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Unusual presentation of a sarcoid patient: Multiple arterial and venous thrombosis with chest lymphadenopathy

Show simple item record Rebeiz T.J. Mahfouz R. Taher A. Charafeddine Kh. Kanj N.
dc.contributor.editor Jan-2009 2017-10-05T15:59:24Z 2017-10-05T15:59:24Z 2009
dc.identifier 10.1007/s11239-008-0270-6
dc.identifier.issn 09295305
dc.description.abstract We depict a case of a 32 year old Mediterranean man, presenting with pulmonary embolism, and diffuse arterial thrombosis of the lower extremities. CT angiography revealed bilateral pulmonary artery occlusions and a mediastinal lymphadenopathy. Duplex Ultrasound of the lower extremities showed no deep venous thrombosis, but occluded popliteal arteries bilaterally with extension to the right distal superficial femoral artery. Mediastinoscopy with hilar lymph node biopsy showed noncaseating granulomas consistent with sarcoidosis. Thrombophilia profile revealed factor II, MTHFR, and factor XIII gene mutations with markedly elevated homocysteine level of 139 μmol-l. This is an atypical rare case of sarcoidosis presenting with pulmonary embolism and multiple arterial thrombosis. © Springer Science+Business Media, LLC 2008.
dc.format.extent Pages: (245-247)
dc.language English
dc.publisher DORDRECHT
dc.relation.ispartof Publication Name: Journal of Thrombosis and Thrombolysis; Publication Year: 2009; Volume: 28; no. 2; Pages: (245-247);
dc.source Scopus
dc.title Unusual presentation of a sarcoid patient: Multiple arterial and venous thrombosis with chest lymphadenopathy
dc.type Article
dc.contributor.affiliation Rebeiz, T.J., American University of Beirut Medical School, Beirut, Lebanon
dc.contributor.affiliation Mahfouz, R., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center (AUBMC), Riad El Solh, 1107 2020 Beirut, Lebanon
dc.contributor.affiliation Taher, A., Department of Internal Medicine, AUBMC, Beirut, Lebanon
dc.contributor.affiliation Charafeddine, Kh., Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center (AUBMC), Riad El Solh, 1107 2020 Beirut, Lebanon
dc.contributor.affiliation Kanj, N., Department of Internal Medicine, AUBMC, Beirut, Lebanon
dc.contributor.authorAddress Mahfouz, R.; Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center (AUBMC), Riad El Solh, 1107 2020 Beirut, Lebanon; email:
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Rebeiz, TJ
dc.contributor.authorInitials Mahfouz, R
dc.contributor.authorInitials Taher, A
dc.contributor.authorInitials Charafeddine, K
dc.contributor.authorInitials Kanj, N
dc.contributor.authorReprintAddress Mahfouz, R (reprint author), AUBMC, Dept Pathol and Lab Med, POBox 11-0236, Beirut 11072020, Lebanon.
dc.contributor.authorUniversity American University of Beirut Medical Center
dc.description.cited Ariens RAS, 2002, BLOOD, V100, P743, DOI 10.1182-blood.V100.3.743; Catto AJ, 1999, BLOOD, V93, P906; DAngelo A, 1997, HAEMATOLOGICA, V82, P211; Esen BA, 2005, EUR J GEN MED, V2, P173; Lentz SR, 2005, J THROMB HAEMOST, V3, P1646, DOI 10.1111-j.1538-7836.2005.01364.x; McLaughlin AM, 2003, THORAX, V58, P552, DOI 10.1136-thorax.58.6.552-a; Pierce T B, 2001, Proc (Bayl Univ Med Cent), V14, P8; Poort SR, 1996, BLOOD, V88, P3698; Rozen R, 1997, THROMB HAEMOSTASIS, V78, P523; Vahid B, 2006, SOUTH MED J, V99, P998, DOI 10.1097-01.smj.0000233188.45688.41
dc.description.citedCount 5
dc.description.citedTotWOSCount 3
dc.description.citedWOSCount 3
dc.format.extentCount 3
dc.identifier.coden JTTHF
dc.identifier.pubmedID 18792762
dc.identifier.scopusID 67849130468
dc.relation.ispartOfISOAbbr J. Thromb. Thrombolysis
dc.relation.ispartOfIssue 2
dc.relation.ispartofPubTitle Journal of Thrombosis and Thrombolysis
dc.relation.ispartofPubTitleAbbr J. Thromb. Trombolysis
dc.relation.ispartOfVolume 28
dc.source.ID WOS:000268275700020
dc.type.publication Journal
dc.subject.otherAuthKeyword Arterial
dc.subject.otherAuthKeyword Sarcoidosis
dc.subject.otherAuthKeyword Thrombosis
dc.subject.otherChemCAS 5,10 methylenetetrahydrofolate reductase (FADH2), 9028-69-7
dc.subject.otherChemCAS blood clotting factor 8, 9001-27-8
dc.subject.otherChemCAS heparin, 37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5
dc.subject.otherChemCAS prothrombin, 9001-26-7
dc.subject.otherIndex 5,10 methylenetetrahydrofolate reductase (FADH2)
dc.subject.otherIndex blood clotting factor 8
dc.subject.otherIndex heparin
dc.subject.otherIndex prothrombin
dc.subject.otherIndex adult
dc.subject.otherIndex artery thrombosis
dc.subject.otherIndex article
dc.subject.otherIndex case report
dc.subject.otherIndex computed tomographic angiography
dc.subject.otherIndex computer assisted tomography
dc.subject.otherIndex dyspnea
dc.subject.otherIndex echocardiography
dc.subject.otherIndex echography
dc.subject.otherIndex gene mutation
dc.subject.otherIndex heterozygote
dc.subject.otherIndex human
dc.subject.otherIndex hyperhomocysteinemia
dc.subject.otherIndex laboratory test
dc.subject.otherIndex leg thrombosis
dc.subject.otherIndex lung embolism
dc.subject.otherIndex lymph node biopsy
dc.subject.otherIndex lymphadenopathy
dc.subject.otherIndex male
dc.subject.otherIndex mediastinoscopy
dc.subject.otherIndex mutational analysis
dc.subject.otherIndex physical examination
dc.subject.otherIndex popliteal artery
dc.subject.otherIndex priority journal
dc.subject.otherIndex pulmonary artery occlusion
dc.subject.otherIndex sarcoidosis
dc.subject.otherIndex superficial femoral artery
dc.subject.otherIndex tachypnea
dc.subject.otherIndex thorax pain
dc.subject.otherIndex thrombophilia
dc.subject.otherIndex vein thrombosis
dc.subject.otherIndex Adult
dc.subject.otherIndex Humans
dc.subject.otherIndex Lymphatic Diseases
dc.subject.otherIndex Male
dc.subject.otherIndex Pulmonary Embolism
dc.subject.otherIndex Sarcoidosis, Pulmonary
dc.subject.otherIndex Venous Thrombosis
dc.subject.otherKeywordPlus FACTOR-XIII
dc.subject.otherKeywordPlus HYPERHOMOCYSTEINEMIA
dc.subject.otherKeywordPlus GENE
dc.subject.otherWOS Hematology
dc.subject.otherWOS Peripheral Vascular Disease

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