AUB ScholarWorks

Prophylactic methylene blue in a patient with congenital methemoglobinemia

Show simple item record

dc.contributor.author Baraka A.S.
dc.contributor.author Ayoub C.M.
dc.contributor.author Yazbeck-Karam V.
dc.contributor.author Kaddoum R.N.
dc.contributor.author Gerges F.J.
dc.contributor.author Hadi U.M.
dc.contributor.author Dagher C.M.
dc.contributor.editor
dc.date Mar-2005
dc.date.accessioned 2017-10-05T15:50:34Z
dc.date.available 2017-10-05T15:50:34Z
dc.date.issued 2005
dc.identifier 10.1007/BF03016060
dc.identifier.isbn
dc.identifier.issn
dc.identifier.uri http://hdl.handle.net/10938/18944
dc.description.abstract Purpose: To report the beneficial effect of prophylactic methylene blue administration before induction of anesthesia in a patient with congenital methemoglobinemia. Clinical features: A 26-yr-old male patient known to have congenital methemoglobinemia was scheduled for turbinectomy under general anesthesia. The patient was clinically cyanotic with a pulse oximetry of 91percent. Arterial blood gas analysis showed a partial pressure of oxygen (PaO 2) of 81.3 mmHg associated with a fractional oxyhemoglobin of 80.7percent, and a methemoglobin fraction of 0.159. Preoperative iv administration of 1 mg·kg -1 of methylene blue resulted, within five minutes, in a decrease of methemoglobin fraction down to 0.05 associated with an increase of the fractional oxyhemoglobin saturation up to 94.7percent. After two hours, the methemoglobin fraction decreased to 0.01 and the fractional oxyhemoglobin concentration increased to 97.7percent. Induction of anesthesia as well as intraoperative and postoperative course were uneventful without any episode of hypoxemia. Postoperatively, the methemoglobin fractions remained low for 24 hr, to be followed by a gradual increase up to 0.02 on the second day to reach 0.094 on the fifth day. Conclusion: The prophylactic preoperative methylene blue administration in a patient with congenital methemoglobinemia significantly decreased the methemoglobin level and increased the fractional oxygen saturation with a consequent increase of the safety margin against perioperative hypoxemia.
dc.format.extent
dc.format.extent Pages: (258-261)
dc.language English
dc.relation.ispartof Publication Name: Canadian Journal of Anesthesia; Publication Year: 2005; Volume: 52; no. 3; Pages: (258-261);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Prophylactic methylene blue in a patient with congenital methemoglobinemia
dc.type Article
dc.contributor.affiliation Baraka, A.S., Department of Anesthesiology and Otorhinolaryngology, American University of Beirut-Medical Center, P.O. Box 11-0236, Beirut 1107-2020, Lebanon
dc.contributor.affiliation Ayoub, C.M., Department of Anesthesiology and Otorhinolaryngology, American University of Beirut-Medical Center, P.O. Box 11-0236, Beirut 1107-2020, Lebanon
dc.contributor.affiliation Yazbeck-Karam, V., Department of Anesthesiology and Otorhinolaryngology, American University of Beirut-Medical Center, P.O. Box 11-0236, Beirut 1107-2020, Lebanon
dc.contributor.affiliation Kaddoum, R.N., Department of Anesthesiology and Otorhinolaryngology, American University of Beirut-Medical Center, P.O. Box 11-0236, Beirut 1107-2020, Lebanon
dc.contributor.affiliation Gerges, F.J., Department of Anesthesiology and Otorhinolaryngology, American University of Beirut-Medical Center, P.O. Box 11-0236, Beirut 1107-2020, Lebanon
dc.contributor.affiliation Hadi, U.M., Department of Anesthesiology and Otorhinolaryngology, American University of Beirut-Medical Center, P.O. Box 11-0236, Beirut 1107-2020, Lebanon
dc.contributor.affiliation Dagher, C.M., Department of Anesthesiology and Otorhinolaryngology, American University of Beirut-Medical Center, P.O. Box 11-0236, Beirut 1107-2020, Lebanon
dc.contributor.authorAddress Baraka, A.S.; Department of Anesthesiology, American University of Beirut, P.O. Box 11-0236, Beirut 1107-2020, Lebanon; email: abaraka@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Otolaryngology;
dc.contributor.authorDepartment Otolaryngology
dc.contributor.authorDivision
dc.contributor.authorEmail
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials empty
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited
dc.description.citedCount 14
dc.description.citedTotWOSCount
dc.description.citedWOSCount
dc.format.extentCount 4
dc.identifier.articleNo
dc.identifier.coden CJOAE
dc.identifier.pubmedID 15753496
dc.identifier.scopusID 18644374613
dc.identifier.url
dc.publisher.address
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr
dc.relation.ispartOfIssue 3
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Canadian Journal of Anesthesia
dc.relation.ispartofPubTitleAbbr Can. J. Anesth.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 52
dc.source.ID
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS isoflurane, 26675-46-7
dc.subject.otherChemCAS lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9
dc.subject.otherChemCAS methylene blue, 61-73-4
dc.subject.otherChemCAS oxygen, 7782-44-7
dc.subject.otherChemCAS oxyhemoglobin, 9061-63-6
dc.subject.otherChemCAS propofol, 2078-54-8
dc.subject.otherChemCAS rocuronium, 119302-91-9
dc.subject.otherChemCAS Methemoglobin, 9008-37-1
dc.subject.otherChemCAS Methylene Blue, 61-73-4
dc.subject.otherChemCAS Oxygen, 77
dc.subject.otherIndex isoflurane
dc.subject.otherIndex lidocaine
dc.subject.otherIndex methemoglobin
dc.subject.otherIndex methylene blue
dc.subject.otherIndex oxygen
dc.subject.otherIndex oxyhemoglobin
dc.subject.otherIndex propofol
dc.subject.otherIndex rocuronium
dc.subject.otherIndex adult
dc.subject.otherIndex anesthesia induction
dc.subject.otherIndex arterial gas
dc.subject.otherIndex article
dc.subject.otherIndex blood gas analysis
dc.subject.otherIndex case report
dc.subject.otherIndex concentration (parameters)
dc.subject.otherIndex cyanosis
dc.subject.otherIndex disease course
dc.subject.otherIndex dose response
dc.subject.otherIndex general anesthesia
dc.subject.otherIndex human
dc.subject.otherIndex hypoxemia
dc.subject.otherIndex intraoperative period
dc.subject.otherIndex male
dc.subject.otherIndex methemoglobinemia
dc.subject.otherIndex nose surgery
dc.subject.otherIndex oxygen saturation
dc.subject.otherIndex oxygen tension
dc.subject.otherIndex patient monitoring
dc.subject.otherIndex postoperative period
dc.subject.otherIndex preoperative evaluation
dc.subject.otherIndex priority journal
dc.subject.otherIndex prophylaxis
dc.subject.otherIndex pulse oximetry
dc.subject.otherIndex safety
dc.subject.otherIndex treatment outcome
dc.subject.otherIndex Adult
dc.subject.otherIndex Anoxemia
dc.subject.otherIndex Humans
dc.subject.otherIndex Male
dc.subject.otherIndex Methemoglobin
dc.subject.otherIndex Methemoglobinemia
dc.subject.otherIndex Methylene Blue
dc.subject.otherIndex Oxygen
dc.subject.otherKeywordPlus
dc.subject.otherWOS


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search AUB ScholarWorks


Browse

My Account