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Progestogens to prevent preterm birth in twin pregnancies: An individual participant data meta-analysis of randomized trials

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dc.contributor.author Schuit E.
dc.contributor.author Stock S.
dc.contributor.author Groenwold R.H.H.
dc.contributor.author Maurel K.
dc.contributor.author Combs C.A.
dc.contributor.author Garite T.
dc.contributor.author Spong C.Y.
dc.contributor.author Thom E.A.
dc.contributor.author Rouse D.J.
dc.contributor.author Caritis S.N.
dc.contributor.author Saade G.R.
dc.contributor.author Zachary J.M.
dc.contributor.author Norman J.E.
dc.contributor.author Rode L.
dc.contributor.author Klein K.
dc.contributor.author Tabor A.
dc.contributor.author Cetingoz E.
dc.contributor.author Morrison J.C.
dc.contributor.author Magann E.F.
dc.contributor.author Briery C.M.
dc.contributor.author Serra V.
dc.contributor.author P
dc.contributor.editor
dc.date Mar-2012
dc.date.accessioned 2017-10-05T15:46:51Z
dc.date.available 2017-10-05T15:46:51Z
dc.date.issued 2012
dc.identifier 10.1186/1471-2393-12-13
dc.identifier.isbn
dc.identifier.issn 14712393
dc.identifier.uri http://hdl.handle.net/10938/18509
dc.description.abstract Background: Preterm birth is the principal factor contributing to adverse outcomes in multiple pregnancies. Randomized controlled trials of progestogens to prevent preterm birth in twin pregnancies have shown no clear benefits. However, individual studies have not had sufficient power to evaluate potential benefits in women at particular high risk of early delivery (for example, women with a previous preterm birth or short cervix) or to determine adverse effects for rare outcomes such as intrauterine death.Methods-design: We propose an individual participant data meta-analysis of high quality randomized, double-blind, placebo-controlled trials of progestogen treatment in women with a twin pregnancy. The primary outcome will be adverse perinatal outcome (a composite measure of perinatal mortality and significant neonatal morbidity). Missing data will be imputed within each original study, before data of the individual studies are pooled. The effects of 17-hydroxyprogesterone caproate or vaginal progesterone treatment in women with twin pregnancies will be estimated by means of a random effects log-binomial model. Analyses will be adjusted for variables used in stratified randomization as appropriate. Pre-specified subgroup analysis will be performed to explore the effect of progestogen treatment in high-risk groups.Discussion: Combining individual patient data from different randomized trials has potential to provide valuable, clinically useful information regarding the benefits and potential harms of progestogens in women with twin pregnancy overall and in relevant subgroups. © 2012 Schuit et al; licensee BioMed Central Ltd.
dc.format.extent
dc.language English
dc.publisher LONDON
dc.relation.ispartof Publication Name: BMC Pregnancy and Childbirth; Publication Year: 2012; Volume: 12;
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Progestogens to prevent preterm birth in twin pregnancies: An individual participant data meta-analysis of randomized trials
dc.type Article
dc.contributor.affiliation Schuit, E., Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, Netherlands
dc.contributor.affiliation Stock, S., MC Centre for Reproductive Health, University of Edinburgh, Edinburgh, Scotland, United States
dc.contributor.affiliation Groenwold, R.H.H., Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, Netherlands
dc.contributor.affiliation Maurel, K., The Centre for Research, Education and Quality (CREQ), Obstetrix Medical Group, Fountain Valley, CA, United States
dc.contributor.affiliation Combs, C.A., Obstetrix Medical Group, San Jose, CA, United States
dc.contributor.affiliation Garite, T., The Centre for Research, Education and Quality (CREQ), Obstetrix Medical Group, Steamboat Springs, CO, United States
dc.contributor.affiliation Spong, C.Y., National Institute of Child Health and Human Development, Bethesda, MD, United States
dc.contributor.affiliation Thom, E.A., The Biostatistics Centre, George Washington University, Rockville, MD, United States
dc.contributor.affiliation Rouse, D.J., Department of Obstetrics and Gynecology, Brown University, Providence, RI, United States, Providence Plantations, United States
dc.contributor.affiliation Caritis, S.N., Department of Obstetrics and Gynecology, Magee Womens Hospital, University of Pittsburgh, Pittsburgh, United States
dc.contributor.affiliation Saade, G.R., Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, United States
dc.contributor.affiliation Zachary, J.M., The Biostatistics Centre, George Washington University, Rockville, MD, United States
dc.contributor.affiliation Norman, J.E., Department of Obstetrics and Feto maternal Medicine, Medical University of Vienna, Vienna, Austria
dc.contributor.affiliation Rode, L., Department of Fetal Medicine 4002, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
dc.contributor.affiliation Klein, K., Department of Obstetrics and Feto maternal Medicine, Medical University of Vienna, Vienna, Austria
dc.contributor.affiliation Tabor, A., Department of Fetal Medicine 4002, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
dc.contributor.affiliation Çetingöz, E., Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children Diseases Education, Research Hospital, Uskudar, Istanbul, Turkey
dc.contributor.affiliation Morrison, J.C., Department of Obstetrics and Gynecology, University of Mississippi Medical Centre, Jackson, United States
dc.contributor.affiliation Magann, E.F., Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR, United States
dc.contributor.affiliation Briery, C.M., Department of Obstetrics and Gynecology, Willis Knighton Medical Centre, Shreveport, LA, United States
dc.contributor.affiliation Serra, V., Maternal-Fetal Medicine Unit, Instituto Valenciano de Infertilidad, University of Valencia, Valencia, Spain
dc.contributor.affiliation Perales, A., Department of Obstetrics and Gynecology, University Hospital La Fe, Valencia, Spain
dc.contributor.affiliation Meseguer, J., Departamento de Obstetricia y Ginecología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
dc.contributor.affiliation Nassar, A.H., Department of Obstetrics and Gynecology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Lim, A.C., Department of Obstetrics and Gynecology, Academic Medical Centre, Amsterdam, Netherlands
dc.contributor.affiliation Moons, K.G.M., Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, Netherlands
dc.contributor.affiliation Kwee, A., Department of Obstetrics, and Gynecology, University Medical Centre Utrecht, Utrecht, Netherlands
dc.contributor.affiliation Mol, B.W.J., Department of Obstetrics and Gynecology, Academic Medical Centre, Amsterdam, Netherlands
dc.contributor.authorAddress Schuit, E.; Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, Netherlands; email: e.schuit@umcutrecht.nl
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Obstetrics and Gynecology;
dc.contributor.authorDepartment Obstetrics and Gynecology
dc.contributor.authorDivision
dc.contributor.authorEmail e.schuit@umcutrecht.nl
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Schuit, E
dc.contributor.authorInitials Stock, S
dc.contributor.authorInitials Groenwold, RHH
dc.contributor.authorInitials Maurel, K
dc.contributor.authorInitials Combs, CA
dc.contributor.authorInitials Garite, T
dc.contributor.authorInitials Spong, CY
dc.contributor.authorInitials Thom, EA
dc.contributor.authorInitials Rouse, DJ
dc.contributor.authorInitials Caritis, SN
dc.contributor.authorInitials Saade, GR
dc.contributor.authorInitials Zachary, JM
dc.contributor.authorInitials Norman, JE
dc.contributor.authorInitials Rode, L
dc.contributor.authorInitials Klein, K
dc.contributor.authorInitials Tabor, A
dc.contributor.authorInitials Cetingoz, E
dc.contributor.authorInitials Morrison, JC
dc.contributor.authorInitials Magann, EF
dc.contributor.authorInitials Briery, CM
dc.contributor.authorInitials Serra, V
dc.contributor.authorInitials Perales, A
dc.contributor.authorInitials Me
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Schuit, E (reprint author), Univ Med Ctr Utrecht, Julius Ctr Hlth Sci and Primary Care, Utrecht, Netherlands.
dc.contributor.authorResearcherID Mol, Ben -I-4526-2012
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 8
dc.description.citedTotWOSCount 6
dc.description.citedWOSCount 6
dc.format.extentCount 1
dc.identifier.articleNo 13
dc.identifier.coden BPCMB
dc.identifier.pubmedID 22420582
dc.identifier.scopusID 84858138328
dc.identifier.url
dc.publisher.address 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
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dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr BMC Pregnancy Childbirth
dc.relation.ispartOfIssue
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle BMC Pregnancy and Childbirth
dc.relation.ispartofPubTitleAbbr BMC Pregnancy Childbirth
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 12
dc.source.ID WOS:000302365000001
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS hydroxyprogesterone caproate, 630-56-8
dc.subject.otherChemCAS progesterone, 57-83-0
dc.subject.otherChemCAS Progestins
dc.subject.otherIndex hydroxyprogesterone caproate
dc.subject.otherIndex placebo
dc.subject.otherIndex progesterone
dc.subject.otherIndex gestagen
dc.subject.otherIndex article
dc.subject.otherIndex drug effect
dc.subject.otherIndex fetus death
dc.subject.otherIndex high risk pregnancy
dc.subject.otherIndex human
dc.subject.otherIndex meta analysis
dc.subject.otherIndex newborn morbidity
dc.subject.otherIndex patient participation
dc.subject.otherIndex perinatal mortality
dc.subject.otherIndex pregnancy outcome
dc.subject.otherIndex premature labor
dc.subject.otherIndex randomized controlled trial (topic)
dc.subject.otherIndex treatment outcome
dc.subject.otherIndex twin pregnancy
dc.subject.otherIndex adult
dc.subject.otherIndex clinical protocol
dc.subject.otherIndex female
dc.subject.otherIndex newborn
dc.subject.otherIndex pregnancy
dc.subject.otherIndex pregnancy complication
dc.subject.otherIndex pregnancy outcome
dc.subject.otherIndex prematurity
dc.subject.otherIndex statistical model
dc.subject.otherIndex Adult
dc.subject.otherIndex Clinical Protocols
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Infant, Newborn
dc.subject.otherIndex Models, Statistical
dc.subject.otherIndex Pregnancy
dc.subject.otherIndex Pregnancy Complications
dc.subject.otherIndex Pregnancy Outcome
dc.subject.otherIndex Pregnancy, Twin
dc.subject.otherIndex Premature Birth
dc.subject.otherIndex Progestins
dc.subject.otherIndex Randomized Controlled Trials as Topic
dc.subject.otherKeywordPlus PATIENT DATA
dc.subject.otherKeywordPlus 17-ALPHA-HYDROXYPROGESTERONE CAPROATE
dc.subject.otherKeywordPlus DOUBLE-BLIND
dc.subject.otherKeywordPlus PROGESTERONE
dc.subject.otherKeywordPlus WOMEN
dc.subject.otherKeywordPlus RISK
dc.subject.otherWOS Obstetrics and Gynecology


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