AUB ScholarWorks

A comparison between prophylaxis and on demand treatment for severe haemophilia

Show simple item record Khoriaty R. Taher A. Inati A. Lee C.
dc.contributor.editor Oct-2005 2017-10-05T15:40:14Z 2017-10-05T15:40:14Z 2005
dc.identifier 10.1111/j.1365-2257.2005.00716.x
dc.identifier.issn 01419854
dc.description.abstract Patients with severe haemophilia can be treated for bleeding either prophylactically or on demand. Each treatment modality has advantages and disadvantages from both a medical and economic point of view. This study aims to find which modality requires more units of clotting factors per body weight per year and to compare the number of bleeds between the two. The study sample consisted of 133 patients with severe haemophilia A and B treated in the Katharine Dormandy Haemophilia Centre at the Royal Free Hampstead NHS Trust in London. The average number of clotting factors used per body weight per year was 2181.7 units for prophylaxis vs. 711 units for on demand treatment (P = 0.000). Although more units used means more money spent, and although prophylaxis has additional complications, namely venipunctures and increased risk of viral contamination, other criteria must be considered including the total number of bleeds and health-related quality of life. The total number of bleeds per year was significantly (P = 0.021) less for prophylactically (7.4) vs. on-demand treated patients (11.4). This suggests that prophylaxis reduces the risk of arthropathies, the number of future hospital visits and orthopaedic surgeries, and is thus the optimal modality of treatment for patients with severe haemophilia. © 2005 Blackwell Publishing Ltd.
dc.format.extent Pages: (320-323)
dc.language English
dc.publisher OXFORD
dc.relation.ispartof Publication Name: Clinical and Laboratory Haematology; Publication Year: 2005; Volume: 27; no. 5; Pages: (320-323);
dc.source Scopus
dc.title A comparison between prophylaxis and on demand treatment for severe haemophilia
dc.type Article
dc.contributor.affiliation Khoriaty, R., American University of Beirut, Beirut, Lebanon, American University of Beirut, PO Box: 11-0236-2182, Riad El-Solh-Beirut 1107 2020, Lebanon
dc.contributor.affiliation Taher, A., American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Inati, A., American University of Beirut, Beirut, Lebanon, Nini Hospital, Tripoli, Lebanon
dc.contributor.affiliation Lee, C., American University of Beirut, Beirut, Lebanon, Katharine Dormandy Haemophilia Centre, Royal Free Hampstead NHS Trust, London, United Kingdom
dc.contributor.authorAddress Khoriaty, R.; American University of Beirut, PO Box: 11-0236-2182, Riad El-Solh-Beirut 1107 2020, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Khoriaty, R
dc.contributor.authorInitials Taher, A
dc.contributor.authorInitials Inati, A
dc.contributor.authorInitials Lee, C
dc.contributor.authorReprintAddress Khoriaty, R (reprint author), Am Univ Beirut, POB 11-0236-2182,Riad Elsolh 1107, Beirut 2020, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Aznar JA, 2000, HAEMOPHILIA, V6, P170, DOI 10.1046-j.1365-2516.2000.00397.x; Berntorp E, 1995, B WORLD HEALTH ORGAN, V73, P691; DIMITRIOS P, 2002, EMEDICINE J, V3; Fischer K, 2002, BLOOD, V99, P2337, DOI 10.1182-blood.V99.7.2337; GIRVAN DP, 1994, J PEDIATR SURG, V29, P1220, DOI 10.1016-0022-3468(94)90806-0; Medeiros D, 1998, HAEMOPHILIA, V4, P10; MICHELSON AD, 1995, CHEST, V108, pS506, DOI 10.1378-chest.108.4_Supplement.506S; Miners AH, 1999, HAEMOPHILIA, V5, P378; Miners AH, 2000, J INTERN MED, V247, P493, DOI 10.1046-j.1365-2796.2000.00633.x; Molho P, 2000, HAEMOPHILIA, V6, P23; NILSSON IM, 1976, ACTA PAEDIATR SCAND, V65, P129, DOI 10.1111-j.1651-2227.1976.tb16525.x; PETTERSSON H, 1981, ACTA PAEDIATR SCAND, V70, P565, DOI 10.1111-j.1651-2227.1981.tb05741.x; Rodriguez-Merchan EC, 1999, HAEMOPHILIA, V5, P53, DOI 10.1046-j.1365-2516.1999.0050s1053.x; Smith PS, 1996, J PEDIATR, V129, P424, DOI 10.1016-S0022-3476(96)70076-8; STEVENS M, 1994, TRANSFUSION, V34, pA133; Szucs TD, 1996, HAEMOPHILIA, V2, P211, DOI 10.1111-j.1365-2516.1996.tb00139.x; WESENBERG F, 1993, PEDIATR HEMAT ONCOL, V10, P233, DOI 10.3109-08880019309029489; ZAPPA SC, 1994, ARCH PEDIAT ADOL MED, V148, P327
dc.description.citedCount 11
dc.description.citedTotWOSCount 10
dc.description.citedWOSCount 9
dc.format.extentCount 4
dc.identifier.coden CLHAD
dc.identifier.pubmedID 16178913
dc.identifier.scopusID 26044455717
dc.publisher.address 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
dc.relation.ispartOfISOAbbr Clin. Lab. Haematol.
dc.relation.ispartOfIssue 5
dc.relation.ispartofPubTitle Clinical and Laboratory Haematology
dc.relation.ispartofPubTitleAbbr Clin. Lab. Haematol.
dc.relation.ispartOfVolume 27
dc.source.ID WOS:000232047000008
dc.type.publication Journal
dc.subject.otherAuthKeyword Bleeding
dc.subject.otherAuthKeyword Coagulation factors
dc.subject.otherAuthKeyword Haemophilia
dc.subject.otherAuthKeyword On demand
dc.subject.otherAuthKeyword Prophylaxis
dc.subject.otherChemCAS recombinant blood clotting factor 9, 177403-26-8, 178900-90-8
dc.subject.otherChemCAS Blood Coagulation Factors
dc.subject.otherIndex blood clotting factor
dc.subject.otherIndex recombinant blood clotting factor 8
dc.subject.otherIndex recombinant blood clotting factor 9
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex arthropathy
dc.subject.otherIndex article
dc.subject.otherIndex bleeding
dc.subject.otherIndex child
dc.subject.otherIndex cost effectiveness analysis
dc.subject.otherIndex disease severity
dc.subject.otherIndex drug therapy
dc.subject.otherIndex hemophilia
dc.subject.otherIndex hospitalization
dc.subject.otherIndex human
dc.subject.otherIndex major clinical study
dc.subject.otherIndex on demand therapy
dc.subject.otherIndex orthopedic surgery
dc.subject.otherIndex priority journal
dc.subject.otherIndex prophylaxis
dc.subject.otherIndex quality of life
dc.subject.otherIndex risk benefit analysis
dc.subject.otherIndex risk reduction
dc.subject.otherIndex vein puncture
dc.subject.otherIndex viral contamination
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Adult
dc.subject.otherIndex Blood Coagulation Factors
dc.subject.otherIndex Child
dc.subject.otherIndex Child, Preschool
dc.subject.otherIndex Cost-Benefit Analysis
dc.subject.otherIndex Hemarthrosis
dc.subject.otherIndex Hemophilia A
dc.subject.otherIndex Hemorrhage
dc.subject.otherIndex Hospitalization
dc.subject.otherIndex Humans
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Orthopedic Procedures
dc.subject.otherIndex Premedication
dc.subject.otherIndex Quality of Life
dc.subject.otherKeywordPlus ORTHOPEDIC STATUS
dc.subject.otherKeywordPlus ACCESS DEVICES
dc.subject.otherKeywordPlus CHILDREN
dc.subject.otherKeywordPlus INDIVIDUALS
dc.subject.otherWOS Hematology

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


My Account