AUB ScholarWorks

Vitamin D in endometriosis: A causative or confounding factor?

Show simple item record

dc.contributor.author Sayegh L.
dc.contributor.author Fuleihan G.E.-H.
dc.contributor.author Nassar A.H.
dc.contributor.editor
dc.date Jan-2014
dc.date.accessioned 2017-10-05T15:46:54Z
dc.date.available 2017-10-05T15:46:54Z
dc.date.issued 2014
dc.identifier 10.1016/j.metabol.2013.09.012
dc.identifier.isbn
dc.identifier.issn 00260495
dc.identifier.uri http://hdl.handle.net/10938/18546
dc.description.abstract Objective The aim of this paper is to review the evidence from studies that evaluated the relationship between vitamin D and endometriosis. Design Comprehensive review. Materials and Methods Systematic literature search in Medline for relevant publications from 1946 until June 2013. Results Endometriosis risk may be influenced by dietary vitamin D intake and plasma hydroxyvitamin D concentration. Vitamin D receptor and vitamin D metabolizing enzymes, 24-hydroxylase and 1-α hydroxylase, are found in the normal cycling endometrium and also in the eutopic and ectopic endometrium of women with endometriosis. The endometrium is a target of 1, 25 dihydroxyvitamin D actions through regulation of specific genes and via immunomodulation. The endometrium in endometriosis expresses dysregulation of some vitamin D enzymes and receptors. If vitamin D and its metabolites are implicated in endometriosis-associated infertility, it is likely through interference with HOXA10 gene expression. The Gc2 phenotype of vitamin D binding protein is prevalent in women with endometriosis and may be implicated in its pathogenesis. In a mouse model, Elocalcitol, a VDR-agonist was shown to reduce the development of endometriotic lesions and recurrence. Conclusion A biological plausibility for a role of vitamin D, as an immunomodulator and anti-inflammatory agent, in the pathogenesis and treatment of endometriosis is suggested in this article, but is difficult to illustrate due to sparse evidence from human studies limited primarily to case-control studies. A significant knowledge gap precludes the establishment of a clear cause-effect relationship. The intriguing leads presented herein need to be investigated further with placebo-controlled supplementation trials. © 2014 Elsevier Inc.
dc.format.extent
dc.format.extent Pages: (32-41)
dc.language English
dc.publisher PHILADELPHIA
dc.relation.ispartof Publication Name: Metabolism: Clinical and Experimental; Publication Year: 2014; Volume: 63; no. 1; Pages: (32-41);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Vitamin D in endometriosis: A causative or confounding factor?
dc.type Article
dc.contributor.affiliation Sayegh, L., Department of Obstetrics and Gynecology, PO BOX: 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
dc.contributor.affiliation Fuleihan, G.E.-H., Department of Internal Medicine, Calcium Metabolism and Osteoporosis Program, American University of Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Nassar, A.H., Department of Obstetrics and Gynecology, PO BOX: 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon
dc.contributor.authorAddress Nassar, A.H.; Department of Obstetrics and Gynecology, PO BOX: 11-0236, Riad El Solh 1107 2020, Beirut, Lebanon; email: an21@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Obstetrics and Gynecology;
dc.contributor.authorDepartment Obstetrics and Gynecology
dc.contributor.authorDivision
dc.contributor.authorEmail an21@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Sayegh, L
dc.contributor.authorInitials Fuleihan, GEH
dc.contributor.authorInitials Nassar, AH
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Nassar, AH (reprint author), POB 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Adorini L, 2010, ANN NY ACAD SCI, V1193, P146, DOI 10.1111-j.1749-6632.2009.05299.x; Adorini L, 2008, NAT CLIN PRACT RHEUM, V4, P404, DOI 10.1038-ncprheum0855; Adorini L, 2007, J STEROID BIOCHEM, V103, P689, DOI 10.1016-j.jsbmb.2006.12.065; Agic A, 2007, REPROD SCI, V14, P486, DOI 10.1177-1933719107304565; Ametzazurra A, 2009, HUM REPROD, V24, P954, DOI 10.1093-humrep-den450; Ashkar S, 2000, SCIENCE, V287, P860, DOI 10.1126-science.287.5454.860; Auboeuf D, 2005, MOL CELL BIOL, V25, P5307, DOI 10.1128-MCB.25.13.5307-5316.2005; Baeke F, 2007, NUTR RES REV, V20, P106, DOI 10.1017-S0954422407742713; Bagot CN, 2000, GENE THER, V7, P1378, DOI 10.1038-sj.gt.3301245; Becker CM, 2010, FERTIL STERIL, V94, P2343, DOI 10.1016-j.fertnstert.2010.02.040; Berkkanoglu M, 2003, AM J REPROD IMMUNOL, V50, P48, DOI 10.1034-j.1600-0897.2003.00042.x; Bertone-Johnson ER, 2010, J STEROID BIOCHEM, V121, P434, DOI 10.1016-j.jsbmb.2010.03.076; Borges CR, 2008, J PROTEOME RES, V7, P4143, DOI 10.1021-pr8002936; Borkowski J, 2008, POSTEP HIG MED DOSW, V62, P103; Burney RO, 2012, FERTIL STERIL, V98, P511, DOI 10.1016-j.fertnstert.2012.06.029; Chen TC, 2003, J CELL BIOCHEM, V88, P315, DOI 10.1002-jcb.10342; Cho S, 2009, AM J REPROD IMMUNOL, V61, P286, DOI 10.1111-j.1600-0897.2009.00692.x; Cho S, 2012, HUM REPROD, V27, P515, DOI 10.1093-humrep-der345; Daftary GS, 2007, FERTIL STERIL, V87, P367, DOI 10.1016-j.fertnstert.2006.06.041; DAIGER SP, 1975, P NATL ACAD SCI USA, V72, P2076, DOI 10.1073-pnas.72.6.2076; D'Ambrosio D, 1998, J CLIN INVEST, V101, P252, DOI 10.1172-JCI1050; Daniel D, 2011, AUST FAM PHYSICIAN, V40, P712; Deng Kai-xian, 2011, Zhonghua Fu Chan Ke Za Zhi, V46, P813; Denhardt D T, 1998, J Cell Biochem Suppl, V30-31, P92; Digesu GA, 2012, UROLOGY, V80, P48, DOI 10.1016-j.urology.2012.03.035; Donaghay M, 2007, SEMIN REPROD MED, V25, P461, DOI 10.1055-s-2007-991044; Donnez J, 2002, GYNECOL OBSTET INVES, V54, P2, DOI 10.1159-000066288; Du HL, 2005, MOL ENDOCRINOL, V19, P2222, DOI 10.1210-me.2004-0336; Duong LT, 1998, J CLIN INVEST, V102, P881, DOI 10.1172-JCI3212; Eisenberg VH, 2012, AUTOIMMUN REV, V11, P806, DOI 10.1016-j.autrev.2012.01.005; El-Kasti MM, 2011, FERTIL STERIL, V95, P1261, DOI 10.1016-j.fertnstert.2010.11.066; Eskenazi B, 1997, OBSTET GYN CLIN N AM, V24, P235, DOI 10.1016-S0889-8545(05)70302-8; Faserl K, 2011, J CLIN ENDOCR METAB, V96, pE233, DOI 10.1210-jc.2010-1532; Ferrero S, 2007, J PROTEOME RES, V6, P3402, DOI 10.1021-pr060680q; GIACHELLI CM, 1995, ANN NY ACAD SCI, V760, P109, DOI 10.1111-j.1749-6632.1995.tb44624.x; GLORIEUX FH, 1995, J CLIN ENDOCR METAB, V80, P2255, DOI 10.1210-jc.80.7.2255; Guo SW, 2008, EXPERT OPIN EMERG DR, V13, P547, DOI 10.1517-14728210802548360 ; Guo SW, 2007, GYNECOL OBSTET INVES, V63, P71, DOI 10.1159-000096047; HALLORAN BP, 1980, J NUTR, V110, P1573; Hapangama DK, 2012, HUM REPROD, V27, P394, DOI 10.1093-humrep-der412; Harris HR, 2013, AM J EPIDEMIOL, V177, P420, DOI 10.1093-aje-kws247; Haussler MR, 2013, CALCIFIED TISSUE INT, V92, P77, DOI 10.1007-s00223-012-9619-0; Helming L, 2005, BLOOD, V106, P4351, DOI 10.1182-blood-2005-03-1029; HILL JA, 1995, JAMA-J AM MED ASSOC, V273, P1933, DOI 10.1001-jama.273.24.1933; Hirani V, 2012, BRIT J NUTR, V107, P1080, DOI 10.1017-S0007114511003965; Jackson LW, 2005, HUM REPROD, V20, P2014, DOI 10.1093-humrep-dei001; Jess T, 2012, GUT, V61, P1279, DOI 10.1136-gutjnl-2011-301095; Johnson GA, 2003, BIOL REPROD, V69, P1458, DOI 10.1095-bioreprod.103.020651; Jones G, 1998, PHYSIOL REV, V78, P1193; KEENAN JA, 1995, AM J REPROD IMMUNOL, V34, P381; Kibota T, 1993, ARCH ORAL BIOL, V38, P23; Kimball S, 2008, CRIT REV CL LAB SCI, V45, P339, DOI 10.1080-10408360802165295 ; Kinuta K, 2000, ENDOCRINOLOGY, V141, P1317, DOI 10.1210-en.141.4.1317; Knutson JC, 1974, BIOCHEMISTRY-US, V13, P1543; Krishnan AV, 2011, ANNU REV PHARMACOL, V51, P311, DOI 10.1146-annurev-pharmtox-010510-100611; Lappe JM, 2007, AM J CLIN NUTR, V85, P1586; Lasco A, 2012, ARCH INTERN MED, V172, P366, DOI 10.1001-archinternmed.2011.715; LEMIRE JM, 1995, J NUTR, V125, pS1704; LESSEY BA, 1994, J CLIN ENDOCR METAB, V79, P643, DOI 10.1210-jc.79.2.643; Likuni N, 2007, RHEUMATOLOGY, V46, P846; Liu PT, 2006, SCIENCE, V311, P1770, DOI 10.1126-science.1123933; Long KZ, 1999, PEDIATR INFECT DIS J, V18, P283, DOI 10.1097-00006454-199903000-00018; Mariani M, 2012, HUM REPROD, V27, P2010, DOI 10.1093-humrep-des150; Mathieu C, 2002, TRENDS MOL MED, V8, P174, DOI 10.1016-S1471-4914(02)02294-3; MCGINNIS W, 1992, CELL, V68, P283, DOI 10.1016-0092-8674(92)90471-N; McLaren J, 1996, J CLIN INVEST, V98, P482, DOI 10.1172-JCI118815; Milingos S, 2006, GYNECOL OBSTET INVES, V62, P48, DOI 10.1159-000092023; Missmer SA, 2004, AM J EPIDEMIOL, V160, P784, DOI 10.1093-aje-kwh275; Nagpal S, 2005, ENDOCR REV, V26, P662, DOI 10.1210-er.2004-0002; Oral E, 2003, EUR J OBSTET GYN R B, V109, P97, DOI 10.1016-S0301-2115(03)00047-2; Peterlik M, 2005, EUR J CLIN INVEST, V35, P290, DOI 10.1111-j.1365-2362.2005.01487.x; Practice Committee of the American Society for Reproductive Medicine, 2012, FERTIL STERIL, V98, p591 ; Prentice A, 1999, COCHRANE DB SYST REV; Ravnsborg T, 2010, BBA-PROTEINS PROTEOM, V1804, P909, DOI 10.1016-j.bbapap.2009.12.022; Salih SM, 2004, AM J OBSTET GYNECOL, V190, P1404, DOI 10.1016-j.ajog.2004.01.066; Sampson JA, 1927, AM J PATHOL, V3, P93; Sasson IE, 2008, ANN NY ACAD SCI, V1127, P106, DOI 10.1196-annals.1434.014; Seubwai W, 2007, CANCER, V109, P2497, DOI 10.1002-cncr.22716; Shuo G, 2013, METABOLISM, V62, P768; Simoens S, 2007, HUM REPROD UPDATE, V13, P395, DOI 10.1093-humupd-dmm010; Somigliana E, 1999, HUM REPROD, V14, P2944, DOI 10.1093-humrep-14.12.2944; Somigliana E, 2007, HUM REPROD, V22, P2273, DOI 10.1093-humrep-dem142; STEELE RW, 1984, AM J REPROD IMMUNOL, V6, P33; Stratton P, 2011, HUM REPROD UPDATE, V17, P327, DOI 10.1093-humupd-dmq050; Taylor HS, 1999, HUM REPROD, V14, P1328, DOI 10.1093-humrep-14.5.1328; Taylor HS, 1998, J CLIN INVEST, V101, P1379, DOI 10.1172-JCI1057; Taylor HS, 1997, BIOL REPROD, V57, P1338, DOI 10.1095-biolreprod57.6.1338; Tokushige N, 2011, FERTIL STERIL, V95, P46, DOI 10.1016-j.fertnstert.2010.05.016; Trump DL, 2010, CANCER J, V16, P1, DOI 10.1097-PPO.0b013e3181c51ee6; Tsai WC, 2012, HISTOPATHOLOGY, V61, P844, DOI 10.1111-j.1365-2559.2012.04277.x; Van Etten E, 2008, NUTR REV S2, V66, P125; Varma R, 2004, REPRODUCTION, V127, P293, DOI 10.1530-rep.1.00020; Vercellini P, 2011, HUM REPROD, V26, P3, DOI 10.1093-humrep-deq302; Vigano P, 2006, J MOL ENDOCRINOL, V36, P415, DOI 10.1677-jme.1.01946; Vodolazkaia A, 2012, HUM REPROD, V27, P2698, DOI 10.1093-humrep-des234; Vuolo Laura, 2012, Front Endocrinol (Lausanne), V3, P58, DOI 10.3389-fendo.2012.00058; Warner AE, 2008, JCR-J CLIN RHEUMATOL, V14, P12, DOI 10.1097-RHU.0b013e31816356a9; Wei QX, 2009, FERTIL STERIL, V91, P1686, DOI 10.1016-j.fertnstert.2008.02.121; Zelenko Z, 2012, REPROD SCI, V19, P152, DOI 10.1177-1933719111415546; ZERWEKH JE, 1986, J CLIN ENDOCR METAB, V62, P192
dc.description.citedCount
dc.description.citedTotWOSCount 1
dc.description.citedWOSCount 1
dc.format.extentCount 10
dc.identifier.articleNo
dc.identifier.coden METAA
dc.identifier.pubmedID 24135500
dc.identifier.scopusID 84890122421
dc.identifier.url
dc.publisher.address 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Metab.-Clin. Exp.
dc.relation.ispartOfIssue 1
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Metabolism: Clinical and Experimental
dc.relation.ispartofPubTitleAbbr Metab. Clin. Exp.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 63
dc.source.ID WOS:000328799400005
dc.type.publication Journal
dc.subject.otherAuthKeyword Elocalcitol
dc.subject.otherAuthKeyword Endometrium
dc.subject.otherAuthKeyword HOXA 10 gene
dc.subject.otherAuthKeyword Vitamin D binding protein
dc.subject.otherChemCAS 25 hydroxyvitamin D, 64719-49-9
dc.subject.otherChemCAS alpha tocopherol succinate, 17407-37-3, 4345-03-3
dc.subject.otherChemCAS atorvastatin, 134523-00-5, 134523-03-8
dc.subject.otherChemCAS cabergoline, 81409-90-7
dc.subject.otherChemCAS calcitriol, 32222-06-3, 32511-63-0, 66772-14-3
dc.subject.otherChemCAS elocalcitol, 199798-84-0
dc.subject.otherChemCAS loxoribine, 121288-39-9
dc.subject.otherChemCAS mevinol
dc.subject.otherIndex 25 hydroxyvitamin D
dc.subject.otherIndex alpha tocopherol succinate
dc.subject.otherIndex aromatase inhibitor
dc.subject.otherIndex atorvastatin
dc.subject.otherIndex cabergoline
dc.subject.otherIndex calcitriol
dc.subject.otherIndex elocalcitol
dc.subject.otherIndex gonadorelin antagonist
dc.subject.otherIndex loxoribine
dc.subject.otherIndex mevinolin
dc.subject.otherIndex osteopontin
dc.subject.otherIndex oxygenase
dc.subject.otherIndex rapamycin
dc.subject.otherIndex selective estrogen receptor modulator
dc.subject.otherIndex transcription factor HoxA10
dc.subject.otherIndex vitamin D
dc.subject.otherIndex vitamin D binding protein
dc.subject.otherIndex vitamin D receptor
dc.subject.otherIndex article
dc.subject.otherIndex dietary intake
dc.subject.otherIndex disease association
dc.subject.otherIndex disease course
dc.subject.otherIndex endometriosis
dc.subject.otherIndex endometrium
dc.subject.otherIndex female infertility
dc.subject.otherIndex gene expression
dc.subject.otherIndex genetic polymorphism
dc.subject.otherIndex genetic regulation
dc.subject.otherIndex human
dc.subject.otherIndex immunomodulation
dc.subject.otherIndex metabolite
dc.subject.otherIndex nonhuman
dc.subject.otherIndex pathogenesis
dc.subject.otherIndex phenotype
dc.subject.otherIndex priority journal
dc.subject.otherIndex recurrent disease
dc.subject.otherIndex risk factor
dc.subject.otherIndex systematic review
dc.subject.otherIndex vitamin blood level
dc.subject.otherIndex 1, 25 dihydroxyvitamin D
dc.subject.otherIndex 1,25(OH)2D
dc.subject.otherIndex 25-hydroxyvitamin-D3
dc.subject.otherIndex 25-OHD
dc.subject.otherIndex DBP
dc.subject.otherIndex Elocalcitol
dc.subject.otherIndex Endometrium
dc.subject.otherIndex Gc
dc.subject.otherIndex Gc-protein derived macrophage-activating factor
dc.subject.otherIndex GcMAF
dc.subject.otherIndex group-specific component
dc.subject.otherIndex homeobox A10
dc.subject.otherIndex HOXA 10 gene
dc.subject.otherIndex HOXA10
dc.subject.otherIndex IBD
dc.subject.otherIndex inflammatory bowel disease
dc.subject.otherIndex matrix metalloproteinase
dc.subject.otherIndex MMP
dc.subject.otherIndex OPN
dc.subject.otherIndex Osteopontin
dc.subject.otherIndex VD
dc.subject.otherIndex VD binding protein
dc.subject.otherIndex VD responsive element
dc.subject.otherIndex VDRE
dc.subject.otherIndex vitamin D
dc.subject.otherIndex Vitamin D binding protein
dc.subject.otherIndex Animals
dc.subject.otherIndex Antineoplastic Agents
dc.subject.otherIndex Autoimmunity
dc.subject.otherIndex Calcitriol
dc.subject.otherIndex Chronic Pain
dc.subject.otherIndex Dietary Supplements
dc.subject.otherIndex Dysmenorrhea
dc.subject.otherIndex Endometriosis
dc.subject.otherIndex Endometrium
dc.subject.otherIndex Female
dc.subject.otherIndex Homeodomain Proteins
dc.subject.otherIndex Humans
dc.subject.otherIndex Immunologic Factors
dc.subject.otherIndex Infertility, Female
dc.subject.otherIndex Mice
dc.subject.otherIndex Osteopontin
dc.subject.otherIndex Receptors, Calcitriol
dc.subject.otherIndex Vitamin D
dc.subject.otherKeywordPlus D-BINDING PROTEIN
dc.subject.otherKeywordPlus CHRONIC PELVIC PAIN
dc.subject.otherKeywordPlus NF-KAPPA-B
dc.subject.otherKeywordPlus 1,25-DIHYDROXYVITAMIN D-3
dc.subject.otherKeywordPlus PERITONEAL-FLUID
dc.subject.otherKeywordPlus D DEFICIENCY
dc.subject.otherKeywordPlus HOXA10 EXPRESSION
dc.subject.otherKeywordPlus NUCLEAR RECEPTOR
dc.subject.otherKeywordPlus GENE-EXPRESSION
dc.subject.otherKeywordPlus DOUBLE-BLIND
dc.subject.otherWOS Endocrinology and Metabolism


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


Browse

My Account