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Renal failure as a risk factor for venous thromboembolism in critically Ill patients: A cohort study

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dc.contributor.author Al-Dorzi H.M.
dc.contributor.author Al-Heijan A.
dc.contributor.author Tamim H.M.
dc.contributor.author Al-Ghamdi G.
dc.contributor.author Arabi Y.M.
dc.contributor.editor
dc.date 2013
dc.date.accessioned 2017-10-05T15:40:10Z
dc.date.available 2017-10-05T15:40:10Z
dc.date.issued 2013
dc.identifier 10.1016/j.thromres.2013.09.036
dc.identifier.isbn
dc.identifier.issn 00493848
dc.identifier.uri http://hdl.handle.net/10938/17277
dc.description.abstract Rationale The relationship between kidney function and venous thromboembolism (VTE) in critically ill patients is not well studied. The main objective of this study was to evaluate this relationship in patients admitted to a medical-surgical intensive care unit (ICU). Methods This was a retrospective study of 798 patients admitted to a tertiary-care ICU and prospectively followed for the development of clinically suspected and radiologically diagnosed deep venous thrombosis or pulmonary embolism. Patients were divided based on admission creatinine and dialysis history into five groups: normal kidney function, RIFLE classes R, I and F (combined = acute kidney injury [AKI]) and endstage renal disease (ESRD). We compared VTE prophylaxis practices and VTE incidence in these groups and evaluated renal failure as a VTE risk factor using multivariate Cox regression analysis. Results Of the 798 patients, 27.2percent had AKI and 10.1percent had ESRD. Unfractionated heparin use was similar in the five groups but enoxaparin use was less frequent in AKI (13.4percent) and ESRD (3.8percent) patients compared with patients with normal kidney function (39.0percent). VTE occurred in 7.6percent of patients with normal renal function, 7.8percent AKI patients and 2.5percent ESRD patients (p = 0.22). The adjusted hazard ratios for VTE compared to patients with normal kidney function were 0.35 (95percent confidence interval [CI], 0.08-1.47) for RIFLE class R, 1.19 (95percent CI, 0.83-1.70) for RIFLE class I, 0.82 (95percent CI, 0.59-1.14) for RIFLE class F and 0.71 (95percent CI, 0.49-1.02, p = 0.06) for ESRD. Conclusions Neither AKI nor ESRD was an independent risk factors for critically ill patients. © 2013 The Authors.
dc.format.extent
dc.format.extent Pages: (671-675)
dc.language English
dc.publisher OXFORD
dc.relation.ispartof Publication Name: Thrombosis Research; Publication Year: 2013; Volume: 132; no. 6; Pages: (671-675);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Renal failure as a risk factor for venous thromboembolism in critically Ill patients: A cohort study
dc.type Article
dc.contributor.affiliation Al-Dorzi, H.M., Intensive Care Department, King Abdulaziz Medical City, Riyadh, 11426, Saudi Arabia, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Mail Code 1425, PO Box 22490, Riyadh, 11426, Saudi Arabia
dc.contributor.affiliation Al-Heijan, A., Intensive Care Department, King Abdulaziz Medical City, Riyadh, 11426, Saudi Arabia
dc.contributor.affiliation Tamim, H.M., Epidemiology and Biostatistics, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, Department of Internal Medicine, American University of Beirut- Medical Center, Beirut-Lebanon, United States
dc.contributor.affiliation Al-Ghamdi, G., Intensive Care Department, King Abdulaziz Medical City, Riyadh, 11426, Saudi Arabia, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Mail Code 1425, PO Box 22490, Riyadh, 11426, Saudi Arabia
dc.contributor.affiliation Arabi, Y.M., Intensive Care Department, King Abdulaziz Medical City, Riyadh, 11426, Saudi Arabia, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Mail Code 1425, PO Box 22490, Riyadh, 11426, Saudi Arabia
dc.contributor.authorAddress Arabi, Y.M.; Intensive Care Department, King Abdulaziz Medical City, Riyadh, 11426, Saudi Arabia; email: yaseenarabi@yahoo.com
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail aldorzih@yahoo.com; drheijan@gmail.com; Hani_t@yahoo.com; galghamdi@gmail.com; yaseenarabi@yahoo.com
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Al-Dorzi, HM
dc.contributor.authorInitials Al-Heijan, A
dc.contributor.authorInitials Tamim, HM
dc.contributor.authorInitials Al-Ghamdi, G
dc.contributor.authorInitials Arabi, YM
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Arabi, YM (reprint author), King Abdul Aziz Med City, Dept Intens Care, Riyadh 11426, Saudi Arabia.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Arabi YM, 2013, CHEST, V144, P152, DOI 10.1378-chest.12-2028; Becker RC, 2002, AM HEART J, V143, P753, DOI 10.1067-mhj.2002.120774; Bellomo R, 2004, CRIT CARE, V8, pR204, DOI 10.1186-cc2872; Cook D, 2005, CRIT CARE MED, V33, P1565, DOI 10.1097-01.CCM.0000171207.95319.B2; Cook D, 2008, CRIT CARE, V12, DOI 10.1186-cc6810; Daneschvar HL, 2008, THROMB HAEMOSTASIS, V99, P1035, DOI 10.1160-TH08-02-0107; Decousus H, 2011, CHEST, V139, P69, DOI 10.1378-chest.09-3081; Douketis J, 2008, ARCH INTERN MED, V168, P1805, DOI 10.1001-archinte.168.16.1805; Geerts W, 2002, J CRIT CARE, V17, P95, DOI 10.1053-jcrc.2002.33941; Geerts WH, 2008, CHEST, V133, p381S, DOI 10.1378-chest.08-0656; Joynt GM, 2000, CHEST, V117, P178, DOI 10.1378-chest.117.1.178; Kayali F, 2008, AM J MED, V121, P226, DOI 10.1016-j.amjmed.2007.08.042; Khorana AA, 2007, CANCER, V110, P2339, DOI 10.1002-cncr.23062; KNAUS WA, 1985, CRIT CARE MED, V13, P818, DOI 10.1097-00003246-198510000-00009; Kumar G, 2012, CLIN J AM SOC NEPHRO, V7, P1584, DOI 10.2215-CJN.00250112; Levey AS, 1999, ANN INTERN MED, V130, P461; Mehta RL, 2007, CRIT CARE, V11, pR31, DOI DOI 10.1186-CC5713; Parikh AM, 2011, AM J KIDNEY DIS, V58, P746, DOI 10.1053-j.ajkd.2011.06.021; Pavord S, 2011, BLOOD REV, V25, P271, DOI 10.1016-j.blre.2011.07.001; RABELINK TJ, 1994, KIDNEY INT, V46, P287, DOI 10.1038-ki.1994.274; Sanderink GJCM, 2002, THROMB RES, V105, P225, DOI 10.1016-S0049-3848(02)00031-2; Taher AT, 2011, J THROMB THROMBOLYS, V31, P47, DOI 10.1007-s11239-010-0492-2; Thakar CV, 2009, CRIT CARE MED, V37, P2552, DOI 10.1097-CCM.0b013e3181a5906f; Tveit DP, 2002, AM J KIDNEY DIS, V39, P1011, DOI 10.1053-ajkd.2002.32774; Wattanakit K, 2008, J AM SOC NEPHROL, V19, P135, DOI 10.1681-ASN.2007030308
dc.description.citedCount
dc.description.citedTotWOSCount 1
dc.description.citedWOSCount 1
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden THBRA
dc.identifier.pubmedID 24144445
dc.identifier.scopusID 84889879526
dc.identifier.url
dc.publisher.address THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Thromb. Res.
dc.relation.ispartOfIssue 6
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Thrombosis Research
dc.relation.ispartofPubTitleAbbr Thromb. Res.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 132
dc.source.ID WOS:000327158000008
dc.type.publication Journal
dc.subject.otherAuthKeyword Acute kidney injury
dc.subject.otherAuthKeyword Chronic kidney failure
dc.subject.otherAuthKeyword Critically ill
dc.subject.otherAuthKeyword Venous thromboembolism
dc.subject.otherChemCAS creatinine, 19230-81-0, 60-27-5
dc.subject.otherChemCAS enoxaparin, 679809-58-6
dc.subject.otherChemCAS heparin, 37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5
dc.subject.otherIndex creatinine
dc.subject.otherIndex enoxaparin
dc.subject.otherIndex heparin
dc.subject.otherIndex acute kidney failure
dc.subject.otherIndex adult
dc.subject.otherIndex aged
dc.subject.otherIndex APACHE
dc.subject.otherIndex article
dc.subject.otherIndex clinical practice
dc.subject.otherIndex cohort analysis
dc.subject.otherIndex comparative study
dc.subject.otherIndex compression stocking
dc.subject.otherIndex controlled study
dc.subject.otherIndex critically ill patient
dc.subject.otherIndex deep vein thrombosis
dc.subject.otherIndex dialysis
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex incidence
dc.subject.otherIndex intensive care unit
dc.subject.otherIndex intermittent pneumatic compression device
dc.subject.otherIndex kidney failure
dc.subject.otherIndex kidney function
dc.subject.otherIndex lung embolism
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex medical history
dc.subject.otherIndex outcome assessment
dc.subject.otherIndex priority journal
dc.subject.otherIndex renal replacement therapy
dc.subject.otherIndex retrospective study
dc.subject.otherIndex risk factor
dc.subject.otherIndex thrombosis prevention
dc.subject.otherIndex venous thromboembolism
dc.subject.otherIndex Acute kidney injury
dc.subject.otherIndex Chronic kidney failure
dc.subject.otherIndex Critically ill
dc.subject.otherIndex Venous thromboembolism
dc.subject.otherIndex Acute Kidney Injury
dc.subject.otherIndex Adult
dc.subject.otherIndex Cohort Studies
dc.subject.otherIndex Critical Illness
dc.subject.otherIndex Female
dc.subject.otherIndex Heparin
dc.subject.otherIndex Humans
dc.subject.otherIndex Kidney Failure, Chronic
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Prospective Studies
dc.subject.otherIndex Pulmonary Embolism
dc.subject.otherIndex Retrospective Studies
dc.subject.otherIndex Risk Factors
dc.subject.otherIndex Venous Thrombosis
dc.subject.otherKeywordPlus CHRONIC KIDNEY-DISEASE
dc.subject.otherKeywordPlus DEEP-VEIN THROMBOSIS
dc.subject.otherKeywordPlus PULMONARY-EMBOLISM
dc.subject.otherKeywordPlus PHARMACODYNAMICS
dc.subject.otherKeywordPlus PHARMACOKINETICS
dc.subject.otherKeywordPlus INSUFFICIENCY
dc.subject.otherKeywordPlus PROPHYLAXIS
dc.subject.otherKeywordPlus PREVALENCE
dc.subject.otherKeywordPlus DALTEPARIN
dc.subject.otherKeywordPlus PREVENTION
dc.subject.otherWOS Hematology
dc.subject.otherWOS Peripheral Vascular Disease


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