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Predictors of quality of life among multiple sclerosis patients: A comprehensive analysis

Show simple item record Yamout B. Issa Z. Herlopian A. El Bejjani M. Khalifa A. Ghadieh A.S. Habib R.H.
dc.contributor.editor 2013 2017-10-05T15:41:47Z 2017-10-05T15:41:47Z 2013
dc.identifier 10.1111/ene.12046
dc.identifier.issn 13515101
dc.description.abstract Background and purpose: Multiple sclerosis (MS) is a debilitating neurological disease of young people with substantial consequences on patients' quality of life (QOL). A variety of QOL instruments have been used to evaluate the efficacy of treatments. However, no study assessed the role of the different demographic, clinical, physical, social, economic and psychological parameters in the perception of patients with MS of their QOL. Methods: Two-hundred and one consecutive patients attending outpatient clinics were prospectively studied and objectively assessed using Expanded Disability Status Scale (EDSS), 8-m walk test, and Symbol Digit Modality Test. Patients completed the following questionnaires: MS QOL-54, Hamilton Depression Rating Scale, Fatigue Severity Scale, Brief Pain Inventory Average Pain Score, Drug Side-Effects Severity Scale, Social Support, Religiosity, Physiotherapy and Exercise, and Socioeconomic Profile. Overall, QOL, physical (PHCS) and mental (MHCS) health composite scores were computed as outcome measures from MSQOL-54. Results: Depression, social support, religiosity, education years and living area predicted overall QOL by linear regression (R2=0.43). Unemployment and absence of fatigue correlated with poor and good QOL, respectively. Fatigue, pain, depression, EDSS, social support, MS type and anti-cholinergic treatment predicted PHCS (R2=0.81). Fatigue, pain, depression, education years and social support predicted MHCS (R2=0.70). Conclusion: The QOL in patients with MS is not solely determined by physical disability, but rather by the level of social support, living area, depression, level of education, employment, fatigue and religiosity. Accordingly, we suggest that these should be evaluated in every patient with MS as they may be modified by targeted interventions. © 2013 The Author(s) European Journal of Neurology © 2013 EFNS.
dc.format.extent Pages: (756-764)
dc.language English
dc.publisher HOBOKEN
dc.relation.ispartof Publication Name: European Journal of Neurology; Publication Year: 2013; Volume: 20; no. 5; Pages: (756-764);
dc.source Scopus
dc.title Predictors of quality of life among multiple sclerosis patients: A comprehensive analysis
dc.type Article
dc.contributor.affiliation Yamout, B., Department of Neurology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Issa, Z., Department of Neurology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Herlopian, A., Internal Medicine, American University of Beirut, Beirut, Lebanon, Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, United States
dc.contributor.affiliation El Bejjani, M., Internal Medicine, American University of Beirut, Beirut, Lebanon, Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI, United States
dc.contributor.affiliation Khalifa, A., Department of Neurology, University of Damascus, Damascus, Syrian Arab Republic
dc.contributor.affiliation Ghadieh, A.S., Department of Neurology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Habib, R.H., Internal Medicine, American University of Beirut, Beirut, Lebanon, Outcomes Research Unit, American University of Beirut, Beirut, Lebanon
dc.contributor.authorAddress Yamout, B.; Doctors' Center, 3rd Floor, Cairo Street, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Internal Medicine;
dc.contributor.authorDepartment Internal Medicine
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Yamout, B
dc.contributor.authorInitials Issa, Z
dc.contributor.authorInitials Herlopian, A
dc.contributor.authorInitials El Bejjani, M
dc.contributor.authorInitials Khalifa, A
dc.contributor.authorInitials Ghadieh, AS
dc.contributor.authorInitials Habib, RH
dc.contributor.authorReprintAddress Yamout, B (reprint author), Doctors Ctr, 3rd Floor,Cairo St, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Alshubaili AF, 2008, ACTA NEUROL SCAND, V117, P384, DOI 10.1111-j.1600-0404.2007.00960.x; Amato MP, 2001, MULT SCLER, V7, P340, DOI 10.1177-135245850100700511; Arnoldus JHA, 2000, MULT SCLER, V6, P338, DOI 10.1177-135245850000600508; Benedict RHB, 2008, MULT SCLER, V14, P940, DOI 10.1177-1352458508090923; Benedict RHB, 2005, J NEUROL SCI, V231, P29, DOI 10.1016-j.jns.2004.12.009; Brochet B, 2009, CLIN J PAIN, V25, P211, DOI 10.1097-AJP.0b013e3181891347; Ford HL, 2001, DISABIL REHABIL, V23, P516; Fruehwald S, 2001, ACTA NEUROL SCAND, V104, P257, DOI 10.1034-j.1600-0404.2001.00022.x; Goretti B, 2009, NEUROL SCI, V30, P15, DOI 10.1007-s10072-008-0009-3; Hart S, 2005, QUAL LIFE RES, V14, P695, DOI 10.1007-s11136-004-1364-z; Hermann BP, 1996, EPILEPSY RES, V25, P113, DOI 10.1016-0920-1211(96)00024-1; Janardhan V, 2002, J NEUROL SCI, V205, P51, DOI 10.1016-S0022-510X(02)00312-X; Kalia LV, 2005, MULT SCLER, V11, P322, DOI 10.1191-1352458505ms1168oa; Kappos L, 2006, NEUROLOGY, V67, P1242, DOI 10.1212-01.wnl.0000237641.33768.8d; BLAND JM, 1986, LANCET, V1, P307; McCabe MP, 2002, J CLIN PSYCHOL MED S, V9, P287, DOI 10.1023-A:1020734901150; McCullagh R, 2008, CLIN REHABIL, V22, P206, DOI 10.1177-0269215507082283; Merkelbach S, 2002, J NERV MENT DIS, V190, P388, DOI 10.1097-01.NMD.0000018964.77906.FB; Miller A, 2006, QUAL LIFE RES, V15, P259, DOI 10.1007-s11136-005-0891-6; Miller DM, 2003, MULT SCLER, V9, P1, DOI 10.1191-1352458503ms888oa; Motl RW, 2008, ANN BEHAV MED, V35, P111, DOI 10.1007-s12160-007-9006-7; Olascoaga J, 2010, REV NEUROLOGIA, V51, P279; Patti F, 2003, J NEUROL SCI, V211, P55, DOI 10.1016-S0022-510X(03)00040-6; Polman CH, 2005, ANN NEUROL, V58, P840, DOI 10.1002-ana.206703; Rogers JM, 2007, J CLIN NEUROSCI, V14, P919, DOI 10.1016-j.jocn.2007.02.006; Rothwell PM, 1997, BRIT MED J, V314, P1580; Rudick RA, 2008, CNS DRUGS, V22, P827, DOI 10.2165-00023210-200822100-00004; Sepulcre J, 2006, MULT SCLER, V12, P187, DOI 10.1191-1352458506ms1258oa; Simone LI, 2006, HEALTH QUAL LIFE OUT, V4, P96; Stuifbergen AK, 2006, ARCH PHYS MED REHAB, V87, P935, DOI 10.1016-j.apmr.2006.04.003; Svendsen KB, 2005, PAIN, V114, P473, DOI 10.1016-j.pain.2005.01.015; VICKREY BG, 1995, QUAL LIFE RES, V4, P187, DOI 10.1007-BF02260859; Wynia K, 2008, MULT SCLER, V14, P972, DOI 10.1177-1352458508091260; Zivadinov R, 2003, J NEUROL SCI, V216, P113, DOI 10.1016-S0022-510X(03)00225-9
dc.description.citedCount 4
dc.description.citedTotWOSCount 6
dc.description.citedWOSCount 6
dc.format.extentCount 9
dc.identifier.coden EJNEF
dc.identifier.pubmedID 23294397
dc.identifier.scopusID 84876319606
dc.publisher.address 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
dc.relation.ispartOfISOAbbr Eur. J. Neurol.
dc.relation.ispartOfIssue 5
dc.relation.ispartofPubTitle European Journal of Neurology
dc.relation.ispartofPubTitleAbbr Eur. J. Neurol.
dc.relation.ispartOfVolume 20
dc.source.ID WOS:000317609800010
dc.type.publication Journal
dc.subject.otherAuthKeyword MSQOL-54
dc.subject.otherAuthKeyword Multiple sclerosis
dc.subject.otherAuthKeyword Multivariate analysis
dc.subject.otherAuthKeyword Overall quality of life
dc.subject.otherAuthKeyword Predictors
dc.subject.otherAuthKeyword Quality of life
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex Brief Pain Inventory Average Pain Score
dc.subject.otherIndex depression
dc.subject.otherIndex Drug Side Effect Severity Scale
dc.subject.otherIndex education
dc.subject.otherIndex Expanded Disability Status Scale
dc.subject.otherIndex fatigue
dc.subject.otherIndex Fatigue Severity Scale
dc.subject.otherIndex female
dc.subject.otherIndex Hamilton scale
dc.subject.otherIndex human
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex multiple sclerosis
dc.subject.otherIndex pain
dc.subject.otherIndex priority journal
dc.subject.otherIndex quality of life
dc.subject.otherIndex questionnaire
dc.subject.otherIndex religion
dc.subject.otherIndex social support
dc.subject.otherIndex Adult
dc.subject.otherIndex Disability Evaluation
dc.subject.otherIndex Exercise
dc.subject.otherIndex Fatigue
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex Multiple Sclerosis
dc.subject.otherIndex Pain
dc.subject.otherIndex Psychiatric Status Rating Scales
dc.subject.otherIndex Quality of Life
dc.subject.otherIndex Religion
dc.subject.otherIndex Social Support
dc.subject.otherKeywordPlus COGNITIVE IMPAIRMENT
dc.subject.otherKeywordPlus PHYSICAL-DISABILITY
dc.subject.otherKeywordPlus DEPRESSION
dc.subject.otherKeywordPlus FATIGUE
dc.subject.otherKeywordPlus IMPACT
dc.subject.otherKeywordPlus PEOPLE
dc.subject.otherKeywordPlus PAIN
dc.subject.otherKeywordPlus MS
dc.subject.otherKeywordPlus SEVERITY
dc.subject.otherWOS Clinical Neurology
dc.subject.otherWOS Neurosciences

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