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The association of Hashimoto disease and congo red negative amyloidosis

Show simple item record Chaiban J.T. Kalache S.M. Abu Alfa A.K. Shabb N.S. Salti I.S.
dc.contributor.editor 2008 2017-10-05T15:59:21Z 2017-10-05T15:59:21Z 2008
dc.identifier 10.1097/MAJ.0b013e31815b9d51
dc.identifier.issn 00029629
dc.description.abstract Systemic amyloidosis which is characterized by extracellular deposition of monoclonal immunoglobulin light chains in various organs may be difficult to diagnose at an early stage, especially when the Congo red stain is negative. We describe herein a case of Congo red negative primary amyloidosis associated with Hashimoto thyroiditis. The patient presented with multiple organ involvement suggestive of amyloidosis including heart failure, renal failure, and macroglossia. Serum and urine immunofixation studies were positive for monoclonal chains. Even though a biopsy taken from the enlarged tongue of the patient was negative when stained with Congo red, electron microscopy showed ultrastructural features of amyloid deposition. In conclusion, we are reporting a rare case of primary amyloidosis with a negative Congo red stain associated with Hashimoto thyroiditis. © Copyright 2008 Southern Society for Clinical Investigation.
dc.format.extent Pages: (293-296)
dc.language English
dc.publisher PHILADELPHIA
dc.relation.ispartof Publication Name: American Journal of the Medical Sciences; Publication Year: 2008; Volume: 336; no. 3; Pages: (293-296);
dc.source Scopus
dc.title The association of Hashimoto disease and congo red negative amyloidosis
dc.type Article
dc.contributor.affiliation Chaiban, J.T., Division of Endocrinology and Metabolism, Department of Internal Medicine, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation Kalache, S.M., Division of Endocrinology and Metabolism, Department of Internal Medicine, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation Abu Alfa, A.K., Section of Nephrology, Department of Internal Medicine, Yale School of Medicine, CT, United States
dc.contributor.affiliation Shabb, N.S., Department of Pathology, American University, Beirut-Medical Center, Beirut, Lebanon
dc.contributor.affiliation Salti, I.S., Division of Endocrinology and Metabolism, Department of Internal Medicine, American University of Beirut-Medical Center, Beirut, Lebanon
dc.contributor.authorAddress Salti, I. S.; Division of Endocrinology and Metabolism, Department of Internal Medicine, American University of Beirut-Medical Center, Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Chaiban, JT
dc.contributor.authorInitials Kalache, SM
dc.contributor.authorInitials Abu Alfa, AK
dc.contributor.authorInitials Shabb, NS
dc.contributor.authorInitials Salti, IS
dc.contributor.authorReprintAddress Salti, IS (reprint author), Amer Univ Beirut, Med Ctr, Dept Internal Med, Div Endocrinol, Beirut, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 5
dc.description.citedTotWOSCount 3
dc.description.citedWOSCount 3
dc.format.extentCount 4
dc.identifier.coden AJMSA
dc.identifier.scopusID 55249088036
dc.publisher.address 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
dc.relation.ispartOfISOAbbr Am. J. Med. Sci.
dc.relation.ispartOfIssue 3
dc.relation.ispartofPubTitle American Journal of the Medical Sciences
dc.relation.ispartofPubTitleAbbr Am. J. Med. Sci.
dc.relation.ispartOfVolume 336
dc.source.ID WOS:000260060300018
dc.type.publication Journal
dc.subject.otherAuthKeyword Amyloidosis
dc.subject.otherAuthKeyword Congo red negative
dc.subject.otherAuthKeyword Hashimoto thyroiditis
dc.subject.otherChemCAS congo red, 573-58-0, 80701-77-5
dc.subject.otherChemCAS furosemide, 54-31-9
dc.subject.otherChemCAS levothyroxine, 51-48-9
dc.subject.otherIndex congo red
dc.subject.otherIndex furosemide
dc.subject.otherIndex levothyroxine
dc.subject.otherIndex adult
dc.subject.otherIndex amyloidosis
dc.subject.otherIndex article
dc.subject.otherIndex cardiomyopathy
dc.subject.otherIndex case report
dc.subject.otherIndex computer assisted tomography
dc.subject.otherIndex disease activity
dc.subject.otherIndex echocardiography
dc.subject.otherIndex electron microscopy
dc.subject.otherIndex electrophoresis
dc.subject.otherIndex exophthalmos
dc.subject.otherIndex Hashimoto disease
dc.subject.otherIndex heart failure
dc.subject.otherIndex hospital admission
dc.subject.otherIndex human
dc.subject.otherIndex hypothyroidism
dc.subject.otherIndex kidney failure
dc.subject.otherIndex leg edema
dc.subject.otherIndex macroglossia
dc.subject.otherIndex male
dc.subject.otherIndex monoclonal immunoglobulinemia
dc.subject.otherIndex periorbital edema
dc.subject.otherIndex physical examination
dc.subject.otherIndex thorax radiography
dc.subject.otherIndex blood
dc.subject.otherIndex edema
dc.subject.otherIndex fatality
dc.subject.otherIndex middle aged
dc.subject.otherIndex pathology
dc.subject.otherIndex purpura
dc.subject.otherIndex tongue
dc.subject.otherIndex ultrastructure
dc.subject.otherIndex Amyloidosis
dc.subject.otherIndex Edema
dc.subject.otherIndex Fatal Outcome
dc.subject.otherIndex Hashimoto Disease
dc.subject.otherIndex Humans
dc.subject.otherIndex Macroglossia
dc.subject.otherIndex Male
dc.subject.otherIndex Microscopy, Electron
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Purpura
dc.subject.otherIndex Tongue
dc.subject.otherKeywordPlus LIGHT-CHAINS
dc.subject.otherKeywordPlus THYROIDITIS
dc.subject.otherKeywordPlus PROTEINS
dc.subject.otherWOS Medicine, General and Internal

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