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PTH level but not 25 (OH) vitamin D level predicts bone loss rates in the elderly

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dc.contributor.author Arabi A.
dc.contributor.author Baddoura R.
dc.contributor.author El-Rassi R.
dc.contributor.author El-Hajj Fuleihan G.
dc.contributor.editor
dc.date Mar-2012
dc.date.accessioned 2017-10-05T15:39:48Z
dc.date.available 2017-10-05T15:39:48Z
dc.date.issued 2012
dc.identifier 10.1007/s00198-011-1659-1
dc.identifier.isbn
dc.identifier.issn
dc.identifier.uri http://hdl.handle.net/10938/17087
dc.description.abstract We assessed the impact of calciotropic hormones on bone loss in 195 elderly subjects. After a median follow up of 4 years, parathyroid hormone (PTH) correlated negatively with changes in bone mineral density (BMD) at all skeletal sites. After adjustment for potential predictors of bone loss in the elderly, PTH level alone explained 3percent of the variance in BMD changes at the hip. Introduction: This study assessed the impact of calciotropic hormones on bone loss rates in an elderly population-based cohort of 195 ambulatory men and women, aged 65-85 years and followed up for a median of 4 years. Methods: Calcium intake, serum calcium, and phosphorus were assessed at baseline. Serum creatinine was measured at follow up visit. The 25 (OH) vitamin D [25-OHD] and PTH were measured at baseline and at follow up. Bone mass at the lumbar spine, hip, forearm and total body, as well as body composition was measured at baseline and at follow up by dual energy X-ray absorptiometry. Results: Mean 25-OHD level was 14.7 ± 6.4 ng-ml and mean PTH level was 47.9 ± 30.4 pg-ml. Age correlated negatively with percent changes in BMD at all skeletal sites (p 0.05). Changes in body mass index (BMI) and in body composition correlated positively with BMD changes at all sites, except at the forearm. There was no correlation between 25-OHD and changes in BMD except at the trochanter (r = 0.19, p 0.008). Conversely, PTH negatively correlated with changes in BMD at all skeletal sites (r = -0.14 to -0.27, p 0.05). This correlation persisted after adjustment for age, changes in BMI, changes in fat mass and lean mass, serum creatinine, calcium intake, and 25-OHD levels. PTH level alone explained 3percent of the variance in BMD changes at all hip subregions. Conclusions: Serum PTH, but not 25-OHD, predicted bone loss rates in the elderly. Thus, it is important to normalize PTH level when correcting hypovitaminosis D in the elderly. © 2011 International Osteoporosis Foundation and National Osteoporosis Foundation.
dc.format.extent
dc.format.extent Pages: (971-980)
dc.language English
dc.publisher LONDON
dc.relation.ispartof Publication Name: Osteoporosis International; Publication Year: 2012; Volume: 23; no. 3; Pages: (971-980);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title PTH level but not 25 (OH) vitamin D level predicts bone loss rates in the elderly
dc.type Article
dc.contributor.affiliation Arabi, A., Calcium Metabolism and Osteoporosis Program, American University, Beirut Medical Center, Bliss street, Beirut 113-6044, Lebanon
dc.contributor.affiliation Baddoura, R., Department of Rheumatology, Saint Joseph University, Beirut, Lebanon
dc.contributor.affiliation El-Rassi, R., Calcium Metabolism and Osteoporosis Program, American University, Beirut Medical Center, Bliss street, Beirut 113-6044, Lebanon
dc.contributor.affiliation El-Hajj Fuleihan, G., Calcium Metabolism and Osteoporosis Program, American University, Beirut Medical Center, Bliss street, Beirut 113-6044, Lebanon
dc.contributor.authorAddress Arabi, A.; Calcium Metabolism and Osteoporosis Program, American University, Beirut Medical Center, Bliss street, Beirut 113-6044, Lebanon; email: aa22@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail aa22@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Arabi, A
dc.contributor.authorInitials Baddoura, R
dc.contributor.authorInitials El-Rassi, R
dc.contributor.authorInitials Fuleihan, GEH
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Arabi, A (reprint author), American Univ, Beirut Med Ctr, Calcium Metab and Osteoporosis Program, Bliss St, Beirut 1136044, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Adami S, 2009, OSTEOPOROSIS INT, V20, P239, DOI 10.1007-s00198-008-0650-y; Arabi A, 2006, BONE, V39, P268, DOI 10.1016-j.bone.2006.01.140; Baddoura R, 2007, BONE, V40, P1066, DOI 10.1016-j.bone.2006.11.016; Bischoff-Ferrari HA, 2005, JAMA-J AM MED ASSOC, V293, P2257, DOI 10.1001-jama.293.18.2257; Bischoff-Ferrari HA, 2004, JAMA-J AM MED ASSOC, V291, P1999, DOI 10.1001-jama.291.16.1999; Bischoff-Ferrari HA, 2004, AM J MED, V116, P634, DOI 10.1016-j.amjmed.2003.12.029; Bjornerem A, 2007, CALCIFIED TISSUE INT, V81, P65, DOI 10.1007-s00223-007-9035-z; Blain H, 2004, J GERONTOL A-BIOL, V59, P1285; Boonen S, 2007, J CLIN ENDOCR METAB, V92, P1415, DOI 10.1210-jc.2006-1404; Collins D, 1998, OSTEOPOROSIS INT, V8, P110, DOI 10.1007-BF02672505; Deane A, 2007, BMC MUSCULOSKEL DIS, V8, DOI 10.1186-1471-2474-8-3; Dennison E, 1999, OSTEOPOROSIS INT, V10, P384, DOI 10.1007-s001980050244; Emaus N, 2006, AM J EPIDEMIOL, V163, P441, DOI 10.1093-aje-kwj055; Ensrud KE, 2009, J CLIN ENDOCR METAB, V94, P2773, DOI 10.1210-jc.2008-2786; Fradinger EE, 2001, OSTEOPOROSIS INT, V12, P24, DOI 10.1007-s001980170153; Garnero P, 2007, BONE, V40, P716, DOI 10.1016-j.bone.2006.09.026; Gennari L, 2003, J CLIN ENDOCR METAB, V88, P5327, DOI 10.1210-jc.2003-030736; Hannan MT, 2000, J BONE MINER RES, V15, P710, DOI 10.1359-jbmr.2000.15.4.710; Ho-Pham LT, 2010, BMC MUSCULOSKEL DIS, V26, P59; KROLNER B, 1982, ACTA RADIOL DIAGN, V23, P517; Kuchuk NO, 2007, CLIN ENDOCRINOL, V67, P295, DOI 10.1111-j.1365-2265.2007.02882.x; Mellstrom D, 2008, J BONE MINER RES, V23, P1548; Mosekilde L, 2008, CLIN ENDOCRINOL, V69, P1, DOI 10.1111-j.1365-2265.2007.03162.x; Pottelbergh V, 2003, J CLIN ENDOCR METAB, V88, P075; Rand T, 1997, CALCIFIED TISSUE INT, V35, P667; Reid IR, 2008, OSTEOPOROSIS INT, V19, P595, DOI 10.1007-s00198-007-0492-z; RIGGS BL, 1986, NEW ENGL J MED, V314, P1676, DOI 10.1056-NEJM198606263142605; Sahota O, 2004, BONE, V35, P312, DOI 10.1016-j.bone.2004.02.003; Salamoun MM, 2005, EUR J CLIN NUTR, V59, P177, DOI 10.1038-sj.ejcn.1602056; Stewart KJ, 2005, AM J PREV MED, V28, P453, DOI 10.1016-j.amepre.2005.02.003; Stone K, 1998, J BONE MINER RES, V13, P1167, DOI 10.1359-jbmr.1998.13.7.1167; van Schoor NM, 2008, BONE, V42, P260, DOI 10.1016-j.bone.2007.11.002; Yoshimura N, 2011, J BONE MINER METAB, V29, P96, DOI 10.1007-s00774-010-0197-9; Zhai G, 2008, OSTEOPOROSIS INT, V19, P1211, DOI 10.1007-s00198-008-0562-x
dc.description.citedCount 17
dc.description.citedTotWOSCount 14
dc.description.citedWOSCount 14
dc.format.extentCount 10
dc.identifier.articleNo
dc.identifier.coden OSINE
dc.identifier.pubmedID 21656018
dc.identifier.scopusID 84857440051
dc.identifier.url
dc.publisher.address 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
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dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Osteoporosis Int.
dc.relation.ispartOfIssue 3
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Osteoporosis International
dc.relation.ispartofPubTitleAbbr Osteoporosis Int.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 23
dc.source.ID WOS:000300251200020
dc.type.publication Journal
dc.subject.otherAuthKeyword Body composition
dc.subject.otherAuthKeyword Bone loss
dc.subject.otherAuthKeyword Elderly
dc.subject.otherAuthKeyword PTH
dc.subject.otherAuthKeyword Vitamin D
dc.subject.otherChemCAS 25 hydroxyvitamin D, 64719-49-9
dc.subject.otherChemCAS calcium, 14092-94-5, 7440-70-2
dc.subject.otherChemCAS creatinine, 19230-81-0, 60-27-5
dc.subject.otherChemCAS parathyroid hormone, 12584-96-2, 68893-82-3, 9002-64-6
dc.subject.otherChemCAS 25-hydroxyvitamin D, 64719-49-9
dc.subject.otherChemCAS Biological Markers
dc.subject.otherChemCAS Calcium, 7440-70-2
dc.subject.otherChemCAS Calcium, Dietary
dc.subject.otherChemCAS Creatinine, 60-27-5
dc.subject.otherChemCAS Parathyroid Hormone
dc.subject.otherChemCAS Phosphorus, 7723-14-0
dc.subject.otherChemCAS Vitamin D, 1406-16-2
dc.subject.otherIndex 25 hydroxyvitamin D
dc.subject.otherIndex calcium
dc.subject.otherIndex creatinine
dc.subject.otherIndex parathyroid hormone
dc.subject.otherIndex aged
dc.subject.otherIndex article
dc.subject.otherIndex body fat
dc.subject.otherIndex bone atrophy
dc.subject.otherIndex bone density
dc.subject.otherIndex calcium intake
dc.subject.otherIndex creatinine blood level
dc.subject.otherIndex female
dc.subject.otherIndex groups by age
dc.subject.otherIndex human
dc.subject.otherIndex lean body weight
dc.subject.otherIndex Lebanon
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex priority journal
dc.subject.otherIndex vitamin D deficiency
dc.subject.otherIndex Aged
dc.subject.otherIndex Aged, 80 and over
dc.subject.otherIndex Biological Markers
dc.subject.otherIndex Body Composition
dc.subject.otherIndex Body Mass Index
dc.subject.otherIndex Bone Density
dc.subject.otherIndex Calcium
dc.subject.otherIndex Calcium, Dietary
dc.subject.otherIndex Creatinine
dc.subject.otherIndex Female
dc.subject.otherIndex Follow-Up Studies
dc.subject.otherIndex Humans
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Male
dc.subject.otherIndex Osteoporosis
dc.subject.otherIndex Osteoporosis, Postmenopausal
dc.subject.otherIndex Parathyroid Hormone
dc.subject.otherIndex Phosphorus
dc.subject.otherIndex Predictive Value of Tests
dc.subject.otherIndex Vitamin D
dc.subject.otherKeywordPlus RANDOMIZED CONTROLLED-TRIALS
dc.subject.otherKeywordPlus SEX-HORMONE LEVELS
dc.subject.otherKeywordPlus MINERAL DENSITY
dc.subject.otherKeywordPlus POSTMENOPAUSAL WOMEN
dc.subject.otherKeywordPlus OSTEOPOROTIC FRACTURES
dc.subject.otherKeywordPlus LONGITUDINAL CHANGES
dc.subject.otherKeywordPlus D SUPPLEMENTATION
dc.subject.otherKeywordPlus RISK-FACTORS
dc.subject.otherKeywordPlus OLDER MEN
dc.subject.otherKeywordPlus FOLLOW-UP
dc.subject.otherWOS Endocrinology and Metabolism


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