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PTH level but not 25 (OH) vitamin D level predicts bone loss rates in the elderly

Show simple item record Arabi A. Baddoura R. El-Rassi R. El-Hajj Fuleihan G.
dc.contributor.editor Mar-2012 2017-10-05T15:39:48Z 2017-10-05T15:39:48Z 2012
dc.identifier 10.1007/s00198-011-1659-1
dc.description.abstract We assessed the impact of calciotropic hormones on bone loss in 195 elderly subjects. After a median follow up of 4 years, parathyroid hormone (PTH) correlated negatively with changes in bone mineral density (BMD) at all skeletal sites. After adjustment for potential predictors of bone loss in the elderly, PTH level alone explained 3percent of the variance in BMD changes at the hip. Introduction: This study assessed the impact of calciotropic hormones on bone loss rates in an elderly population-based cohort of 195 ambulatory men and women, aged 65-85 years and followed up for a median of 4 years. Methods: Calcium intake, serum calcium, and phosphorus were assessed at baseline. Serum creatinine was measured at follow up visit. The 25 (OH) vitamin D [25-OHD] and PTH were measured at baseline and at follow up. Bone mass at the lumbar spine, hip, forearm and total body, as well as body composition was measured at baseline and at follow up by dual energy X-ray absorptiometry. Results: Mean 25-OHD level was 14.7 ± 6.4 ng-ml and mean PTH level was 47.9 ± 30.4 pg-ml. Age correlated negatively with percent changes in BMD at all skeletal sites (p 0.05). Changes in body mass index (BMI) and in body composition correlated positively with BMD changes at all sites, except at the forearm. There was no correlation between 25-OHD and changes in BMD except at the trochanter (r = 0.19, p 0.008). Conversely, PTH negatively correlated with changes in BMD at all skeletal sites (r = -0.14 to -0.27, p 0.05). This correlation persisted after adjustment for age, changes in BMI, changes in fat mass and lean mass, serum creatinine, calcium intake, and 25-OHD levels. PTH level alone explained 3percent of the variance in BMD changes at all hip subregions. Conclusions: Serum PTH, but not 25-OHD, predicted bone loss rates in the elderly. Thus, it is important to normalize PTH level when correcting hypovitaminosis D in the elderly. © 2011 International Osteoporosis Foundation and National Osteoporosis Foundation.
dc.format.extent Pages: (971-980)
dc.language English
dc.publisher LONDON
dc.relation.ispartof Publication Name: Osteoporosis International; Publication Year: 2012; Volume: 23; no. 3; Pages: (971-980);
dc.source Scopus
dc.title PTH level but not 25 (OH) vitamin D level predicts bone loss rates in the elderly
dc.type Article
dc.contributor.affiliation Arabi, A., Calcium Metabolism and Osteoporosis Program, American University, Beirut Medical Center, Bliss street, Beirut 113-6044, Lebanon
dc.contributor.affiliation Baddoura, R., Department of Rheumatology, Saint Joseph University, Beirut, Lebanon
dc.contributor.affiliation El-Rassi, R., Calcium Metabolism and Osteoporosis Program, American University, Beirut Medical Center, Bliss street, Beirut 113-6044, Lebanon
dc.contributor.affiliation El-Hajj Fuleihan, G., Calcium Metabolism and Osteoporosis Program, American University, Beirut Medical Center, Bliss street, Beirut 113-6044, Lebanon
dc.contributor.authorAddress Arabi, A.; Calcium Metabolism and Osteoporosis Program, American University, Beirut Medical Center, Bliss street, Beirut 113-6044, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Arabi, A
dc.contributor.authorInitials Baddoura, R
dc.contributor.authorInitials El-Rassi, R
dc.contributor.authorInitials Fuleihan, GEH
dc.contributor.authorReprintAddress Arabi, A (reprint author), American Univ, Beirut Med Ctr, Calcium Metab and Osteoporosis Program, Bliss St, Beirut 1136044, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 17
dc.description.citedTotWOSCount 14
dc.description.citedWOSCount 14
dc.format.extentCount 10
dc.identifier.coden OSINE
dc.identifier.pubmedID 21656018
dc.identifier.scopusID 84857440051
dc.publisher.address 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
dc.relation.ispartOfISOAbbr Osteoporosis Int.
dc.relation.ispartOfIssue 3
dc.relation.ispartofPubTitle Osteoporosis International
dc.relation.ispartofPubTitleAbbr Osteoporosis Int.
dc.relation.ispartOfVolume 23
dc.source.ID WOS:000300251200020
dc.type.publication Journal
dc.subject.otherAuthKeyword Body composition
dc.subject.otherAuthKeyword Bone loss
dc.subject.otherAuthKeyword Elderly
dc.subject.otherAuthKeyword PTH
dc.subject.otherAuthKeyword Vitamin D
dc.subject.otherChemCAS 25 hydroxyvitamin D, 64719-49-9
dc.subject.otherChemCAS calcium, 14092-94-5, 7440-70-2
dc.subject.otherChemCAS creatinine, 19230-81-0, 60-27-5
dc.subject.otherChemCAS parathyroid hormone, 12584-96-2, 68893-82-3, 9002-64-6
dc.subject.otherChemCAS 25-hydroxyvitamin D, 64719-49-9
dc.subject.otherChemCAS Biological Markers
dc.subject.otherChemCAS Calcium, 7440-70-2
dc.subject.otherChemCAS Calcium, Dietary
dc.subject.otherChemCAS Creatinine, 60-27-5
dc.subject.otherChemCAS Parathyroid Hormone
dc.subject.otherChemCAS Phosphorus, 7723-14-0
dc.subject.otherChemCAS Vitamin D, 1406-16-2
dc.subject.otherIndex 25 hydroxyvitamin D
dc.subject.otherIndex calcium
dc.subject.otherIndex creatinine
dc.subject.otherIndex parathyroid hormone
dc.subject.otherIndex aged
dc.subject.otherIndex article
dc.subject.otherIndex body fat
dc.subject.otherIndex bone atrophy
dc.subject.otherIndex bone density
dc.subject.otherIndex calcium intake
dc.subject.otherIndex creatinine blood level
dc.subject.otherIndex female
dc.subject.otherIndex groups by age
dc.subject.otherIndex human
dc.subject.otherIndex lean body weight
dc.subject.otherIndex Lebanon
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex priority journal
dc.subject.otherIndex vitamin D deficiency
dc.subject.otherIndex Aged
dc.subject.otherIndex Aged, 80 and over
dc.subject.otherIndex Biological Markers
dc.subject.otherIndex Body Composition
dc.subject.otherIndex Body Mass Index
dc.subject.otherIndex Bone Density
dc.subject.otherIndex Calcium
dc.subject.otherIndex Calcium, Dietary
dc.subject.otherIndex Creatinine
dc.subject.otherIndex Female
dc.subject.otherIndex Follow-Up Studies
dc.subject.otherIndex Humans
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Male
dc.subject.otherIndex Osteoporosis
dc.subject.otherIndex Osteoporosis, Postmenopausal
dc.subject.otherIndex Parathyroid Hormone
dc.subject.otherIndex Phosphorus
dc.subject.otherIndex Predictive Value of Tests
dc.subject.otherIndex Vitamin D
dc.subject.otherKeywordPlus RANDOMIZED CONTROLLED-TRIALS
dc.subject.otherKeywordPlus SEX-HORMONE LEVELS
dc.subject.otherKeywordPlus MINERAL DENSITY
dc.subject.otherKeywordPlus POSTMENOPAUSAL WOMEN
dc.subject.otherKeywordPlus OSTEOPOROTIC FRACTURES
dc.subject.otherKeywordPlus LONGITUDINAL CHANGES
dc.subject.otherKeywordPlus D SUPPLEMENTATION
dc.subject.otherKeywordPlus RISK-FACTORS
dc.subject.otherKeywordPlus OLDER MEN
dc.subject.otherKeywordPlus FOLLOW-UP
dc.subject.otherWOS Endocrinology and Metabolism

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