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Effects of clopidogrel therapy on oxidative stress, inflammation, vascular function, and progenitor cells in stable coronary artery disease

Show simple item record Ramadan R. Dhawan S.S. Syed H. Pohlel F.K. Binongo J.N.G. Ghazzal Z.B. Quyyumi A.A.
dc.contributor.editor 2014 2017-10-05T15:40:20Z 2017-10-05T15:40:20Z 2014
dc.identifier 10.1097/FJC.0000000000000057
dc.identifier.issn 01602446
dc.description.abstract Background:Traditional cardiovascular risk factors lead to endothelial injury and activation of leukocytes and platelets that initiate and propagate atherosclerosis. We proposed that clopidogrel therapy in patients with stable coronary artery disease imparts a pleiotropic effect that extends beyond antiplatelet aggregation to other atheroprotective processes. Methods: Forty-one subjects were randomized in a double-blind, placebo-controlled, crossover study to receive either clopidogrel 75 mg daily or placebo for 6 weeks and then transitioned immediately to the other treatment for an additional 6 weeks. We assessed (1) endothelial function as flow-mediated dilation of the brachial artery, (2) arterial stiffness and central augmentation index using applanation tonometry, (3) vascular function as fingertip reactive hyperemia index, (4) inflammation by measuring plasma CD40 ligand and serum high-sensitivity c-reactive protein levels, (5) oxidative stress by measuring plasma aminothiols, and (6) circulating progenitor cells, at baseline and at the end of each 6-week treatment period. Results: Clopidogrel therapy resulted in a significant reduction in soluble CD40 ligand (P = 0.03), a prothrombotic and proinflammatory molecule derived mainly from activated platelets. However, clopidogrel therapy had no effect on endothelial function, arterial stiffness, inflammatory and oxidative stress markers, or progenitor cells. Conclusions: Our findings suggest a solitary antiplatelet effect of clopidogrel therapy in patients with stable coronary artery disease, with no effect on other subclinical markers of cardiovascular disease risk. © 2013 by Lippincott Williams and Wilkins.
dc.format.extent Pages: (369-374)
dc.language English
dc.publisher Lippincott Williams and Wilkins; PHILADELPHIA
dc.relation.ispartof Publication Name: Journal of Cardiovascular Pharmacology; Publication Year: 2014; Volume: 63; no. 4; Pages: (369-374);
dc.source Scopus
dc.title Effects of clopidogrel therapy on oxidative stress, inflammation, vascular function, and progenitor cells in stable coronary artery disease
dc.type Article
dc.contributor.affiliation Ramadan, R., Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1462 Clifton Road N.E., Atlanta, GA 30322, United States
dc.contributor.affiliation Dhawan, S.S., Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1462 Clifton Road N.E., Atlanta, GA 30322, United States
dc.contributor.affiliation Syed, H., Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1462 Clifton Road N.E., Atlanta, GA 30322, United States
dc.contributor.affiliation Pohlel, F.K., Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1462 Clifton Road N.E., Atlanta, GA 30322, United States
dc.contributor.affiliation Binongo, J.N.G., Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Atlanta, GA, United States
dc.contributor.affiliation Ghazzal, Z.B., Division of Cardiology, Department of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Quyyumi, A.A., Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1462 Clifton Road N.E., Atlanta, GA 30322, United States
dc.contributor.authorAddress Ramadan, R.; Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1462 Clifton Road N.E., Atlanta, GA 30322, United States; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Cardiology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Cardiology
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Ramadan, R
dc.contributor.authorInitials Dhawan, SS
dc.contributor.authorInitials Syed, H
dc.contributor.authorInitials Pohlel, FK
dc.contributor.authorInitials Binongo, JNG
dc.contributor.authorInitials Ghazzal, ZB
dc.contributor.authorInitials Quyyumi, AA
dc.contributor.authorReprintAddress Ramadan, R (reprint author), Emory Clin Cardiovasc Res Inst, Dept Med, Div Cardiol, 1462 Clifton Rd NE Suite 507, Atlanta, GA 30322 USA.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedTotWOSCount 0
dc.description.citedWOSCount 0
dc.format.extentCount 6
dc.identifier.coden JCPCD
dc.identifier.scopusID 84898600199
dc.publisher.address 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
dc.relation.ispartOfISOAbbr J. Cardiovasc. Pharmacol.
dc.relation.ispartOfIssue 4
dc.relation.ispartofPubTitle Journal of Cardiovascular Pharmacology
dc.relation.ispartofPubTitleAbbr J. Cardiovasc. Pharmacol.
dc.relation.ispartOfVolume 63
dc.source.ID WOS:000334336300010
dc.type.publication Journal
dc.subject.otherAuthKeyword Antiplatelet
dc.subject.otherAuthKeyword atherosclerosis
dc.subject.otherAuthKeyword endothelial function
dc.subject.otherAuthKeyword oxidative stress
dc.subject.otherAuthKeyword progenitor cells
dc.subject.otherChemCAS acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1
dc.subject.otherChemCAS C reactive protein, 9007-41-4
dc.subject.otherChemCAS CD40 ligand, 226713-27-5
dc.subject.otherChemCAS clopidogrel, 113665-84-2, 120202-66-6, 90055-48-4, 94188-84-8
dc.subject.otherChemCAS cysteine, 4371-52-2, 52-89-1, 52-90-4
dc.subject.otherChemCAS cystine, 24645-67-8, 56-89-3, 6020-39-9
dc.subject.otherChemCAS dipeptidyl carboxypeptidase, 9015-82-1
dc.subject.otherChemCAS glutathione, 70-18-8
dc.subject.otherChemCAS glyceryl trinitrate, 55-63-0
dc.subject.otherIndex acetylsalicylic acid
dc.subject.otherIndex aminothiol
dc.subject.otherIndex antithrombocytic agent
dc.subject.otherIndex beta adrenergic receptor blocking agent
dc.subject.otherIndex C reactive protein
dc.subject.otherIndex calcium channel blocking agent
dc.subject.otherIndex CD40 ligand
dc.subject.otherIndex clopidogrel
dc.subject.otherIndex cysteine
dc.subject.otherIndex cystine
dc.subject.otherIndex dipeptidyl carboxypeptidase
dc.subject.otherIndex glutathione
dc.subject.otherIndex glyceryl trinitrate
dc.subject.otherIndex hydroxymethylglutaryl coenzyme A reductase inhibitor
dc.subject.otherIndex placebo
dc.subject.otherIndex adult
dc.subject.otherIndex arterial stiffness
dc.subject.otherIndex article
dc.subject.otherIndex atherosclerosis
dc.subject.otherIndex brachial artery
dc.subject.otherIndex cardiovascular function
dc.subject.otherIndex clinical article
dc.subject.otherIndex controlled study
dc.subject.otherIndex coronary artery disease
dc.subject.otherIndex crossover procedure
dc.subject.otherIndex double blind procedure
dc.subject.otherIndex drug effect
dc.subject.otherIndex endothelial progenitor cell
dc.subject.otherIndex female
dc.subject.otherIndex flow cytometry
dc.subject.otherIndex human
dc.subject.otherIndex inflammation
dc.subject.otherIndex male
dc.subject.otherIndex oxidative stress
dc.subject.otherIndex priority journal
dc.subject.otherIndex randomized controlled trial
dc.subject.otherIndex tonometry
dc.subject.otherIndex vascular endothelium
dc.subject.otherIndex vasodilatation
dc.subject.otherKeywordPlus AMERICAN-HEART-ASSOCIATION
dc.subject.otherKeywordPlus ST-SEGMENT ELEVATION
dc.subject.otherKeywordPlus C-REACTIVE PROTEIN
dc.subject.otherKeywordPlus MYOCARDIAL-INFARCTION
dc.subject.otherKeywordPlus ENDOTHELIAL DYSFUNCTION
dc.subject.otherKeywordPlus HUMAN PLASMA
dc.subject.otherKeywordPlus CARDIOVASCULAR-DISEASE
dc.subject.otherKeywordPlus ANTIPLATELET THERAPY
dc.subject.otherKeywordPlus CONTROLLED TRIAL
dc.subject.otherKeywordPlus RISK-FACTORS
dc.subject.otherWOS Cardiac and Cardiovascular Systems
dc.subject.otherWOS Pharmacology and Pharmacy

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