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MR imaging findings in autosomal recessive hereditary spastic paraplegia

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dc.contributor.author Hourani R.
dc.contributor.author El-Hajj T.
dc.contributor.author Barada W.H.
dc.contributor.author Hourani M.
dc.contributor.author Yamout B.I.
dc.contributor.editor
dc.date May-2009
dc.date.accessioned 2017-10-05T15:41:02Z
dc.date.available 2017-10-05T15:41:02Z
dc.date.issued 2009
dc.identifier 10.3174/ajnr.A1483
dc.identifier.isbn
dc.identifier.issn 01956108
dc.identifier.uri http://hdl.handle.net/10938/17781
dc.description.abstract BACKGROUND AND PURPOSE: Hereditary spastic paraplegia (HSP) is a disorder characterized by degeneration of the corticospinal tracts and posterior column of the spinal cord. Previously described radiologic findings included nonspecific brain abnormalities such as brain atrophy and white matter lesions, as well as atrophy of the spinal cord. In our study, we aimed to better characterize brain and spine MR imaging findings in a series of patients with HSP. MATERIALS AND METHODS: Nine patients from 4 different Lebanese families with the autosomal recessive form of HSP were included in the study. All patients underwent brain and whole-spine MR imaging. We assessed the presence of white matter abnormalities mainly along the corticospinal tracts, brain atrophy, thinning of the corpus callosum, and the presence of spinal cord atrophy or abnormal signal intensity. RESULTS: Imaging revealed mild brain atrophy (44percent), atrophy of the corpus callosum (55percent), white matter lesions (67percent), abnormal T2 high signal intensity in the posterior limb of the internal capsule (55percent), and mild spinal cord atrophy (33percent). CONCLUSIONS: The MR imaging findings of HSP are nonspecific and variable; however, the most prominent features include atrophy of the corpus callosum, T2 signal intensity in the posterior limb of the internal capsule, and spinal cord atrophy.
dc.format.extent
dc.format.extent Pages: (936-940)
dc.language English
dc.publisher OAK BROOK
dc.relation.ispartof Publication Name: American Journal of Neuroradiology; Publication Year: 2009; Volume: 30; no. 5; Pages: (936-940);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title MR imaging findings in autosomal recessive hereditary spastic paraplegia
dc.type Article
dc.contributor.affiliation Hourani, R., Department of Diagnostic Radiology, American University of Beirut Medical Center, Beirut, Lebanon, Department of Clinical Radiology, American University of Beirut Medical Center, Department of Diagnostic Radiology, Bliss St, Beirut, Lebanon
dc.contributor.affiliation El-Hajj, T., Department of Internal Medicine, Neurology Division, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Barada, W.H., Department of Internal Medicine, Neurology Division, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Hourani, M., Department of Diagnostic Radiology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Yamout, B.I., Department of Internal Medicine, Neurology Division, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Hourani, R.; Department of Clinical Radiology, American University of Beirut Medical Center, Department of Diagnostic Radiology, Bliss St, Beirut, Lebanon; email: rh64@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Neurology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Neurology
dc.contributor.authorEmail rh64@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Hourani, R
dc.contributor.authorInitials El-Hajj, T
dc.contributor.authorInitials Barada, WH
dc.contributor.authorInitials Hourani, M
dc.contributor.authorInitials Yamout, BI
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Hourani, R (reprint author), Amer Univ Beirut, Med Ctr, Dept Diagnost Radiol, Bliss St, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 8
dc.description.citedTotWOSCount 10
dc.description.citedWOSCount 9
dc.format.extentCount 5
dc.identifier.articleNo
dc.identifier.coden AAJND
dc.identifier.pubmedID 19193756
dc.identifier.scopusID 65949116827
dc.identifier.url
dc.publisher.address 2210 MIDWEST RD, OAK BROOK, IL 60521 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Am. J. Neuroradiol.
dc.relation.ispartOfIssue 5
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle American Journal of Neuroradiology
dc.relation.ispartofPubTitleAbbr Am. J. Neuroradiol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 30
dc.source.ID WOS:000266133000012
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex autosomal recessive inheritance
dc.subject.otherIndex brain
dc.subject.otherIndex brain atrophy
dc.subject.otherIndex capsula interna
dc.subject.otherIndex clinical article
dc.subject.otherIndex corpus callosum
dc.subject.otherIndex diagnostic imaging
dc.subject.otherIndex female
dc.subject.otherIndex hereditary motor sensory neuropathy
dc.subject.otherIndex human
dc.subject.otherIndex Lebanon
dc.subject.otherIndex male
dc.subject.otherIndex neuroimaging
dc.subject.otherIndex nuclear magnetic resonance imaging
dc.subject.otherIndex pyramidal tract
dc.subject.otherIndex signal transduction
dc.subject.otherIndex spinal cord atrophy
dc.subject.otherIndex spine
dc.subject.otherIndex white matter
dc.subject.otherIndex Adult
dc.subject.otherIndex Brain
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Magnetic Resonance Imaging
dc.subject.otherIndex Male
dc.subject.otherIndex Spastic Paraplegia, Hereditary
dc.subject.otherIndex Spinal Cord
dc.subject.otherIndex Young Adult
dc.subject.otherKeywordPlus THIN CORPUS-CALLOSUM
dc.subject.otherKeywordPlus UPPER SPINAL-CORD
dc.subject.otherKeywordPlus TROYER-SYNDROME
dc.subject.otherKeywordPlus PURE
dc.subject.otherKeywordPlus PARAPARESIS
dc.subject.otherKeywordPlus HETEROGENEITY
dc.subject.otherKeywordPlus PROGRESSION
dc.subject.otherKeywordPlus PHENOTYPE
dc.subject.otherKeywordPlus FAMILIES
dc.subject.otherKeywordPlus DISEASES
dc.subject.otherWOS Clinical Neurology
dc.subject.otherWOS Neuroimaging
dc.subject.otherWOS Radiology, Nuclear Medicine and Medical Imaging


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