AUB ScholarWorks

Negative effect of leptin on bone mass in type 1 diabetes

Show simple item record

dc.contributor.author Kassem H.S.
dc.contributor.author Arabi A.
dc.contributor.author Zantout M.S.
dc.contributor.author Azar S.T.
dc.contributor.editor
dc.date Dec-2008
dc.date.accessioned 2017-10-05T15:40:55Z
dc.date.available 2017-10-05T15:40:55Z
dc.date.issued 2008
dc.identifier 10.1007/s00592-008-0050-y
dc.identifier.isbn
dc.identifier.issn 09405429
dc.identifier.uri http://hdl.handle.net/10938/17705
dc.description.abstract Studies investigating the effect of leptin on bone mass were inconsistent and some related it to the effect of insulin. We intend in this cross-sectional study to investigate the effect of leptin on bone mass in type 1 diabetic patients. We recruited 42 patients with type 1 diabetes for which we determined weight, height, HbA1c, microalbuminuria, serum leptin, bone mineral content (BMC) and density (BMD), and body composition. The patients had an average age of 20.1 ± 0.6 years, an average body mass index (BMI) of 23.6 ± 0.5 kg-cm2 and an average duration of diabetes of 9.1 ± 1.0 years. The Z-score was not correlated with HbA1c or duration of the disease, and the average Z-score was not different in patients with microalbuminuria as compared to patients with no reported microalbuminuria. On the other hand, Z-score and BMC correlated negatively with leptin (r = -0.31; p = 0.04 and -0.60, p andlt; 0.01, respectively). These correlations persisted after adjustment for fat mass. We conclude that not metabolic control of diabetes, but serum leptin has a negative effect on bone density in young patients with type 1 diabetes. This negative effect of leptin on bone density maybe, in part, due to deficiency of endogenous insulin secretion in these patients. © 2008 Springer-Verlag.
dc.format.extent
dc.format.extent Pages: (237-241)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Acta Diabetologica; Publication Year: 2008; Volume: 45; no. 4; Pages: (237-241);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Negative effect of leptin on bone mass in type 1 diabetes
dc.type Article
dc.contributor.affiliation Kassem, H.S., Department of Internal Medicine, Division of Endocrinology, American University of Beirut-Medical Center, Bliss Street, Beirut, Lebanon
dc.contributor.affiliation Arabi, A., Department of Internal Medicine, Division of Endocrinology, American University of Beirut-Medical Center, Bliss Street, Beirut, Lebanon
dc.contributor.affiliation Zantout, M.S., Department of Internal Medicine, Division of Endocrinology, American University of Beirut-Medical Center, Bliss Street, Beirut, Lebanon
dc.contributor.affiliation Azar, S.T., Department of Internal Medicine, Division of Endocrinology, American University of Beirut-Medical Center, Bliss Street, Beirut, Lebanon
dc.contributor.authorAddress Azar, S. T.; Department of Internal Medicine, Division of Endocrinology, American University of Beirut-Medical Center, Bliss Street, Beirut, Lebanon; email: sazar@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Endocrinology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Endocrinology
dc.contributor.authorEmail sazar@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Kassem, HS
dc.contributor.authorInitials Arabi, A
dc.contributor.authorInitials Zantout, MS
dc.contributor.authorInitials Azar, ST
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Azar, ST (reprint author), Amer Univ Beirut, Med Ctr, Div Endocrinol, Dept Internal Med, Bliss St, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Abou Samra R, 2005, J CLIN ENDOCR METAB, V90, P2588, DOI 10.1210-jc.2004-2049; Alexopoulou O, 2006, DIABETES METAB, V32, P453, DOI 10.1016-S1262-3636(07)70303-8; Bartos V, 2001, Cas Lek Cesk, V140, P299; Blum M, 2003, CALCIFIED TISSUE INT, V73, P27, DOI 10.1007-s00223-002-1019-4; Chau Diane L, 2003, Curr Diab Rep, V3, P37, DOI 10.1007-s11892-003-0051-8; Ducy P, 2000, CELL, V100, P197, DOI 10.1016-S0092-8674(00)81558-5; Goulding A, 1998, CALCIFIED TISSUE INT, V63, P456, DOI 10.1007-s002239900557; HUI SL, 1985, J CLIN ENDOCR METAB, V60, P74; Iwamoto I, 2000, ACTA OBSTET GYN SCAN, V79, P1060, DOI 10.1034-j.1600-0412.2000.0790121060.x; Johnstone AM, 2005, AM J CLIN NUTR, V82, P941; KIEL D, 1999, J BONE MINER RES, V14, P475; Kontogianni MD, 2004, J BONE MINER RES, V19, P546, DOI 10.1359-JBMR.040107; LEVIN ME, 1976, NEW ENGL J MED, V294, P241, DOI 10.1056-NEJM197601292940502; LONNQVIST F, 1995, NAT MED, V1, P950, DOI 10.1038-nm0995-950; López-Ibarra P J, 2001, Endocr Pract, V7, P346; Martini G, 2001, BONE, V28, P113, DOI 10.1016-S8756-3282(00)00408-7; Matkovic V, 1997, J CLIN ENDOCR METAB, V82, P3239, DOI 10.1210-jc.82.10.3239; MCNAIR P, 1981, EUR J CLIN INVEST, V11, P55, DOI 10.1111-j.1365-2362.1981.tb01765.x; Miazgowski T, 1998, OSTEOPOROSIS INT, V8, P399, DOI 10.1007-s001980050082; Morberg CM, 2003, J CLIN ENDOCR METAB, V88, P5795, DOI 10.1210-jc.2003-030496; Odabasi E, 2000, EUR J ENDOCRINOL, V142, P170, DOI 10.1530-eje.0.1420170; OLMOS JM, 1994, BONE MINER, V26, P1, DOI 10.1016-S0169-6009(08)80157-2; Ormarsdottir S, 2001, J GASTROEN HEPATOL, V16, P1409, DOI 10.1046-j.1440-1746.2001.02631.x; Pasco JA, 2001, J CLIN ENDOCR METAB, V86, P1884, DOI 10.1210-jc.86.5.1884; Rauch F, 1998, CALCIFIED TISSUE INT, V63, P453, DOI 10.1007-s002239900556; Rozadilla A, 2000, JOINT BONE SPINE, V67, P215; Ruhl CE, 2002, J BONE MINER RES, V17, P1896, DOI 10.1359-jbmr.2002.17.10.1896; Sato M, 2001, J CLIN ENDOCR METAB, V86, P5273, DOI 10.1210-jc.86.11.5273; SIMON EV, 2000, AN ESP PEDIATR, V52, P507; Thomas T, 2002, J BONE MINER RES, V17, P1563, DOI 10.1359-jbmr.2002.17.9.1563; Thomas T, 1999, ENDOCRINOLOGY, V140, P1630, DOI 10.1210-en.140.4.1630; Watanabe S, 2003, J BONE MINER METAB, V21, P166, DOI 10.1007-s007740300026; Yamauchi M, 2001, CLIN ENDOCRINOL, V55, P341, DOI 10.1046-j.1365-2265.2001.01361.x
dc.description.citedCount 4
dc.description.citedTotWOSCount 3
dc.description.citedWOSCount 2
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden ACDAE
dc.identifier.pubmedID 18690407
dc.identifier.scopusID 55949108685
dc.identifier.url
dc.publisher.address 233 SPRING ST, NEW YORK, NY 10013 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Acta Diabetol.
dc.relation.ispartOfIssue 4
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Acta Diabetologica
dc.relation.ispartofPubTitleAbbr Acta Diabetol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 45
dc.source.ID WOS:000260538200007
dc.type.publication Journal
dc.subject.otherAuthKeyword Bone
dc.subject.otherAuthKeyword Bone mineral density
dc.subject.otherAuthKeyword Leptin
dc.subject.otherAuthKeyword Osteoporosis
dc.subject.otherAuthKeyword Type 1 diabetes
dc.subject.otherChemCAS hemoglobin A1c, 62572-11-6
dc.subject.otherChemCAS Hemoglobin A, Glycosylated
dc.subject.otherChemCAS Insulin, 11061-68-0
dc.subject.otherChemCAS Leptin
dc.subject.otherIndex hemoglobin A1c
dc.subject.otherIndex leptin
dc.subject.otherIndex adult
dc.subject.otherIndex analytic method
dc.subject.otherIndex article
dc.subject.otherIndex body composition
dc.subject.otherIndex body height
dc.subject.otherIndex body mass
dc.subject.otherIndex body weight
dc.subject.otherIndex bone density
dc.subject.otherIndex bone mass
dc.subject.otherIndex bone mineral
dc.subject.otherIndex clinical article
dc.subject.otherIndex cross-sectional study
dc.subject.otherIndex diabetic patient
dc.subject.otherIndex disease duration
dc.subject.otherIndex fat body
dc.subject.otherIndex female
dc.subject.otherIndex hormone action
dc.subject.otherIndex hormone blood level
dc.subject.otherIndex human
dc.subject.otherIndex insulin dependent diabetes mellitus
dc.subject.otherIndex male
dc.subject.otherIndex metabolic regulation
dc.subject.otherIndex microalbuminuria
dc.subject.otherIndex priority journal
dc.subject.otherIndex Adipose Tissue
dc.subject.otherIndex Age of Onset
dc.subject.otherIndex Body Mass Index
dc.subject.otherIndex Bone Density
dc.subject.otherIndex Chromatography, High Pressure Liquid
dc.subject.otherIndex Diabetes Mellitus, Type 1
dc.subject.otherIndex Female
dc.subject.otherIndex Hemoglobin A, Glycosylated
dc.subject.otherIndex Humans
dc.subject.otherIndex Insulin
dc.subject.otherIndex Leptin
dc.subject.otherIndex Male
dc.subject.otherIndex Young Adult
dc.subject.otherKeywordPlus MINERAL DENSITY
dc.subject.otherKeywordPlus SERUM LEPTIN
dc.subject.otherKeywordPlus PLASMA LEPTIN
dc.subject.otherKeywordPlus POSTMENOPAUSAL WOMEN
dc.subject.otherKeywordPlus BIOCHEMICAL MARKERS
dc.subject.otherKeywordPlus FAT MASS
dc.subject.otherKeywordPlus MELLITUS
dc.subject.otherKeywordPlus OBESE
dc.subject.otherKeywordPlus TURNOVER
dc.subject.otherKeywordPlus MEN
dc.subject.otherWOS Endocrinology and Metabolism


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


Browse

My Account