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Hypertriglyceridemia and peripheral neuropathy in neurologically asymptomatic patients

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dc.contributor.author Kassem H.S.
dc.contributor.author Azar S.T.
dc.contributor.author Zantout M.S.
dc.contributor.author Sawaya R.A.
dc.contributor.editor
dc.date Dec-2005
dc.date.accessioned 2017-10-05T15:40:25Z
dc.date.available 2017-10-05T15:40:25Z
dc.date.issued 2005
dc.identifier
dc.identifier.isbn
dc.identifier.issn
dc.identifier.uri http://hdl.handle.net/10938/17440
dc.description.abstract Objectives: In this study we intended to find a correlation between hypertriglyceridemia and peripheral neuropathy (PN) in patients with a high triglyceride level and no neurological complaints. Methods: We rec ruited 24 patients (21 males and 3 females) having a triglyceride level above 300 mg-dl with no neurologic complaints and none of the other common causes of PN and they underwent an electroneurographic study. The distal motor or sensory latencies (DL), motor or sensory conduction velocities (CV), and motor or sensory amplitudes (AMP) were collected for the peroneal, posterior tibial, sural, median, and ulnar nerves and were considered abnormal if they fall above or below 2 standard deviations of reference values. Results: Our results show that 70.8percent of the patients had a significant delay in the DL of the sural nerves and 66.7percent had a significant delay in the DL of the median sensory fibers. 54.2percent of the patients had a significant decrease in the motor CV in the posterior tibial nerves and 33.3percent had a significant decrease in the sensory CV in the sural nerves. The means of the DL and CV were significantly different from reference values in most of the nerves. Amplitudes were the least if at all affected. Conclusion: The pattern of the abnormalities affecting more t he DL, the sensory nerves and the longer nerves of the lower extremities is suggestive of an early axonal polyneuropathy. We conclude that hypertriglyceridemia affects conduction parameters in peripheral nerves in a trend suggestive of early peripheral neuropathy. © Neuroendocrinology Letters.
dc.format.extent
dc.format.extent Pages: (775-779)
dc.language English
dc.publisher STOCKHOLM
dc.relation.ispartof Publication Name: Neuroendocrinology Letters; Publication Year: 2005; Volume: 26; no. 6; Pages: (775-779);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Hypertriglyceridemia and peripheral neuropathy in neurologically asymptomatic patients
dc.type Article
dc.contributor.affiliation Kassem, H.S., Department of Internal Medicine, American University of Beirut-Medical Center, Bliss Street, Beirut, Lebanon
dc.contributor.affiliation Azar, S.T., Department of Internal Medicine, American University of Beirut-Medical Center, Bliss Street, Beirut, Lebanon
dc.contributor.affiliation Zantout, M.S., Department of Internal Medicine, American University of Beirut-Medical Center, Bliss Street, Beirut, Lebanon
dc.contributor.affiliation Sawaya, R.A., Department of Internal Medicine, American University of Beirut-Medical Center, Bliss Street, Beirut, Lebanon
dc.contributor.authorAddress Azar, S.T.; Department of Internal Medicine, Division of Endocrinology, American University of Beirut-Medical Center, Bliss Street, Beirut, Lebanon; email: sazar@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Neurology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Neurology
dc.contributor.authorEmail sazar@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Kassem, HS
dc.contributor.authorInitials Azar, ST
dc.contributor.authorInitials Zantout, MS
dc.contributor.authorInitials Sawaya, RA
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Azar, ST (reprint author), Amer Univ Beirut, Med Ctr, Div Endocrinol, Dept Internal Med, Bliss St, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited David W S, 1999, Electromyogr Clin Neurophysiol, V39, P227; Drory V E, 1999, Electromyogr Clin Neurophysiol, V39, P39; FESSEL WJ, 1971, BRAIN, V94, P531, DOI 10.1093-brain-94.3.531; Hughes RAC, 2002, BRIT MED J, V324, P466, DOI 10.1136-bmj.324.7335.466; Hughes RAC, 2004, BRAIN, V127, P1723, DOI 10.1093-brain-awh192; Kimura J., 1989, ELECTRODIAGNOSIS DIS; Martyn C, 1997, J NEUROL NEUROSUR PS, V62, P310, DOI 10.1136-jnnp.62.4.310; MCMANIS PG, 1994, NEUROLOGY, V44, P2185; SANDBANK U, 1971, ACTA NEUROPATHOL, V19, P290; SANDBANK U, 1973, BRAIN, V96, P355, DOI 10.1093-brain-96.2.355
dc.description.citedCount 15
dc.description.citedTotWOSCount 11
dc.description.citedWOSCount 11
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden NLETD
dc.identifier.pubmedID 16380709
dc.identifier.scopusID 33644993135
dc.identifier.url
dc.publisher.address PO BOX 26132, S-100 41 STOCKHOLM, SWEDEN
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dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Neuroendocrinol. Lett.
dc.relation.ispartOfIssue 6
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Neuroendocrinology Letters
dc.relation.ispartofPubTitleAbbr Neuroendocrinol. Lett.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 26
dc.source.ID WOS:000236048900031
dc.type.publication Journal
dc.subject.otherAuthKeyword Electrophysiological parameters
dc.subject.otherAuthKeyword Peripheral neuropathy
dc.subject.otherAuthKeyword Triglycerides
dc.subject.otherChemCAS
dc.subject.otherIndex triacylglycerol
dc.subject.otherIndex adult
dc.subject.otherIndex amplitude modulation
dc.subject.otherIndex article
dc.subject.otherIndex clinical article
dc.subject.otherIndex controlled study
dc.subject.otherIndex correlation analysis
dc.subject.otherIndex disease association
dc.subject.otherIndex electroneurography
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex hypertriglyceridemia
dc.subject.otherIndex latent period
dc.subject.otherIndex male
dc.subject.otherIndex median nerve
dc.subject.otherIndex motor nerve conduction
dc.subject.otherIndex pathogenesis
dc.subject.otherIndex peripheral neuropathy
dc.subject.otherIndex peroneal neuropathy
dc.subject.otherIndex posterior tibial nerve
dc.subject.otherIndex reference value
dc.subject.otherIndex sensory nerve conduction
dc.subject.otherIndex sural nerve
dc.subject.otherIndex triacylglycerol blood level
dc.subject.otherIndex ulnar nerve paralysis
dc.subject.otherIndex Adult
dc.subject.otherIndex Electric Stimulation
dc.subject.otherIndex Electrophysiology
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Hypertriglyceridemia
dc.subject.otherIndex Male
dc.subject.otherIndex Median Nerve
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Motor Neurons
dc.subject.otherIndex Neural Conduction
dc.subject.otherIndex Neurons, Afferent
dc.subject.otherIndex Peripheral Nerves
dc.subject.otherIndex Peripheral Nervous System Diseases
dc.subject.otherIndex Peroneal Nerve
dc.subject.otherIndex Reaction Time
dc.subject.otherIndex Spinal Nerves
dc.subject.otherIndex Sural Nerve
dc.subject.otherIndex Tibial Nerve
dc.subject.otherIndex Ulnar Nerve
dc.subject.otherKeywordPlus POLYNEUROPATHY
dc.subject.otherWOS Endocrinology and Metabolism
dc.subject.otherWOS Neurosciences


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