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Brain magnetic resonance angiography in splenectomized adults with β-thalassemia intermedia

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dc.contributor.author Musallam K.M.
dc.contributor.author Beydoun A.
dc.contributor.author Hourani R.
dc.contributor.author Nasreddine W.
dc.contributor.author Raad R.
dc.contributor.author Koussa S.
dc.contributor.author Taher A.T.
dc.contributor.editor
dc.date Dec-2011
dc.date.accessioned 2017-10-05T15:41:29Z
dc.date.available 2017-10-05T15:41:29Z
dc.date.issued 2011
dc.identifier 10.1111/j.1600-0609.2011.01706.x
dc.identifier.isbn
dc.identifier.issn 09024441
dc.identifier.uri http://hdl.handle.net/10938/17998
dc.description.abstract Background: Hypercoagulability and venous thromboembolism are common in patients with β-thalassemia intermedia (TI), especially in the splenectomized adult. Although arterial involvement is not commonly reported, we have recently observed a high prevalence (60percent) of silent brain infarction on brain MRI in 30 splenectomized adults with TI. The pathophysiology of these white matter lesions remains unknown. Methods:In this prospective work, we evaluated magnetic resonance angiography (MRA) scans of the same cohort of 30 patients. Data collected were the presence or absence of vascular lesions, their locations, and severity. Correlations between MRA abnormality and patients-disease characteristics were evaluated. Comparisons between MRA and previous MRI findings were made. Results: Of 29 evaluable patients, 8 (27.6percent) had evidence of arterial stenosis on MRA. The majority of lesions had mild narrowing and mostly involved the internal carotid artery. Five patients (17.2percent) had evidence of aneurysms. Low total hemoglobin and high non-transferrin-bound iron levels independently characterized patients with evidence of stenosis on MRA. Among the 18 patients with silent brain infarction on MRI, three had evidence of stenosis on MRA with only one patient having lesions that could explain the silent infarcts. Conclusions:Cerebral vasculopathy is common in splenectomized adults with TI. However, large-vessel disease does not explain the occurrence of silent brain infarction. The combined use of MRA and MRI better identifies splenectomized TI adults with neuroimaging abnormalities. © 2011 John Wiley and Sons A-S.
dc.format.extent
dc.format.extent Pages: (539-546)
dc.language English
dc.publisher MALDEN
dc.relation.ispartof Publication Name: European Journal of Haematology; Publication Year: 2011; Volume: 87; no. 6; Pages: (539-546);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Brain magnetic resonance angiography in splenectomized adults with β-thalassemia intermedia
dc.type Article
dc.contributor.affiliation Musallam, K.M., Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Beydoun, A., Division of Neurology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Hourani, R., Department of Diagnostic Radiology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Nasreddine, W., Division of Neurology, Rafik Hariri University Hospital, Beirut, Lebanon
dc.contributor.affiliation Raad, R., Department of Diagnostic Radiology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Koussa, S., Chronic Care Center, Hazmieh, Lebanon
dc.contributor.affiliation Taher, A.T., Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Taher, A.T.; Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11-0236, Riad El-Solh 1107 2020, Beirut, Lebanon; email: ataher@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Neurology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Neurology
dc.contributor.authorEmail ataher@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Musallam, KM
dc.contributor.authorInitials Beydoun, A
dc.contributor.authorInitials Hourani, R
dc.contributor.authorInitials Nasreddine, W
dc.contributor.authorInitials Raad, R
dc.contributor.authorInitials Koussa, S
dc.contributor.authorInitials Taher, AT
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Taher, AT (reprint author), Amer Univ Beirut, Med Ctr, Div Hematol and Oncol, Dept Internal Med, POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 14
dc.description.citedTotWOSCount 14
dc.description.citedWOSCount 12
dc.format.extentCount 8
dc.identifier.articleNo
dc.identifier.coden EJHAE
dc.identifier.pubmedID 21913989
dc.identifier.scopusID 81255176258
dc.identifier.url
dc.publisher.address COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Eur. J. Haematol.
dc.relation.ispartOfIssue 6
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle European Journal of Haematology
dc.relation.ispartofPubTitleAbbr Eur. J. Haematol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 87
dc.source.ID WOS:000297018100009
dc.type.publication Journal
dc.subject.otherAuthKeyword Brain
dc.subject.otherAuthKeyword Magnetic resonance angiography
dc.subject.otherAuthKeyword Silent stroke
dc.subject.otherAuthKeyword Splenectomy
dc.subject.otherAuthKeyword Thalassemia intermedia
dc.subject.otherChemCAS
dc.subject.otherIndex adult
dc.subject.otherIndex aneurysm
dc.subject.otherIndex artery occlusion
dc.subject.otherIndex article
dc.subject.otherIndex beta thalassemia
dc.subject.otherIndex brain infarction
dc.subject.otherIndex clinical article
dc.subject.otherIndex clinical evaluation
dc.subject.otherIndex clinical trial
dc.subject.otherIndex cohort analysis
dc.subject.otherIndex disease severity
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex internal carotid artery
dc.subject.otherIndex magnetic resonance angiography
dc.subject.otherIndex male
dc.subject.otherIndex priority journal
dc.subject.otherIndex splenectomy
dc.subject.otherIndex Adult
dc.subject.otherIndex beta-Thalassemia
dc.subject.otherIndex Brain
dc.subject.otherIndex Humans
dc.subject.otherIndex Magnetic Resonance Angiography
dc.subject.otherIndex Models, Molecular
dc.subject.otherIndex Prospective Studies
dc.subject.otherIndex Splenectomy
dc.subject.otherKeywordPlus SICKLE-CELL-DISEASE
dc.subject.otherKeywordPlus INCIDENTAL FINDINGS
dc.subject.otherKeywordPlus INTRACRANIAL ANEURYSMS
dc.subject.otherKeywordPlus HYPERCOAGULABLE STATE
dc.subject.otherKeywordPlus CHILDREN
dc.subject.otherKeywordPlus IRON
dc.subject.otherKeywordPlus ATHEROSCLEROSIS
dc.subject.otherKeywordPlus MANAGEMENT
dc.subject.otherKeywordPlus ANEMIA
dc.subject.otherKeywordPlus STROKE
dc.subject.otherWOS Hematology


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