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Experiences with a novel policy for managing conflicts of interest of guideline developers: A descriptive qualitative study

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dc.contributor.author Neumann I.
dc.contributor.author Karl R.
dc.contributor.author Rajpal A.
dc.contributor.author Akl E.A.
dc.contributor.author Guyatt G.H.
dc.contributor.editor
dc.date Aug-2013
dc.date.accessioned 2017-10-05T15:48:06Z
dc.date.available 2017-10-05T15:48:06Z
dc.date.issued 2013
dc.identifier 10.1378/chest.12-2390
dc.identifier.isbn
dc.identifier.issn 00123692
dc.identifier.uri http://hdl.handle.net/10938/18668
dc.description.abstract Background: The executive committee of the Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (AT9) developed a novel policy for managing confl icts of interest (COIs): Methodologists bore primary responsibility for each chapter, there was equal emphasis on intellectual and fi nancial COI, and content experts with COIs participated, but with restrictions for recommendations on which they had confl icts. The objective of this study was to explore the experiences of the methodologists and content experts with the COI policy after its implementation. Methods: One investigator conducted two rounds of semistructured interviews with the methodologist and the leading content expert of each chapter until data saturation was achieved. Two investigators analyzed the transcripts of the interviews in duplicate using an immersion-crystallization approach. We also conducted member checking. Results: We interviewed 15 participants and presented the results to the remaining four for verifi cation. In comparison with their views expressed prior to AT9 development, methodologists remained more positive about the policy than content experts. Six of 10 content experts expressed a more positive view than prior to participation in the AT9 process. The other four content experts remained skeptical, especially regarding the emphasis on intellectual COI. The restrictions of the policy on confl icted individuals were not fully implemented. Conclusions: After its implementation, some content experts were more favorable to the policy, but some retained major reservations. The infl uence of the policy on recommendations may have been more through the leading role of the methodologists than exclusion of confl icted participants in making recommendations. © 2013 American College of Chest Physicians.
dc.format.extent
dc.format.extent Pages: (398-404)
dc.language English
dc.publisher NORTHBROOK
dc.relation.ispartof Publication Name: Chest; Publication Year: 2013; Volume: 144; no. 2; Pages: (398-404);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Experiences with a novel policy for managing conflicts of interest of guideline developers: A descriptive qualitative study
dc.type Article
dc.contributor.affiliation Neumann, I., Department of Clinical Epidemiology and Biostatistics, Clinical Epidemiology and Biostatistics, 1280 Main St W, Hamilton, ON, L8S 4K1, Canada, Department of Internal Medicine, School of Medicine, Pontifi Cia Universidad Catolica de Chile, Santiago, Chile
dc.contributor.affiliation Karl, R., Department of Family Medicine, State University of New York at Buffalo, Buffalo, NY, United States
dc.contributor.affiliation Rajpal, A., Department of Internal Medicine, Drexel School of Medicine, New Brunswick, NJ, United States
dc.contributor.affiliation Akl, E.A., Department of Clinical Epidemiology and Biostatistics, Clinical Epidemiology and Biostatistics, 1280 Main St W, Hamilton, ON, L8S 4K1, Canada, Department of Medicine, State University of New York at Buffalo, Buffalo, NY, United States, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Guyatt, G.H., Department of Clinical Epidemiology and Biostatistics, Clinical Epidemiology and Biostatistics, 1280 Main St W, Hamilton, ON, L8S 4K1, Canada
dc.contributor.authorAddress Neumann, I.; Department of Clinical Epidemiology and Biostatistics, Clinical Epidemiology and Biostatistics, 1280 Main St W, Hamilton, ON, L8S 4K1, Canada; email: ignacio.neumann@gmail.com
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Office of the VP for Medical Affairs;
dc.contributor.authorDepartment Office of the VP for Medical Affairs
dc.contributor.authorDivision
dc.contributor.authorEmail ignacio.neumann@gmail.com
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Neumann, I
dc.contributor.authorInitials Karl, R
dc.contributor.authorInitials Rajpal, A
dc.contributor.authorInitials Akl, EA
dc.contributor.authorInitials Guyatt, GH
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Neumann, I (reprint author), McMaster Univ, Hlth Sci Ctr, Room 2C12,1280 Main St W, Hamilton, ON L8S 4K1, Canada.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Akl EA, 2012, J CLIN EPIDEMIOL, V65, P734; Bahtsevani C, 2004, INT J TECHNOL ASSESS, V20, P427; Bion J, 2009, CURR OPIN CRIT CARE, V15, P583, DOI 10.1097-MCC.0b013e328332f53a; Choudhry NK, 2002, JAMA-J AM MED ASSOC, V287, P612, DOI 10.1001-jama.287.5.612; Cosgrove L, 2009, PSYCHOTHER PSYCHOSOM, V78, P228, DOI 10.1159-000214444; Detsky AS, 2006, CAN MED ASSOC J, V175, P1033, DOI 10.1503-cmaj.061181; Graham R, 2011, CLIN PRACTICE GUIDEL; Guyatt G, 2010, ANN INTERN MED, V152, P738, DOI 10.7326-0003-4819-152-11-201006010-00254; Guyatt G, 2011, J CLIN EPIDEMIOL, V64, P383, DOI 10.1016-j.jclinepi.2010.04.026; Holloway RG, 2008, NEUROLOGY, V71, P57, DOI 10.1212-01.wnl.0000316319.19159.c3; Ioarnnidis JP, 2005, PLOS MED, V2, pe124; Johnson K, 2011, CAN MED ASSOC J, V183, pE443, DOI 10.1503-cmaj.109-3841; Kahn JM, 2010, CRIT CARE MED, V38, P1755, DOI 10.1097-CCM.0b013e3181de19d9; Kahneman D, 2003, AM PSYCHOL, V58, P697, DOI 10.1037-0003-066X.58.9.697; Lohr KN, 1998, HEALTH POLICY, V46, P1, DOI 10.1016-S0168-8510(98)00044-X; McGraw AP, 2010, PSYCHOL SCI, V21, P1438, DOI 10.1177-0956797610381504; Mendelson TB, 2011, ARCH INTERN MED, V171, P577, DOI 10.1001-archinternmed.2011.96; Neuman J, 2011, BRIT MED J, V343, DOI 10.1136-bmj.d5621; Norris SL, 2012, J CLIN EPIDEMIOL, V65, P725, DOI 10.1016-j.jclinepi.2011.12.011; Norris SL, 2011, PLOS ONE, V6, DOI 10.1371-journal.pone.0025153; Poole D, 2008, CRIT CARE MED, V36, P1688, DOI 10.1097-CCM.0b013e3181710b6a; Sniderman AD, 2012, J CLIN EPIDEMIOL, V65, P705, DOI 10.1016-j.jclinepi.2012.01.009; Strauss A. L., 1987, QUALITATIVE ANAL SOC; Woolf SH, 1999, BRIT MED J, V318, P527
dc.description.citedCount 2
dc.description.citedTotWOSCount 3
dc.description.citedWOSCount 3
dc.format.extentCount 7
dc.identifier.articleNo
dc.identifier.coden CHETB
dc.identifier.pubmedID 23412682
dc.identifier.scopusID 84881533112
dc.identifier.url
dc.publisher.address 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA
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dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Chest
dc.relation.ispartOfIssue 2
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Chest
dc.relation.ispartofPubTitleAbbr Chest
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 144
dc.source.ID WOS:000323021400011
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS
dc.subject.otherIndex article
dc.subject.otherIndex conflict of interest
dc.subject.otherIndex experience
dc.subject.otherIndex female
dc.subject.otherIndex health care policy
dc.subject.otherIndex human
dc.subject.otherIndex male
dc.subject.otherIndex methodology
dc.subject.otherIndex practice guideline
dc.subject.otherIndex priority journal
dc.subject.otherIndex qualitative research
dc.subject.otherIndex semi structured interview
dc.subject.otherIndex Conflict of Interest
dc.subject.otherIndex Evidence-Based Medicine
dc.subject.otherIndex Humans
dc.subject.otherIndex Interviews as Topic
dc.subject.otherIndex Policy
dc.subject.otherIndex Practice Guidelines as Topic
dc.subject.otherIndex Societies, Medical
dc.subject.otherIndex Thrombosis
dc.subject.otherKeywordPlus CLINICAL-PRACTICE GUIDELINES
dc.subject.otherKeywordPlus AUTHORS
dc.subject.otherKeywordPlus DISCLOSURE
dc.subject.otherWOS Critical Care Medicine
dc.subject.otherWOS Respiratory System


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