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Induction of final follicle maturation with a gonadotropin-releasing hormone agonist in women at risk of ovarian hyperstimulation syndrome undergoing gonadotropin stimulation and intrauterine insemination: Proof-of-concept study

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dc.contributor.author Awwad J.T.
dc.contributor.author Hannoun A.B.
dc.contributor.author Khalil A.
dc.contributor.author Younes Z.M.H.
dc.contributor.author Ghazeeri G.S.
dc.contributor.editor
dc.date Dec-2012
dc.date.accessioned 2017-10-05T15:46:52Z
dc.date.available 2017-10-05T15:46:52Z
dc.date.issued 2012
dc.identifier
dc.identifier.isbn
dc.identifier.issn 03906663
dc.identifier.uri http://hdl.handle.net/10938/18526
dc.description.abstract Objective: To evaluate the reproductive performance and safety of gonadotropin-stimulated intrauterine insemination (IUI) cycles in women at risk for ovarian hyperstimulation syndrome (OHSS) when final follicle maturation was induced using a gonadotropin-releasing hormone (GnRH) agonist. Materials and Methods: Thirty-three women presenting with a history of cancelled ovarian stimulation for fear of OHSS, underwent repeat gonadotropin ovarian stimulation for IUI. They were all found to be at high-risk for OHSS once more, and were counseled to receive a GnRH agonist to trigger final follicle maturation before insemination. GnRH agonist trigger of ovulation (triptorelin) was given subcutaneously every 12 hours in three repeated doses: 0.3, 0.2, 0.2 mg, respectively. Results: Induction with the agonist was associated with a 30.3percent take-home pregnancy rate and 20percent miscarriage rate. Multiple pregnancy rates were 26.7percent. There were no reported cases of clinically significant moderate-severe ovarian hyperstimulation syndrome. Conclusions: The use of a GnRH agonist to trigger final follicle maturation in stimulated cycles of hyper responders was associated with a favorable reproductive outcome and no incidence of OHSS. The rate of multiple pregnancies nevertheless was found to be uncontrollably elevated, raising serious concerns regarding the safety of this protocol in standard clinical practice in the context of IUI.
dc.format.extent
dc.format.extent Pages: (436-439)
dc.language English
dc.relation.ispartof Publication Name: Clinical and Experimental Obstetrics and Gynecology; Publication Year: 2012; Volume: 39; no. 4; Pages: (436-439);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Induction of final follicle maturation with a gonadotropin-releasing hormone agonist in women at risk of ovarian hyperstimulation syndrome undergoing gonadotropin stimulation and intrauterine insemination: Proof-of-concept study
dc.type Article
dc.contributor.affiliation Awwad, J.T., American University of Beirut Medical Center, Department of Obstetrics and Gynecology, P.O. Box: 113-6044, Beirut, Lebanon
dc.contributor.affiliation Hannoun, A.B., American University of Beirut Medical Center, Department of Obstetrics and Gynecology, P.O. Box: 113-6044, Beirut, Lebanon
dc.contributor.affiliation Khalil, A., American University of Beirut Medical Center, Department of Obstetrics and Gynecology, P.O. Box: 113-6044, Beirut, Lebanon
dc.contributor.affiliation Younes, Z.M.H., American University of Beirut Medical Center, Department of Obstetrics and Gynecology, P.O. Box: 113-6044, Beirut, Lebanon
dc.contributor.affiliation Ghazeeri, G.S., American University of Beirut Medical Center, Department of Obstetrics and Gynecology, P.O. Box: 113-6044, Beirut, Lebanon
dc.contributor.authorAddress Ghazeeri, G.S.; American University of Beirut Medical Center, Department of Obstetrics and Gynecology, P.O. Box: 113-6044, Beirut, Lebanon; email: gg02@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Obstetrics and Gynecology;
dc.contributor.authorDepartment Obstetrics and Gynecology
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited
dc.description.citedCount
dc.description.citedTotWOSCount
dc.description.citedWOSCount
dc.format.extentCount 4
dc.identifier.articleNo
dc.identifier.coden CEOGA
dc.identifier.pubmedID 23444737
dc.identifier.scopusID 84872744892
dc.identifier.url
dc.publisher.address
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr
dc.relation.ispartOfIssue 4
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Clinical and Experimental Obstetrics and Gynecology
dc.relation.ispartofPubTitleAbbr Clin. Exp. Obstet. Gynecol.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 39
dc.source.ID
dc.type.publication Journal
dc.subject.otherAuthKeyword Follicle maturation
dc.subject.otherAuthKeyword Gonadotropin-releasing hormone agonist
dc.subject.otherAuthKeyword Intrauterine insemination
dc.subject.otherAuthKeyword Multiple gestations
dc.subject.otherAuthKeyword Ovarian hyperstimulation syndrome
dc.subject.otherChemCAS triptorelin, 57773-63-4
dc.subject.otherChemCAS Fertility Agents, Female
dc.subject.otherChemCAS Gonadotropin-Releasing Hormone, 33515-09-2
dc.subject.otherChemCAS Menotropins, 61489-71-2
dc.subject.otherChemCAS Triptorelin Pamoate, 57773-63-4
dc.subject.otherIndex gonadorelin agonist
dc.subject.otherIndex triptorelin
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex clinical article
dc.subject.otherIndex fear
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex intrauterine insemination
dc.subject.otherIndex ovary follicle maturation
dc.subject.otherIndex ovary hyperstimulation
dc.subject.otherIndex pregnancy rate
dc.subject.otherIndex repeated drug dose
dc.subject.otherIndex spontaneous abortion
dc.subject.otherIndex Adult
dc.subject.otherIndex Female
dc.subject.otherIndex Fertility Agents, Female
dc.subject.otherIndex Gonadotropin-Releasing Hormone
dc.subject.otherIndex Humans
dc.subject.otherIndex Insemination, Artificial
dc.subject.otherIndex Menotropins
dc.subject.otherIndex Ovarian Follicle
dc.subject.otherIndex Ovarian Hyperstimulation Syndrome
dc.subject.otherIndex Pregnancy
dc.subject.otherIndex Pregnancy, Multiple
dc.subject.otherIndex Triptorelin Pamoate
dc.subject.otherKeywordPlus
dc.subject.otherWOS


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