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Endosonographic and cyst fluid characteristics of cystic pancreatic neuroendocrine tumours: A multicentre case series

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dc.contributor.author Ho H.C.
dc.contributor.author Eloubeidi M.A.
dc.contributor.author Siddiqui U.D.
dc.contributor.author Brugge W.R.
dc.contributor.author Rossi F.
dc.contributor.author Bounds B.W.
dc.contributor.author Aslanian H.R.
dc.contributor.editor
dc.date 2013
dc.date.accessioned 2017-10-05T15:40:06Z
dc.date.available 2017-10-05T15:40:06Z
dc.date.issued 2013
dc.identifier 10.1016/j.dld.2013.02.021
dc.identifier.isbn
dc.identifier.issn 15908658
dc.identifier.uri http://hdl.handle.net/10938/17257
dc.description.abstract Background: Pancreatic neuroendocrine tumours are uncommon neoplasms which may rarely be cystic. Differentiation from other more common cystic neoplasms may be difficult. Aims: To describe the morphologic, cytologic, and cyst fluid characteristics of cystic pancreatic neuroendocrine tumours. Methods: Retrospective analysis of consecutive patients referred for endosonographic evaluation of pancreatic cysts at four centres. Results: 27 patients (12 males) with cystic pancreatic neuroendocrine tumours were identified. Prior to endosonography, this tumour was suspected in only 2 patients based on presenting symptoms (7.4percent). The median cyst size was 35. mm (range 8-80. mm). Wall thickening was identified in 13 cases. The median carcinoembryonic antigen level was 1.25 (range 0.6-500). Fine needle aspiration cytology in 17 of 24 patients confirmed neuroendocrine tumour (71percent). In 8 of 9 patients who had needle targeting of the cyst wall, cytology was consistent with neuroendocrine tumour (88.9percent). 18 patients underwent surgical resection. Conclusions: Cystic pancreatic neuroendocrine tumour was rarely suspected, including by cross-sectional imaging. Wall thickening was identified in approximately half of cases on endosonography. Cyst fluid was typically non-viscous with very low carcinoembryonic antigen levels. Targeting the wall during fine needle aspiration had a high diagnostic yield and should be performed. © 2013 Editrice Gastroenterologica Italiana S.r.l.
dc.format.extent
dc.format.extent Pages: (750-753)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Digestive and Liver Disease; Publication Year: 2013; Volume: 45; no. 9; Pages: (750-753);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Endosonographic and cyst fluid characteristics of cystic pancreatic neuroendocrine tumours: A multicentre case series
dc.type Article
dc.contributor.affiliation Ho, H.C., Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, United States
dc.contributor.affiliation Eloubeidi, M.A., Division of Gastroenterology and Hepatology, American University of Beirut School of Medicine, Beirut, Lebanon
dc.contributor.affiliation Siddiqui, U.D., Section of Gastroenterology, University of Chicago Department of Medicine, Chicago, IL, United States
dc.contributor.affiliation Brugge, W.R., Department of Internal Medicine, GI Unit, Harvard University, Massachusetts General Hospital, Boston, MA, United States
dc.contributor.affiliation Rossi, F., Minnesota Gastroenterology, P.A., Minneapolis, MN, United States
dc.contributor.affiliation Bounds, B.W., Department of Internal Medicine, GI Unit, Harvard University, Massachusetts General Hospital, Boston, MA, United States
dc.contributor.affiliation Aslanian, H.R., Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, United States
dc.contributor.authorAddress Ho, H.C.; Section of Digestive Diseases, 333 Cedar Street, 1080 LMP, New Haven, CT 06520-8019, United States; email: henry.ho@yale.edu
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Gastroenterology and Hepatology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Gastroenterology and Hepatology
dc.contributor.authorEmail henry.ho@yale.edu
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Ho, HC
dc.contributor.authorInitials Eloubeidi, MA
dc.contributor.authorInitials Siddiqui, UD
dc.contributor.authorInitials Brugge, WR
dc.contributor.authorInitials Rossi, F
dc.contributor.authorInitials Bounds, BW
dc.contributor.authorInitials Aslanian, HR
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Ho, HC (reprint author), Sect Digest Dis, 333 Cedar St,1080 LMP, New Haven, CT 06520 USA.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Ahrendt SA, 2002, J GASTROINTEST SURG, V6, P66, DOI 10.1016-S1091-255X(01)00020-8; Baker MS, 2008, J GASTROINTEST SURG, V12, P450, DOI 10.1007-s11605-007-0219-7; BUETOW PC, 1995, AM J ROENTGENOL, V165, P1175; CENTENO BA, 1994, AM J CLIN PATHOL, V101, P483; DAVTYAN H, 1990, PANCREAS, V5, P230, DOI 10.1097-00006676-199003000-00017; de Jong K, 2010, CLIN GASTROENTEROL H, V8, P806, DOI 10.1016-j.cgh.2010.05.017; Deshpande V, 2007, CANCER CYTOPATHOL, V111, P47, DOI 10.1002-cncr.22422; Federle MP, 2007, GASTROENTEROL CLIN N, V36, P365, DOI 10.1016-j.gtc.2007.03.014; Frossard JL, 2003, AM J GASTROENTEROL, V98, P1516, DOI 10.1016-S0002-9270(03)00359-9; Goh BKP, 2006, EJSO-EUR J SURG ONC, V32, P553, DOI 10.1016-j.ejso.2006.02.017; Halfdanarson TR, 2008, ANN ONCOL, V19, P1727, DOI 10.1093-annonc-mdn351; Hong SKS, 2012, GASTROINTEST ENDOSC, V75, P775, DOI 10.1016-j.gie.2011.12.015; KAMISAWA T, 1987, AM J GASTROENTEROL, V82, P86; Kongkam P, 2008, ENDOSCOPY, V40, P602, DOI 10.1055-s-2007-995740; Kosmahl M, 2004, VIRCHOWS ARCH, V445, P168, DOI 10.1007-s00428-004-1043-z; Ligneau B, 2001, AM J SURG PATHOL, V25, P752, DOI 10.1097-00000478-200106000-00006; Maletta F, 2011, ENDOSCOPY, V43, pE34, DOI 10.1055-s-0030-1256036; Sakorafas GH, 2005, CANCER TREAT REV, V31, P507, DOI 10.1016-j.ctrv.2005.09.001; Warshaw AL, 1995, SURG CLIN N AM, V75, P1001
dc.description.citedCount 2
dc.description.citedTotWOSCount 2
dc.description.citedWOSCount 2
dc.format.extentCount 4
dc.identifier.articleNo
dc.identifier.coden DLDIF
dc.identifier.pubmedID 23582348
dc.identifier.scopusID 84882283340
dc.identifier.url
dc.publisher.address 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Dig. Liver Dis.
dc.relation.ispartOfIssue 9
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Digestive and Liver Disease
dc.relation.ispartofPubTitleAbbr Dig. Liver Dis.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 45
dc.source.ID WOS:000323601900009
dc.type.publication Journal
dc.subject.otherAuthKeyword Cyst fluid analysis
dc.subject.otherAuthKeyword EUS
dc.subject.otherAuthKeyword Fine needle aspiration
dc.subject.otherAuthKeyword Neuroendocrine tumours
dc.subject.otherAuthKeyword Pancreatic cysts
dc.subject.otherChemCAS amylase, 9000-90-2, 9000-92-4, 9001-19-8
dc.subject.otherIndex amylase
dc.subject.otherIndex carcinoembryonic antigen
dc.subject.otherIndex adult
dc.subject.otherIndex aged
dc.subject.otherIndex article
dc.subject.otherIndex aspiration cytology
dc.subject.otherIndex case study
dc.subject.otherIndex clinical article
dc.subject.otherIndex clinical evaluation
dc.subject.otherIndex clinical feature
dc.subject.otherIndex cohort analysis
dc.subject.otherIndex cross-sectional study
dc.subject.otherIndex cyst fluid
dc.subject.otherIndex diagnostic value
dc.subject.otherIndex endoscopic echography
dc.subject.otherIndex female
dc.subject.otherIndex fine needle aspiration biopsy
dc.subject.otherIndex human
dc.subject.otherIndex male
dc.subject.otherIndex multicenter study
dc.subject.otherIndex pancreas cyst
dc.subject.otherIndex pancreatic neuroendocrine tumor
dc.subject.otherIndex patient referral
dc.subject.otherIndex priority journal
dc.subject.otherIndex retrospective study
dc.subject.otherIndex tumor volume
dc.subject.otherIndex ultrasound scanner
dc.subject.otherIndex Cyst fluid analysis
dc.subject.otherIndex EUS
dc.subject.otherIndex Fine needle aspiration
dc.subject.otherIndex Neuroendocrine tumours
dc.subject.otherIndex Pancreatic cysts
dc.subject.otherIndex Adult
dc.subject.otherIndex Aged
dc.subject.otherIndex Aged, 80 and over
dc.subject.otherIndex Carcinoembryonic Antigen
dc.subject.otherIndex Cohort Studies
dc.subject.otherIndex Cyst Fluid
dc.subject.otherIndex Endoscopic Ultrasound-Guided Fine Needle Aspiration
dc.subject.otherIndex Endosonography
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Neuroendocrine Tumors
dc.subject.otherIndex Pancreatic Neoplasms
dc.subject.otherIndex Retrospective Studies
dc.subject.otherKeywordPlus FINE-NEEDLE-ASPIRATION
dc.subject.otherKeywordPlus PREOPERATIVE DIAGNOSIS
dc.subject.otherKeywordPlus ENDOSCOPIC ULTRASOUND
dc.subject.otherKeywordPlus ENDOCRINE NEOPLASMS
dc.subject.otherKeywordPlus FEATURES
dc.subject.otherKeywordPlus LESIONS
dc.subject.otherKeywordPlus EUS
dc.subject.otherWOS Gastroenterology and Hepatology


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