.otherIndex ferritin
dc.subject.otherIndex growth differentiation factor 15
dc.subject.otherIndex hemoglobin
dc.subject.otherIndex acquired hemolytic anemia
dc.subject.otherIndex adult
dc.subject.otherIndex aged
dc.subject.otherIndex article
dc.subject.otherIndex beta thalassemia
dc.subject.otherIndex child
dc.subject.otherIndex clinical evaluation
dc.subject.otherIndex controlled study
dc.subject.otherIndex cytokine production
dc.subject.otherIndex disease association
dc.subject.otherIndex disease marker
dc.subject.otherIndex disease severity
dc.subject.otherIndex erythropoiesis
dc.subject.otherIndex female
dc.subject.otherIndex ferritin blood level
dc.subject.otherIndex hemoglobin blood level
dc.subject.otherIndex human
dc.subject.otherIndex iron overload
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex medical record review
dc.subject.otherIndex priority journal
dc.subject.otherIndex protein analysis
dc.subject.otherIndex protein blood level
dc.subject.otherIndex school child
dc.subject.otherIndex sex difference
dc.subject.otherIndex splenectomy
dc.subject.otherIndex thalassemia major
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Adult
dc.subject.otherIndex Aged
dc.subject.otherIndex beta-Thalassemia
dc.subject.otherIndex Blood Transfusion
dc.subject.otherIndex Child
dc.subject.otherIndex Cross-Sectional Studies
dc.subject.otherIndex Female
dc.subject.otherIndex Growth Differentiation Factor 15
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Severity of Illness Index
dc.subject.otherIndex Young Adult
dc.subject.otherKeywordPlus LIVER IRON CONCENTRATIONS
dc.subject.otherKeywordPlus MAGNETIC-RESONANCE
dc.subject.otherKeywordPlus MANAGEMENT
dc.subject.otherKeywordPlus HEPCIDIN
dc.subject.otherKeywordPlus OVERLOAD
dc.subject.otherKeywordPlus R2
dc.subject.otherWOS Hematology


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