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Possible role of GLP-1 and its agonists in the treatment of type 1 diabetes mellitus

Show simple item record Issa C.M. Azar S.T.
dc.contributor.editor Oct-2012 2017-10-05T15:41:38Z 2017-10-05T15:41:38Z 2012
dc.identifier 10.1007/s11892-012-0291-6
dc.identifier.issn 15344827
dc.description.abstract Unfortunately, the only approved medical treatment for type 1 diabetesmellitus (DM) is insulin, despite the fact that tight control cannot be reached without some serious side effects such as hypoglycemia and weight gain.More and more importance is now shifted towards developing new drugs that can reach a better glycemic control with lesser side effects. Some of these promising drugs are the glucagon-like peptides 1 (GLP-1) and their agonists, which have been FDA approved for the treatment of type 2 DM. The purpose of this article is to review all of the relevant literature on the potential role of GLP-1 in the treatment of type 1 DM. Themajor source of data acquisition includedMedline search strategies, using the words type 1 diabetes mellitus and GLP-1. Articles published in the last 20 years were screened. GLP-1 increases insulin secretion in humans with existing beta cells; it also decreases glucagon secretion, and blunts appetite. Of note, new animal studies demonstrate a role in beta cell-proliferation and decreased apoptosis. Because of all the effects mentioned above, GLP-1 seems to be a promising drug for type 1 DM treatment, but more studies are still needed before solid conclusions can be drawn. © Springer Science+Business Media, LLC 2012.
dc.format.extent Pages: (560-567)
dc.language English
dc.publisher PHILADELPHIA
dc.relation.ispartof Publication Name: Current Diabetes Reports; Publication Year: 2012; Volume: 12; no. 5; Pages: (560-567);
dc.source Scopus
dc.title Possible role of GLP-1 and its agonists in the treatment of type 1 diabetes mellitus
dc.type Article
dc.contributor.affiliation Issa, C.M., Department of Internal Medicine, Division of Endocrinology and Metabolism, American University of Beirut-Medical Center, 3 Dag Hammarskjold Plaza, 8th floor, New York, NY 10017, United States
dc.contributor.affiliation Azar, S.T., Department of Internal Medicine, Division of Endocrinology and Metabolism, American University of Beirut-Medical Center, 3 Dag Hammarskjold Plaza, 8th floor, New York, NY 10017, United States
dc.contributor.authorAddress Azar, S.T.; Department of Internal Medicine, Division of Endocrinology and Metabolism, American University of Beirut-Medical Center, 3 Dag Hammarskjold Plaza, 8th floor, New York, NY 10017, United States; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine; Division: Endocrinology;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision Endocrinology
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Issa, CM
dc.contributor.authorInitials Azar, ST
dc.contributor.authorReprintAddress Azar, ST (reprint author), Amer Univ Beirut, Dept Internal Med, Div Endocrinol and Metab, Med Ctr, 3 Dag Hammarskjold Plaza,8th Floor, New York, NY 10017 USA.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 7
dc.description.citedTotWOSCount 7
dc.description.citedWOSCount 7
dc.format.extentCount 8
dc.identifier.coden CDRUA
dc.identifier.pubmedID 22767380
dc.identifier.scopusID 84870787581
dc.publisher.address 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
dc.relation.ispartOfISOAbbr Curr. Diabetes Rep.
dc.relation.ispartOfIssue 5
dc.relation.ispartofPubTitle Current Diabetes Reports
dc.relation.ispartofPubTitleAbbr Curr. Diabetes Rep.
dc.relation.ispartOfVolume 12
dc.source.ID WOS:000308286400014
dc.type.publication Journal
dc.subject.otherAuthKeyword GLP-1
dc.subject.otherAuthKeyword Glucagon
dc.subject.otherAuthKeyword Glycemic control
dc.subject.otherAuthKeyword Insulin
dc.subject.otherAuthKeyword Type 1 diabetesmellitus
dc.subject.otherChemCAS C peptide, 59112-80-0
dc.subject.otherChemCAS arginine, 1119-34-2, 15595-35-4, 7004-12-8, 74-79-3
dc.subject.otherChemCAS exendin 4, 141732-76-5, 141758-74-9
dc.subject.otherChemCAS gastrin, 9002-76-0
dc.subject.otherChemCAS glucagon, 11140-85-5, 62340-29-8, 9007-92-5
dc.subject.otherChemCAS glucagon like peptide 1, 89750-14-1
dc.subject.otherChemCAS glucose, 50-99-7, 84778-64-3
dc.subject.otherChemCAS insulin, 9004-10-8
dc.subject.otherChemCAS lisofylline, 100324-81-0, 151852-32-3, 6493-06-7
dc.subject.otherChemCAS Blood Glucose
dc.subject.otherChemCAS Glucagon-Like Peptide 1, 89750-14-1
dc.subject.otherChemCAS Hypoglycemic Agents
dc.subject.otherChemCAS Insulin
dc.subject.otherIndex arginine
dc.subject.otherIndex C peptide
dc.subject.otherIndex exendin 4
dc.subject.otherIndex gastrin
dc.subject.otherIndex glucagon
dc.subject.otherIndex glucagon like peptide 1
dc.subject.otherIndex glucagon like peptide 1 receptor agonist
dc.subject.otherIndex glucagon like peptide 2
dc.subject.otherIndex glucose
dc.subject.otherIndex insulin
dc.subject.otherIndex lisofylline
dc.subject.otherIndex lymphocyte antibody
dc.subject.otherIndex placebo
dc.subject.otherIndex apoptosis
dc.subject.otherIndex article
dc.subject.otherIndex cell proliferation
dc.subject.otherIndex continuous infusion
dc.subject.otherIndex dietary intake
dc.subject.otherIndex drug dose comparison
dc.subject.otherIndex drug efficacy
dc.subject.otherIndex drug mechanism
dc.subject.otherIndex glucose blood level
dc.subject.otherIndex glucose transport
dc.subject.otherIndex glycemic control
dc.subject.otherIndex human
dc.subject.otherIndex hyperglycemia
dc.subject.otherIndex insulin dependent diabetes mellitus
dc.subject.otherIndex insulin release
dc.subject.otherIndex insulin resistance
dc.subject.otherIndex Medline
dc.subject.otherIndex morning dosage
dc.subject.otherIndex non insulin dependent diabetes mellitus
dc.subject.otherIndex nonhuman
dc.subject.otherIndex pancreas islet beta cell
dc.subject.otherIndex pancreas islet cell function
dc.subject.otherIndex pathophysiology
dc.subject.otherIndex postprandial state
dc.subject.otherIndex protein function
dc.subject.otherIndex protein interaction
dc.subject.otherIndex randomized controlled trial (topic)
dc.subject.otherIndex signal transduction
dc.subject.otherIndex stomach emptying
dc.subject.otherIndex treatment duration
dc.subject.otherIndex Animals
dc.subject.otherIndex Blood Glucose
dc.subject.otherIndex Diabetes Mellitus, Type 1
dc.subject.otherIndex Glucagon-Like Peptide 1
dc.subject.otherIndex Humans
dc.subject.otherIndex Hypoglycemic Agents
dc.subject.otherIndex Insulin
dc.subject.otherKeywordPlus GLUCAGON-LIKE PEPTIDE-1
dc.subject.otherKeywordPlus NOD MICE
dc.subject.otherKeywordPlus BETA-CELLS
dc.subject.otherKeywordPlus 7-36 AMIDE
dc.subject.otherKeywordPlus GLYCEMIC EXCURSIONS
dc.subject.otherKeywordPlus PANCREATIC GLUCAGON
dc.subject.otherKeywordPlus INSULIN-SECRETION
dc.subject.otherKeywordPlus GLYCOGEN-SYNTHASE
dc.subject.otherKeywordPlus GLUCOSE-TOLERANCE
dc.subject.otherWOS Endocrinology and Metabolism

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