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Prevalence of asthmatic symptoms in Lebanese patients with type 1 diabetes and their unaffected siblings compared to age-matched controls

Show simple item record Taleb N. Bou Khalil P. Zantout M.S. Zalloua P. Azar S.T.
dc.contributor.editor Dec-2010 2017-10-05T15:41:20Z 2017-10-05T15:41:20Z 2010
dc.identifier 10.1007/s00592-009-0108-5
dc.identifier.issn 09405429
dc.description.abstract Patients with type 1 diabetes (a TH1 disease) have been reported to be at a lower risk of developing asthma (a TH2 disease). Both diseases are affected by environmental and genetic factors. Our objective is to examine this relationship in Lebanon, a Middle-Eastern country, where no previous similar studies are available. This is a cross-sectional observational study conducted at the Chronic Care Center, a referral medical center for type 1 diabetics. Patients with type 1 diabetes aged 6-39 years old, their unaffected siblings and age-matched control completed the International Primary Care Airways Group asthma screening questionnaire. The prevalence of asthma symptoms was compared among the three groups and separately within a subgroup of diabetics in relation to their carrier state of previously collected genetic data. Among 305 diabetics, 776 siblings and 187 controls, diabetics were at lower risk of having any asthma symptoms than controls; OR 0.48 (95percent CI 0.32-0.72, p 0.001) and siblings were at lower risk than diabetics and controls; OR 0.64 (95percent CI 0.45-0.91, p = 0.01) and 0.28 (95percent CI 0.19-0.42, p 0.001), respectively. Among 66 diabetics, carriers of the HLA-DQB1*0201 allele were at lower risk of having any asthma symptoms than non-carriers (25.5 vs. 53.3percent, p = 0.04). Only a statistically non-significant trend of higher risk was observed in carriers of HLA-DQB1*0301 and G allele at the 49 (A-G) nucleotide of CTLA-4 gene. The TH1-TH2 paradigm might partially explain these findings, since siblings were the least to report asthma symptoms. Future research is needed with diagnostic tests for asthma and extensive genetic testing. © 2009 Springer-Verlag.
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Acta Diabetologica; Publication Year: 2010; Volume: 47; suppl. 1;
dc.source Scopus
dc.title Prevalence of asthmatic symptoms in Lebanese patients with type 1 diabetes and their unaffected siblings compared to age-matched controls
dc.type Article
dc.contributor.affiliation Taleb, N., American University, Department of Internal Medicine, Beirut Medical Center, 3 Dag Hammarskjold Plaza, New York, NY 10017 2324, United States
dc.contributor.affiliation Bou Khalil, P., Division of Pulmonary and Critical Care, American University, Beirut Medical Center, New York, NY 10017 2324, United States
dc.contributor.affiliation Zantout, M.S., American University, Department of Internal Medicine, Beirut Medical Center, 3 Dag Hammarskjold Plaza, New York, NY 10017 2324, United States
dc.contributor.affiliation Zalloua, P., School of Medicine, Lebanese American University, Harvard School of Public Health, Boston, MA 02215, United States
dc.contributor.affiliation Azar, S.T., American University, Department of Internal Medicine, Beirut Medical Center, 3 Dag Hammarskjold Plaza, New York, NY 10017 2324, United States
dc.contributor.authorAddress Azar, S. T.; Division of Endocrinology and Metabolism, Department of Internal Medicine, American University of Beirut Medical Center, 3 Dag Hammarskjold Plaza, 8th Floor, New York, NY 10017 2324, United States; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Pulmonary and Critical Care Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Pulmonary and Critical Care Medicine
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Taleb, N
dc.contributor.authorInitials Khalil, PB
dc.contributor.authorInitials Zantout, MS
dc.contributor.authorInitials Zalloua, P
dc.contributor.authorInitials Azar, ST
dc.contributor.authorReprintAddress Azar, ST (reprint author), Amer Univ Beirut, Med Ctr, Div Endocrinol and Metab, Dept Internal Med, 3 Dag Hammarskjold Plaza,8th Floor, New York, NY 10017 USA.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 1
dc.description.citedTotWOSCount 2
dc.description.citedWOSCount 1
dc.identifier.coden ACDAE
dc.identifier.pubmedID 19319467
dc.identifier.scopusID 78751594987
dc.publisher.address 233 SPRING ST, NEW YORK, NY 10013 USA
dc.relation.ispartOfISOAbbr Acta Diabetol.
dc.relation.ispartofPubTitle Acta Diabetologica
dc.relation.ispartofPubTitleAbbr Acta Diabetol.
dc.relation.ispartOfSuppl 1
dc.relation.ispartOfVolume 47
dc.source.ID WOS:000289680000003
dc.type.publication Journal
dc.subject.otherAuthKeyword 49 (A-G) CTLA4
dc.subject.otherAuthKeyword Asthma
dc.subject.otherAuthKeyword HLA-DQB1
dc.subject.otherAuthKeyword TH1-TH2 paradigm
dc.subject.otherAuthKeyword Type 1 diabetes
dc.subject.otherChemCAS HLA-DQ Antigens
dc.subject.otherChemCAS HLA-DQB1 antigen
dc.subject.otherIndex cytotoxic T lymphocyte antigen 4
dc.subject.otherIndex HLA DQB1 antigen
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex asthma
dc.subject.otherIndex child
dc.subject.otherIndex controlled study
dc.subject.otherIndex cross-sectional study
dc.subject.otherIndex disease carrier
dc.subject.otherIndex female
dc.subject.otherIndex genetic polymorphism
dc.subject.otherIndex genetic risk
dc.subject.otherIndex genetic susceptibility
dc.subject.otherIndex high risk population
dc.subject.otherIndex human
dc.subject.otherIndex insulin dependent diabetes mellitus
dc.subject.otherIndex Lebanon
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex observational study
dc.subject.otherIndex preschool child
dc.subject.otherIndex priority journal
dc.subject.otherIndex questionnaire
dc.subject.otherIndex risk assessment
dc.subject.otherIndex sibling
dc.subject.otherIndex symptomatology
dc.subject.otherIndex Th1 cell
dc.subject.otherIndex Th2 cell
dc.subject.otherIndex Adolescent
dc.subject.otherIndex Adult
dc.subject.otherIndex Asthma
dc.subject.otherIndex Child
dc.subject.otherIndex Cross-Sectional Studies
dc.subject.otherIndex Diabetes Mellitus, Type 1
dc.subject.otherIndex Female
dc.subject.otherIndex HLA-DQ Antigens
dc.subject.otherIndex Humans
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Male
dc.subject.otherIndex Prevalence
dc.subject.otherIndex Questionnaires
dc.subject.otherIndex Risk Factors
dc.subject.otherIndex Siblings
dc.subject.otherIndex Young Adult
dc.subject.otherKeywordPlus CTLA-4 POLYMORPHISMS
dc.subject.otherKeywordPlus ATOPIC DISEASE
dc.subject.otherKeywordPlus CHILDREN
dc.subject.otherKeywordPlus ASSOCIATION
dc.subject.otherKeywordPlus GENE
dc.subject.otherKeywordPlus TH1
dc.subject.otherKeywordPlus AUTOIMMUNITY
dc.subject.otherKeywordPlus RESPONSES
dc.subject.otherKeywordPlus PARADIGM
dc.subject.otherKeywordPlus MELLITUS
dc.subject.otherWOS Endocrinology and Metabolism

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