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Prevalence and determinants of albuminuria in a cohort of diabetic patients in Lebanon

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dc.contributor.author Taleb N.
dc.contributor.author Salti H.
dc.contributor.author Al-Mokaddam M.
dc.contributor.author Merheb M.
dc.contributor.author Salti I.
dc.contributor.author Nasrallah M.
dc.contributor.editor
dc.date Nov-2008
dc.date.accessioned 2017-10-05T15:49:18Z
dc.date.available 2017-10-05T15:49:18Z
dc.date.issued 2008
dc.identifier 10.4103/0256-4947.51674
dc.identifier.isbn
dc.identifier.issn 02564947
dc.identifier.uri http://hdl.handle.net/10938/18773
dc.description.abstract BACKGROUND AND OBJECTIVES: Few data are available on the extent of albuminuria in diabetic populations in the Middle East generally and in Lebanon specifically. We conducted this study to determine the prevalence of albuminuria and its major risk factors in a cohort of diabetic patients in Lebanon. PATIENTS AND METHODS: Diabetic patients followed in the outpatient department at the American University of Beirut Medical Center (AUBMC) were included in a prospective observational study. AUBMC is a tertiary referral center and the outpatient department typically handles patients of low socioeconomic status with advvanced disease. Patients were classified according to their urinary albumin-to-creatinine ratio (ACR) as having normoalbuminuria (ACR30 mg-g creatinine), microalbuminuria (ACR=30 to 300 mg-g creatinine), or macroaalbuminuria (ACR =300 mg-g creatinine). The three groups were compared to analyze the association between albuminuria and its risk factors. In addition, independent predictors of albuminuria were determined using multivariate logistic regression and presented as an odds ratio. RESULTS: Microalbuminuria and macroalbuminuria were present in 33.3percent and 12.7percent of 222 patients (mean age 56.4 years, mean deviation of diabetes 8.6 years, 58.7percent women, 43.8percent obese), respectively. Factors significcantly associated with microalbuminuria included glycemic control, insulin use, and total and LDL cholesterol. Those associated with macroalbuminuria included in addition to glycemic control and insulin use, duration of diabetes, hypertension, elevated mean arterial pressure (MAP), and presence of neuropathy, retinopathy and peripheral vascular disease by bivariate analysis. Only glycemic control was an independent risk factor for both in addition to MAP and retinopathy for macroalbuminuria by multivariate analysis. CONCLUSION: Albuminuria is highly prevalent among this cohort of diabetic patients in Lebanon. Both glycemmic control and blood pressure need to be better targeted in its management. © Annals of Saudi Medicine.
dc.format.extent
dc.format.extent Pages: (420-425)
dc.language English
dc.publisher RIYADH
dc.relation.ispartof Publication Name: Annals of Saudi Medicine; Publication Year: 2008; Volume: 28; no. 6; Pages: (420-425);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Prevalence and determinants of albuminuria in a cohort of diabetic patients in Lebanon
dc.type Article
dc.contributor.affiliation Taleb, N., Department of Internal Medicine Endocrinology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Salti, H., Department of Ophthalmology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Al-Mokaddam, M., Department of Internal Medicine Endocrinology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Merheb, M., Department of Internal Medicine Endocrinology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Salti, I., Department of Ophthalmology, American University of Beirut, Beirut, Lebanon
dc.contributor.affiliation Nasrallah, M., Department of Internal Medicine Endocrinology, American University of Beirut, Beirut, Lebanon
dc.contributor.authorAddress Nasrallah, M.; Department of Internal Medicine Endocrinology, American University of Beirut, Beirut, Lebanon; email: mn36@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Ophthalmology;
dc.contributor.authorDepartment Ophthalmology
dc.contributor.authorDivision
dc.contributor.authorEmail mn36@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Taleb, N
dc.contributor.authorInitials Salti, H
dc.contributor.authorInitials Al-Mokaddam, M
dc.contributor.authorInitials Merheb, M
dc.contributor.authorInitials Salti, I
dc.contributor.authorInitials Nasrallah, M
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Nasrallah, M (reprint author), Amer Univ Beirut, Dept Internal Med, POB 11-0236 D23, Beirut, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Adler AI, 2003, KIDNEY INT, V63, P225, DOI 10.1046-j.1523-1755.2003.00712.x; Amos A F, 1997, Diabet Med, V14 Suppl 5, pS1; BAKRIS G, OVERVIEW DIABETIC NE; Brenner BM, 2001, NEW ENGL J MED, V345, P861, DOI 10.1056-NEJMoa011161; CHATURVEDI N, 1995, DIABETES CARE, V18, P785, DOI 10.2337-diacare.18.6.785; de Boer IH, 2007, J AM SOC NEPHROL, V18, P235, DOI 10.1681-ASN.2006040394; de Zeeuw D, 2004, CIRCULATION, V110, P921, DOI 10.1161-01.CIR.0000139860.33974.28; Ewens KG, 2005, DIABETES, V54, P3305, DOI 10.2337-diabetes.54.11.3305; Gelber RP, 2005, AM J KIDNEY DIS, V46, P871, DOI 10.1053-j.ajkd.2005.08.015; GIRACH A, 2006, INT J CLIN PRACT, V11, P1471; Gross JL, 2005, DIABETES CARE, V28, P164, DOI 10.2337-diacare.28.1.164; HOMMEL E, 1986, DIABETOLOGIA, V29, P211, DOI 10.1007-BF00454877; MARRE M, 1987, BRIT MED J, V294, P1448; Ritz E, 1999, NEW ENGL J MED, V341, P1127, DOI 10.1056-NEJM199910073411506; Rosario Rey F, 2006, Curr Diab Rep, V6, P455, DOI 10.1007-s11892-006-0079-7; SAWICKI PT, 1994, DIABETES CARE, V17, P126, DOI 10.2337-diacare.17.2.126; Taleb N, 2008, BR J DIABETES VASC D, V8, P80, DOI 10.1177-14746514080080020501; Turner RC, 1998, LANCET, V352, P837; Unnikrishnan R, 2007, DIABETES CARE, V30, P2019, DOI 10.2337-dc06-2554
dc.description.citedCount 2
dc.description.citedTotWOSCount 1
dc.description.citedWOSCount 1
dc.format.extentCount 6
dc.identifier.articleNo
dc.identifier.coden ANSME
dc.identifier.pubmedID 19011313
dc.identifier.scopusID 59849129388
dc.identifier.url
dc.publisher.address PUBLICATIONS OFFICE PO BOX 3354, RIYADH 11211, SAUDI ARABIA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Ann. Saudi Med.
dc.relation.ispartOfIssue 6
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Annals of Saudi Medicine
dc.relation.ispartofPubTitleAbbr Ann. Saudi Med.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 28
dc.source.ID WOS:000262202400002
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS Cholesterol, HDL
dc.subject.otherChemCAS Cholesterol, LDL
dc.subject.otherIndex high density lipoprotein cholesterol
dc.subject.otherIndex low density lipoprotein cholesterol
dc.subject.otherIndex albuminuria
dc.subject.otherIndex article
dc.subject.otherIndex blood
dc.subject.otherIndex blood pressure
dc.subject.otherIndex diabetic nephropathy
dc.subject.otherIndex human
dc.subject.otherIndex Lebanon
dc.subject.otherIndex obesity
dc.subject.otherIndex prevalence
dc.subject.otherIndex risk factor
dc.subject.otherIndex statistical model
dc.subject.otherIndex Albuminuria
dc.subject.otherIndex Blood Pressure
dc.subject.otherIndex Cholesterol, HDL
dc.subject.otherIndex Cholesterol, LDL
dc.subject.otherIndex Diabetic Nephropathies
dc.subject.otherIndex Humans
dc.subject.otherIndex Lebanon
dc.subject.otherIndex Logistic Models
dc.subject.otherIndex Obesity
dc.subject.otherIndex Prevalence
dc.subject.otherIndex Risk Factors
dc.subject.otherKeywordPlus NEPHROPATHY
dc.subject.otherKeywordPlus COMPLICATIONS
dc.subject.otherKeywordPlus MICROALBUMINURIA
dc.subject.otherKeywordPlus EPIDEMIOLOGY
dc.subject.otherKeywordPlus PROGRESSION
dc.subject.otherKeywordPlus SMOKING
dc.subject.otherKeywordPlus RISK
dc.subject.otherWOS Medicine, General and Internal


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