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Consanguinity and family clustering of male factor infertility in Lebanon

Show simple item record Inhorn M.C. Kobeissi L. Nassar Z. Lakkis D. Fakih M.H.
dc.contributor.editor 2009 2017-10-05T15:47:07Z 2017-10-05T15:47:07Z 2009
dc.identifier 10.1016/j.fertnstert.2008.01.008
dc.identifier.issn 00150282
dc.description.abstract Objective: To investigate the influence of consanguineous marriage on male factor infertility in Lebanon, where rates of consanguineous marriage remain high (29.6percent among Muslims, 16.5percent among Christians). Design: Clinic-based, case-control study, using reproductive history, risk factor interview, and laboratory-based semen analysis. Setting: Two IVF clinics in Beirut, Lebanon, during an 8-month period (January-August 2003). Patient(s): One hundred twenty infertile male patients and 100 fertile male controls, distinguished by semen analysis and reproductive history. Intervention(s): None. Main Outcome Measure(s): Standard clinical semen analysis. Result(s): The rates of consanguineous marriage were relatively high among the study sample. Patients (46percent) were more likely than controls (37percent) to report first-degree (parental) and second-degree (grandparental) consanguinity. The study demonstrated a clear pattern of family clustering of male factor infertility, with patients significantly more likely than controls to report infertility among close male relatives (odds ratio = 2.58). Men with azoospermia and severe oligospermia showed high rates of both consanguinity (50percent) and family clustering (41percent). Conclusion(s): Consanguineous marriage is a socially supported institution throughout the Muslim world, yet its relationship to infertility is poorly understood. This study demonstrated a significant association between consanguinity and family clustering of male factor infertility cases, suggesting a strong genetic component. © 2009 American Society for Reproductive Medicine.
dc.format.extent Pages: (1104-1109)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Fertility and Sterility; Publication Year: 2009; Volume: 91; no. 4; Pages: (1104-1109);
dc.source Scopus
dc.title Consanguinity and family clustering of male factor infertility in Lebanon
dc.type Article
dc.contributor.affiliation Inhorn, M.C., Department of Health Behavior and Health Education, School of Public Health, University of Michigan, Ann Arbor, MI, United States
dc.contributor.affiliation Kobeissi, L., American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Nassar, Z., FIRST-IVF, Beirut, Lebanon
dc.contributor.affiliation Lakkis, D., FIRST-IVF, Beirut, Lebanon
dc.contributor.affiliation Fakih, M.H., FIRST-IVF, Beirut, Lebanon, IVF Michigan, Rochester Hills, MI, United States
dc.contributor.authorAddress Inhorn, M.C.; Department of Health Behavior and Health Education, School of Public Health, University of Michigan, Ann Arbor, MI, United States; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Obstetrics and Gynecology;
dc.contributor.authorDepartment Obstetrics and Gynecology
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Inhorn, MC
dc.contributor.authorInitials Kobeissi, L
dc.contributor.authorInitials Nassar, Z
dc.contributor.authorInitials Lakkis, D
dc.contributor.authorInitials Fakih, MH
dc.contributor.authorReprintAddress Inhorn, MC (reprint author), Univ Michigan, Sch Publ Hlth, Dept Hlth Behav and Hlth Educ, 109 S Observ, Ann Arbor, MI 48109 USA.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 7
dc.description.citedTotWOSCount 6
dc.description.citedWOSCount 6
dc.format.extentCount 6
dc.identifier.coden FESTA
dc.identifier.pubmedID 18367181
dc.identifier.scopusID 62949228448
dc.publisher.address 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
dc.relation.ispartOfISOAbbr Fertil. Steril.
dc.relation.ispartOfIssue 4
dc.relation.ispartofPubTitle Fertility and Sterility
dc.relation.ispartofPubTitleAbbr Fertil. Steril.
dc.relation.ispartOfVolume 91
dc.source.ID WOS:000265132300021
dc.type.publication Journal
dc.subject.otherAuthKeyword consanguinity
dc.subject.otherAuthKeyword inbreeding
dc.subject.otherAuthKeyword Lebanon
dc.subject.otherAuthKeyword Male infertility
dc.subject.otherAuthKeyword Middle East
dc.subject.otherAuthKeyword Muslim world
dc.subject.otherAuthKeyword recessive genetic disorders
dc.subject.otherIndex adult
dc.subject.otherIndex article
dc.subject.otherIndex consanguinity
dc.subject.otherIndex controlled study
dc.subject.otherIndex human
dc.subject.otherIndex Lebanon
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex male infertility
dc.subject.otherIndex moslem
dc.subject.otherIndex outcome assessment
dc.subject.otherIndex priority journal
dc.subject.otherIndex semen analysis
dc.subject.otherIndex Adult
dc.subject.otherIndex Case-Control Studies
dc.subject.otherIndex Cluster Analysis
dc.subject.otherIndex Consanguinity
dc.subject.otherIndex Family
dc.subject.otherIndex Humans
dc.subject.otherIndex Infertility, Male
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Male
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Religion
dc.subject.otherIndex Socioeconomic Factors
dc.subject.otherKeywordPlus SAUDI-ARABIA
dc.subject.otherKeywordPlus MARRIAGES
dc.subject.otherKeywordPlus FERTILITY
dc.subject.otherKeywordPlus POPULATION
dc.subject.otherKeywordPlus DISORDERS
dc.subject.otherKeywordPlus HEALTH
dc.subject.otherKeywordPlus JORDAN
dc.subject.otherKeywordPlus YEMEN
dc.subject.otherWOS Obstetrics and Gynecology
dc.subject.otherWOS Reproductive Biology

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