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Proton pump inhibitors have no measurable effect on calcium and bone metabolism in healthy young males: A prospective matched controlled study

Show simple item record Sharara A.I. El-Halabi M.M. Ghaith O.A. Habib R.H. Mansour N.M. Malli A. El Hajj-Fuleihan G.
dc.contributor.editor Apr-2013 2017-10-05T15:40:07Z 2017-10-05T15:40:07Z 2013
dc.identifier 10.1016/j.metabol.2012.09.011
dc.identifier.issn 00260495
dc.description.abstract Objectives: Proton pump inhibitors (PPIs) are associated with an increased risk of bone fractures. This study sought to evaluate the effect of PPIs on biochemical markers of calcium and bone metabolism. Methods: Prospective matched controlled study involving healthy adult males (age 18-50 years) suffering from frequent heartburn. Patients received standard-dose PPI for 12 weeks and were matched by age with healthy controls. Blood studies were taken at 0, 1 and 3 months for biochemical markers of mineral and bone metabolism. Two-way (time and PPI treatment) repeated measures analysis of variance (RM-ANOVA) and multiple linear regression were used for analysis. Results: A total of 58 participants (29 per group) completed the study. Mean age of participants was 33.2 ± 7.5 years. Baseline characteristics and biomarkers were similar for both groups except for higher BMI (28.6 vs. 25.6 kg-m2, p = 0.008) and serum C-terminal cross linked telopeptides of type I collagen [CrossLaps, (300 vs. 228 pg-ml, p = 0.028)] in the PPI group. There was no difference in parathormone (PTH), ionized calcium, vitamin D, osteocalcin and CrossLaps between the PPI and control subjects (all non-significant; 2-way RM-ANOVA). Multiple linear regression modeling showed no effect of PPIs on any of the studied calcium or bone metabolism biomarkers. Conclusion: PPI intake for 12 weeks has no measurable effect on calcium or bone metabolism in healthy young males. © 2013 Elsevier Inc.
dc.format.extent Pages: (518-526)
dc.language English
dc.publisher PHILADELPHIA
dc.relation.ispartof Publication Name: Metabolism: Clinical and Experimental; Publication Year: 2013; Volume: 62; no. 4; Pages: (518-526);
dc.source Scopus
dc.title Proton pump inhibitors have no measurable effect on calcium and bone metabolism in healthy young males: A prospective matched controlled study
dc.type Article
dc.contributor.affiliation Sharara, A.I., Division of Gastroenterology, American University of Beirut Medical Center, P.O. Box 11-0236-16-B, Beirut, Lebanon
dc.contributor.affiliation El-Halabi, M.M., Division of Gastroenterology, American University of Beirut Medical Center, P.O. Box 11-0236-16-B, Beirut, Lebanon
dc.contributor.affiliation Ghaith, O.A., Division of Gastroenterology, American University of Beirut Medical Center, P.O. Box 11-0236-16-B, Beirut, Lebanon
dc.contributor.affiliation Habib, R.H., Outcomes Research Unit, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Mansour, N.M., Division of Gastroenterology, American University of Beirut Medical Center, P.O. Box 11-0236-16-B, Beirut, Lebanon
dc.contributor.affiliation Malli, A., Division of Gastroenterology, American University of Beirut Medical Center, P.O. Box 11-0236-16-B, Beirut, Lebanon
dc.contributor.affiliation El Hajj-Fuleihan, G., Division of Endocrinology, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Sharara, A.I.; Division of Gastroenterology, American University of Beirut Medical Center, P.O. Box 11-0236-16-B, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Gastroenterology and Hepatology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Gastroenterology and Hepatology
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Sharara, AI
dc.contributor.authorInitials El-Halabi, MM
dc.contributor.authorInitials Ghaith, OA
dc.contributor.authorInitials Habib, RH
dc.contributor.authorInitials Mansour, NM
dc.contributor.authorInitials Malli, A
dc.contributor.authorInitials El Hajj-Fuleihan, G
dc.contributor.authorReprintAddress Sharara, AI (reprint author), Amer Univ Beirut, Med Ctr, Div Gastroenterol, POB 11-0236-16-B, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 2
dc.description.citedTotWOSCount 1
dc.description.citedWOSCount 1
dc.format.extentCount 9
dc.identifier.coden METAA
dc.identifier.pubmedID 23102518
dc.identifier.scopusID 84884211484
dc.publisher.address 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
dc.relation.ispartOfISOAbbr Metab.-Clin. Exp.
dc.relation.ispartOfIssue 4
dc.relation.ispartofPubTitle Metabolism: Clinical and Experimental
dc.relation.ispartofPubTitleAbbr Metab. Clin. Exp.
dc.relation.ispartOfVolume 62
dc.source.ID WOS:000317530800006
dc.type.publication Journal
dc.subject.otherAuthKeyword Acid
dc.subject.otherAuthKeyword Bone turnover
dc.subject.otherAuthKeyword Calciotropic hormones
dc.subject.otherAuthKeyword Fracture
dc.subject.otherAuthKeyword Osteoporosis
dc.subject.otherChemCAS calcium, 14092-94-5, 7440-70-2
dc.subject.otherChemCAS calcium ion, 14127-61-8
dc.subject.otherChemCAS creatinine, 19230-81-0, 60-27-5
dc.subject.otherChemCAS esomeprazole, 119141-88-7, 161796-84-5, 202742-32-3, 217087-09-7, 217087-10-0
dc.subject.otherChemCAS lansoprazole, 103577-45-3, 138530-94-6, 138530-95-7
dc.subject.otherChemCAS osteocalcin, 136461-80-8
dc.subject.otherChemCAS parathyroid hormone, 12584-96-2, 68893-82-3, 9002-64-6
dc.subject.otherChemCAS phosphate, 14066-19-4, 14265-44-2
dc.subject.otherChemCAS rabeprazole, 117976-89-3, 117976-90-6
dc.subject.otherChemCAS Biological Markers
dc.subject.otherChemCAS Calcium, 7440-70-2
dc.subject.otherChemCAS Collagen Type I
dc.subject.otherChemCAS Parathyroid Hormone
dc.subject.otherChemCAS Proton Pump Inhibitors
dc.subject.otherIndex albumin
dc.subject.otherIndex calcium
dc.subject.otherIndex calcium ion
dc.subject.otherIndex carboxy terminal telopeptide
dc.subject.otherIndex collagen type 1
dc.subject.otherIndex creatinine
dc.subject.otherIndex esomeprazole
dc.subject.otherIndex lansoprazole
dc.subject.otherIndex osteocalcin
dc.subject.otherIndex parathyroid hormone
dc.subject.otherIndex phosphate
dc.subject.otherIndex rabeprazole
dc.subject.otherIndex vitamin D
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex bone metabolism
dc.subject.otherIndex calcium intake
dc.subject.otherIndex calcium metabolism
dc.subject.otherIndex controlled study
dc.subject.otherIndex creatinine blood level
dc.subject.otherIndex drug effect
dc.subject.otherIndex human
dc.subject.otherIndex male
dc.subject.otherIndex normal human
dc.subject.otherIndex priority journal
dc.subject.otherIndex prospective study
dc.subject.otherIndex vitamin deficiency
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Adult
dc.subject.otherIndex Analysis of Variance
dc.subject.otherIndex Biological Markers
dc.subject.otherIndex Bone and Bones
dc.subject.otherIndex Calcium
dc.subject.otherIndex Collagen Type I
dc.subject.otherIndex Endpoint Determination
dc.subject.otherIndex Heartburn
dc.subject.otherIndex Humans
dc.subject.otherIndex Linear Models
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Parathyroid Hormone
dc.subject.otherIndex Prospective Studies
dc.subject.otherIndex Proton Pump Inhibitors
dc.subject.otherIndex Young Adult
dc.subject.otherKeywordPlus TERM OMEPRAZOLE TREATMENT
dc.subject.otherKeywordPlus GASTRIC-ACID SECRETION
dc.subject.otherKeywordPlus HIP FRACTURE
dc.subject.otherKeywordPlus MINERAL DENSITY
dc.subject.otherKeywordPlus MAGNESIUM-DEFICIENCY
dc.subject.otherKeywordPlus OLDER-ADULTS
dc.subject.otherKeywordPlus RISK-FACTORS
dc.subject.otherKeywordPlus K+-ATPASE
dc.subject.otherKeywordPlus ABSORPTION
dc.subject.otherKeywordPlus RESORPTION
dc.subject.otherWOS Endocrinology and Metabolism

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