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Circulating immune complexes and complement C3 and C4 levels in a selected group of patients with rhinitis in Lebanon

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dc.contributor.author Abdelnoor A.M.
dc.contributor.author Kobeissy F.
dc.contributor.author Farhart D.
dc.contributor.author Hadi U.
dc.contributor.editor
dc.date 2004
dc.date.accessioned 2017-10-05T15:50:28Z
dc.date.available 2017-10-05T15:50:28Z
dc.date.issued 2004
dc.identifier 10.1186/1476-7961-2-6
dc.identifier.isbn
dc.identifier.issn 14767961
dc.identifier.uri http://hdl.handle.net/10938/18878
dc.description.abstract Background: A number of reports indicate that circulating immune complexes (CIC) and activation of the complement system contribute to the pathogenesis of Type I allergy. The aim of this study was to investigate the status of CIC in 113 patients with rhinitis in Lebanon and determine complement components C3 and C4 serum levels in the CIC-positive patients. Serum specific IgE antibodies were previously detected and reported in 74 of the 113 patients. Methods: CIC were detected by polyethylene glycol precipitation and serum C3 and C4 levels quantified by radial immunodiffusion. Results: CIC was positive in 20 of the specific IgE-positive and 13 of the specific IgE-negative patients. C3 and C4 levels were within the normal range in all the 33 CIC-positive patients. Conclusions: The antibody class that constitutes the complexes does not seem to be IgG or IgM. Moreover, complement activation does not seem to be involved in the allergic reaction since both C3 and C4 levels were normal in all patients. The role of these complexes, if any, in the pathogenesis of rhinitis is yet to be determined. © 2004 Abdelnoor et al; licensee BioMed Central Ltd.
dc.format.extent
dc.language English
dc.relation.ispartof Publication Name: Clinical and Molecular Allergy; Publication Year: 2004; Volume: 2;
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Circulating immune complexes and complement C3 and C4 levels in a selected group of patients with rhinitis in Lebanon
dc.type Article
dc.contributor.affiliation Abdelnoor, A.M., Dept. of Microbiology and Immunology, Faculty of Medicine, American University of Beirut, P.O. Box 11-0236, Riad el-Solh, Beirut 11072020, Lebanon
dc.contributor.affiliation Kobeissy, F., Dept. of Microbiology and Immunology, Faculty of Medicine, American University of Beirut, P.O. Box 11-0236, Riad el-Solh, Beirut 11072020, Lebanon, Department of Neuroscience, University of Florida, Gainesville, FL 32608, United States
dc.contributor.affiliation Farhart, D., Dept. of Microbiology and Immunology, Faculty of Medicine, American University of Beirut, P.O. Box 11-0236, Riad el-Solh, Beirut 11072020, Lebanon
dc.contributor.affiliation Hadi, U., Department of Otolaryngology, Faculty of Medicine, American University of Beirut, P.O. Box 11-0236, Riad el-Solh, Beirut 11072020, Lebanon
dc.contributor.authorAddress Abdelnoor, A.M.; Dept. of Microbiology and Immunology, Faculty of Medicine, American University of Beirut, P.O. Box 11-0236, Riad el-Solh, Beirut 11072020, Lebanon; email: aanoor@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Otolaryngology;
dc.contributor.authorDepartment Otolaryngology
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials empty
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited
dc.description.citedCount 3
dc.description.citedTotWOSCount
dc.description.citedWOSCount
dc.format.extentCount 1
dc.identifier.articleNo 6
dc.identifier.coden
dc.identifier.pubmedID
dc.identifier.scopusID 4243102906
dc.identifier.url
dc.publisher.address
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr
dc.relation.ispartOfIssue
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Clinical and Molecular Allergy
dc.relation.ispartofPubTitleAbbr Clin. Mol. Allergy
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 2
dc.source.ID
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS complement component C3, 80295-41-6
dc.subject.otherChemCAS complement component C4, 80295-48-3, 80295-71-2
dc.subject.otherChemCAS immunoglobulin E, 37341-29-0
dc.subject.otherChemCAS immunoglobulin G, 97794-27-9
dc.subject.otherChemCAS immunoglobulin M, 9007-85-6
dc.subject.otherChemCAS macrogol, 25322-68-3
dc.subject.otherIndex complement component C3
dc.subject.otherIndex complement component C4
dc.subject.otherIndex immunoglobulin E
dc.subject.otherIndex immunoglobulin G
dc.subject.otherIndex immunoglobulin M
dc.subject.otherIndex macrogol
dc.subject.otherIndex adolescent
dc.subject.otherIndex adult
dc.subject.otherIndex aged
dc.subject.otherIndex antibody blood level
dc.subject.otherIndex antibody specificity
dc.subject.otherIndex antigen antibody complex
dc.subject.otherIndex article
dc.subject.otherIndex blood sampling
dc.subject.otherIndex child
dc.subject.otherIndex complement activation
dc.subject.otherIndex controlled study
dc.subject.otherIndex female
dc.subject.otherIndex human
dc.subject.otherIndex immunodiffusion
dc.subject.otherIndex Lebanon
dc.subject.otherIndex major clinical study
dc.subject.otherIndex male
dc.subject.otherIndex protein blood level
dc.subject.otherIndex rhinitis
dc.subject.otherKeywordPlus
dc.subject.otherWOS


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