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Negative effect of leptin on bone mass in type 1 diabetes

Show simple item record Kassem H.S. Arabi A. Zantout M.S. Azar S.T.
dc.contributor.editor Dec-2008 2017-10-05T15:40:55Z 2017-10-05T15:40:55Z 2008
dc.identifier 10.1007/s00592-008-0050-y
dc.identifier.issn 09405429
dc.description.abstract Studies investigating the effect of leptin on bone mass were inconsistent and some related it to the effect of insulin. We intend in this cross-sectional study to investigate the effect of leptin on bone mass in type 1 diabetic patients. We recruited 42 patients with type 1 diabetes for which we determined weight, height, HbA1c, microalbuminuria, serum leptin, bone mineral content (BMC) and density (BMD), and body composition. The patients had an average age of 20.1 ± 0.6 years, an average body mass index (BMI) of 23.6 ± 0.5 kg-cm2 and an average duration of diabetes of 9.1 ± 1.0 years. The Z-score was not correlated with HbA1c or duration of the disease, and the average Z-score was not different in patients with microalbuminuria as compared to patients with no reported microalbuminuria. On the other hand, Z-score and BMC correlated negatively with leptin (r = -0.31; p = 0.04 and -0.60, p andlt; 0.01, respectively). These correlations persisted after adjustment for fat mass. We conclude that not metabolic control of diabetes, but serum leptin has a negative effect on bone density in young patients with type 1 diabetes. This negative effect of leptin on bone density maybe, in part, due to deficiency of endogenous insulin secretion in these patients. © 2008 Springer-Verlag.
dc.format.extent Pages: (237-241)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Acta Diabetologica; Publication Year: 2008; Volume: 45; no. 4; Pages: (237-241);
dc.source Scopus
dc.title Negative effect of leptin on bone mass in type 1 diabetes
dc.type Article
dc.contributor.affiliation Kassem, H.S., Department of Internal Medicine, Division of Endocrinology, American University of Beirut-Medical Center, Bliss Street, Beirut, Lebanon
dc.contributor.affiliation Arabi, A., Department of Internal Medicine, Division of Endocrinology, American University of Beirut-Medical Center, Bliss Street, Beirut, Lebanon
dc.contributor.affiliation Zantout, M.S., Department of Internal Medicine, Division of Endocrinology, American University of Beirut-Medical Center, Bliss Street, Beirut, Lebanon
dc.contributor.affiliation Azar, S.T., Department of Internal Medicine, Division of Endocrinology, American University of Beirut-Medical Center, Bliss Street, Beirut, Lebanon
dc.contributor.authorAddress Azar, S. T.; Department of Internal Medicine, Division of Endocrinology, American University of Beirut-Medical Center, Bliss Street, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Endocrinology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Endocrinology
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Kassem, HS
dc.contributor.authorInitials Arabi, A
dc.contributor.authorInitials Zantout, MS
dc.contributor.authorInitials Azar, ST
dc.contributor.authorReprintAddress Azar, ST (reprint author), Amer Univ Beirut, Med Ctr, Div Endocrinol, Dept Internal Med, Bliss St, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 4
dc.description.citedTotWOSCount 3
dc.description.citedWOSCount 2
dc.format.extentCount 5
dc.identifier.coden ACDAE
dc.identifier.pubmedID 18690407
dc.identifier.scopusID 55949108685
dc.publisher.address 233 SPRING ST, NEW YORK, NY 10013 USA
dc.relation.ispartOfISOAbbr Acta Diabetol.
dc.relation.ispartOfIssue 4
dc.relation.ispartofPubTitle Acta Diabetologica
dc.relation.ispartofPubTitleAbbr Acta Diabetol.
dc.relation.ispartOfVolume 45
dc.source.ID WOS:000260538200007
dc.type.publication Journal
dc.subject.otherAuthKeyword Bone
dc.subject.otherAuthKeyword Bone mineral density
dc.subject.otherAuthKeyword Leptin
dc.subject.otherAuthKeyword Osteoporosis
dc.subject.otherAuthKeyword Type 1 diabetes
dc.subject.otherChemCAS hemoglobin A1c, 62572-11-6
dc.subject.otherChemCAS Hemoglobin A, Glycosylated
dc.subject.otherChemCAS Insulin, 11061-68-0
dc.subject.otherChemCAS Leptin
dc.subject.otherIndex hemoglobin A1c
dc.subject.otherIndex leptin
dc.subject.otherIndex adult
dc.subject.otherIndex analytic method
dc.subject.otherIndex article
dc.subject.otherIndex body composition
dc.subject.otherIndex body height
dc.subject.otherIndex body mass
dc.subject.otherIndex body weight
dc.subject.otherIndex bone density
dc.subject.otherIndex bone mass
dc.subject.otherIndex bone mineral
dc.subject.otherIndex clinical article
dc.subject.otherIndex cross-sectional study
dc.subject.otherIndex diabetic patient
dc.subject.otherIndex disease duration
dc.subject.otherIndex fat body
dc.subject.otherIndex female
dc.subject.otherIndex hormone action
dc.subject.otherIndex hormone blood level
dc.subject.otherIndex human
dc.subject.otherIndex insulin dependent diabetes mellitus
dc.subject.otherIndex male
dc.subject.otherIndex metabolic regulation
dc.subject.otherIndex microalbuminuria
dc.subject.otherIndex priority journal
dc.subject.otherIndex Adipose Tissue
dc.subject.otherIndex Age of Onset
dc.subject.otherIndex Body Mass Index
dc.subject.otherIndex Bone Density
dc.subject.otherIndex Chromatography, High Pressure Liquid
dc.subject.otherIndex Diabetes Mellitus, Type 1
dc.subject.otherIndex Female
dc.subject.otherIndex Hemoglobin A, Glycosylated
dc.subject.otherIndex Humans
dc.subject.otherIndex Insulin
dc.subject.otherIndex Leptin
dc.subject.otherIndex Male
dc.subject.otherIndex Young Adult
dc.subject.otherKeywordPlus MINERAL DENSITY
dc.subject.otherKeywordPlus SERUM LEPTIN
dc.subject.otherKeywordPlus PLASMA LEPTIN
dc.subject.otherKeywordPlus POSTMENOPAUSAL WOMEN
dc.subject.otherKeywordPlus BIOCHEMICAL MARKERS
dc.subject.otherKeywordPlus FAT MASS
dc.subject.otherKeywordPlus MELLITUS
dc.subject.otherKeywordPlus OBESE
dc.subject.otherKeywordPlus TURNOVER
dc.subject.otherKeywordPlus MEN
dc.subject.otherWOS Endocrinology and Metabolism

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