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Cytokine imbalance in acute coronary syndrome

Show simple item record Alam S.E. Nasser S. Fernainy K.E. Habib A.A. Badr K.F.
dc.contributor.editor Apr-2004 2017-10-05T15:48:07Z 2017-10-05T15:48:07Z 2004
dc.identifier 10.1016/j.coph.2003.10.011
dc.identifier.issn 14714892
dc.description.abstract The excessive mortality of coronary heart disease is attributed primarily to rupture and thrombotic transformation of the atherosclerotic plaque. Inflammation plays a critical role in plaque destabilization and vulnerability. Inflammation is not confined to the culprit segment but is convincingly widespread in the coronary and remote vascular beds. Systemic inflammatory, thrombotic and hemodynamic factors are relevant to the pathological and clinical outcome. In addition to their fundamental role in thrombosis, there is ample evidence that platelets contribute significantly to promoting plaque inflammation. A new paradigm of unbalanced cytokine-mediated inflammation is emerging, providing diagnostic and therapeutic opportunity for intervention. Amplifying intrinsic anti-inflammatory mechanisms constitutes attractive avenues for future investigation. © Elsevier Ltd. All rights reserved.
dc.format.extent Pages: (166-170)
dc.language English
dc.publisher OXFORD
dc.relation.ispartof Publication Name: Current Opinion in Pharmacology; Publication Year: 2004; Volume: 4; no. 2; Pages: (166-170);
dc.source Scopus
dc.title Cytokine imbalance in acute coronary syndrome
dc.type Review
dc.contributor.affiliation Alam, S.E., American Univ. of Beirut Med. Center, Division of Cardiology, PO Box 113-6044, Beirut, Lebanon
dc.contributor.affiliation Nasser, S., American Univ. of Beirut Med. Center, Division of Cardiology, PO Box 113-6044, Beirut, Lebanon
dc.contributor.affiliation Fernainy, K.E., American Univ. of Beirut Med. Center, Division of Cardiology, PO Box 113-6044, Beirut, Lebanon
dc.contributor.affiliation Habib, A.A., American Univ. of Beirut Med. Center, Division of Cardiology, PO Box 113-6044, Beirut, Lebanon
dc.contributor.affiliation Badr, K.F., American Univ. of Beirut Med. Center, Division of Cardiology, PO Box 113-6044, Beirut, Lebanon
dc.contributor.authorAddress Alam, S.E.; American Univ. of Beirut Med. Center, Division of Cardiology, PO Box 113-6044, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Office of the VP for Medical Affairs;
dc.contributor.authorDepartment Office of the VP for Medical Affairs
dc.contributor.faculty Faculty of Medicine
dc.contributor.authorInitials Alam, SE
dc.contributor.authorInitials Nasser, SS
dc.contributor.authorInitials Fernainy, KE
dc.contributor.authorInitials Habib, AA
dc.contributor.authorInitials Badr, KF
dc.contributor.authorReprintAddress Alam, SE (reprint author), Amer Univ Beirut, Ctr Med, Div Cardiol, POB 113-6044, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 34
dc.description.citedTotWOSCount 30
dc.description.citedWOSCount 26
dc.format.extentCount 5
dc.identifier.coden COPUB
dc.identifier.pubmedID 15063361
dc.identifier.scopusID 1842453952
dc.relation.ispartOfISOAbbr Curr. Opin. Pharmacol.
dc.relation.ispartOfIssue 2
dc.relation.ispartofPubTitle Current Opinion in Pharmacology
dc.relation.ispartofPubTitleAbbr Curr. Opin. Pharmacol.
dc.relation.ispartOfVolume 4
dc.source.ID WOS:000220780500010
dc.type.publication Journal
dc.subject.otherChemCAS angiotensin, 1407-47-2
dc.subject.otherChemCAS C reactive protein, 9007-41-4
dc.subject.otherChemCAS interleukin 18, 189304-55-0
dc.subject.otherChemCAS interleukin 8, 114308-91-7
dc.subject.otherChemCAS Cytokines
dc.subject.otherChemCAS NF-kappa B
dc.subject.otherIndex angiotensin
dc.subject.otherIndex angiotensin receptor antagonist
dc.subject.otherIndex C reactive protein
dc.subject.otherIndex cytokine
dc.subject.otherIndex hydroxymethylglutaryl coenzyme A reductase inhibitor
dc.subject.otherIndex interleukin 10
dc.subject.otherIndex interleukin 18
dc.subject.otherIndex interleukin 6
dc.subject.otherIndex interleukin 7
dc.subject.otherIndex interleukin 8
dc.subject.otherIndex monocyte chemotactic protein 1
dc.subject.otherIndex Ras protein
dc.subject.otherIndex Rho factor
dc.subject.otherIndex tumor necrosis factor
dc.subject.otherIndex tumor necrosis factor alpha
dc.subject.otherIndex antiinflammatory activity
dc.subject.otherIndex atherosclerotic plaque
dc.subject.otherIndex clinical trial
dc.subject.otherIndex coronary blood vessel
dc.subject.otherIndex diagnostic procedure
dc.subject.otherIndex evidence based medicine
dc.subject.otherIndex heart muscle ischemia
dc.subject.otherIndex hemodynamics
dc.subject.otherIndex human
dc.subject.otherIndex inflammation
dc.subject.otherIndex ischemic heart disease
dc.subject.otherIndex mortality
dc.subject.otherIndex outcomes research
dc.subject.otherIndex priority journal
dc.subject.otherIndex review
dc.subject.otherIndex thrombocyte
dc.subject.otherIndex thrombosis
dc.subject.otherIndex Acute Disease
dc.subject.otherIndex Angina, Unstable
dc.subject.otherIndex Coronary Arteriosclerosis
dc.subject.otherIndex Coronary Thrombosis
dc.subject.otherIndex Cytokines
dc.subject.otherIndex Humans
dc.subject.otherIndex Myocardial Infarction
dc.subject.otherIndex NF-kappa B
dc.subject.otherIndex Signal Transduction
dc.subject.otherIndex Syndrome
dc.subject.otherKeywordPlus C-REACTIVE PROTEIN
dc.subject.otherKeywordPlus UNSTABLE ANGINA-PECTORIS
dc.subject.otherKeywordPlus CARDIOVASCULAR-DISEASE
dc.subject.otherKeywordPlus ATHEROSCLEROTIC PLAQUE
dc.subject.otherKeywordPlus VASCULAR INFLAMMATION
dc.subject.otherKeywordPlus PPAR-GAMMA
dc.subject.otherKeywordPlus KAPPA-B
dc.subject.otherKeywordPlus ATHEROGENESIS
dc.subject.otherKeywordPlus REDUCTION
dc.subject.otherKeywordPlus TRIAL
dc.subject.otherWOS Pharmacology and Pharmacy

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