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Postprandial glycemic and insulinemic responses to high-carbohydrate vs high-protein meals in obese normoglycemic subjects with varied insulin sensitivity

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dc.contributor.author Hwalla N.
dc.contributor.author Shaker L.
dc.contributor.author Torbay N.
dc.contributor.author Azar S.T.
dc.contributor.author Habbal Z.
dc.contributor.author Adra N.
dc.contributor.editor
dc.date 2005
dc.date.accessioned 2017-10-05T15:59:29Z
dc.date.available 2017-10-05T15:59:29Z
dc.date.issued 2005
dc.identifier 10.1016/j.nutres.2005.05.002
dc.identifier.isbn
dc.identifier.issn 02715317
dc.identifier.uri http://hdl.handle.net/10938/19044
dc.description.abstract The aim of this study was to investigate whether metabolic responses to diet composition differ between obese subjects with varied insulin sensitivity. Fourteen healthy obese normoglycemic male subjects were divided according to their homeostasis model assessment of insulin resistance (HOMA-IR) values: group A, HOMA-IR ≤2.6 (n = 5); group B, 2.6 HOMA-IR 5.0 (n = 4); and group C, HOMA-IR ≥5.0 (n = 5) and given, on 2 separate days, either a high-carbohydrate (HC) (58percent carbohydrates, 12percent protein, and 30percent fat) or an equicaloric high-protein meal (52percent protein, 18percent carbohydrates, and 30percent fat). Glucose, insulin, and lactate were determined before and during 4 hours after ingesting the meals. Results showed that within the HC meal, postprandial glucose and insulin responses and the area under the curve for glucose, insulin, and lactate were significantly higher in group C than group A. Comparing meals, the HC meal resulted in significantly higher area under the curve for glucose and insulin in groups A, B, and C and higher lactic acid in B and C than the corresponding values on the high-protein meal. This study illustrates that diet composition should be an important consideration in dietary management of obesity when accompanied by insulin resistance. © 2005 Elsevier Inc. All rights reserved.
dc.format.extent
dc.format.extent Pages: (535-548)
dc.language English
dc.publisher OXFORD
dc.relation.ispartof Publication Name: Nutrition Research; Publication Year: 2005; Volume: 25; no. 6; Pages: (535-548);
dc.relation.ispartofseries
dc.relation.uri
dc.source Scopus
dc.subject.other
dc.title Postprandial glycemic and insulinemic responses to high-carbohydrate vs high-protein meals in obese normoglycemic subjects with varied insulin sensitivity
dc.type Article
dc.contributor.affiliation Hwalla, N., Department of Nutrition and Food Science, American University of Beirut, P.O. Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Shaker, L., Department of Nutrition and Food Science, American University of Beirut, P.O. Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Torbay, N., Department of Nutrition and Food Science, American University of Beirut, P.O. Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Azar, S.T., Division of Endocrinology, Department of Internal Medicine, American University of Beirut, P.O. Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon
dc.contributor.affiliation Habbal, Z., Department of Pathology and Laboratory Medicine, American University of Beirut, P.O. Box 11-0236, Riad El Solh, Beirut, 1107 2020, Lebanon
dc.contributor.affiliation Adra, N., Department of Nutrition and Food Science, American University of Beirut, P.O. Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon
dc.contributor.authorAddress Hwalla, N.; Department of Nutrition and Food Science, American University of Beirut, P.O. Box 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon; email: nahla@aub.edu.lb
dc.contributor.authorCorporate University: American University of Beirut Medical Center; Faculty: Faculty of Medicine; Department: Pathology and Laboratory Medicine;
dc.contributor.authorDepartment Pathology and Laboratory Medicine
dc.contributor.authorDivision
dc.contributor.authorEmail nahla@aub.edu.lb
dc.contributor.authorFaculty Faculty of Medicine
dc.contributor.authorInitials Hwalla, N
dc.contributor.authorInitials Shaker, L
dc.contributor.authorInitials Torbay, N
dc.contributor.authorInitials Azar, ST
dc.contributor.authorInitials Habbal, Z
dc.contributor.authorInitials Adra, N
dc.contributor.authorOrcidID
dc.contributor.authorReprintAddress Hwalla, N (reprint author), Amer Univ Beirut, Dept Nutr and Food Sci, POB 11-0236, Beirut 2020, Lebanon.
dc.contributor.authorResearcherID
dc.contributor.authorUniversity American University of Beirut Medical Center
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dc.description.citedCount 5
dc.description.citedTotWOSCount 4
dc.description.citedWOSCount 4
dc.format.extentCount 14
dc.identifier.articleNo
dc.identifier.coden NTRSD
dc.identifier.pubmedID
dc.identifier.scopusID 23644455848
dc.identifier.url
dc.publisher.address THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
dc.relation.ispartofConference
dc.relation.ispartofConferenceCode
dc.relation.ispartofConferenceDate
dc.relation.ispartofConferenceHosting
dc.relation.ispartofConferenceLoc
dc.relation.ispartofConferenceSponsor
dc.relation.ispartofConferenceTitle
dc.relation.ispartofFundingAgency
dc.relation.ispartOfISOAbbr Nutr. Res.
dc.relation.ispartOfIssue 6
dc.relation.ispartOfPart
dc.relation.ispartofPubTitle Nutrition Research
dc.relation.ispartofPubTitleAbbr Nutr. Res.
dc.relation.ispartOfSpecialIssue
dc.relation.ispartOfSuppl
dc.relation.ispartOfVolume 25
dc.source.ID WOS:000231781500002
dc.type.publication Journal
dc.subject.otherAuthKeyword Diet composition
dc.subject.otherAuthKeyword Homeostasis model assessment
dc.subject.otherAuthKeyword Insulin resistance
dc.subject.otherAuthKeyword Male
dc.subject.otherAuthKeyword Obese
dc.subject.otherAuthKeyword Postprandial substrate use
dc.subject.otherChemCAS glucose, 50-99-7, 84778-64-3
dc.subject.otherChemCAS insulin, 9004-10-8
dc.subject.otherChemCAS lactic acid, 113-21-3, 50-21-5
dc.subject.otherChemCAS protein, 67254-75-5
dc.subject.otherIndex carbohydrate
dc.subject.otherIndex fat
dc.subject.otherIndex glucose
dc.subject.otherIndex insulin
dc.subject.otherIndex lactic acid
dc.subject.otherIndex protein
dc.subject.otherIndex adult
dc.subject.otherIndex area under the curve
dc.subject.otherIndex article
dc.subject.otherIndex caloric intake
dc.subject.otherIndex carbohydrate diet
dc.subject.otherIndex controlled study
dc.subject.otherIndex diet
dc.subject.otherIndex diet therapy
dc.subject.otherIndex experimental model
dc.subject.otherIndex glucose blood level
dc.subject.otherIndex human
dc.subject.otherIndex human experiment
dc.subject.otherIndex insulin blood level
dc.subject.otherIndex insulin resistance
dc.subject.otherIndex insulin sensitivity
dc.subject.otherIndex insulinemia
dc.subject.otherIndex lactate blood level
dc.subject.otherIndex male
dc.subject.otherIndex meal
dc.subject.otherIndex metabolism
dc.subject.otherIndex normal human
dc.subject.otherIndex obesity
dc.subject.otherIndex postprandial state
dc.subject.otherIndex priority journal
dc.subject.otherIndex protein diet
dc.subject.otherIndex statistical significance
dc.subject.otherKeywordPlus DEPENDENT DIABETES-MELLITUS
dc.subject.otherKeywordPlus HYPERINSULINEMIC SUBJECTS
dc.subject.otherKeywordPlus CARDIOVASCULAR-DISEASE
dc.subject.otherKeywordPlus INTRAVENOUS GLUCOSE
dc.subject.otherKeywordPlus HYPOENERGETIC DIET
dc.subject.otherKeywordPlus RESISTANCE
dc.subject.otherKeywordPlus PLASMA
dc.subject.otherKeywordPlus NIDDM
dc.subject.otherKeywordPlus MECHANISMS
dc.subject.otherKeywordPlus FIBER
dc.subject.otherWOS Nutrition and Dietetics


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