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Calcium channel blockers for the management of preterm birth: A review

Show simple item record Nassar A.H. Aoun J. Usta I.M.
dc.contributor.editor Jan-2011 2017-10-05T15:46:50Z 2017-10-05T15:46:50Z 2011
dc.identifier 10.1055/s-0030-1262512
dc.identifier.issn 07351631
dc.description.abstract Preterm birth continues to be the leading cause of perinatal morbidity and mortality. A wide range of tocolytics have been utilized for the management of preterm labor. Calcium channel blockers, namely nifedipine, gained popularity as tocolytics due to the oral route of administration, availability of immediate- and slow-release preparations, the low incidence of maternal adverse effects associated with their use, and the fact that they are inexpensive. This article reviews the available literature on the clinical utility of calcium channel blockers for acute and maintenance tocolysis with special emphasis on potential adverse effects, the most appropriate dose-regimen, and contemporary practice patterns among obstetricians. There are no randomized, placebo-controlled studies demonstrating the benefit of nifedipine in preterm labor. A suggested tocolytic protocol would be to start with the lowest dose of oral immediate-release nifedipine. For the first 48 hours thereafter, all attempts should be made not to exceed 60-mg daily doses. Copyright © 2011 by Thieme Medical Publishers, Inc.
dc.format.extent Pages: (57-65)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: American Journal of Perinatology; Publication Year: 2011; Volume: 28; no. 1; Pages: (57-65);
dc.source Scopus
dc.title Calcium channel blockers for the management of preterm birth: A review
dc.type Review
dc.contributor.affiliation Nassar, A.H., Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Aoun, J., Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Usta, I.M., Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Nassar, A. H.; American University of Beirut Medical Center, P.O. Box 113-6044-B36, Hamra 110 32090, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Obstetrics and Gynecology;
dc.contributor.authorDepartment Obstetrics and Gynecology
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Nassar, AH
dc.contributor.authorInitials Aoun, J
dc.contributor.authorInitials Usta, IM
dc.contributor.authorReprintAddress Nassar, AH (reprint author), Amer Univ Beirut Med Ctr, Dept Obstet and Gynecol, POB 113-6044-B36,Hamra 110 32090, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 9
dc.description.citedTotWOSCount 9
dc.description.citedWOSCount 8
dc.format.extentCount 9
dc.identifier.coden AJPEE
dc.identifier.pubmedID 20640972
dc.identifier.scopusID 78650917471
dc.publisher.address 333 SEVENTH AVE, NEW YORK, NY 10001 USA
dc.relation.ispartOfISOAbbr Am. J. Perinatol.
dc.relation.ispartOfIssue 1
dc.relation.ispartofPubTitle American Journal of Perinatology
dc.relation.ispartofPubTitleAbbr Am. J. Perinatol.
dc.relation.ispartOfVolume 28
dc.source.ID WOS:000285742900009
dc.type.publication Journal
dc.subject.otherAuthKeyword adverse effects
dc.subject.otherAuthKeyword Calcium channel blockers
dc.subject.otherAuthKeyword dose
dc.subject.otherAuthKeyword preterm labor
dc.subject.otherAuthKeyword tocolysis
dc.subject.otherChemCAS atosiban, 90779-69-4
dc.subject.otherChemCAS magnesium sulfate, 7487-88-9
dc.subject.otherChemCAS nicardipine, 54527-84-3, 55985-32-5
dc.subject.otherChemCAS nifedipine, 21829-25-4
dc.subject.otherChemCAS ritodrine, 23239-51-2, 26652-09-5
dc.subject.otherChemCAS Calcium Channel Blockers
dc.subject.otherChemCAS Nifedipine, 21829-25-4
dc.subject.otherChemCAS Tocolytic Agents
dc.subject.otherIndex atosiban
dc.subject.otherIndex calcium channel blocking agent
dc.subject.otherIndex magnesium sulfate
dc.subject.otherIndex nicardipine
dc.subject.otherIndex nifedipine
dc.subject.otherIndex ritodrine
dc.subject.otherIndex bradycardia
dc.subject.otherIndex cause of death
dc.subject.otherIndex controlled release formulation
dc.subject.otherIndex dizziness
dc.subject.otherIndex drug dose increase
dc.subject.otherIndex drug fatality
dc.subject.otherIndex drug mechanism
dc.subject.otherIndex drug megadose
dc.subject.otherIndex drug safety
dc.subject.otherIndex drug withdrawal
dc.subject.otherIndex dyspnea
dc.subject.otherIndex edema
dc.subject.otherIndex fetus death
dc.subject.otherIndex fetus distress
dc.subject.otherIndex headache
dc.subject.otherIndex heart atrium fibrillation
dc.subject.otherIndex heart infarction
dc.subject.otherIndex heart palpitation
dc.subject.otherIndex hot flush
dc.subject.otherIndex human
dc.subject.otherIndex hypotension
dc.subject.otherIndex hypoxia
dc.subject.otherIndex incidence
dc.subject.otherIndex loading drug dose
dc.subject.otherIndex lung edema
dc.subject.otherIndex maintenance therapy
dc.subject.otherIndex medical practice
dc.subject.otherIndex nausea
dc.subject.otherIndex nonhuman
dc.subject.otherIndex perinatal morbidity
dc.subject.otherIndex perinatal mortality
dc.subject.otherIndex premature labor
dc.subject.otherIndex priority journal
dc.subject.otherIndex randomized controlled trial (topic)
dc.subject.otherIndex review
dc.subject.otherIndex risk benefit analysis
dc.subject.otherIndex side effect
dc.subject.otherIndex systematic review
dc.subject.otherIndex tachycardia
dc.subject.otherIndex tocolysis
dc.subject.otherIndex Calcium Channel Blockers
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Nifedipine
dc.subject.otherIndex Obstetric Labor, Premature
dc.subject.otherIndex Physician's Practice Patterns
dc.subject.otherIndex Pregnancy
dc.subject.otherIndex Premature Birth
dc.subject.otherIndex Tocolytic Agents
dc.subject.otherKeywordPlus RANDOMIZED CONTROLLED-TRIAL
dc.subject.otherKeywordPlus MATERNAL-FETAL MEDICINE
dc.subject.otherKeywordPlus ACUTE PULMONARY-EDEMA
dc.subject.otherKeywordPlus MAGNESIUM-SULFATE
dc.subject.otherKeywordPlus PREMATURE LABOR
dc.subject.otherKeywordPlus MYOCARDIAL-INFARCTION
dc.subject.otherKeywordPlus ACUTE TOCOLYSIS
dc.subject.otherKeywordPlus ANTAGONIST NIFEDIPINE
dc.subject.otherKeywordPlus NICARDIPINE THERAPY
dc.subject.otherKeywordPlus SEVERE HYPOTENSION
dc.subject.otherWOS Obstetrics and Gynecology
dc.subject.otherWOS Pediatrics

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