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Vitamin D in endometriosis: A causative or confounding factor?

Show simple item record Sayegh L. Fuleihan G.E.-H. Nassar A.H.
dc.contributor.editor Jan-2014 2017-10-05T15:46:54Z 2017-10-05T15:46:54Z 2014
dc.identifier 10.1016/j.metabol.2013.09.012
dc.identifier.issn 00260495
dc.description.abstract Objective The aim of this paper is to review the evidence from studies that evaluated the relationship between vitamin D and endometriosis. Design Comprehensive review. Materials and Methods Systematic literature search in Medline for relevant publications from 1946 until June 2013. Results Endometriosis risk may be influenced by dietary vitamin D intake and plasma hydroxyvitamin D concentration. Vitamin D receptor and vitamin D metabolizing enzymes, 24-hydroxylase and 1-α hydroxylase, are found in the normal cycling endometrium and also in the eutopic and ectopic endometrium of women with endometriosis. The endometrium is a target of 1, 25 dihydroxyvitamin D actions through regulation of specific genes and via immunomodulation. The endometrium in endometriosis expresses dysregulation of some vitamin D enzymes and receptors. If vitamin D and its metabolites are implicated in endometriosis-associated infertility, it is likely through interference with HOXA10 gene expression. The Gc2 phenotype of vitamin D binding protein is prevalent in women with endometriosis and may be implicated in its pathogenesis. In a mouse model, Elocalcitol, a VDR-agonist was shown to reduce the development of endometriotic lesions and recurrence. Conclusion A biological plausibility for a role of vitamin D, as an immunomodulator and anti-inflammatory agent, in the pathogenesis and treatment of endometriosis is suggested in this article, but is difficult to illustrate due to sparse evidence from human studies limited primarily to case-control studies. A significant knowledge gap precludes the establishment of a clear cause-effect relationship. The intriguing leads presented herein need to be investigated further with placebo-controlled supplementation trials. © 2014 Elsevier Inc.
dc.format.extent Pages: (32-41)
dc.language English
dc.publisher PHILADELPHIA
dc.relation.ispartof Publication Name: Metabolism: Clinical and Experimental; Publication Year: 2014; Volume: 63; no. 1; Pages: (32-41);
dc.source Scopus
dc.title Vitamin D in endometriosis: A causative or confounding factor?
dc.type Article
dc.contributor.affiliation Sayegh, L., Department of Obstetrics and Gynecology, PO BOX: 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Fuleihan, G.E.-H., Department of Internal Medicine, Calcium Metabolism and Osteoporosis Program, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Nassar, A.H., Department of Obstetrics and Gynecology, PO BOX: 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
dc.contributor.authorAddress Nassar, A.H.; Department of Obstetrics and Gynecology, PO BOX: 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Obstetrics and Gynecology;
dc.contributor.authorDepartment Obstetrics and Gynecology
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Sayegh, L
dc.contributor.authorInitials Fuleihan, GEH
dc.contributor.authorInitials Nassar, AH
dc.contributor.authorReprintAddress Nassar, AH (reprint author), POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedTotWOSCount 1
dc.description.citedWOSCount 1
dc.format.extentCount 10
dc.identifier.coden METAA
dc.identifier.pubmedID 24135500
dc.identifier.scopusID 84890122421
dc.publisher.address 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
dc.relation.ispartOfISOAbbr Metab.-Clin. Exp.
dc.relation.ispartOfIssue 1
dc.relation.ispartofPubTitle Metabolism: Clinical and Experimental
dc.relation.ispartofPubTitleAbbr Metab. Clin. Exp.
dc.relation.ispartOfVolume 63
dc.source.ID WOS:000328799400005
dc.type.publication Journal
dc.subject.otherAuthKeyword Elocalcitol
dc.subject.otherAuthKeyword Endometrium
dc.subject.otherAuthKeyword HOXA 10 gene
dc.subject.otherAuthKeyword Vitamin D binding protein
dc.subject.otherChemCAS 25 hydroxyvitamin D, 64719-49-9
dc.subject.otherChemCAS alpha tocopherol succinate, 17407-37-3, 4345-03-3
dc.subject.otherChemCAS atorvastatin, 134523-00-5, 134523-03-8
dc.subject.otherChemCAS cabergoline, 81409-90-7
dc.subject.otherChemCAS calcitriol, 32222-06-3, 32511-63-0, 66772-14-3
dc.subject.otherChemCAS elocalcitol, 199798-84-0
dc.subject.otherChemCAS loxoribine, 121288-39-9
dc.subject.otherChemCAS mevinol
dc.subject.otherIndex 25 hydroxyvitamin D
dc.subject.otherIndex alpha tocopherol succinate
dc.subject.otherIndex aromatase inhibitor
dc.subject.otherIndex atorvastatin
dc.subject.otherIndex cabergoline
dc.subject.otherIndex calcitriol
dc.subject.otherIndex elocalcitol
dc.subject.otherIndex gonadorelin antagonist
dc.subject.otherIndex loxoribine
dc.subject.otherIndex mevinolin
dc.subject.otherIndex osteopontin
dc.subject.otherIndex oxygenase
dc.subject.otherIndex rapamycin
dc.subject.otherIndex selective estrogen receptor modulator
dc.subject.otherIndex transcription factor HoxA10
dc.subject.otherIndex vitamin D
dc.subject.otherIndex vitamin D binding protein
dc.subject.otherIndex vitamin D receptor
dc.subject.otherIndex article
dc.subject.otherIndex dietary intake
dc.subject.otherIndex disease association
dc.subject.otherIndex disease course
dc.subject.otherIndex endometriosis
dc.subject.otherIndex endometrium
dc.subject.otherIndex female infertility
dc.subject.otherIndex gene expression
dc.subject.otherIndex genetic polymorphism
dc.subject.otherIndex genetic regulation
dc.subject.otherIndex human
dc.subject.otherIndex immunomodulation
dc.subject.otherIndex metabolite
dc.subject.otherIndex nonhuman
dc.subject.otherIndex pathogenesis
dc.subject.otherIndex phenotype
dc.subject.otherIndex priority journal
dc.subject.otherIndex recurrent disease
dc.subject.otherIndex risk factor
dc.subject.otherIndex systematic review
dc.subject.otherIndex vitamin blood level
dc.subject.otherIndex 1, 25 dihydroxyvitamin D
dc.subject.otherIndex 1,25(OH)2D
dc.subject.otherIndex 25-hydroxyvitamin-D3
dc.subject.otherIndex 25-OHD
dc.subject.otherIndex DBP
dc.subject.otherIndex Elocalcitol
dc.subject.otherIndex Endometrium
dc.subject.otherIndex Gc
dc.subject.otherIndex Gc-protein derived macrophage-activating factor
dc.subject.otherIndex GcMAF
dc.subject.otherIndex group-specific component
dc.subject.otherIndex homeobox A10
dc.subject.otherIndex HOXA 10 gene
dc.subject.otherIndex HOXA10
dc.subject.otherIndex IBD
dc.subject.otherIndex inflammatory bowel disease
dc.subject.otherIndex matrix metalloproteinase
dc.subject.otherIndex MMP
dc.subject.otherIndex OPN
dc.subject.otherIndex Osteopontin
dc.subject.otherIndex VD
dc.subject.otherIndex VD binding protein
dc.subject.otherIndex VD responsive element
dc.subject.otherIndex VDRE
dc.subject.otherIndex vitamin D
dc.subject.otherIndex Vitamin D binding protein
dc.subject.otherIndex Animals
dc.subject.otherIndex Antineoplastic Agents
dc.subject.otherIndex Autoimmunity
dc.subject.otherIndex Calcitriol
dc.subject.otherIndex Chronic Pain
dc.subject.otherIndex Dietary Supplements
dc.subject.otherIndex Dysmenorrhea
dc.subject.otherIndex Endometriosis
dc.subject.otherIndex Endometrium
dc.subject.otherIndex Female
dc.subject.otherIndex Homeodomain Proteins
dc.subject.otherIndex Humans
dc.subject.otherIndex Immunologic Factors
dc.subject.otherIndex Infertility, Female
dc.subject.otherIndex Mice
dc.subject.otherIndex Osteopontin
dc.subject.otherIndex Receptors, Calcitriol
dc.subject.otherIndex Vitamin D
dc.subject.otherKeywordPlus D-BINDING PROTEIN
dc.subject.otherKeywordPlus CHRONIC PELVIC PAIN
dc.subject.otherKeywordPlus NF-KAPPA-B
dc.subject.otherKeywordPlus 1,25-DIHYDROXYVITAMIN D-3
dc.subject.otherKeywordPlus PERITONEAL-FLUID
dc.subject.otherKeywordPlus D DEFICIENCY
dc.subject.otherKeywordPlus HOXA10 EXPRESSION
dc.subject.otherKeywordPlus NUCLEAR RECEPTOR
dc.subject.otherKeywordPlus GENE-EXPRESSION
dc.subject.otherKeywordPlus DOUBLE-BLIND
dc.subject.otherWOS Endocrinology and Metabolism

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