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Epidemiology and prognosis of breast cancer in young women

Show simple item record Hussein A. Khoury K.E. Dbouk H. Khalil L.E. Mouhieddine T.H. El Saghir N.S.
dc.contributor.editor 2013 2017-10-05T15:43:28Z 2017-10-05T15:43:28Z 2013
dc.identifier 10.3978/j.issn.2072-1439.2013.04.13
dc.identifier.issn 20721439
dc.description.abstract Breast cancer is the most common malignancy in women with 6.6percent of cases diagnosed in young women below the age of 40. Despite variances in risk factors, Age Standardized Incidence Rates of breast cancer in young women vary little between different countries. Review of modifiable risk factors shows that long-term use of oral contraceptives, low body mass index (BMI) and high animal fat diet consumption are associated with increased risk of premenopausal breast cancer. Decreased physical activity and obesity increase risks of breast cancer in postmenopausal women, but data on premenopausal women rather shows that high BMI is associated with decreased risk of breast cancer. Non-modifiable risk factors such as family history and genetic mutations do account for increased risks of breast cancer in premenopausal women. Breast cancer in young women is associated with adverse pathological factors, including high grade tumors, hormone receptor negativity, and HER2 overexpression. This has a significant negative impact on the rate of local recurrence and overall survival. Moreover, younger women often tend to present with breast cancer at a later stage than their older counterparts, which further explains worse outcome. Despite these factors, age per se is still being advocated as an independent role player in the prognosis. This entails more aggressive treatment modalities and the need for closer monitoring and follow-up © Pioneer Bioscience Publishing Company.
dc.language English
dc.publisher HONG KONG
dc.relation.ispartof Publication Name: Journal of Thoracic Disease; Publication Year: 2013; Volume: 5; suppl. 1;
dc.source Scopus
dc.title Epidemiology and prognosis of breast cancer in young women
dc.type Review
dc.contributor.affiliation Hussein, A., Breast Center of Excellence, Naef K. Basile Cancer Institute and Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Khoury, K.E., Breast Center of Excellence, Naef K. Basile Cancer Institute and Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Dbouk, H., Breast Center of Excellence, Naef K. Basile Cancer Institute and Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Khalil, L.E., Breast Center of Excellence, Naef K. Basile Cancer Institute and Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Mouhieddine, T.H., Breast Center of Excellence, Naef K. Basile Cancer Institute and Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation El Saghir, N.S., Breast Center of Excellence, Naef K. Basile Cancer Institute and Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress El Saghir, N.S.; Clinical Medicine-Hematology-Oncology, Breast Center of Excellence, Naef K. Basile Cancer Institute, American University of Beirut Medical Center, P.O. Box: 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Naef K. Basile Cancer Institute (NKBCI);
dc.contributor.authorDepartment Naef K. Basile Cancer Institute (NKBCI)
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Assi, HA
dc.contributor.authorInitials Khoury, KE
dc.contributor.authorInitials Dbouk, H
dc.contributor.authorInitials Khalil, LE
dc.contributor.authorInitials Mouhieddine, TH
dc.contributor.authorInitials El Saghir, NS
dc.contributor.authorReprintAddress El Saghir, NS (reprint author), Amer Univ Beirut, Med Ctr, Naef K Basile Canc Inst, Breast Ctr Excellence, POB 11-0236,Riad El Solh 1107 2020, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 12
dc.description.citedTotWOSCount 15
dc.description.citedWOSCount 14
dc.identifier.scopusID 84881518585
dc.relation.ispartOfISOAbbr J. Thorac. Dis.
dc.relation.ispartofPubTitle Journal of Thoracic Disease
dc.relation.ispartofPubTitleAbbr J. Thorac. Dis.
dc.relation.ispartOfSuppl 1
dc.relation.ispartOfVolume 5
dc.source.ID WOS:000321746200002
dc.type.publication Journal
dc.subject.otherAuthKeyword Breast cancer
dc.subject.otherAuthKeyword Epidemiology
dc.subject.otherAuthKeyword Prognosis
dc.subject.otherAuthKeyword Young age
dc.subject.otherChemCAS epidermal growth factor receptor 2, 137632-09-8
dc.subject.otherIndex epidermal growth factor receptor 2
dc.subject.otherIndex estrogen receptor
dc.subject.otherIndex oral contraceptive agent
dc.subject.otherIndex progesterone receptor
dc.subject.otherIndex age
dc.subject.otherIndex age distribution
dc.subject.otherIndex body mass
dc.subject.otherIndex breast cancer
dc.subject.otherIndex cancer classification
dc.subject.otherIndex cancer epidemiology
dc.subject.otherIndex cancer grading
dc.subject.otherIndex cancer incidence
dc.subject.otherIndex cancer prognosis
dc.subject.otherIndex cancer recurrence
dc.subject.otherIndex cancer staging
dc.subject.otherIndex clinical trial (topic)
dc.subject.otherIndex DNA microarray
dc.subject.otherIndex environmental factor
dc.subject.otherIndex family history
dc.subject.otherIndex female
dc.subject.otherIndex gene mutation
dc.subject.otherIndex geographic distribution
dc.subject.otherIndex human
dc.subject.otherIndex lipid diet
dc.subject.otherIndex obesity
dc.subject.otherIndex overall survival
dc.subject.otherIndex partial mastectomy
dc.subject.otherIndex physical activity
dc.subject.otherIndex postmenopause
dc.subject.otherIndex premenopause
dc.subject.otherIndex review
dc.subject.otherIndex risk factor
dc.subject.otherIndex women's health
dc.subject.otherIndex young age
dc.subject.otherKeywordPlus POPULATION-BASED COHORT
dc.subject.otherKeywordPlus BRCA2 GENE-MUTATIONS
dc.subject.otherKeywordPlus CONSERVING THERAPY
dc.subject.otherKeywordPlus PHYSICAL-ACTIVITY
dc.subject.otherKeywordPlus COLLABORATIVE REANALYSIS
dc.subject.otherKeywordPlus PATHOLOGICAL FEATURES
dc.subject.otherKeywordPlus TUMOR CHARACTERISTICS
dc.subject.otherKeywordPlus INDIVIDUAL DATA
dc.subject.otherKeywordPlus RISK-FACTORS
dc.subject.otherKeywordPlus PATIENT AGE
dc.subject.otherWOS Respiratory System

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