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Utility of endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and staging of colorectal carcinoma

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dc.contributor.author Knight C.S.
dc.contributor.author Eloubeidi M.A.
dc.contributor.author Crowe R.
dc.contributor.author Jhala N.C.
dc.contributor.author Jhala D.N.
dc.contributor.author Chhieng D.C.
dc.contributor.author Eltoum I.A.
dc.contributor.editor
dc.date 2013
dc.date.accessioned 2017-10-05T15:40:10Z
dc.date.available 2017-10-05T15:40:10Z
dc.date.issued 2013
dc.identifier 10.1002/dc.21804
dc.identifier.isbn
dc.identifier.issn 87551039
dc.identifier.uri http://hdl.handle.net/10938/17275
dc.description.abstract The objective of this study is to assess the utility of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in the diagnosis and staging of colorectal cancer. The study includes patients who underwent EUS-FNA at our institution for staging of colorectal carcinoma or for evaluation peri-rectal masses or distal metastases from August 2000 to November 2010. We assessed the frequency with which EUS-FNA procedure confirms the diagnosis of malignancy and the percent of cases in which it modifies staging of colorectal carcinoma. Using histology as a reference standard, we also assessed the diagnostic performance. We identified 79 cases of EUS-FNA from 77 patients, mean (SD) age of 60 (12.5), 44 males. Twenty-seven (34percent) aspirates were from patients with primary rectal-peri-rectal masses, 15 (19percent) were from patients with suspected regional lymph node metastasis, and 37 (47percent) were cases of suspected of distal metastasis. All lesions were clinically suspicious for primary or metastatic colorectal carcinoma. On cytologic examinations, 43 (54percent) cases were confirmed as malignant, 6 (8percent) were benign neoplasms, 4 (5percent) were suspicious for malignant neoplasm, 2 (3percent) showed atypical cells, and the rest 24 (30percent) were negative for neoplasms. Fourteen of 27 (52percent) of the local rectal masses were confirmed as colorectal carcinoma. Eleven of 15 (73percent) regional lymph nodes were positive for metastasis - all, but two of these metastases, were of colorectal origin. Twenty of 37(54percent) distal lesions were metastatic neoplasms and 15 of those were colorectal in origin. Diagnosis of primary colorectal carcinoma was confirmed in 52percent of the clinically suspicious primary lesions and in 42percent regional or distal metastatic lesions. Using histology as a reference standard in 27 of 79 (29percent) cases, we calculated an overall sensitivity, specificity, and positive and negative predictive values (C.I) of EUS-FNA of 89percent (74-100percent), 79percent (50-100percent) 89percent (74-100percent), and 79percent (51-100percent). EUS-FNA is useful for assessing primary and metastatic colorectal lesion. This technique improves staging of suspected nodal or distant metastases. Copyright © 2011 Wiley Periodicals, Inc., A Wiley Company.
dc.format.extent
dc.format.extent Pages: (1031-1037)
dc.language English
dc.publisher HOBOKEN
dc.relation.ispartof Publication Name: Diagnostic Cytopathology; Publication Year: 2013; Volume: 41; no. 12; Pages: (1031-1037);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Utility of endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and staging of colorectal carcinoma
dc.type Article
dc.contributor.affiliation Knight, C.S., Department of Pathology, University of Alabama at Birmingham, 1922 7th Avenue South, KB609, Birmingham, AL 35233, United States
dc.contributor.affiliation Eloubeidi, M.A., Department of Medicine, Division of Gastroenterology, American University, Beirut, Lebanon
dc.contributor.affiliation Crowe, R., Department of Pathology, University of Alabama at Birmingham, 1922 7th Avenue South, KB609, Birmingham, AL 35233, United States
dc.contributor.affiliation Jhala, N.C., Department of Pathology, University of Pennsylvania, Philadelphia, PA, United States
dc.contributor.affiliation Jhala, D.N., Department of Pathology, University of Pennsylvania, Philadelphia, PA, United States
dc.contributor.affiliation Chhieng, D.C., Department of Pathology, Yale University, New Haven, CT, United States
dc.contributor.affiliation Eltoum, I.A., Department of Pathology, University of Alabama at Birmingham, 1922 7th Avenue South, KB609, Birmingham, AL 35233, United States
dc.contributor.authorAddress Eltoum, I.A.; Department of Pathology, University of Alabama at Birmingham, 1922 7th Avenue South, KB609, Birmingham, AL 35233, United States; email: ieltoum@uab.edu
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Gastroenterology and Hepatology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Gastroenterology and Hepatology
dc.contributor.authorEmail ieltoum@uab.edu
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Knight, CS
dc.contributor.authorInitials Eloubeidi, MA
dc.contributor.authorInitials Crowe, R
dc.contributor.authorInitials Jhala, NC
dc.contributor.authorInitials Jhala, DN
dc.contributor.authorInitials Chhieng, DC
dc.contributor.authorInitials Eltoum, IA
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Eltoum, IA (reprint author), UAB Dept Pathol, 1922 7th Ave South,KB609, Birmingham, AL 35233 USA.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Ballo MS, 2001, DIAGN CYTOPATHOL, V24, P16, DOI 10.1002-1097-0339(200101)24:116::AID-DC10023.0.CO;2-T; Chen VK, 2004, AM J GASTROENTEROL, V99, P628, DOI 10.1111-j.1572-0241.2004.04064.x; Eloubeidi MA, 2006, AM J GASTROENTEROL, V101, P2841, DOI 10.1111-j.1572-0241.2006.00852.x; Gleeson FC, 2009, GASTROINTEST ENDOSC, V69, P896, DOI 10.1016-j.gie.2008.04.051; Harewood GC, 2002, GASTROENTEROLOGY, V123, P24, DOI 10.1053-gast.2002.34163; Harewood GC, 2004, AM J GASTROENTEROL, V99, P623, DOI 10.1111-j.1572-0241.2004.04116.x; Hunerbein M, 2001, SURGERY, V129, P164, DOI 10.1067-msy.2001.110428; Lievre A, 2008, J CLIN ONCOL, V26, P374, DOI 10.1200-JCO.2007.12.5906; Maor Y, 2006, J GASTROEN HEPATOL, V21, P454, DOI 10.1111-j.1440-1746.2005.03927.x; Misra SP, 1998, DIAGN CYTOPATHOL, V19, P330, DOI 10.1002-(SICI)1097-0339(199811)19:5330::AID-DC33.0.CO;2-V; Sasaki Y, 2005, ENDOSCOPY, V37, P154, DOI 10.1055-5-2004-826152; Siddiqui Ali A, 2006, Int Semin Surg Oncol, V3, P36, DOI 10.1186-1477-7800-3-36; Vander Noot MR, 2004, CANCER CYTOPATHOL, V102, P157, DOI 10.1002-cncr.20360
dc.description.citedCount 1
dc.description.citedTotWOSCount 0
dc.description.citedWOSCount 0
dc.format.extentCount 7
dc.identifier.articleNo
dc.identifier.coden DICYE
dc.identifier.pubmedID 21932358
dc.identifier.scopusID 84888029882
dc.identifier.url
dc.publisher.address 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Diagn. Cytopathol.
dc.relation.ispartOfIssue 12
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Diagnostic Cytopathology
dc.relation.ispartofPubTitleAbbr Diagn. Cytopathol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 41
dc.source.ID WOS:000330177100004
dc.type.publication Journal
dc.subject.otherAuthKeyword colorectal cancer
dc.subject.otherAuthKeyword fine-needle aspiration
dc.subject.otherAuthKeyword staging of rectal disease
dc.subject.otherChemCAS
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex benign tumor
dc.subject.otherIndex cancer diagnosis
dc.subject.otherIndex cancer patient
dc.subject.otherIndex cancer staging
dc.subject.otherIndex colorectal carcinoma
dc.subject.otherIndex cytology
dc.subject.otherIndex diagnostic test accuracy study
dc.subject.otherIndex distant metastasis
dc.subject.otherIndex endoscopic ultrasound guided fine needle biopsy
dc.subject.otherIndex female
dc.subject.otherIndex histology
dc.subject.otherIndex human
dc.subject.otherIndex human tissue
dc.subject.otherIndex lymph node metastasis
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex malignant neoplastic disease
dc.subject.otherIndex predictive value
dc.subject.otherIndex priority journal
dc.subject.otherIndex rectum tumor
dc.subject.otherIndex colorectal cancer
dc.subject.otherIndex fine-needle aspiration
dc.subject.otherIndex staging of rectal disease
dc.subject.otherIndex Adenocarcinoma
dc.subject.otherIndex Adult
dc.subject.otherIndex Aged
dc.subject.otherIndex Aged, 80 and over
dc.subject.otherIndex Carcinoma, Ductal
dc.subject.otherIndex Colorectal Neoplasms
dc.subject.otherIndex Endoscopic Ultrasound-Guided Fine Needle Aspiration
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Lung Neoplasms
dc.subject.otherIndex Lymph Nodes
dc.subject.otherIndex Lymphatic Metastasis
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Neoplasm Recurrence, Local
dc.subject.otherIndex Neoplasm Staging
dc.subject.otherIndex Pancreatic Neoplasms
dc.subject.otherKeywordPlus RECTAL-CANCER
dc.subject.otherKeywordPlus BIOPSY
dc.subject.otherKeywordPlus LYMPHADENOPATHY
dc.subject.otherKeywordPlus MANAGEMENT
dc.subject.otherKeywordPlus LESIONS
dc.subject.otherKeywordPlus MASSES
dc.subject.otherKeywordPlus IMPACT
dc.subject.otherWOS Medical Laboratory Technology
dc.subject.otherWOS Pathology


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