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Chapter 17 Treatment of Late Pregnancy Complications in the Antiphospholipid Syndrome

Show simple item record Nassar A. Uthman I. Khamashta M.A.
dc.contributor.editor Cervera R.Reverter J.C.Khamashta M. 2009 2017-10-05T15:47:06Z 2017-10-05T15:47:06Z 2009
dc.identifier 10.1016/S1571-5078(08)00417-0
dc.identifier.isbn 9.7804445317e+012
dc.identifier.issn 15715078
dc.description.abstract The antiphospholipid syndrome (APS) is characterized by arterial and venous thrombosis and pregnancy complications that include recurrent early pregnancy loss and late adverse pregnancy outcomes such as fetal death, severe preeclampsia, placental insufficiency, and fetal growth restriction. The goals of treatment for APS during pregnancy are to reduce or eliminate the risk of thromboembolic events and to improve maternal and fetal outcome by reducing the risk of these complications. Although the routine use of prophylactic-dose unfractionated heparin or low-molecular-weight heparin plus low-dose aspirin is generally advocated for pregnant women with APS and adverse obstetric outcome, this approach is supported by questionable data since these women are underrepresented in clinical trials. Corticosteroids and intravenous immunoglobulin (IVIG) are not recommended for first-line management of treatment of pregnant women with APS. Warfarin is generally contraindicated, and its use should be limited to special conditions. Since most treatment regimens proposed for women with APS carry a significant risk for both the mother and the fetus, each woman should be extensively counseled, and therapeutic options should be individually tailored based on her individual risk of antiphospholipid antibody (aPL)-mediated complications. © 2009 Elsevier B.V. All rights reserved.
dc.format.extent Pages: (203-214)
dc.language English
dc.publisher AMSTERDAM
dc.relation.ispartof Publication Name: Handbook of Systemic Autoimmune Diseases; Publication Year: 2009; Volume: 10; Pages: (203-214);
dc.source Scopus
dc.title Chapter 17 Treatment of Late Pregnancy Complications in the Antiphospholipid Syndrome
dc.type Review
dc.contributor.affiliation Nassar, A., Department of Obstetrics and Gynecology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Uthman, I., Division of Rheumatology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Khamashta, M.A., Lupus Research Unit, The Rayne Institute, St. Thomas' Hospital, London, United Kingdom
dc.contributor.authorAddress Khamashta, M.A.; Lupus Research Unit, The Rayne Institute, St. Thomas' Hospital, London, United Kingdom; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Obstetrics and Gynecology;
dc.contributor.authorDepartment Obstetrics and Gynecology
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Nassar, A
dc.contributor.authorInitials Uthman, I
dc.contributor.authorInitials Khamashta, MA
dc.contributor.authorReprintAddress Khamashta, MA (reprint author), St Thomas Hosp, Rayne Inst, Lupus Res Unit, London SE1 7EH, England.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 1
dc.description.citedTotWOSCount 0
dc.description.citedWOSCount 0
dc.format.extentCount 12
dc.identifier.scopusID 67649644217
dc.relation.ispartofPubTitle Handbook of Systemic Autoimmune Diseases
dc.relation.ispartofPubTitleAbbr Handb. Syst. Autoimmun. Dis.
dc.relation.ispartOfVolume 10
dc.source.ID WOS:000311051800019
dc.type.publication Book
dc.subject.otherAuthKeyword anticardiolipin
dc.subject.otherAuthKeyword fetal loss
dc.subject.otherAuthKeyword growth restriction
dc.subject.otherAuthKeyword lupus anticoagulant
dc.subject.otherAuthKeyword preeclampsia
dc.subject.otherAuthKeyword premature delivery
dc.subject.otherKeywordPlus MOLECULAR-WEIGHT HEPARIN
dc.subject.otherKeywordPlus SYSTEMIC-LUPUS-ERYTHEMATOSUS
dc.subject.otherKeywordPlus RECURRENT FETAL LOSS
dc.subject.otherKeywordPlus RANDOMIZED CONTROLLED-TRIAL
dc.subject.otherKeywordPlus LOW-DOSE ASPIRIN
dc.subject.otherKeywordPlus UNFRACTIONATED HEPARIN
dc.subject.otherKeywordPlus RISK-FACTORS
dc.subject.otherKeywordPlus INTRAVENOUS IMMUNOGLOBULIN
dc.subject.otherKeywordPlus INDUCED THROMBOCYTOPENIA
dc.subject.otherWOS Immunology

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