AUB ScholarWorks

Epidemiology and prognosis of breast cancer in young women

Show simple item record

dc.contributor.author Hussein A.
dc.contributor.author Khoury K.E.
dc.contributor.author Dbouk H.
dc.contributor.author Khalil L.E.
dc.contributor.author Mouhieddine T.H.
dc.contributor.author El Saghir N.S.
dc.contributor.editor
dc.date 2013
dc.date.accessioned 2017-10-05T15:43:28Z
dc.date.available 2017-10-05T15:43:28Z
dc.date.issued 2013
dc.identifier 10.3978/j.issn.2072-1439.2013.04.13
dc.identifier.isbn
dc.identifier.issn 20721439
dc.identifier.uri http://hdl.handle.net/10938/18477
dc.description.abstract Breast cancer is the most common malignancy in women with 6.6percent of cases diagnosed in young women below the age of 40. Despite variances in risk factors, Age Standardized Incidence Rates of breast cancer in young women vary little between different countries. Review of modifiable risk factors shows that long-term use of oral contraceptives, low body mass index (BMI) and high animal fat diet consumption are associated with increased risk of premenopausal breast cancer. Decreased physical activity and obesity increase risks of breast cancer in postmenopausal women, but data on premenopausal women rather shows that high BMI is associated with decreased risk of breast cancer. Non-modifiable risk factors such as family history and genetic mutations do account for increased risks of breast cancer in premenopausal women. Breast cancer in young women is associated with adverse pathological factors, including high grade tumors, hormone receptor negativity, and HER2 overexpression. This has a significant negative impact on the rate of local recurrence and overall survival. Moreover, younger women often tend to present with breast cancer at a later stage than their older counterparts, which further explains worse outcome. Despite these factors, age per se is still being advocated as an independent role player in the prognosis. This entails more aggressive treatment modalities and the need for closer monitoring and follow-up © Pioneer Bioscience Publishing Company.
dc.format.extent
dc.language English
dc.publisher HONG KONG
dc.relation.ispartof Publication Name: Journal of Thoracic Disease; Publication Year: 2013; Volume: 5; suppl. 1;
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Epidemiology and prognosis of breast cancer in young women
dc.type Review
dc.contributor.affiliation Hussein, A., Breast Center of Excellence, Naef K. Basile Cancer Institute and Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Khoury, K.E., Breast Center of Excellence, Naef K. Basile Cancer Institute and Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Dbouk, H., Breast Center of Excellence, Naef K. Basile Cancer Institute and Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Khalil, L.E., Breast Center of Excellence, Naef K. Basile Cancer Institute and Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Mouhieddine, T.H., Breast Center of Excellence, Naef K. Basile Cancer Institute and Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation El Saghir, N.S., Breast Center of Excellence, Naef K. Basile Cancer Institute and Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress El Saghir, N.S.; Clinical Medicine-Hematology-Oncology, Breast Center of Excellence, Naef K. Basile Cancer Institute, American University of Beirut Medical Center, P.O. Box: 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon; email: nagi.saghir@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Naef K. Basile Cancer Institute (NKBCI);
dc.contributor.authorDepartment Naef K. Basile Cancer Institute (NKBCI)
dc.contributor.authorDivision
dc.contributor.authorEmail nagi.saghir@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Assi, HA
dc.contributor.authorInitials Khoury, KE
dc.contributor.authorInitials Dbouk, H
dc.contributor.authorInitials Khalil, LE
dc.contributor.authorInitials Mouhieddine, TH
dc.contributor.authorInitials El Saghir, NS
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress El Saghir, NS (reprint author), Amer Univ Beirut, Med Ctr, Naef K Basile Canc Inst, Breast Ctr Excellence, POB 11-0236,Riad El Solh 1107 2020, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited ADAMI HO, 1986, NEW ENGL J MED, V315, P559, DOI 10.1056-NEJM198608283150906; Ahlgren M, 2004, NEW ENGL J MED, V351, P1619, DOI 10.1056-NEJMoa040576; Ahlgren M, 2003, INT J CANCER, V107, P997, DOI 10.1002-ijc.11481; Albain KS, 1994, J NATL CANC I MONOGR, P35; Anders CK, 2008, J CLIN ONCOL, V26, P3324, DOI 10.1200-JCO.2007.14.2471; Anders CK, 2011, J CLIN ONCOL, V29, pE18, DOI 10.1200-JCO.2010.28.9199; Anders CK, 2009, SEMIN ONCOL, V36, P237, DOI 10.1053-j.seminoncol.2009.03.001; [Anonymous], 2000, BR J CANC, V83, P1301; Beral V, 2002, LANCET, V360, P187; Arvold ND, 2011, J CLIN ONCOL, V29, P3885, DOI 10.1200-JCO.2011.36.1105; Azim HA, 2012, CLIN CANCER RES, V18, P1341, DOI 10.1158-1078-0432.CCR-11-2599; Bharat A, 2009, J SURG ONCOL, V100, P248, DOI 10.1002-jso.21268; Boyle P, 2010, BREAST CANCER RES, V12, DOI 10.1186-bcr2736; Brennan Meagan, 2005, Aust Fam Physician, V34, P851; Caldarella A, 2011, PATHOL ONCOL RES, V17, P753, DOI 10.1007-s12253-011-9381-z; Carey LA, 2006, JAMA-J AM MED ASSOC, V295, P2492, DOI 10.1001-jama.295.21.2492; Carmichael AR, 2004, BREAST, V13, P85, DOI 10.1016-j.breast.2003.03.001; Carvalho FM, 2010, CLINICS, V65, P1033, DOI 10.1590-S1807-59322010001000019; Central Intelligence Agency, 2013, WORLD FACTB 2013 14; Cho EY, 2003, JNCI-J NATL CANCER I, V95, P1079, DOI 10.1093-jnci-95.14.1079; Clavel-Chapelon F, 2002, BREAST CANCER RES TR, V72, P107, DOI 10.1023-A:1014891216621; Collaborative Group on Hormonal Factors in Breast Cancer, 1996, LANCET, V347, P1713; Colleoni M, 2002, ANN ONCOL, V13, P273, DOI 10.1093-annonc-mdf039; Collins LC, 2012, BREAST CANCER RES TR, V131, P1061, DOI 10.1007-s10549-011-1872-9; CROWE JP, 1994, ARCH SURG-CHICAGO, V129, P483; DELAROCHEFORDIERE A, 1993, LANCET, V341, P1039, DOI 10.1016-0140-6736(93)92407-K; de Bock GH, 2006, EUR J CANCER, V42, P351, DOI 10.1016-j.ejca.2005.10.006; DeSantis C, 2011, CA-CANCER J CLIN, V61, P409, DOI 10.3322-caac.20134; Eccles B, 2012, LIV UK 8 NCRI CANC C; El Saghir NS, 2006, BMC CANCER, V6, DOI 10.1186-1471-2407-6-194; Escrich E, 2011, PUBLIC HEALTH NUTR, V14, P2323, DOI 10.1017-S1368980011002588; Ezzat A, 1998, EUR J SURG ONCOL, V24, P23, DOI 10.1016-S0748-7983(98)80120-0; Ferguson NL, 2013, BREAST J, V19, P22, DOI 10.1111-tbj.12059; Ferlay J, 2010, IARC CANCERBASE; Ferlay J, 2010, INT J CANCER, V127, P2893, DOI 10.1002-ijc.25516; Figueiredo JC, 2007, BREAST CANCER RES TR, V105, P69, DOI 10.1007-s10549-006-9433-3; Fredholm H, 2009, PLOS ONE, V4, pA38, DOI 10.1371-journal.pone.0007695; Gajdos C, 2000, J AM COLL SURGEONS, V190, P523, DOI 10.1016-S1072-7515(00)00257-X; Dubsky Peter C, 2002, Clin Breast Cancer, V3, P65, DOI 10.3816-CBC.2002.n.013; Gnerlich JL, 2009, J AM COLL SURGEONS, V208, P341, DOI 10.1016-j.jamcollsurg.2008.12.001; Gomes MCB, 2012, HERED CANCER CLIN PR, V10, DOI 10.1186-1897-4287-10-3; Han WS, 2004, BMC CANCER, V4, DOI 10.1186-1471-2407-4-82; Hartman M, 2005, LANCET ONCOL, V6, P377, DOI 10.1016-S1470-2045(05)70174-1; Jemal A, 2011, CA-CANCER J CLIN, V61, P69, DOI 10.3322-caac.20107; Kollias J, 1999, EUR J SURG ONCOL, V25, P584, DOI 10.1053-ejso.1999.0711; Kroman N, 2000, BRIT MED J, V320, P474, DOI 10.1136-bmj.320.7233.474; Lahmann PH, 2007, CANCER EPIDEM BIOMAR, V16, P36, DOI 10.1158-1055-9965.EPI-06-0582; Loprinzi PD, 2012, ONCOL NURS FORUM, V39, P269, DOI 10.1188-12.ONF.269-274; Lund MJ, 2010, CANCER-AM CANCER SOC, V116, P2549, DOI 10.1002-cncr.25016; Lynch BM, 2013, CANCER CAUSE CONTROL, V24, P1257, DOI 10.1007-s10552-013-0194-0; Malone KE, 2000, CANCER, V88, P1393, DOI 10.1002-(SICI)1097-0142(20000315)88:61393::AID-CNCR173.0.CO;2-P; Maruti SS, 2008, J NATL CANCER I, V100, P728, DOI 10.1093-jnci-djn135; Narod SA, 2012, NAT REV CLIN ONCOL, V9, P460, DOI 10.1038-nrclinonc.2012.102; Nichols KE, 2001, CANCER EPIDEM BIOMAR, V10, P83; NIXON AJ, 1994, J CLIN ONCOL, V12, P888; Palmero EI, 2008, CANCER LETT, V261, P21, DOI 10.1016-j.canlet.2007.10.044; Peto J, 1999, J NATL CANCER I, V91, P943, DOI 10.1093-jnci-91.11.943; Sorlie T, 2001, P NATL ACAD SCI USA, V98, P10869, DOI 10.1073-pnas.191367098; Sotiriou C, 2003, P NATL ACAD SCI USA, V100, P10393, DOI 10.1073-pnas.1732912100; Tamimi RM, 2008, BREAST CANCER RES, V10, DOI 10.1186-bcr2128; Trichopoulos D, 2008, INT J CANCER, V122, P481, DOI 10.1002-ijc.23303; van Gils CH, 2005, JAMA-J AM MED ASSOC, V293, P183, DOI 10.1001-jama.293.2.183; Voogd AC, 2001, J CLIN ONCOL, V19, P1688; Wapnir IL, 2006, J CLIN ONCOL, V24, P2028, DOI 10.1200-JCO.2005.04.3273; Warner E, 1999, J NATL CANCER I, V91, P1241, DOI 10.1093-jnci-91.14.1241; Winchester DP, 1996, CANCER, V78, P1838, DOI 10.1002-(SICI)1097-0142(19961015)78:81838::AID-CNCR273.0.CO;2-Y; Xiong QH, 2001, CANCER, V92, P2523, DOI 10.1002-1097-0142(20011115)92:102523::AID-CNCR16033.0.CO;2-6; Yang XR, 2007, CANCER EPIDEM BIOMAR, V16, P439, DOI 10.1158-1055-9965.EPI-06-0806
dc.description.citedCount 12
dc.description.citedTotWOSCount 15
dc.description.citedWOSCount 14
dc.format.extentCount
dc.identifier.articleNo
dc.identifier.coden
dc.identifier.pubmedID
dc.identifier.scopusID 84881518585
dc.identifier.url
dc.publisher.address 9A GOLD SHINE TOWER, 346-348 QUEEN'S RD CENTRAL, SHEUNG WAN, HONG KONG, 00000, PEOPLES R CHINA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr J. Thorac. Dis.
dc.relation.ispartOfIssue
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Journal of Thoracic Disease
dc.relation.ispartofPubTitleAbbr J. Thorac. Dis.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl 1
dc.relation.ispartOfVolume 5
dc.source.ID WOS:000321746200002
dc.type.publication Journal
dc.subject.otherAuthKeyword Breast cancer
dc.subject.otherAuthKeyword Epidemiology
dc.subject.otherAuthKeyword Prognosis
dc.subject.otherAuthKeyword Young age
dc.subject.otherChemCAS epidermal growth factor receptor 2, 137632-09-8
dc.subject.otherIndex epidermal growth factor receptor 2
dc.subject.otherIndex estrogen receptor
dc.subject.otherIndex oral contraceptive agent
dc.subject.otherIndex progesterone receptor
dc.subject.otherIndex age
dc.subject.otherIndex age distribution
dc.subject.otherIndex body mass
dc.subject.otherIndex breast cancer
dc.subject.otherIndex cancer classification
dc.subject.otherIndex cancer epidemiology
dc.subject.otherIndex cancer grading
dc.subject.otherIndex cancer incidence
dc.subject.otherIndex cancer prognosis
dc.subject.otherIndex cancer recurrence
dc.subject.otherIndex cancer staging
dc.subject.otherIndex clinical trial (topic)
dc.subject.otherIndex DNA microarray
dc.subject.otherIndex environmental factor
dc.subject.otherIndex family history
dc.subject.otherIndex female
dc.subject.otherIndex gene mutation
dc.subject.otherIndex geographic distribution
dc.subject.otherIndex human
dc.subject.otherIndex lipid diet
dc.subject.otherIndex obesity
dc.subject.otherIndex overall survival
dc.subject.otherIndex partial mastectomy
dc.subject.otherIndex physical activity
dc.subject.otherIndex postmenopause
dc.subject.otherIndex premenopause
dc.subject.otherIndex review
dc.subject.otherIndex risk factor
dc.subject.otherIndex women's health
dc.subject.otherIndex young age
dc.subject.otherKeywordPlus POPULATION-BASED COHORT
dc.subject.otherKeywordPlus BRCA2 GENE-MUTATIONS
dc.subject.otherKeywordPlus CONSERVING THERAPY
dc.subject.otherKeywordPlus PHYSICAL-ACTIVITY
dc.subject.otherKeywordPlus COLLABORATIVE REANALYSIS
dc.subject.otherKeywordPlus PATHOLOGICAL FEATURES
dc.subject.otherKeywordPlus TUMOR CHARACTERISTICS
dc.subject.otherKeywordPlus INDIVIDUAL DATA
dc.subject.otherKeywordPlus RISK-FACTORS
dc.subject.otherKeywordPlus PATIENT AGE
dc.subject.otherWOS Respiratory System


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


Browse

My Account