Predictors of coronary artery disease in the Lebanese population

Abchee A.; Puzantian H.; Azar S.T.; Shbaklo H.; Nasrallah A.; Sawaya F.J.; Alam S.; Zalloua P.A.

AUB ScholarWorks Home
→
Faculty of Medicine (FM)
→
Obstetrics and Gynecology - Faculty Publications
→
View Item

dc.contributor.author	Abchee A.
dc.contributor.author	Puzantian H.
dc.contributor.author	Azar S.T.
dc.contributor.author	Shbaklo H.
dc.contributor.author	Nasrallah A.
dc.contributor.author	Sawaya F.J.
dc.contributor.author	Alam S.
dc.contributor.author	Zalloua P.A.
dc.contributor.editor
dc.date	May-2006
dc.date.accessioned	2017-10-05T15:46:56Z
dc.date.available	2017-10-05T15:46:56Z
dc.date.issued	2006
dc.identifier	10.1016/j.thromres.2005.05.022
dc.identifier.isbn
dc.identifier.issn	00493848
dc.identifier.uri	http://hdl.handle.net/10938/18566
dc.description.abstract	Background: Coronary artery disease (CAD) is one of the major causes of morbidity and mortality in the world. The disease is determined by many risk factors such as age, gender, diabetes, dyslipidemia, smoking, as well as elevated serum levels of lipoprotein (a) (Lp(a)), homocysteine, C-reactive protein (CRP) and uric acid. In this study, we evaluated the association of biologic and metabolic parameters with CAD in a group of Lebanese patients. Methods: Three hundred patients were recruited for the study. Biologic and blood metabolic parameters were measured. Patients were then divided into 3 groups according to their catheterization result: 0percent stenosis (controls), 50percent stenosis and ≥ 50percent stenosis. Results: Hyperlipidemias, CRP, homocysteine and uric acid levels in CAD patients were not different from those of the controls. However, age, elevated fasting blood glucose (FBG) and elevated serum Lp(a) levels were found to be strong independent predictors of CAD in our study population. Association with CAD was also shown for gender, hypertension, diabetes and family history of CAD. Conclusion: We report the importance of serum Lp(a) levels and FBG in the prediction and prevention of CAD in our population. © 2005 Elsevier Ltd. All rights reserved.
dc.format.extent
dc.format.extent	Pages: (631-637)
dc.language	English
dc.publisher	OXFORD
dc.relation.ispartof	Publication Name: Thrombosis Research; Publication Year: 2006; Volume: 117; no. 6; Pages: (631-637);
dc.relation.ispartofseries
dc.relation.uri
dc.source	Scopus
dc.subject.other
dc.title	Predictors of coronary artery disease in the Lebanese population
dc.type	Article
dc.contributor.affiliation	Abchee, A., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation	Puzantian, H., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation	Azar, S.T., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation	Shbaklo, H., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation	Nasrallah, A., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation	Sawaya, F.J., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation	Alam, S., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation	Zalloua, P.A., Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon, Harvard School of Public Health, Boston, United States
dc.contributor.authorAddress	Zalloua, P.A.; Department of Internal Medicine, American University, Beirut Medical Center, Beirut, Lebanon; email: pz02@aub.edu.lb
dc.contributor.authorCorporate	University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Obstetrics and Gynecology;
dc.contributor.authorDepartment	Obstetrics and Gynecology
dc.contributor.authorDivision
dc.contributor.authorEmail	pz02@aub.edu.lb
dc.contributor.faculty	Faculty of Medicine
dc.contributor.authorInitials	Abchee, A
dc.contributor.authorInitials	Puzantian, H
dc.contributor.authorInitials	Azar, ST
dc.contributor.authorInitials	Shbaklo, H
dc.contributor.authorInitials	Nasrallah, A
dc.contributor.authorInitials	Sawaya, FJ
dc.contributor.authorInitials	Alam, S
dc.contributor.authorInitials	Zalloua, PA
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress	Zalloua, PA (reprint author), Amer Univ Beirut, Dept Internal Med, Med Ctr, POB 11-0236, Beirut, Lebanon.
dc.contributor.authorResearcherID	王, 强-F-4212-2011
dc.contributor.authorUniversity	American University of Beirut Medical Center
dc.description.cited	Acarturk E, 2004, CLIN CHIM ACTA, V339, P123, DOI 10.1016-j.cccn.2003.10.001; Albert AL, 2004, BMC CELL BIOL, V5, DOI 10.1186-1471-2121-5-22; American Diabetes Association, 1998, DIABETES CARE, V21, P1551; Anderson JL, 1998, J AM COLL CARDIOL, V32, P35, DOI 10.1016-S0735-1097(98)00203-4; Antonio CM, 1997, BIOCHEM J, V328, P165; Aydenian H, 1999, ANN BIOL CLIN-PARIS, V57, P697; Bhopal R, 1999, BRIT MED J, V319, P215; Bickel C, 2002, AM J CARDIOL, V89, P12, DOI 10.1016-S0002-9149(01)02155-5; Boufidou AI, 2004, CURR MED RES OPIN, V20, P175, DOI 10.1185-030079903125002856; BOUSHEY CJ, 1995, JAMA-J AM MED ASSOC, V274, P1049, DOI 10.1001-jama.274.13.1049; BRAND FN, 1985, AM J EPIDEMIOL, V121, P11; Cooke JP, 1997, ANNU REV MED, V48, P489; Corella Dolores, 2004, Curr Atheroscler Rep, V6, P186, DOI 10.1007-s11883-004-0031-8; Danesh J, 2000, CIRCULATION, V102, P1082; Dangas G, 1999, AM J CARDIOL, V83, P583, DOI 10.1016-S0002-9149(98)00917-5; Durand P, 2001, LAB INVEST, V81, P645; FREEDMAN DS, 1995, AM J EPIDEMIOL, V141, P637; Gazzaruso C, 2001, DIABETIC MED, V18, P589, DOI 10.1046-j.1464-5491.2001.00536.x; Gazzaruso C, 2002, CARDIOVASC DIABETOL, V1, DOI 10.1186-1475-2840-1-5; HAFFNER SM, 1990, JAMA-J AM MED ASSOC, V263, P2893, DOI 10.1001-jama.263.21.2893; Haffner SM, 2000, CIRCULATION, V101, P975; ISRAELSSON B, 1988, ATHEROSCLEROSIS, V71, P227, DOI 10.1016-0021-9150(88)90147-5; KOSTNER GM, 1981, ATHEROSCLEROSIS, V38, P51, DOI 10.1016-0021-9150(81)90103-9; Kukreja N, 2004, INT J CARDIOL, V97, P77, DOI 10.1016-j.ijcard.2003.08.012; Luc G, 2002, ARTERIOSCL THROM VAS, V22, P1155, DOI 10.1161-01.ATV.0000022850.59845.E0; Faglia E, 1997, AM J CARDIOL, V79, P134; National Cholesterol Education Program, 1994, CIRCULATION, V89, P1333; PARRA HJ, 1992, ARTERIOSCLER THROMB, V12, P701; Paultre F, 2000, ARTERIOSCL THROM VAS, V20, P2619; Refsum H, 1998, ANNU REV MED, V49, P31; Rohde LEP, 1999, AM J CARDIOL, V84, P1018, DOI 10.1016-S0002-9149(99)00491-9; RUIZ J, 1994, DIABETOLOGIA, V37, P585, DOI 10.1007-BF00403377; Schwartzman RA, 1998, J AM COLL CARDIOL, V31, P1260, DOI 10.1016-S0735-1097(98)00096-5; Sibai AM, 2003, OBES RES, V11, P1353, DOI 10.1038-oby.2003.183; Gavin JR, 1997, DIABETES CARE, V20, P1183; UBBINK JB, 1991, KLIN WOCHENSCHR, V69, P527, DOI 10.1007-BF01649290; Upchurch GR, 1997, J BIOL CHEM, V272, P17012, DOI 10.1074-jbc.272.27.17012; Wannamethee SG, 1997, HEART, V78, P147; Watson Karol E, 2004, Rev Cardiovasc Med, V5 Suppl 3, pS14; WEINER DA, 1991, AM J CARDIOL, V68, P729, DOI 10.1016-0002-9149(91)90644-Z; WILCKEN DEL, 1983, METABOLISM, V32, P363, DOI 10.1016-0026-0495(83)90045-8
dc.description.citedCount	11
dc.description.citedTotWOSCount	8
dc.description.citedWOSCount	8
dc.format.extentCount	7
dc.identifier.articleNo
dc.identifier.coden	THBRA
dc.identifier.pubmedID	15985286
dc.identifier.scopusID	33646075437
dc.identifier.url
dc.publisher.address	THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr	Thromb. Res.
dc.relation.ispartOfIssue	6
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle	Thrombosis Research
dc.relation.ispartofPubTitleAbbr	Thromb. Res.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume	117
dc.source.ID	WOS:000237369500004
dc.type.publication	Journal
dc.subject.otherAuthKeyword	Coronary artery disease
dc.subject.otherAuthKeyword	Fasting blood glucose
dc.subject.otherAuthKeyword	Lipoprotein (a)
dc.subject.otherChemCAS	C reactive protein, 9007-41-4
dc.subject.otherChemCAS	glucose, 50-99-7, 84778-64-3
dc.subject.otherChemCAS	homocysteine, 454-28-4, 6027-13-0
dc.subject.otherChemCAS	uric acid, 69-93-2
dc.subject.otherChemCAS	Blood Glucose
dc.subject.otherChemCAS	Lipoprotein(a)
dc.subject.otherIndex	C reactive protein
dc.subject.otherIndex	glucose
dc.subject.otherIndex	homocysteine
dc.subject.otherIndex	lipoprotein A
dc.subject.otherIndex	uric acid
dc.subject.otherIndex	adult
dc.subject.otherIndex	age distribution
dc.subject.otherIndex	aged
dc.subject.otherIndex	amino acid blood level
dc.subject.otherIndex	article
dc.subject.otherIndex	cardiovascular risk
dc.subject.otherIndex	controlled study
dc.subject.otherIndex	coronary artery disease
dc.subject.otherIndex	diabetes mellitus
dc.subject.otherIndex	disease association
dc.subject.otherIndex	family history
dc.subject.otherIndex	female
dc.subject.otherIndex	human
dc.subject.otherIndex	hyperglycemia
dc.subject.otherIndex	hyperlipidemia
dc.subject.otherIndex	hypertension
dc.subject.otherIndex	Lebanon
dc.subject.otherIndex	lipoprotein blood level
dc.subject.otherIndex	major clinical study
dc.subject.otherIndex	male
dc.subject.otherIndex	prediction
dc.subject.otherIndex	priority journal
dc.subject.otherIndex	risk assessment
dc.subject.otherIndex	sex difference
dc.subject.otherIndex	uric acid blood level
dc.subject.otherIndex	Aged
dc.subject.otherIndex	Blood Glucose
dc.subject.otherIndex	Case-Control Studies
dc.subject.otherIndex	Coronary Angiography
dc.subject.otherIndex	Coronary Arteriosclerosis
dc.subject.otherIndex	Fasting
dc.subject.otherIndex	Female
dc.subject.otherIndex	Humans
dc.subject.otherIndex	Lebanon
dc.subject.otherIndex	Lipoprotein(a)
dc.subject.otherIndex	Male
dc.subject.otherIndex	Middle Aged
dc.subject.otherIndex	Predictive Value of Tests
dc.subject.otherIndex	Risk Factors
dc.subject.otherKeywordPlus	CARDIOVASCULAR RISK-FACTORS
dc.subject.otherKeywordPlus	SILENT-MYOCARDIAL-ISCHEMIA
dc.subject.otherKeywordPlus	C-REACTIVE PROTEIN
dc.subject.otherKeywordPlus	SERUM URIC-ACID
dc.subject.otherKeywordPlus	HEART-DISEASE
dc.subject.otherKeywordPlus	DIABETES-MELLITUS
dc.subject.otherKeywordPlus	APOLIPOPROTEIN(A) PHENOTYPES
dc.subject.otherKeywordPlus	LIPOPROTEIN(A) LEVELS
dc.subject.otherKeywordPlus	PLASMA HOMOCYSTEINE
dc.subject.otherKeywordPlus	VASCULAR-DISEASE
dc.subject.otherWOS	Hematology
dc.subject.otherWOS	Peripheral Vascular Disease

Files in this item

Files	Size	Format	View
There are no files associated with this item.

This item appears in the following Collection(s)

Obstetrics and Gynecology - Faculty Publications [162]

Show simple item record

Search AUB ScholarWorks

Browse

All of AUB ScholarWorks
This Collection
- By Issue Date
- Authors
- Titles
- Subjects

My Account

Copyright Statement

All materials included in the institutional repository are protected by copyright laws and are the property of their respective copyright holders. Materials may be used for non-commercial, educational, or research purposes only, and must be cited or attributed to the original source. Permission for any other use must be obtained from the copyright holder(s) directly. The American University of Beirut Libraries does not assume responsibility for any infringement of copyright laws that may occur as a result of the use of materials in the repository. If you believe that your copyright has been infringed upon in the repository, please contact the AUB Libraries immediately.

For further information, please contact us at scholarworks@aub.edu.lb