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Predictors of quality of life among multiple sclerosis patients: A comprehensive analysis

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dc.contributor.author Yamout B.
dc.contributor.author Issa Z.
dc.contributor.author Herlopian A.
dc.contributor.author El Bejjani M.
dc.contributor.author Khalifa A.
dc.contributor.author Ghadieh A.S.
dc.contributor.author Habib R.H.
dc.contributor.editor
dc.date 2013
dc.date.accessioned 2017-10-05T15:41:47Z
dc.date.available 2017-10-05T15:41:47Z
dc.date.issued 2013
dc.identifier 10.1111/ene.12046
dc.identifier.isbn
dc.identifier.issn 13515101
dc.identifier.uri http://hdl.handle.net/10938/18195
dc.description.abstract Background and purpose: Multiple sclerosis (MS) is a debilitating neurological disease of young people with substantial consequences on patients' quality of life (QOL). A variety of QOL instruments have been used to evaluate the efficacy of treatments. However, no study assessed the role of the different demographic, clinical, physical, social, economic and psychological parameters in the perception of patients with MS of their QOL. Methods: Two-hundred and one consecutive patients attending outpatient clinics were prospectively studied and objectively assessed using Expanded Disability Status Scale (EDSS), 8-m walk test, and Symbol Digit Modality Test. Patients completed the following questionnaires: MS QOL-54, Hamilton Depression Rating Scale, Fatigue Severity Scale, Brief Pain Inventory Average Pain Score, Drug Side-Effects Severity Scale, Social Support, Religiosity, Physiotherapy and Exercise, and Socioeconomic Profile. Overall, QOL, physical (PHCS) and mental (MHCS) health composite scores were computed as outcome measures from MSQOL-54. Results: Depression, social support, religiosity, education years and living area predicted overall QOL by linear regression (R2=0.43). Unemployment and absence of fatigue correlated with poor and good QOL, respectively. Fatigue, pain, depression, EDSS, social support, MS type and anti-cholinergic treatment predicted PHCS (R2=0.81). Fatigue, pain, depression, education years and social support predicted MHCS (R2=0.70). Conclusion: The QOL in patients with MS is not solely determined by physical disability, but rather by the level of social support, living area, depression, level of education, employment, fatigue and religiosity. Accordingly, we suggest that these should be evaluated in every patient with MS as they may be modified by targeted interventions. © 2013 The Author(s) European Journal of Neurology © 2013 EFNS.
dc.format.extent
dc.format.extent Pages: (756-764)
dc.language English
dc.publisher HOBOKEN
dc.relation.ispartof Publication Name: European Journal of Neurology; Publication Year: 2013; Volume: 20; no. 5; Pages: (756-764);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Predictors of quality of life among multiple sclerosis patients: A comprehensive analysis
dc.type Article
dc.contributor.affiliation Yamout, B., Department of Neurology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Issa, Z., Department of Neurology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Herlopian, A., Internal Medicine, American University of Beirut, Beirut, Lebanon, Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, United States
dc.contributor.affiliation El Bejjani, M., Internal Medicine, American University of Beirut, Beirut, Lebanon, Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI, United States
dc.contributor.affiliation Khalifa, A., Department of Neurology, University of Damascus, Damascus, Syrian Arab Republic
dc.contributor.affiliation Ghadieh, A.S., Department of Neurology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Habib, R.H., Internal Medicine, American University of Beirut, Beirut, Lebanon, Outcomes Research Unit, American University of Beirut, Beirut, Lebanon
dc.contributor.authorAddress Yamout, B.; Doctors' Center, 3rd Floor, Cairo Street, Beirut, Lebanon; email: yamoutba@idm.net.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail yamoutba@idm.net.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Yamout, B
dc.contributor.authorInitials Issa, Z
dc.contributor.authorInitials Herlopian, A
dc.contributor.authorInitials El Bejjani, M
dc.contributor.authorInitials Khalifa, A
dc.contributor.authorInitials Ghadieh, AS
dc.contributor.authorInitials Habib, RH
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Yamout, B (reprint author), Doctors Ctr, 3rd Floor,Cairo St, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 4
dc.description.citedTotWOSCount 6
dc.description.citedWOSCount 6
dc.format.extentCount 9
dc.identifier.articleNo
dc.identifier.coden EJNEF
dc.identifier.pubmedID 23294397
dc.identifier.scopusID 84876319606
dc.identifier.url
dc.publisher.address 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Eur. J. Neurol.
dc.relation.ispartOfIssue 5
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle European Journal of Neurology
dc.relation.ispartofPubTitleAbbr Eur. J. Neurol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 20
dc.source.ID WOS:000317609800010
dc.type.publication Journal
dc.subject.otherAuthKeyword MSQOL-54
dc.subject.otherAuthKeyword Multiple sclerosis
dc.subject.otherAuthKeyword Multivariate analysis
dc.subject.otherAuthKeyword Overall quality of life
dc.subject.otherAuthKeyword Predictors
dc.subject.otherAuthKeyword Quality of life
dc.subject.otherChemCAS
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex Brief Pain Inventory Average Pain Score
dc.subject.otherIndex depression
dc.subject.otherIndex Drug Side Effect Severity Scale
dc.subject.otherIndex education
dc.subject.otherIndex Expanded Disability Status Scale
dc.subject.otherIndex fatigue
dc.subject.otherIndex Fatigue Severity Scale
dc.subject.otherIndex female
dc.subject.otherIndex Hamilton scale
dc.subject.otherIndex human
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex multiple sclerosis
dc.subject.otherIndex pain
dc.subject.otherIndex priority journal
dc.subject.otherIndex quality of life
dc.subject.otherIndex questionnaire
dc.subject.otherIndex religion
dc.subject.otherIndex social support
dc.subject.otherIndex Adult
dc.subject.otherIndex Disability Evaluation
dc.subject.otherIndex Exercise
dc.subject.otherIndex Fatigue
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex Multiple Sclerosis
dc.subject.otherIndex Pain
dc.subject.otherIndex Psychiatric Status Rating Scales
dc.subject.otherIndex Quality of Life
dc.subject.otherIndex Religion
dc.subject.otherIndex Social Support
dc.subject.otherKeywordPlus COGNITIVE IMPAIRMENT
dc.subject.otherKeywordPlus PHYSICAL-DISABILITY
dc.subject.otherKeywordPlus DEPRESSION
dc.subject.otherKeywordPlus FATIGUE
dc.subject.otherKeywordPlus IMPACT
dc.subject.otherKeywordPlus PEOPLE
dc.subject.otherKeywordPlus PAIN
dc.subject.otherKeywordPlus MS
dc.subject.otherKeywordPlus SEVERITY
dc.subject.otherWOS Clinical Neurology
dc.subject.otherWOS Neurosciences


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