AUB ScholarWorks

Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: An overview

Show simple item record Ghazeeri G.S. Nassar A.H. Younes Z. Awwad J.T.
dc.contributor.editor Jun-2012 2017-10-05T15:46:52Z 2017-10-05T15:46:52Z 2012
dc.identifier 10.1111/j.1600-0412.2012.01385.x
dc.identifier.issn 00016349
dc.description.abstract This article is a review of the literature assessing pregnancy outcomes and the effect of metformin treatment among women with polycystic ovary syndrome (PCOS). A review of research published in English was undertaken using PubMed and MEDLINE databases. The weight of the available evidence suggests that pregnant women with PCOS are at an increased risk of developing gestational diabetes, hypertensive disorders of pregnancy, preterm birth and early pregnancy loss. Obesity is a contributory factor for the increased risk of gestational diabetes in this group of women and is estimated to affect 5-40percent of pregnant women with PCOS. The prevalence of other obstetric complications is estimated at 10-30percent for gestational hypertension, 8-15percent for pre-eclampsia and 6-15percent for preterm birth. The association between PCOS and early pregnancy loss may not be direct, wherein the presence of PCOS-associated hyperinsulinemia, leading to hyperandrogenemia, has been implicated in the pathophysiology of early pregnancy loss. Apart from the role of metformin in improving the metabolic consequences accompanying PCOS, it has been shown to improve pregnancy rates in women with PCOS who are resistant to clomiphene citrate. In conclusion, pregnancy in women with PCOS is associated with adverse obstetric outcomes (multiple adverse obstetric risk). Whether metformin should be administered throughout pregnancy still remains controversial. Further prospective studies that foster a larger number of participants and adjust for all potentially confounding factors are needed. © 2012 Nordic Federation of Societies of Obstetrics and Gynecology.
dc.format.extent Pages: (658-678)
dc.language English
dc.publisher HOBOKEN
dc.relation.ispartof Publication Name: Acta Obstetricia et Gynecologica Scandinavica; Publication Year: 2012; Volume: 91; no. 6; Pages: (658-678);
dc.source Scopus
dc.title Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: An overview
dc.type Review
dc.contributor.affiliation Ghazeeri, G.S., Department of Obstetrics and Gynecology, American University of Beirut Medical Center, PO Box 113-6044-A1, Beirut, Lebanon
dc.contributor.affiliation Nassar, A.H., Department of Obstetrics and Gynecology, American University of Beirut Medical Center, PO Box 113-6044-A1, Beirut, Lebanon
dc.contributor.affiliation Younes, Z., Department of Obstetrics and Gynecology, American University of Beirut Medical Center, PO Box 113-6044-A1, Beirut, Lebanon
dc.contributor.affiliation Awwad, J.T., Department of Obstetrics and Gynecology, American University of Beirut Medical Center, PO Box 113-6044-A1, Beirut, Lebanon
dc.contributor.authorAddress Awwad, J.T.; Department of Obstetrics and Gynecology, American University of Beirut Medical Center, PO Box 113-6044-A1, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Obstetrics and Gynecology;
dc.contributor.authorDepartment Obstetrics and Gynecology
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Ghazeeri, GS
dc.contributor.authorInitials Nassar, AH
dc.contributor.authorInitials Younes, Z
dc.contributor.authorInitials Awwad, JT
dc.contributor.authorReprintAddress Awwad, JT (reprint author), Amer Univ Beirut, Med Ctr, Dept Obstet and Gynecol, POB 113-6044-A1, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Altieri P, 2010, EUR J OBSTET GYN R B, V149, P31, DOI 10.1016-j.ejogrb.2009.11.010; Bjercke S, 2002, GYNECOL OBSTET INVES, V54, P94, DOI 10.1159-000067719; Bolton S, 2009, EUR J PEDIATR, V168, P203, DOI 10.1007-s00431-008-0737-7; Boomsma CM, 2006, HUM REPROD UPDATE, V12, P673, DOI 10.1093-humupd-dml036; Carmina E, 2006, FERTIL STERIL, V86, pS7, DOI 10.1016-j.fertnstert.2006.03.012; Costello MF, 2003, FERTIL STERIL, V79, P1, DOI 10.1016-S0015-0282(02)04554-5; de Vries MJ, 1998, EUR J OBSTET GYN R B, V76, P91, DOI 10.1016-S0301-2115(97)00164-4; DIAMANT YZ, 1982, EUR J OBSTET GYN R B, V14, P199, DOI 10.1016-0028-2243(82)90097-1; Diamanti-Kandarakis E, 2005, EUR J ENDOCRINOL, V152, P749, DOI 10.1530-eje.1.01910; Duleba AJ, 2006, FERTIL STERIL, V85, P996, DOI 10.1016-j.fertnstert.2005.09.030; Fougner KJ, 2008, SCAND J CLIN LAB INV, V68, P771, DOI 10.1080-00365510802254620; Franks S, 2012, FERTIL STERIL, V97, P2, DOI 10.1016-j.fertnstert.2011.11.029; Gambineri A, 2002, INT J OBESITY, V26, P883, DOI [10.1038-sj.ijo-0801994, 10.1038-sj.ijo.0801994]; Glueck CJ, 2004, DIABETIC MED, V21, P829, DOI 10.1111-j.1464-5491.2004.01251.x; Glueck CJ, 1999, METABOLISM, V48, P1589, DOI 10.1016-S0026-0495(99)90250-0; Glueck CJ, 2002, FERTIL STERIL, V77, P520, DOI 10.1016-S0015-0282(01)03202-2; Glueck CJ, 2004, HUM REPROD, V19, P510, DOI 10.1093-humrep-deh109; Glueck CJ, 2001, FERTIL STERIL, V75, P46, DOI 10.1016-S0015-0282(00)01666-6; Glueck CJ, 2002, HUM REPROD, V17, P2858, DOI 10.1093-humrep-17.11.2858; Glueck CJ, 2008, FERTIL STERIL, V89, P625, DOI 10.1016-j.fertnstert.2007.03.036; Haakova L, 2003, HUM REPROD, V18, P1438, DOI 10.1093-humrep-deg289; Homburg R, 2006, BEST PRACT RES CL EN, V20, P281, DOI 10.1016-j.beem.2006.03.009; Hu S, 2007, HUM REPROD, V22, P1532, DOI 10.1093-humrep-dem028; Jakubowicz D, 2007, CONT ENDOCRINOLOGY I, P451; Jakubowicz DJ, 2002, J CLIN ENDOCR METAB, V87, P524, DOI 10.1210-jc.87.2.524; Kashanian M, 2008, DIABETES RES CLIN PR, V80, P289, DOI 10.1016-j.diabres.2007.12.022; Kashyap S, 2000, J REPROD MED, V45, P991; Kaya C, 2009, FERTIL STERIL, V92, P635, DOI 10.1016-j.fertnstert.2008.06.006; Kjerulff LE, 2011, AM J OBSTET GYNECOL, V204, P558; Kocak M, 2002, FERTIL STERIL, V77, P101, DOI 10.1016-S0015-0282(01)02941-7; LANZONE A, 1995, J REPROD MED, V40, P312; Lesser K B, 1997, J Matern Fetal Med, V6, P303, DOI 10.1002-(SICI)1520-6661(199709-10)6:5303::AID-MFM143.0.CO;2-L; Lo JC, 2006, DIABETES CARE, V29, P1915, DOI 10.2337-dc06-0877; Mathur R, 2008, AM J OBSTET GYNECOL, P596; Mikola M, 2001, HUM REPROD, V16, P226, DOI 10.1093-humrep-16.2.226; Nawaz FH, 2008, J OBSTET GYNAECOL RE, V34, P832, DOI 10.1111-j.1447-0756.2008.00856.x; Nestler JE, 2008, NEW ENGL J MED, V358, P47, DOI 10.1056-NEJMct0707092; NESTLER JE, 1989, AM J OBSTET GYNECOL, V161, P1095; Palomba S, 2010, FERTIL STERIL, V94, P1805, DOI 10.1016-j.fertnstert.2009.10.043; Palomba S, 2009, FERTIL STERIL, V92, P1646, DOI 10.1016-j.fertnstert.2008.08.087; Paradisi G, 1998, HUM REPROD, V13, P542, DOI 10.1093-humrep-13.3.542; Radon PA, 1999, OBSTET GYNECOL, V94, P194, DOI 10.1016-S0029-7844(99)00252-5; Fauser BCJM, 2004, HUM REPROD, V19, P41, DOI 10.1093-humrep-deh098; Sir-Petermann T, 2007, HUM REPROD, V22, P1830, DOI 10.1093-humrep-dem090; Thatcher SS, 2006, FERTIL STERIL, V85, P1002, DOI 10.1016-j.fertnstert.2005.09.047; Toulis KA, 2009, FERTIL STERIL, V92, P667, DOI 10.1016-j.fertnstert.2008.06.045; Turhan NO, 2003, INT J GYNECOL OBSTET, V81, P163, DOI 10.1016-S0020-7292(03)0003-1; Urman B, 1997, J REPROD MED, V42, P501; Vandermolen DT, 2001, FERTIL STERIL, V75, P310, DOI 10.1016-S0015-0282(00)01675-7; Vanky E, 2010, J CLIN ENDOCR METAB, V95, pE448, DOI 10.1210-jc.2010-0853; Vanky E, 2004, HUM REPROD, V19, P1734, DOI 10.1093-humrep-deh347; Veltman-Verhulst SM, 2010, HUM REPROD, V25, P3123, DOI 10.1093-humrep-deq272; Vollenhoven B, 2000, AUST NZ J OBSTET GYN, V40, P54, DOI 10.1111-j.1479-828X.2000.tb03167.x; Wang JX, 2001, HUM REPROD, V16, P2606, DOI 10.1093-humrep-16.12.2606; Weerakiet S, 2004, GYNECOL ENDOCRINOL, V19, P134
dc.description.citedCount 8
dc.description.citedTotWOSCount 14
dc.description.citedWOSCount 11
dc.format.extentCount 21
dc.identifier.coden AOGSA
dc.identifier.pubmedID 22375613
dc.identifier.scopusID 84862097793
dc.publisher.address 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
dc.relation.ispartOfISOAbbr Acta Obstet. Gynecol. Scand.
dc.relation.ispartOfIssue 6
dc.relation.ispartofPubTitle Acta Obstetricia et Gynecologica Scandinavica
dc.relation.ispartofPubTitleAbbr Acta Obstet. Gynecol. Scand.
dc.relation.ispartOfVolume 91
dc.source.ID WOS:000304087500004
dc.type.publication Journal
dc.subject.otherAuthKeyword Metformin
dc.subject.otherAuthKeyword polycystic ovary syndrome
dc.subject.otherAuthKeyword pregnancy outcome
dc.subject.otherChemCAS clomifene citrate, 50-41-9
dc.subject.otherChemCAS metformin, 1115-70-4, 657-24-9
dc.subject.otherChemCAS Hypoglycemic Agents
dc.subject.otherChemCAS Metformin, 657-24-9
dc.subject.otherIndex clomifene citrate
dc.subject.otherIndex metformin
dc.subject.otherIndex placebo
dc.subject.otherIndex clinical trial
dc.subject.otherIndex drug effect
dc.subject.otherIndex first trimester pregnancy
dc.subject.otherIndex human
dc.subject.otherIndex hyperandrogenism
dc.subject.otherIndex hyperinsulinemia
dc.subject.otherIndex hypertension
dc.subject.otherIndex maternal hypertension
dc.subject.otherIndex obesity
dc.subject.otherIndex ovary polycystic disease
dc.subject.otherIndex pathophysiology
dc.subject.otherIndex preeclampsia
dc.subject.otherIndex pregnancy diabetes mellitus
dc.subject.otherIndex pregnancy outcome
dc.subject.otherIndex pregnant woman
dc.subject.otherIndex premature labor
dc.subject.otherIndex priority journal
dc.subject.otherIndex review
dc.subject.otherIndex Abortion, Spontaneous
dc.subject.otherIndex Diabetes, Gestational
dc.subject.otherIndex Female
dc.subject.otherIndex Humans
dc.subject.otherIndex Hyperandrogenism
dc.subject.otherIndex Hyperinsulinism
dc.subject.otherIndex Hypertension, Pregnancy-Induced
dc.subject.otherIndex Hypoglycemic Agents
dc.subject.otherIndex Infertility, Female
dc.subject.otherIndex Metformin
dc.subject.otherIndex Obesity
dc.subject.otherIndex Polycystic Ovary Syndrome
dc.subject.otherIndex Pregnancy
dc.subject.otherIndex Pregnancy Outcome
dc.subject.otherIndex Premature Birth
dc.subject.otherKeywordPlus SPONTANEOUS-ABORTION
dc.subject.otherKeywordPlus CLOMIPHENE CITRATE
dc.subject.otherKeywordPlus INSULIN-RESISTANCE
dc.subject.otherKeywordPlus GLUCOSE-TOLERANCE
dc.subject.otherKeywordPlus 1ST TRIMESTER
dc.subject.otherKeywordPlus SYNDROME PCOS
dc.subject.otherKeywordPlus RISK-FACTOR
dc.subject.otherKeywordPlus COMPLICATIONS
dc.subject.otherKeywordPlus PREVALENCE
dc.subject.otherWOS Obstetrics and Gynecology

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


My Account