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Hypovitaminosis D osteopathy: Is it mediated through PTH, lean mass, or is it a direct effect?

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dc.contributor.author Arabi A.
dc.contributor.author Baddoura R.
dc.contributor.author Awada H.
dc.contributor.author Salamoun M.
dc.contributor.author Ayoub G.
dc.contributor.author El-Hajj Fuleihan G.
dc.contributor.editor
dc.date Aug-2006
dc.date.accessioned 2017-10-05T15:40:37Z
dc.date.available 2017-10-05T15:40:37Z
dc.date.issued 2006
dc.identifier 10.1016/j.bone.2006.01.140
dc.identifier.isbn
dc.identifier.issn 87563282
dc.identifier.uri http://hdl.handle.net/10938/17543
dc.description.abstract Hypovitaminosis D is increasing worldwide and is associated with low bone mass. The effects of hypovitaminosis D on bone might be direct or mediated through decreased muscle mass and function and-or secondary hyperparathyroidism. This study systematically investigated the relative contribution of lean mass, PTH, and the direct effect of vitamin D as predictors of vitamin D mediated osteopathy in elderly individuals. 460 ambulatory subjects aged 65-85 years had their bone mass and lean body mass measured by a dual-energy X-ray absorptiometry. Serum calcium, phosphorus and alkaline phosphatase, intact parathyroid hormone (PTH) and 25-hydroxyvitamin D (25 OHD) were also measured. Serum 25 OHD correlated with lean body mass in men, r = 0.24, P = 0.002, but not in women; and with bone mass at all skeletal sites in men, r = 0.20-0.30, P  0.02. Correlations were also noted at all skeletal sites in women except for the spine, r = 0.13-0.18, P  0.04. In both genders, BMD at sites enriched in cortical bone was 0.4-0.7 SD lower in the group with the lowest vitamin D tertile than that in the group in the highest tertile. After controlling for PTH, the magnitude of the correlations between BMD and 25 OHD remained significant in both genders. After controlling for lean body mass, the magnitude of these correlations did not change in women and decreased but remained significant in men. After adjustment for age and height, both lean body mass and PTH had significant independent contributions to BMD variance at all skeletal sites. After adjustment for age, height, lean mass, and PTH, 25 OHD did not have any significant residual contribution to BMD variance except at the trochanter in men. This study demonstrates that vitamin D osteopathy in the elderly is in large part mediated through lean mass in men and through PTH levels in both genders, with a greater contribution of PTH in women than in men. There was little demonstrable independent relation between serum 25 OHD and bone mass. © 2006 Elsevier Inc. All rights reserved.
dc.format.extent
dc.format.extent Pages: (268-275)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Bone; Publication Year: 2006; Volume: 39; no. 2; Pages: (268-275);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Hypovitaminosis D osteopathy: Is it mediated through PTH, lean mass, or is it a direct effect?
dc.type Article
dc.contributor.affiliation Arabi, A., Calcium Metabolism and Osteoporosis Program, American University, Beirut-Medical Center, Bliss street, Beirut, 113-6044, Lebanon
dc.contributor.affiliation Baddoura, R., Division of Rheumatology, Saint Joseph University, Beirut, Lebanon
dc.contributor.affiliation Awada, H., Division of Rheumatology, Saint Joseph University, Beirut, Lebanon
dc.contributor.affiliation Salamoun, M., Calcium Metabolism and Osteoporosis Program, American University, Beirut-Medical Center, Bliss street, Beirut, 113-6044, Lebanon
dc.contributor.affiliation Ayoub, G., Division of Rheumatology, Saint Joseph University, Beirut, Lebanon
dc.contributor.affiliation El-Hajj Fuleihan, G., Calcium Metabolism and Osteoporosis Program, American University, Beirut-Medical Center, Bliss street, Beirut, 113-6044, Lebanon
dc.contributor.authorAddress El-Hajj Fuleihan, G.; Calcium Metabolism and Osteoporosis Program, American University, Beirut-Medical Center, Bliss street, Beirut, 113-6044, Lebanon; email: gf01@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail gf0l@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Arabi, A
dc.contributor.authorInitials Baddoura, R
dc.contributor.authorInitials Awada, H
dc.contributor.authorInitials Salamoun, M
dc.contributor.authorInitials Ayoub, G
dc.contributor.authorInitials Fuleihan, GEH
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Fuleihan, GEH (reprint author), Amer Univ Beirut, Med Ctr, Calcium Metab and Osteoporosis Program, Bliss St, Beirut 1136044, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 31
dc.description.citedTotWOSCount 27
dc.description.citedWOSCount 26
dc.format.extentCount 8
dc.identifier.articleNo
dc.identifier.coden BONED
dc.identifier.pubmedID 16495164
dc.identifier.scopusID 33744931640
dc.identifier.url
dc.publisher.address 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
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dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Bone
dc.relation.ispartOfIssue 2
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Bone
dc.relation.ispartofPubTitleAbbr Bone
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 39
dc.source.ID WOS:000238708400006
dc.type.publication Journal
dc.subject.otherAuthKeyword BMD
dc.subject.otherAuthKeyword Elderly
dc.subject.otherAuthKeyword Lean mass
dc.subject.otherAuthKeyword PTH
dc.subject.otherAuthKeyword Vitamin D osteopathy
dc.subject.otherChemCAS 25 hydroxyvitamin D, 64719-49-9
dc.subject.otherChemCAS parathyroid hormone, 12584-96-2, 68893-82-3, 9002-64-6
dc.subject.otherChemCAS 25-hydroxyvitamin D, 64719-49-9
dc.subject.otherChemCAS Alkaline Phosphatase, EC 3.1.3.1
dc.subject.otherChemCAS Calcium, 7440-70-2
dc.subject.otherChemCAS Parathyroid Hormone
dc.subject.otherChemCAS PTH protein, human
dc.subject.otherChemCAS Vitamin D, 1406-16-2
dc.subject.otherIndex 25 hydroxyvitamin D
dc.subject.otherIndex parathyroid hormone
dc.subject.otherIndex adult
dc.subject.otherIndex aged
dc.subject.otherIndex alkaline phosphatase blood level
dc.subject.otherIndex article
dc.subject.otherIndex body height
dc.subject.otherIndex body weight
dc.subject.otherIndex bone density
dc.subject.otherIndex bone mass
dc.subject.otherIndex calcium blood level
dc.subject.otherIndex dual energy X ray absorptiometry
dc.subject.otherIndex female
dc.subject.otherIndex gender
dc.subject.otherIndex human
dc.subject.otherIndex hyperparathyroidism
dc.subject.otherIndex lean body weight
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex osteopathic medicine
dc.subject.otherIndex parathyroid hormone blood level
dc.subject.otherIndex phosphate blood level
dc.subject.otherIndex spine
dc.subject.otherIndex vitamin deficiency
dc.subject.otherIndex Aged
dc.subject.otherIndex Aged, 80 and over
dc.subject.otherIndex Alkaline Phosphatase
dc.subject.otherIndex Body Composition
dc.subject.otherIndex Bone Density
dc.subject.otherIndex Calcium
dc.subject.otherIndex Densitometry, X-Ray
dc.subject.otherIndex Female
dc.subject.otherIndex Femur
dc.subject.otherIndex Humans
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Linear Models
dc.subject.otherIndex Male
dc.subject.otherIndex Parathyroid Hormone
dc.subject.otherIndex Retrospective Studies
dc.subject.otherIndex Rickets
dc.subject.otherIndex Sex Factors
dc.subject.otherIndex Thinness
dc.subject.otherIndex Urban Population
dc.subject.otherIndex Vitamin D
dc.subject.otherIndex Vitamin D Deficiency
dc.subject.otherKeywordPlus BONE-MINERAL DENSITY
dc.subject.otherKeywordPlus VITAMIN-D DEFICIENCY
dc.subject.otherKeywordPlus HEALTHY POSTMENOPAUSAL WOMEN
dc.subject.otherKeywordPlus PARATHYROID-HORMONE
dc.subject.otherKeywordPlus BODY-COMPOSITION
dc.subject.otherKeywordPlus ELDERLY-WOMEN
dc.subject.otherKeywordPlus SECONDARY HYPERPARATHYROIDISM
dc.subject.otherKeywordPlus D SUPPLEMENTATION
dc.subject.otherKeywordPlus MUSCLE STRENGTH
dc.subject.otherKeywordPlus D INSUFFICIENCY
dc.subject.otherWOS Endocrinology and Metabolism


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