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Heritable variation of ERBB2 and breast cancer risk

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dc.contributor.author Breyer J.P.
dc.contributor.author Sanders M.E.
dc.contributor.author Airey D.C.
dc.contributor.author Cai Q.
dc.contributor.author Yaspan B.L.
dc.contributor.author Schuyler P.A.
dc.contributor.author Dai Q.
dc.contributor.author Boulos F.
dc.contributor.author Olivares M.G.
dc.contributor.author Bradley K.M.
dc.contributor.author Gao Y.-T.
dc.contributor.author Page D.L.
dc.contributor.author Dupont W.D.
dc.contributor.author Zheng W.
dc.contributor.author Smith J.R.
dc.contributor.editor
dc.date Apr-2009
dc.date.accessioned 2017-10-05T15:59:24Z
dc.date.available 2017-10-05T15:59:24Z
dc.date.issued 2009
dc.identifier 10.1158/1055-9965.EPI-08-1202
dc.identifier.isbn
dc.identifier.issn 10559965
dc.identifier.uri http://hdl.handle.net/10938/18988
dc.description.abstract Amplification of the epithelial growth factor receptor gene ERBB2 (HER2, NEU) in breast cancer is associated with a poor clinical prognosis. In mammary gland development, this receptor plays a role in ductal and lobuloalveolar differentiation. We conducted a systematic investigation of the role of genetic variation of the ERBB2 gene in breast cancer risk in a study of 842 histologically confirmed invasive breast cancer cases and 1,108 controls from the Shanghai Breast Cancer Study. We observed that the ERBB2 gene resides within a locus of high linkage disequilibrium, composed of three major ancestral haplotypes in the study population. These haplotypes are marked by simple tandem repeat and single nucleotide polymorphisms, includingthe missense variants I655V and P1170A. We observed a risk-modifyingeffect of a highly polymorphic simple tandem repeat within an evolutionarily conserved region, 4.4 kb upstream from the ERBB2 transcription start site. Under a dominant genetic model, the age-adjusted odds ratio was 1.74 (95percent confidence interval, 1.27-2.37). Its association with breast cancer, and with breast cancer stratified by histology, by histologic grade, and by stage, remained significant after correction for multiple comparisons. In contrast, we observed no association of ERBB2 single nucleotide polymorphism haplotypes with breast cancer predisposition. Copyright © 2009 American Association for Cancer Research.
dc.format.extent
dc.format.extent Pages: (1252-1258)
dc.language English
dc.publisher PHILADELPHIA
dc.relation.ispartof Publication Name: Cancer Epidemiology Biomarkers and Prevention; Publication Year: 2009; Volume: 18; no. 4; Pages: (1252-1258);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other GENBANK: NM_004448
dc.title Heritable variation of ERBB2 and breast cancer risk
dc.type Article
dc.contributor.affiliation Breyer, J.P., Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States
dc.contributor.affiliation Sanders, M.E., Department of Pathology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States
dc.contributor.affiliation Airey, D.C., Department of Pharmacology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States
dc.contributor.affiliation Cai, Q., Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States
dc.contributor.affiliation Yaspan, B.L., Department of Molecular Physiology and Biophysics, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States
dc.contributor.affiliation Schuyler, P.A., Department of Biostatistics, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States
dc.contributor.affiliation Dai, Q., Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States
dc.contributor.affiliation Boulos, F., Department of Pathology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States, Department of Pathology and Laboratory Medicine, American University, Beirut Medical Center, Beirut, Lebanon
dc.contributor.affiliation Olivares, M.G., Department of Pathology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States
dc.contributor.affiliation Bradley, K.M., Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States
dc.contributor.affiliation Gao, Y.-T., Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
dc.contributor.affiliation Page, D.L., Department of Pathology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States
dc.contributor.affiliation Dupont, W.D., Department of Biostatistics, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States
dc.contributor.affiliation Zheng, W., Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States, Department of Medicine, Vanderbilt University School of Medicine, 2525 West End Avenue, Nashville, TN 37203-1738, United States
dc.contributor.affiliation Smith, J.R., Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States, Medical Research Service, VA Tennessee Valley Healthcare System, Nashville, TN, United States, Department of Medicine, Vanderbilt University School of Medicine, 529 Light Hall, 2215 Garland Avenue, Nashville, TN 37232-0275, United States
dc.contributor.authorAddress Zheng, W.; Department of Medicine, Vanderbilt University School of Medicine, 2525 West End Avenue, Nashville, TN 37203-1738, United States; email: wei.zheng@vanderbilt.edu
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail wei.zheng@vanderbilt.edu; jeffrey.smith@vanderbilt.edu
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Breyer, JP
dc.contributor.authorInitials Sanders, ME
dc.contributor.authorInitials Airey, DC
dc.contributor.authorInitials Cai, QY
dc.contributor.authorInitials Yaspan, BL
dc.contributor.authorInitials Schuyler, PA
dc.contributor.authorInitials Dai, Q
dc.contributor.authorInitials Boulos, F
dc.contributor.authorInitials Olivares, MG
dc.contributor.authorInitials Bradley, KM
dc.contributor.authorInitials Gao, YT
dc.contributor.authorInitials Page, DL
dc.contributor.authorInitials Dupont, WD
dc.contributor.authorInitials Zheng, W
dc.contributor.authorInitials Smith, JR
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Smith, JR (reprint author), Vanderbilt Univ, Sch Med, Dept Med, 529 Light Hall,2215 Garland Ave, Nashville, TN 37232 USA.
dc.contributor.authorResearcherID Smith, Jeff-C-3484-2012; Dupont, William-I-4430-2012
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Abd El-Rehim DM, 2004, BRIT J CANCER, V91, P1532, DOI 10.1038-sj.bjc.6602184; Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093-bioinformatics-bth457; Benusiglio PR, 2006, BRIT J CANCER, V95, P1689, DOI 10.1038-sj.bjc.6603473; Benusiglio PR, 2005, BREAST CANCER RES, V7, pR204, DOI 10.1186-bcr982; Bilous M, 2003, BREAST, V12, P92, DOI 10.1016-S0960-9776(02)00273-4; Brownstein MJ, 1996, BIOTECHNIQUES, V20, P1004; Brownstein MJ, 1996, BIOTECHNIQUES, V20, P1008; Casalini P, 2004, J CELL PHYSIOL, V200, P343, DOI 10.1002-jcp.20007; Chen XN, 1999, GENOME RES, V9, P492; Cristofanilli M, 2005, J CLIN ONCOL, V23, P41, DOI 10.1200-JCO.2005.03.111; ELSTON CW, 1991, HISTOPATHOLOGY, V19, P403, DOI 10.1111-j.1365-2559.1991.tb00229.x; Frank B, 2005, CARCINOGENESIS, V26, P1649, DOI 10.1093-carcin-bgi108; Gao YT, 2000, INT J CANCER, V87, P295, DOI 10.1002-1097-0215(20000715)87:2295::AID-IJC233.0.CO;2-7; Gaunt TR, 2006, BMC BIOINFORMATICS, V7, DOI 10.1186-1471-2105-7-227; Han W, 2005, CLIN CANCER RES, V11, P4775, DOI 10.1158-1078-0432.CCR-04-2208; Harris JR, 2004, DIS BREAST; Hoff ER, 2002, AM J CLIN PATHOL, V117, P916; Hunter DJ, 2007, NAT GENET, V39, P870, DOI 10.1038-ng2075; Janocko LE, 2001, CYTOMETRY, V46, P136, DOI 10.1002-cyto.1098; Kirschbaum MH, 2000, J CELL BIOCHEM, P52; KOMMOSS F, 1990, MOL CELL PROBE, V4, P11, DOI 10.1016-0890-8508(90)90035-X; Marchini J, 2006, AM J HUM GENET, V78, P437, DOI 10.1086-500808; Page DL, 2003, AM J SURG PATHOL, V27, P832, DOI 10.1097-00000478-200306000-00016; Page DL, 1987, DIAGNOSTIC HISTOPATH; RAMACHANDRA S, 1990, J PATHOL, V161, P7, DOI 10.1002-path.1711610104; Ross JS, 2003, ONCOLOGIST, V8, P307, DOI 10.1634-theoncologist.8-4-307; SastreGarau X, 1996, CANCER, V77, P113, DOI 10.1002-(SICI)1097-0142(19960101)77:1113::AID-CNCR193.0.CO;2-8; Singletary SE, 2002, J CLIN ONCOL, V20, P3628, DOI 10.1200-JCO.2002.02.026; Stephens M, 2003, AM J HUM GENET, V73, P1162, DOI 10.1086-379378; Stephens M, 2001, AM J HUM GENET, V68, P978, DOI 10.1086-319501; Stern DF, 2003, EXP CELL RES, V284, P89, DOI 10.1016-S0014-4827(02)00103-9; Frazer KA, 2007, NATURE, V449, P851, DOI 10.1038-nature06258; Troyer KL, 2001, J MAMMARY GLAND BIOL, V6, P7, DOI 10.1023-A:1009560330359; Xie DW, 2000, J NATL CANCER I, V92, P412, DOI 10.1093-jnci-92.5.412; Yaspan BL, 2007, CANCER RES, V67, P5673, DOI 10.1158-0008-5472.CAN-07-0467; Zheng W, 2004, CANCER EPIDEM BIOMAR, V13, P709
dc.description.citedCount 5
dc.description.citedTotWOSCount 5
dc.description.citedWOSCount 5
dc.format.extentCount 7
dc.identifier.articleNo
dc.identifier.coden CEBPE
dc.identifier.pubmedID 19336545
dc.identifier.scopusID 66649133396
dc.identifier.url
dc.publisher.address 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
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dc.relation.ispartofConferenceDate
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dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Cancer Epidemiol. Biomarkers Prev.
dc.relation.ispartOfIssue 4
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Cancer Epidemiology Biomarkers and Prevention
dc.relation.ispartofPubTitleAbbr Cancer Epidemiol. Biomarkers Prev.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 18
dc.source.ID WOS:000265125000032
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS epidermal growth factor receptor 2, 137632-09-8
dc.subject.otherChemCAS Receptor, erbB-2, 2.7.1.112
dc.subject.otherIndex epidermal growth factor receptor 2
dc.subject.otherIndex adult
dc.subject.otherIndex allele
dc.subject.otherIndex article
dc.subject.otherIndex breast cancer
dc.subject.otherIndex cancer grading
dc.subject.otherIndex cancer invasion
dc.subject.otherIndex cancer risk
dc.subject.otherIndex cancer staging
dc.subject.otherIndex cancer susceptibility
dc.subject.otherIndex Chinese
dc.subject.otherIndex controlled study
dc.subject.otherIndex correlation analysis
dc.subject.otherIndex female
dc.subject.otherIndex gene linkage disequilibrium
dc.subject.otherIndex gene location
dc.subject.otherIndex gene locus
dc.subject.otherIndex genetic model
dc.subject.otherIndex genetic variability
dc.subject.otherIndex genotype
dc.subject.otherIndex germ line
dc.subject.otherIndex haplotype
dc.subject.otherIndex histopathology
dc.subject.otherIndex human
dc.subject.otherIndex human tissue
dc.subject.otherIndex major clinical study
dc.subject.otherIndex missense mutation
dc.subject.otherIndex nucleotide sequence
dc.subject.otherIndex priority journal
dc.subject.otherIndex risk assessment
dc.subject.otherIndex single nucleotide polymorphism
dc.subject.otherIndex tandem repeat
dc.subject.otherIndex Adenocarcinoma
dc.subject.otherIndex Adult
dc.subject.otherIndex Breast Neoplasms
dc.subject.otherIndex Carcinoma, Ductal, Breast
dc.subject.otherIndex Carcinoma, Lobular
dc.subject.otherIndex Case-Control Studies
dc.subject.otherIndex China
dc.subject.otherIndex Female
dc.subject.otherIndex Genetic Predisposition to Disease
dc.subject.otherIndex Haplotypes
dc.subject.otherIndex Humans
dc.subject.otherIndex Linkage Disequilibrium
dc.subject.otherIndex Middle Aged
dc.subject.otherIndex Mutation, Missense
dc.subject.otherIndex Polymorphism, Single Nucleotide
dc.subject.otherIndex Prognosis
dc.subject.otherIndex Receptor, erbB-2
dc.subject.otherIndex Risk Factors
dc.subject.otherIndex Tandem Repeat Sequences
dc.subject.otherKeywordPlus HAPLOTYPE RECONSTRUCTION
dc.subject.otherKeywordPlus LOBULAR CARCINOMA
dc.subject.otherKeywordPlus POPULATION
dc.subject.otherKeywordPlus GENE
dc.subject.otherKeywordPlus ASSOCIATION
dc.subject.otherKeywordPlus FAMILY
dc.subject.otherKeywordPlus POLYMORPHISMS
dc.subject.otherKeywordPlus VISUALIZATION
dc.subject.otherKeywordPlus AMPLIFICATION
dc.subject.otherKeywordPlus EXPRESSION
dc.subject.otherWOS Oncology
dc.subject.otherWOS Public, Environmental and Occupational Health


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