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Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: An overview

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dc.contributor.author Ghazeeri G.S.
dc.contributor.author Nassar A.H.
dc.contributor.author Younes Z.
dc.contributor.author Awwad J.T.
dc.contributor.editor
dc.date Jun-2012
dc.date.accessioned 2017-10-05T15:46:52Z
dc.date.available 2017-10-05T15:46:52Z
dc.date.issued 2012
dc.identifier 10.1111/j.1600-0412.2012.01385.x
dc.identifier.isbn
dc.identifier.issn 00016349
dc.identifier.uri http://hdl.handle.net/10938/18525
dc.description.abstract This article is a review of the literature assessing pregnancy outcomes and the effect of metformin treatment among women with polycystic ovary syndrome (PCOS). A review of research published in English was undertaken using PubMed and MEDLINE databases. The weight of the available evidence suggests that pregnant women with PCOS are at an increased risk of developing gestational diabetes, hypertensive disorders of pregnancy, preterm birth and early pregnancy loss. Obesity is a contributory factor for the increased risk of gestational diabetes in this group of women and is estimated to affect 5-40percent of pregnant women with PCOS. The prevalence of other obstetric complications is estimated at 10-30percent for gestational hypertension, 8-15percent for pre-eclampsia and 6-15percent for preterm birth. The association between PCOS and early pregnancy loss may not be direct, wherein the presence of PCOS-associated hyperinsulinemia, leading to hyperandrogenemia, has been implicated in the pathophysiology of early pregnancy loss. Apart from the role of metformin in improving the metabolic consequences accompanying PCOS, it has been shown to improve pregnancy rates in women with PCOS who are resistant to clomiphene citrate. In conclusion, pregnancy in women with PCOS is associated with adverse obstetric outcomes (multiple adverse obstetric risk). Whether metformin should be administered throughout pregnancy still remains controversial. Further prospective studies that foster a larger number of participants and adjust for all potentially confounding factors are needed. © 2012 Nordic Federation of Societies of Obstetrics and Gynecology.
dc.format.extent
dc.format.extent Pages: (658-678)
dc.language English
dc.publisher HOBOKEN
dc.relation.ispartof Publication Name: Acta Obstetricia et Gynecologica Scandinavica; Publication Year: 2012; Volume: 91; no. 6; Pages: (658-678);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: An overview
dc.type Review
dc.contributor.affiliation Ghazeeri, G.S., Department of Obstetrics and Gynecology, American University of Beirut Medical Center, PO Box 113-6044-A1, Beirut, Lebanon
dc.contributor.affiliation Nassar, A.H., Department of Obstetrics and Gynecology, American University of Beirut Medical Center, PO Box 113-6044-A1, Beirut, Lebanon
dc.contributor.affiliation Younes, Z., Department of Obstetrics and Gynecology, American University of Beirut Medical Center, PO Box 113-6044-A1, Beirut, Lebanon
dc.contributor.affiliation Awwad, J.T., Department of Obstetrics and Gynecology, American University of Beirut Medical Center, PO Box 113-6044-A1, Beirut, Lebanon
dc.contributor.authorAddress Awwad, J.T.; Department of Obstetrics and Gynecology, American University of Beirut Medical Center, PO Box 113-6044-A1, Beirut, Lebanon; email: jawwad@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Obstetrics and Gynecology;
dc.contributor.authorDepartment Obstetrics and Gynecology
dc.contributor.authorDivision
dc.contributor.authorEmail jawwad@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Ghazeeri, GS
dc.contributor.authorInitials Nassar, AH
dc.contributor.authorInitials Younes, Z
dc.contributor.authorInitials Awwad, JT
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Awwad, JT (reprint author), Amer Univ Beirut, Med Ctr, Dept Obstet and Gynecol, POB 113-6044-A1, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 8
dc.description.citedTotWOSCount 14
dc.description.citedWOSCount 11
dc.format.extentCount 21
dc.identifier.articleNo
dc.identifier.coden AOGSA
dc.identifier.pubmedID 22375613
dc.identifier.scopusID 84862097793
dc.identifier.url
dc.publisher.address 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
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dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Acta Obstet. Gynecol. Scand.
dc.relation.ispartOfIssue 6
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Acta Obstetricia et Gynecologica Scandinavica
dc.relation.ispartofPubTitleAbbr Acta Obstet. Gynecol. Scand.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 91
dc.source.ID WOS:000304087500004
dc.type.publication Journal
dc.subject.otherAuthKeyword Metformin
dc.subject.otherAuthKeyword polycystic ovary syndrome
dc.subject.otherAuthKeyword pregnancy outcome
dc.subject.otherChemCAS clomifene citrate, 50-41-9
dc.subject.otherChemCAS metformin, 1115-70-4, 657-24-9
dc.subject.otherChemCAS Hypoglycemic Agents
dc.subject.otherChemCAS Metformin, 657-24-9
dc.subject.otherIndex clomifene citrate
dc.subject.otherIndex metformin
dc.subject.otherIndex placebo
dc.subject.otherIndex clinical trial
dc.subject.otherIndex drug effect
dc.subject.otherIndex first trimester pregnancy
dc.subject.otherIndex human
dc.subject.otherIndex hyperandrogenism
dc.subject.otherIndex hyperinsulinemia
dc.subject.otherIndex hypertension
dc.subject.otherIndex maternal hypertension
dc.subject.otherIndex obesity
dc.subject.otherIndex ovary polycystic disease
dc.subject.otherIndex pathophysiology
dc.subject.otherIndex preeclampsia
dc.subject.otherIndex pregnancy diabetes mellitus
dc.subject.otherIndex pregnancy outcome
dc.subject.otherIndex pregnant woman
dc.subject.otherIndex premature labor
dc.subject.otherIndex priority journal
dc.subject.otherIndex review
dc.subject.otherIndex Abortion, Spontaneous
dc.subject.otherIndex Diabetes, Gestational
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Hyperandrogenism
dc.subject.otherIndex Hyperinsulinism
dc.subject.otherIndex Hypertension, Pregnancy-Induced
dc.subject.otherIndex Hypoglycemic Agents
dc.subject.otherIndex Infertility, Female
dc.subject.otherIndex Metformin
dc.subject.otherIndex Obesity
dc.subject.otherIndex Polycystic Ovary Syndrome
dc.subject.otherIndex Pregnancy
dc.subject.otherIndex Pregnancy Outcome
dc.subject.otherIndex Premature Birth
dc.subject.otherKeywordPlus GESTATIONAL DIABETES-MELLITUS
dc.subject.otherKeywordPlus SPONTANEOUS-ABORTION
dc.subject.otherKeywordPlus CLOMIPHENE CITRATE
dc.subject.otherKeywordPlus INSULIN-RESISTANCE
dc.subject.otherKeywordPlus GLUCOSE-TOLERANCE
dc.subject.otherKeywordPlus 1ST TRIMESTER
dc.subject.otherKeywordPlus SYNDROME PCOS
dc.subject.otherKeywordPlus RISK-FACTOR
dc.subject.otherKeywordPlus COMPLICATIONS
dc.subject.otherKeywordPlus PREVALENCE
dc.subject.otherWOS Obstetrics and Gynecology


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