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Candida infective endocarditis

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dc.contributor.author Baddley J.W.
dc.contributor.author Benjamin Jr. D.K.
dc.contributor.author Patel M.
dc.contributor.author Miro J.
dc.contributor.author Athan E.
dc.contributor.author Barsic B.
dc.contributor.author Bouza E.
dc.contributor.author Clara L.
dc.contributor.author Elliott T.
dc.contributor.author Kanafani Z.
dc.contributor.author Klein J.
dc.contributor.author Lerakis S.
dc.contributor.author Levine D.
dc.contributor.author Spelman D.
dc.contributor.author Rubinstein E.
dc.contributor.author Tornos P.
dc.contributor.author Morris A.J.
dc.contributor.author Pappas P.
dc.contributor.author Fowler Jr. V.G.
dc.contributor.author Chu V.H.
dc.contributor.author Cabell C.
dc.contributor.editor
dc.date Jul-2008
dc.date.accessioned 2017-10-05T15:40:51Z
dc.date.available 2017-10-05T15:40:51Z
dc.date.issued 2008
dc.identifier 10.1007/s10096-008-0466-x
dc.identifier.isbn
dc.identifier.issn 09349723
dc.identifier.uri http://hdl.handle.net/10938/17688
dc.description.abstract Candida infective endocarditis (IE) is uncommon but often fatal. Most epidemiologic data are derived from small case series or case reports. This study was conducted to explore the epidemiology, treatment patterns, and outcomes of patients with Candida IE. We compared 33 Candida IE cases to 2,716 patients with non-fungal IE in the International Collaboration on Endocarditis - Prospective Cohort Study (ICE-PCS). Patients were enrolled and the data collected from June 2000 until August 2005. We noted that patients with Candida IE were more likely to have prosthetic valves (p0.001), short-term indwelling catheters (p0.0001), and have healthcare-associated infections (p0.001). The reasons for surgery differed between the two groups: myocardial abscess (46.7percent vs. 22.2percent, p=0.026) and persistent positive blood cultures (33.3percent vs. 9.9percent, p=0.003) were more common among those with Candida IE. Mortality at discharge was higher in patients with Candida IE (30.3percent) when compared to non-fungal cases (17percent, p=0.046). Among Candida patients, mortality was similar in patients who received combination surgical and antifungal therapy versus antifungal therapy alone (33.3percent vs. 27.8percent, p=0.26). New antifungal drugs, particularly echinocandins, were used frequently. These multi-center data suggest distinct epidemiologic features of Candida IE when compared to non-fungal cases. Indications for surgical intervention are different and mortality is increased. Newer antifungal treatment options are increasingly used. Large, multi-center studies are needed to help better define Candida IE. © 2008 Springer-Verlag.
dc.format.extent
dc.format.extent Pages: (519-529)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: European Journal of Clinical Microbiology and Infectious Diseases; Publication Year: 2008; Volume: 27; no. 7; Pages: (519-529);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Candida infective endocarditis
dc.type Article
dc.contributor.affiliation Baddley, J.W., Department of Medicine, University of Alabama at Birmingham, 229 Tinsley Harrison Tower, 1900 University Boulevard, Birmingham, AL 35294-0006, United States, Department of Medicine, Infectious Diseases Section, Birmingham Veterans Administration Medical Center, 700 19th Street South, Birmingham, AL 35233, United States
dc.contributor.affiliation Benjamin Jr., D.K., Department of Medicine, Duke University Medical Center, P.O. Box 1799, Durham, NC 27715, United States
dc.contributor.affiliation Patel, M., Department of Medicine, University of Alabama at Birmingham, 229 Tinsley Harrison Tower, 1900 University Boulevard, Birmingham, AL 35294-0006, United States, Department of Medicine, Infectious Diseases Section, Birmingham Veterans Administration Medical Center, 700 19th Street South, Birmingham, AL 35233, United States
dc.contributor.affiliation Miró, J., Department of Medicine, Institut d'Investigacions Biomediques August Pi I Sunyer-Hospital Clinic, University of Barcelona, Villarroel, 170, Barcelona 08036, Spain
dc.contributor.affiliation Athan, E., Department of Infectious Diseases, Barwon Health, Geelong Hospital, P.O. Box 281, Geelong, VIC 3220, Australia
dc.contributor.affiliation Barsic, B., Department of Infectious Diseases, University Hospital for Infectious Diseases, Mirogojska 8, Zagreb, Croatia
dc.contributor.affiliation Bouza, E., Department of Medical Microbiology, Hospital General Universitario Gregorio Marañón, Dr. Esquerdo 46, Madrid 28007, Spain
dc.contributor.affiliation Clara, L., Hospital Italiano, Buenos Aires, Argentina
dc.contributor.affiliation Elliott, T., Department of Clinical Microbiology and Infection Control, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, United Kingdom
dc.contributor.affiliation Kanafani, Z., Department of Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Klein, J., Department of Microbiology, St. Thomas' Hospital, North Wing, Lambeth Palace Road, London SE1 7EH, United Kingdom
dc.contributor.affiliation Lerakis, S., Department of Medicine, Emory University, 1365A Clifton Road, NE, Atlanta, GA 30322, United States
dc.contributor.affiliation Levine, D., Department of Medicine, Wayne State University, 4201 St. Antoine Boulevard, Detroit, MI 48201, United States
dc.contributor.affiliation Spelman, D., Department of Microbiology, Alfred Hospital, Commercial Road, Melbourne, VIC 3004, Australia
dc.contributor.affiliation Rubinstein, E., Department of Medicine, Section of Infectious Diseases, University of Manitoba, 543-730 William Avenue, Winnipeg, MB R3E0W3, Canada
dc.contributor.affiliation Tornos, P., Department of Cardiology, Hospital Universitari Vall d'Hebron, P Vall d'Hebron 119-129, Barcelona 08035, Spain
dc.contributor.affiliation Morris, A.J., Department of Microbiology, Auckland City Hospital, Grafton, Auckland, New Zealand
dc.contributor.affiliation Pappas, P., Outcomes Research and Assessment Group, Duke Clinical Research Institute, Durham, NC 17969, United States
dc.contributor.affiliation Fowler Jr., V.G., Department of Medicine, Duke University Medical Center, P.O. Box 1799, Durham, NC 27715, United States
dc.contributor.affiliation Chu, V.H., Department of Medicine, Duke University Medical Center, P.O. Box 1799, Durham, NC 27715, United States
dc.contributor.affiliation Cabell, C., Department of Medicine, Duke University Medical Center, P.O. Box 1799, Durham, NC 27715, United States
dc.contributor.authorAddress Baddley, J. W.; Department of Medicine, University of Alabama at Birmingham, 229 Tinsley Harrison Tower, 1900 University Boulevard, Birmingham, AL 35294-0006, United States; email: jbaddley@uab.edu
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail jbaddley@uab.edu
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Baddley, JW
dc.contributor.authorInitials Benjamin, DK
dc.contributor.authorInitials Patel, M
dc.contributor.authorInitials Miro, J
dc.contributor.authorInitials Athan, E
dc.contributor.authorInitials Barsic, B
dc.contributor.authorInitials Bouza, E
dc.contributor.authorInitials Clara, L
dc.contributor.authorInitials Elliott, T
dc.contributor.authorInitials Kanafani, Z
dc.contributor.authorInitials Klein, J
dc.contributor.authorInitials Lerakis, S
dc.contributor.authorInitials Levine, D
dc.contributor.authorInitials Spelman, D
dc.contributor.authorInitials Rubinstein, E
dc.contributor.authorInitials Tornos, P
dc.contributor.authorInitials Morris, AJ
dc.contributor.authorInitials Pappas, P
dc.contributor.authorInitials Fowler, VG
dc.contributor.authorInitials Chu, VH
dc.contributor.authorInitials Cabell, C
dc.contributor.authorOrcidID Bouza, Emilio-0000-0001-6967-9267; Benito, Natividad-0000-0001-6410-013X
dc.contributor.authorReprintAddress Baddley, JW (reprint author), Univ Alabama, Div Infect Dis, Dept Med, 1900 Univ Blvd,229 Tinsley Harrison Tower, Birmingham, AL 35294 USA.
dc.contributor.authorResearcherID De Rosa, Francesco Giuseppe-J-3049-2013; Bouza, Emilio-D-8661-2014; Benito, Natividad-D-1855-2010
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 48
dc.description.citedTotWOSCount 50
dc.description.citedWOSCount 46
dc.format.extentCount 11
dc.identifier.articleNo
dc.identifier.coden EJCDE
dc.identifier.pubmedID 18283504
dc.identifier.scopusID 45449103062
dc.identifier.url
dc.publisher.address 233 SPRING ST, NEW YORK, NY 10013 USA
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dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Eur. J. Clin. Microbiol. Infect. Dis.
dc.relation.ispartOfIssue 7
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle European Journal of Clinical Microbiology and Infectious Diseases
dc.relation.ispartofPubTitleAbbr Eur. J. Clin. Microbiol. Infect. Dis.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 27
dc.source.ID WOS:000256755000005
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS amphotericin B, 1397-89-3, 30652-87-0
dc.subject.otherChemCAS caspofungin, 189768-38-5
dc.subject.otherChemCAS fluconazole, 86386-73-4
dc.subject.otherChemCAS voriconazole, 137234-62-9
dc.subject.otherChemCAS Antifungal Agents
dc.subject.otherIndex amphotericin B
dc.subject.otherIndex amphotericin B lipid complex
dc.subject.otherIndex caspofungin
dc.subject.otherIndex fluconazole
dc.subject.otherIndex voriconazole
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex blood culture
dc.subject.otherIndex Candida endocarditis
dc.subject.otherIndex controlled study
dc.subject.otherIndex female
dc.subject.otherIndex heart abscess
dc.subject.otherIndex heart valve prosthesis
dc.subject.otherIndex hospital infection
dc.subject.otherIndex human
dc.subject.otherIndex indwelling catheter
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex mortality
dc.subject.otherIndex postoperative complication
dc.subject.otherIndex priority journal
dc.subject.otherIndex treatment outcome
dc.subject.otherIndex Adult
dc.subject.otherIndex Aged
dc.subject.otherIndex Antifungal Agents
dc.subject.otherIndex Candida
dc.subject.otherIndex Candidiasis
dc.subject.otherIndex Catheters, Indwelling
dc.subject.otherIndex Cross Infection
dc.subject.otherIndex Endocarditis
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Prostheses and Implants
dc.subject.otherIndex Risk Factors
dc.subject.otherKeywordPlus PROSTHETIC VALVE ENDOCARDITIS
dc.subject.otherKeywordPlus FUNGAL ENDOCARDITIS
dc.subject.otherKeywordPlus INTERNATIONAL COLLABORATION
dc.subject.otherKeywordPlus AMPHOTERICIN-B
dc.subject.otherKeywordPlus CASPOFUNGIN
dc.subject.otherKeywordPlus VORICONAZOLE
dc.subject.otherKeywordPlus FLUCONAZOLE
dc.subject.otherKeywordPlus REPLACEMENT
dc.subject.otherKeywordPlus PROGRESS
dc.subject.otherKeywordPlus THERAPY
dc.subject.otherWOS Infectious Diseases
dc.subject.otherWOS Microbiology


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