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Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia

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dc.contributor.author El Hajj H.
dc.contributor.author El-Sabban M.
dc.contributor.author Hasegawa H.
dc.contributor.author Zaatari G.
dc.contributor.author Ablain J.
dc.contributor.author Saab S.T.
dc.contributor.author Janin A.
dc.contributor.author Mahfouz R.
dc.contributor.author Nasr R.
dc.contributor.author Kfoury Y.
dc.contributor.author Nicot C.
dc.contributor.author Hermine O.
dc.contributor.author Hall W.
dc.contributor.author De The H.
dc.contributor.author Bazarbachi A.
dc.contributor.editor
dc.date Dec-2010
dc.date.accessioned 2017-10-05T15:59:28Z
dc.date.available 2017-10-05T15:59:28Z
dc.date.issued 2010
dc.identifier 10.1084/jem.20101095
dc.identifier.isbn
dc.identifier.issn 00221007
dc.identifier.uri http://hdl.handle.net/10938/19032
dc.description.abstract Chronic HTLV-I (human T cell lymphotropic virus type I) infection may cause adult T cell leukemia-lymphoma (ATL), a disease with dismal long-term prognosis. The HTLV-I transactivator, Tax, initiates ATL in transgenic mice. In this study, we demonstrate that an As2O3 and IFN-α combination, known to trigger Tax proteolysis, cures Tax-driven ATL in mice. Unexpectedly, this combination therapy abrogated initial leukemia engraftment into secondary recipients, whereas the primary tumor bulk still grew in the primary hosts, only to ultimately abate later on. This loss of initial transplantability required proteasome function. A similar regimen recently yielded unprecedented disease control in human ATL. Our demonstration that this drug combination targeting Tax stability abrogates tumor cell immortality but not short-term growth may foretell a favorable long-term efficiency of this regimen in patients. © 2010 El Hajj et al.
dc.format.extent
dc.format.extent Pages: (2785-2792)
dc.language English
dc.publisher NEW YORK
dc.relation.ispartof Publication Name: Journal of Experimental Medicine; Publication Year: 2010; Volume: 207; no. 13; Pages: (2785-2792);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia
dc.type Article
dc.contributor.affiliation El Hajj, H., Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut 1107 2020, Lebanon
dc.contributor.affiliation El-Sabban, M., Department of Human Morphology, American University of Beirut, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Hasegawa, H., Department of Pathology, National Institute of Infectious Diseases, Shinjuku-Ku, Tokyo 162 8640, Japan, Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland
dc.contributor.affiliation Zaatari, G., Department of Pathology and Laboratory Medicine, American University of Beirut, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Ablain, J., Service de Biochimie, Equipe Labellisée, Université Paris Diderot Unité Mixte de Recherche 7212, 75475 Paris, Cedex 10, France
dc.contributor.affiliation Saab, S.T., Department of Pathology and Laboratory Medicine, American University of Beirut, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Janin, A., Service de Pathologie, Institut National de la Santé et de la Recherche Médicale, Hôpital Saint Louis, 75475 Paris, Cedex 10, France
dc.contributor.affiliation Mahfouz, R., Department of Pathology and Laboratory Medicine, American University of Beirut, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Nasr, R., Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Kfoury, Y., Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Nicot, C., Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, United States, University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS 66160, United States, Center for Viral Oncology, University of Kansas Medical Center, Kansas City, KS 66160, United States
dc.contributor.affiliation Hermine, O., Service d'Hématologie, Equipe Labellisée, Hôpital Necker-Enfants Malades, 75015 Paris, Cedex 15, France
dc.contributor.affiliation Hall, W., Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland
dc.contributor.affiliation De Thé, H., Service de Biochimie, Equipe Labellisée, Université Paris Diderot Unité Mixte de Recherche 7212, 75475 Paris, Cedex 10, France
dc.contributor.affiliation Bazarbachi, A., Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut 1107 2020, Lebanon
dc.contributor.authorAddress Bazarbachi, A.; Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut 1107 2020, Lebanon; email: bazarbac@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail dethe@univ-paris-diderot.fr; bazarbac@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials El Hajj, H
dc.contributor.authorInitials El-Sabban, M
dc.contributor.authorInitials Hasegawa, H
dc.contributor.authorInitials Zaatari, G
dc.contributor.authorInitials Ablain, J
dc.contributor.authorInitials Saab, ST
dc.contributor.authorInitials Janin, A
dc.contributor.authorInitials Mahfouz, R
dc.contributor.authorInitials Nasr, R
dc.contributor.authorInitials Kfoury, Y
dc.contributor.authorInitials Nicot, C
dc.contributor.authorInitials Hermine, O
dc.contributor.authorInitials Hall, W
dc.contributor.authorInitials de The, H
dc.contributor.authorInitials Bazarbachi, A
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Bazarbachi, A (reprint author), Amer Univ Beirut, Dept Internal Med, Fac Med, Beirut 11072020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 31
dc.description.citedTotWOSCount 32
dc.description.citedWOSCount 32
dc.format.extentCount 8
dc.identifier.articleNo
dc.identifier.coden JEMEA
dc.identifier.pubmedID 21135137
dc.identifier.scopusID 78650373635
dc.identifier.url
dc.publisher.address 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 USA
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr J. Exp. Med.
dc.relation.ispartOfIssue 13
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Journal of Experimental Medicine
dc.relation.ispartofPubTitleAbbr J. Exp. Med.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 207
dc.source.ID WOS:000285503000002
dc.type.publication Journal
dc.subject.otherAuthKeyword
dc.subject.otherChemCAS arsenic trioxide, 1303-24-8, 1327-53-3, 13464-58-9, 15502-74-6
dc.subject.otherChemCAS proteasome, 140879-24-9
dc.subject.otherChemCAS Arsenicals
dc.subject.otherChemCAS Gene Products, tax
dc.subject.otherChemCAS Interferon-alpha
dc.subject.otherChemCAS Oxides
dc.subject.otherChemCAS arsenic trioxide, 1327-53-3
dc.subject.otherIndex arsenic trioxide
dc.subject.otherIndex proteasome
dc.subject.otherIndex recombinant alpha2a interferon
dc.subject.otherIndex Tax protein
dc.subject.otherIndex animal experiment
dc.subject.otherIndex animal model
dc.subject.otherIndex animal tissue
dc.subject.otherIndex article
dc.subject.otherIndex controlled study
dc.subject.otherIndex disease control
dc.subject.otherIndex engraftment
dc.subject.otherIndex Human T cell leukemia virus 1
dc.subject.otherIndex mouse
dc.subject.otherIndex nonhuman
dc.subject.otherIndex priority journal
dc.subject.otherIndex protein degradation
dc.subject.otherIndex recipient
dc.subject.otherIndex T cell leukemia
dc.subject.otherIndex transgenic mouse
dc.subject.otherIndex tumor growth
dc.subject.otherIndex Animals
dc.subject.otherIndex Antineoplastic Combined Chemotherapy Protocols
dc.subject.otherIndex Apoptosis
dc.subject.otherIndex Arsenicals
dc.subject.otherIndex Cell Cycle
dc.subject.otherIndex Gene Products, tax
dc.subject.otherIndex Human T-lymphotropic virus 1
dc.subject.otherIndex Humans
dc.subject.otherIndex In Situ Nick-End Labeling
dc.subject.otherIndex Interferon-alpha
dc.subject.otherIndex Leukemia-Lymphoma, Adult T-Cell
dc.subject.otherIndex Mice
dc.subject.otherIndex Mice, SCID
dc.subject.otherIndex Mice, Transgenic
dc.subject.otherIndex Organ Size
dc.subject.otherIndex Oxides
dc.subject.otherIndex Reverse Transcriptase Polymerase Chain Reaction
dc.subject.otherIndex Spleen
dc.subject.otherIndex Treatment Outcome
dc.subject.otherKeywordPlus ACUTE PROMYELOCYTIC LEUKEMIA
dc.subject.otherKeywordPlus VIRUS TYPE-I
dc.subject.otherKeywordPlus KAPPA-B ACTIVATION
dc.subject.otherKeywordPlus INTERFERON-ALPHA
dc.subject.otherKeywordPlus ARSENIC TRIOXIDE
dc.subject.otherKeywordPlus TRANSFORMED-CELLS
dc.subject.otherKeywordPlus STEM-CELLS
dc.subject.otherKeywordPlus PML
dc.subject.otherKeywordPlus LEUKEMIA-LYMPHOMA
dc.subject.otherKeywordPlus GENE
dc.subject.otherWOS Immunology
dc.subject.otherWOS Medicine, Research and Experimental


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