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Thrombosis in thalassemia: Why are we so concerned?

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dc.contributor.author Musallam K.M.
dc.contributor.author Taher A.T.
dc.contributor.editor
dc.date Oct-2011
dc.date.accessioned 2017-10-05T15:39:44Z
dc.date.available 2017-10-05T15:39:44Z
dc.date.issued 2011
dc.identifier 10.3109/03630269.2011.605499
dc.identifier.isbn
dc.identifier.issn 03630269
dc.identifier.uri http://hdl.handle.net/10938/17054
dc.description.abstract Although life expectancy of thalassemia patients has markedly improved over the last few decades, patients still suffer from many complications of this congenital disease. The presence of a high incidence of thromboembolic events (TEE), mainly in β-thalassemia intermedia (β-TI), has led to the identification of a hypercoagulable state in these patients. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, with a special focus on thalassemia intermedia being the group with the highest incidence of thrombotic events as compared to other types of thalassemia. Clinical experience and available clues on optimal management are also discussed. © 2011 Informa Healthcare USA, Inc.
dc.format.extent
dc.format.extent Pages: (503-510)
dc.language English
dc.publisher LONDON
dc.relation.ispartof Publication Name: Hemoglobin; Publication Year: 2011; Volume: 35; no. 41765; Pages: (503-510);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Thrombosis in thalassemia: Why are we so concerned?
dc.type Review
dc.contributor.affiliation Musallam, K.M., Department of Internal Medicine, Hematology-Oncology Division, American University of Beirut Medical Centre, P.O. Box: 11-0236, Riad El-Solh 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Taher, A.T., Department of Internal Medicine, Hematology-Oncology Division, American University of Beirut Medical Centre, P.O. Box: 11-0236, Riad El-Solh 1107 2020, Beirut, Lebanon
dc.contributor.authorAddress Taher, A.T.; Department of Internal Medicine, Hematology-Oncology Division, American University of Beirut Medical Centre, P.O. Box: 11-0236, Riad El-Solh 1107 2020, Beirut, Lebanon; email: ataher@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Hematology-Oncology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Hematology-Oncology
dc.contributor.authorEmail ataher@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Musallam, KM
dc.contributor.authorInitials Taher, AT
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Taher, AT (reprint author), Amer Univ Beirut, Hematol Oncol Div, Dept Internal Med, Med Ctr, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 16
dc.description.citedTotWOSCount 19
dc.description.citedWOSCount 19
dc.format.extentCount 8
dc.identifier.articleNo
dc.identifier.coden HEMOD
dc.identifier.pubmedID 21910599
dc.identifier.scopusID 81055144362
dc.identifier.url
dc.publisher.address TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Hemoglobin
dc.relation.ispartOfIssue 41765
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Hemoglobin
dc.relation.ispartofPubTitleAbbr Hemoglobin
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 35
dc.source.ID WOS:000296879400008
dc.type.publication Journal
dc.subject.otherAuthKeyword Hypercoagulability
dc.subject.otherAuthKeyword Splenectomy
dc.subject.otherAuthKeyword Stroke
dc.subject.otherAuthKeyword Thalassemia
dc.subject.otherAuthKeyword Thromboembolism
dc.subject.otherAuthKeyword Transfusion
dc.subject.otherChemCAS endothelial leukocyte adhesion molecule 1, 128875-25-2
dc.subject.otherChemCAS ferritin, 9007-73-2
dc.subject.otherChemCAS hemoglobin, 9008-02-0
dc.subject.otherChemCAS intercellular adhesion molecule 1, 126547-89-5
dc.subject.otherChemCAS iron, 14093-02-8, 53858-86-9, 7439-89-6
dc.subject.otherChemCAS prostacyclin, 35121-78-9, 61849-14-7
dc.subject.otherChemCAS thromboxane A2, 57576-52-0
dc.subject.otherChemCAS von Willebrand factor, 109319-16-6
dc.subject.otherIndex biological marker
dc.subject.otherIndex CD63 antigen
dc.subject.otherIndex endothelial leukocyte adhesion molecule 1
dc.subject.otherIndex ferritin
dc.subject.otherIndex hemoglobin
dc.subject.otherIndex intercellular adhesion molecule 1
dc.subject.otherIndex iron
dc.subject.otherIndex PADGEM protein
dc.subject.otherIndex phospholipid antibody
dc.subject.otherIndex prostacyclin
dc.subject.otherIndex thromboxane A2
dc.subject.otherIndex vascular cell adhesion molecule 1
dc.subject.otherIndex von Willebrand factor
dc.subject.otherIndex beta thalassemia
dc.subject.otherIndex blood transfusion
dc.subject.otherIndex cell adhesion
dc.subject.otherIndex disease association
dc.subject.otherIndex endothelium cell
dc.subject.otherIndex erythrocyte
dc.subject.otherIndex ferritin blood level
dc.subject.otherIndex hemoglobin blood level
dc.subject.otherIndex human
dc.subject.otherIndex hypercoagulability
dc.subject.otherIndex in vivo culture
dc.subject.otherIndex incidence
dc.subject.otherIndex iron overload
dc.subject.otherIndex lifespan
dc.subject.otherIndex primary prevention
dc.subject.otherIndex protein expression
dc.subject.otherIndex pulmonary hypertension
dc.subject.otherIndex review
dc.subject.otherIndex risk assessment
dc.subject.otherIndex splenectomy
dc.subject.otherIndex thrombocyte activation
dc.subject.otherIndex thrombocyte aggregation
dc.subject.otherIndex thrombocyte count
dc.subject.otherIndex thromboembolism
dc.subject.otherIndex thrombophilia
dc.subject.otherIndex transient ischemic attack
dc.subject.otherIndex white matter
dc.subject.otherIndex Humans
dc.subject.otherIndex Thalassemia
dc.subject.otherIndex Thrombophilia
dc.subject.otherIndex Thrombosis
dc.subject.otherKeywordPlus VIVO PLATELET ACTIVATION
dc.subject.otherKeywordPlus BETA-THALASSEMIA
dc.subject.otherKeywordPlus THROMBOEMBOLIC EVENTS
dc.subject.otherKeywordPlus INTERMEDIA
dc.subject.otherKeywordPlus HYPERCOAGULABILITY
dc.subject.otherKeywordPlus COMPLICATIONS
dc.subject.otherKeywordPlus ERYTHROCYTES
dc.subject.otherKeywordPlus SPLENECTOMY
dc.subject.otherKeywordPlus SURVIVAL
dc.subject.otherKeywordPlus MANAGEMENT
dc.subject.otherWOS Biochemistry and Molecular Biology
dc.subject.otherWOS Hematology


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